Timothy Su, M.D., Ph.D.

Research Assistant Professor

timothy.su@vanderbilt.edu
Faculty Appointments
Research Assistant Professor of Medicine
Education
Ph.D., Molecular Pathology, Shanghai Medical University, Shanghai, ChinaM.S., Pathology, Anhui University, Anhui, ChinaM.D., Medicine, Shanghai Medical University, Shanghai, China
Office Address
MCN B2120
1161 21st Avenue South
Nashville, TN 37232-8300
Research Description
My research is focused on prognostic and predictive biomarkers in breast and lung cancers, colorectal adenoma recurrence biomarkers, and colorectal cancer prevention. The main goal of these studies is to translate the fast growing information of cancer molecular biology into advances in patient care so that the new sensitive and specific diagnostic, prognostic and predictive tests may be developed.
Research Keywords
Cancer biomarkers
Publications
Su T, Washington MK, Ness RM, Rex DK, Smalley WE, Ulbright TM, Cai Q, Zheng W, Shrubsole MJ. Comparison of biomarker expression between proximal and distal colorectal adenomas: The Tennessee-Indiana Adenoma Recurrence Study. Mol. Carcinog [print-electronic]. 2017 Feb; 56(2): 761-73. PMID: 27479195, DOI: 10.1002/mc.22533, ISSN: 1098-2744.

Davenport JR, Su T, Zhao Z, Coleman HG, Smalley WE, Ness RM, Zheng W, Shrubsole MJ. Modifiable lifestyle factors associated with risk of sessile serrated polyps, conventional adenomas and hyperplastic polyps. Gut [print-electronic]. 2016 Nov 11/15/2016; PMID: 27852795, PII: gutjnl-2016-312893, DOI: 10.1136/gutjnl-2016-312893, ISSN: 1468-3288.

Su Timothy, Cai Hui, Zheng Ying, Qiu Qingchao, Lu Wei, Shu Xiao-Ou, Cai Qiuying. Associations of the Transforming Growth Factor ß/Smad Pathway, Body Mass Index, and Physical Activity With Breast Cancer Outcomes: Results From the Shanghai Breast Cancer Study. Am J Epidemiol. 2016 Sep 9/19/2016; 184(7): 501-9.

Huo Y, Su T, Cai Q, Macara IG. An In Vivo Gain-of-Function Screen Identifies the Williams-Beuren Syndrome Gene GTF2IRD1 as a Mammary Tumor Promoter. Cell Rep [print-electronic]. 2016 Jun 6/7/2016; 15(10): 2089-96. PMID: 27239038, PII: S2211-1247(16)30578-2, DOI: 10.1016/j.celrep.2016.05.011, ISSN: 2211-1247.

Bao PP, Cai H, Peng P, Gu K, Su Y, Shu XO, Zheng Y. Body mass index and weight change in relation to triple-negative breast cancer survival. Cancer Causes Control [print-electronic]. 2016 Feb; 27(2): 229-36. PMID: 26621544, PII: 10.1007/s10552-015-0700-7, DOI: 10.1007/s10552-015-0700-7, ISSN: 1573-7225.

Guo Y, Wu J, Zhao S, Ye F, Su Y, Clark T, Sheng Q, Lehmann B, Shu XO, Cai Q. RNA Sequencing of Formalin-Fixed, Paraffin-Embedded Specimens for Gene Expression Quantification and Data Mining. Int J Genomics [print-electronic]. 2016; 2016: 9837310. PMID: 27774452, PMCID: PMC5059559, DOI: 10.1155/2016/9837310, ISSN: 2314-436X.

Liu Y, Cai Q, Bao PP, Su Y, Cai H, Wu J, Ye F, Guo X, Zheng W, Zheng Y, Shu XO. Tumor tissue microRNA expression in association with triple-negative breast cancer outcomes. Breast Cancer Res. Treat [print-electronic]. 2015 Jul; 152(1): 183-91. PMID: 26062749, PMCID: PMC4484742, DOI: 10.1007/s10549-015-3460-x, ISSN: 1573-7217.

Qiu Q, Su Y, Zheng Y, Cai H, Wu S, Lu W, Zheng W, Shu XO, Cai Q. Increased pSmad2 expression and cytoplasmic predominant presence of TGF-ßRII in breast cancer tissue are associated with poor prognosis: results from the Shanghai Breast Cancer Study. Breast Cancer Res. Treat [print-electronic]. 2015 Jan; 149(2): 467-77. PMID: 25542272, PMCID: PMC4310807, DOI: 10.1007/s10549-014-3251-9, ISSN: 1573-7217.

Baglia ML, Cai Q, Zheng Y, Wu J, Su Y, Ye F, Bao PP, Cai H, Zhao Z, Balko J, Zheng W, Lu W, Shu XO. Dual specificity phosphatase 4 gene expression in association with triple-negative breast cancer outcome. Breast Cancer Res. Treat [print-electronic]. 2014 Nov; 148(1): 211-20. PMID: 25281216, PMCID: PMC4200532, DOI: 10.1007/s10549-014-3127-z, ISSN: 1573-7217.

Bao PP, Shu XO, Zheng Y, Cai H, Ruan ZX, Gu K, Su Y, Gao YT, Zheng W, Lu W. Fruit, vegetable, and animal food intake and breast cancer risk by hormone receptor status. Nutr Cancer [print-electronic]. 2012 Aug; 64(6): 806-19. PMID: 22860889, PMCID: PMC3758811, DOI: 10.1080/01635581.2012.707277, ISSN: 1532-7914.

Bao PP, Shu XO, Gao YT, Zheng Y, Cai H, Deming SL, Ruan ZX, Su Y, Gu K, Lu W, Zheng W. Association of hormone-related characteristics and breast cancer risk by estrogen receptor/progesterone receptor status in the shanghai breast cancer study. Am. J. Epidemiol [print-electronic]. 2011 Sep 9/15/2011; 174(6): 661-71. PMID: 21768404, PMCID: PMC3166707, PII: kwr145, DOI: 10.1093/aje/kwr145, ISSN: 1476-6256.

Su Y, Zheng Y, Zheng W, Gu K, Chen Z, Li G, Cai Q, Lu W, Shu XO. Distinct distribution and prognostic significance of molecular subtypes of breast cancer in Chinese women: a population-based cohort study. BMC Cancer. 2011 Jul 7/12/2011; 11: 292. PMID: 21749714, PMCID: PMC3157458, PII: 1471-2407-11-292, DOI: 10.1186/1471-2407-11-292, ISSN: 1471-2407.

Su Y, Zheng Y, Zheng W, Gu K, Chen Z, Li G, Cai Q, Lu W, Shu XO. Distinct distribution and prognostic significance of molecular subtypes of breast cancer in Chinese women: a population-based cohort study. BMC Cancer. 2011; 11: 292. PMID: 21749714, PMCID: PMC3157458, PII: 1471-2407-11-292, DOI: 10.1186/1471-2407-11-292, ISSN: 1471-2407.

Zhang MZ, Su Y, Yao B, Zheng W, Decaestecker M, Harris RC. Assessing the application of tissue microarray technology to kidney research. J. Histochem. Cytochem [print-electronic]. 2010 May; 58(5): 413-20. PMID: 20086233, PMCID: PMC2857813, PII: jhc.2009.954966, DOI: 10.1369/jhc.2009.954966, ISSN: 1551-5044.

Qu S, Cai Q, Gao YT, Lu W, Cai H, Su Y, Wang SE, Shu XO, Zheng W. ERBB2 genetic polymorphism and breast cancer risk in Chinese women: a population-based case-control study. Breast Cancer Res. Treat [print-electronic]. 2008 Jul; 110(1): 169-76. PMID: 17687647, DOI: 10.1007/s10549-007-9691-8, ISSN: 0167-6806.

Chen X, Qin R, Liu B, Ma Y, Su Y, Yang CS, Glickman JN, Odze RD, Shaheen NJ. Multilayered epithelium in a rat model and human Barrett's esophagus: similar expression patterns of transcription factors and differentiation markers. BMC Gastroenterol. 2008; 8: 1. PMID: 18190713, PMCID: PMC2267197, PII: 1471-230X-8-1, DOI: 10.1186/1471-230X-8-1, ISSN: 1471-230X.

Su Y, Davies S, Davis M, Lu H, Giller R, Krailo M, Cai Q, Robison L, Shu XO. Expression of LINE-1 p40 protein in pediatric malignant germ cell tumors and its association with clinicopathological parameters: A report from the Children?s Oncology Group. Cancer Letter. 2007; 247: 204-12.

Su Y, Shrubsole MJ, Ness RM, Cai Q, Kataoka N, Washington K, Zheng W. Immunohistochemical expressions of Ki-67, cyclin D1, beta-catenin, cyclooxygenase-2, and epidermal growth factor receptor in human colorectal adenoma: a validation study of tissue microarrays. Cancer Epidemiol. Biomarkers Prev. 2006 Sep; 15(9): 1719-26. PMID: 16985035, PII: 15/9/1719, DOI: 10.1158/1055-9965.EPI-05-0946, ISSN: 1055-9965.

Su Y, Shrubsole MJ, Ness RM, Cai Q, Kataoka N, Washington K, Wei Zheng. Immunohistochemical Expressions of Ki-67, Cyclin D1, β-Catenin, COX-2 and EGFR in Human Colorectal Adenoma: A Validation Study of Tissue Microarrays. Cancer Epidemiology, Biomarkers & Prevention. 2006; 15((9)): 1719-26.

Su Y, Chen X, Klein M, Fang M, Wang S, Yang CS, Goyal RK. Phenotype of Columnar Lined Esophagus in rats with esophagogastroduodenal anastomosis: Similarity with human Barrett's esophagus. Lab Invest. 2004; 84((6)): 753-65.

Fang M, Lew E, Klein M, Sebo T, Su Y, Goyal R. DNA abnormalities as marker of risk for progression of Barretts esophagus to adenocarcinoma: image cytometric DNA analysis in formalin-fixed tissues. Am J Gastroenterol. 2004; 99((10)): 1887-94.

Su YH, Lu SL, Gu YH, Zhu TF, Zhu SN. In situ RT-PCR detection of hepatitis C virus genotypes in Chinese patients with hepatocellular carcinoma. J Exp Clin Cancer Res. 2002; 21((4)): 591-8.

Su YH, Zhu SN, Lu SL, Gu YH. HCV genotypes expression in hepatocellular carcinoma by reverse transcription in situ polymerase chain reaction. World Chinese J Digestol. 2000; 8((8)): 874-8.

Su YH, Zhu SN, Lu SL, Zhang WH. Detection of hepatitis C virus genotypes in hepatocellular carcinoma using RT-nested PCR. J Shanghai Med Univ. 2000; 27((1)): 16-9.

Rong Qin, Yinghao Su, Hongyang Wu, et al. In situ electronic microscopic labelling of ras and APC oncogenes in gastric cancer. J Clin Exp Pathol. 2000; 14((5)): 437-8.

Zhang WH, Zhu SN, Lu SL, Cong WM, Su YH, Wu MC. In situ detection of hepatitis C virus in hepatocellular carcinoma. WORLD CHINESE J DIGESTOLOGY. 2000; 8((8)): 90.

Lu JP, Zhu SN, Song BP, Mao JQ, Lu SL, Su YH, Zhang WH. In situ telomeric repeat amplification protocol (TRAP) detecting telomerase activity in human hepatocellular carcinoma. Acta Histochemica Et Cytochemica. 1999; 32((6)): 477-80.

Su YH, Yang F, Wang DB, Liu M, Zhu SN. Malignant rhabdoid tumor of the kidney in the adult: A case report and review of the literature. Chinese J Histochem Cytochem. 1999; 8((4)): 466-9.

Su YH, Zhu SN, Lu SL. The significance of HCV genotyping. Foreign Medical Science ( Part of Microbiology )[Chinese]. 1999; 22((1)): 8-11.

Yang GL, Dong YM, Du WD, Su YH, Zhang H, Wu JF, Wang DB, Xu AL. Ultrastructural enzyme cytochemical study on signet-ring cells of gastric cancer. XinXiaoHuaBingXue Zazhi. 1997; 5((3)): 146-7.

Su YH, Yang GL, Dong YM, Zhang H, Wu JF, Wang DB. An enzymocytochemical study of alkaline phosphatase isoenzymes in gastric cancer: light and electron microscopic observations. Chinese J Cancer Research. 1995; 7((2)): 141-7.

Yan SQ, Feng LY, Su YH. Experimental study on the protective effect of Weitongling on gastric mucosa. J Traditional Chinese Medicine. 1995; 36((1)): 44-6.

Yan SQ, Feng LY, Su YH, Chen XT, Xu JL. Protective effect of "wei tong ling" on gastric mucosa and influence on quality of gastric ulcer healing. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1995; 15((10)): 612-4.

Su YH, Yang GL, Dong YM. Light and electron microscopic histochemical studies of alkaline phosphatase (ALP) isoenzymes in gastric cancer. Zhonghua Bing Li Xue Za Zhi. 1994; 23((6)): 338-40.

Su YH. Perspectives on the classification of gastritis. J Clin Exp Pathol. 1994; 10((1)): 86-9.

Su YH, Feng LY, Yan SQ, Wang DB. Experimental study on the regenerated mucosa of healed gastric ulcer. Journal of Anhui Medical University. Journal of Anhui Medical University. 1994; 29((2)): 101-4.

Su YH, Yang GL, Dong YM, Wang DB. Electron microscopy enzymocytochemistry of alkaline phosphotase isoenzymes and its application in the study of gastric cancer. Journal of Anhui Medical University. 1994; 29((2)): 147.

Su YH, Wang DB. Two cases of primary myocardiopathy. Journal of Anhui Medical University. 1994; 29((2)): 107.

Jiang XP, Zhao XY, Zhang ZY, Su YH. The infection of HBV and hepatocellular carcinoma: a clinicopathologic analysis of 70 cases. Journal of Anhui Medical University. 1993; 28((2)): 153-5.

Su YH, Zhang HF, Wei YH, Wang XH. Bronchial adenoma --- mixed type of oncocytic and mucous adenoma. J Clin Exp Pathol. 1993; 9((3)): 26.

Su YH, Yang GL, Dong YM, Wang DB. The histochemical staining method of alkaline phosphotase isoenzymes and its application in the study of gastric cancer. J Clin Exp Pathol. 1992; 8((4)): 312.