James A. S. Muldowney, M.D.

Assistant Professor

james.muldowney.iii@vanderbilt.edu
Faculty Appointments
Assistant Professor of Medicine
Education
M.D., Medicine , Vanderbilt University, Nashville, TennesseeA.B., Chemistry, Princeton University, Princeton, New Jersey
Office Address
383 Preston Research Building
Division of Cardiovascular Medicine
2220 Pierce Avenue
Nashville, TN 37232-6300
Publications
Schoenhard JA, Muldowney JA, Emens JS, Lewy AJ, Vaughan DE. Plasminogen activator inhibitor-1 has a circadian rhythm in blind individuals [letter]. Thromb. Haemost. 2007 Aug; 98(2): 479-81. PMID: 17721638, PII: 07080479, ISSN: 0340-6245.

Muldowney JA, Painter CA, Sanders-Bush E, Brown NJ, Vaughan DE. Acute tissue-type plasminogen activator release in human microvascular endothelial cells: the roles of Galphaq, PLC-beta, IP3 and 5,6-epoxyeicosatrienoic acid. Thromb. Haemost. 2007 Feb; 97(2): 263-71. PMID: 17264956, PII: 07020263, ISSN: 0340-6245.

Muldowney JA, Stringham JR, Levy SE, Gleaves LA, Eren M, Piana RN, Vaughan DE. Antiproliferative agents alter vascular plasminogen activator inhibitor-1 expression: a potential prothrombotic mechanism of drug-eluting stents. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2007 Feb; 27(2): 400-6. PMID: 17158352, PII: 01.ATV.0000254677.12861.b8, DOI: 10.1161/01.ATV.0000254677.12861.b8, ISSN: 1524-4636.

Brown NJ, Muldowney JA, Vaughan DE. Endogenous NO regulates plasminogen activator inhibitor-1 during angiotensin-converting enzyme inhibition. Hypertension [print-electronic]. 2006 Mar; 47(3): 441-8. PMID: 16432054, PII: 01.HYP.0000202478.79587.1a, DOI: 10.1161/01.HYP.0000202478.79587.1a, ISSN: 1524-4563.

McLaughlin JN, Mazzoni MR, Cleator JH, Earls L, Perdigoto AL, Brooks JD, Muldowney JA, Vaughan DE, Hamm HE. Thrombin modulates the expression of a set of genes including thrombospondin-1 in human microvascular endothelial cells. J. Biol. Chem [print-electronic]. 2005 Jun 6/10/2005; 280(23): 22172-80. PMID: 15817447, PII: M500721200, DOI: 10.1074/jbc.M500721200, ISSN: 0021-9258.

Shaklee JF, Talbot TR, Muldowney JA, Vaughan DE, Butler J, House F, Crowe JE, Smith LH, Edwards KM. Smallpox vaccination does not elevate systemic levels of prothrombotic proteins associated with ischemic cardiac events. J. Infect. Dis [print-electronic]. 2005 Mar 3/1/2005; 191(5): 724-30. PMID: 15688286, PII: JID33581, DOI: 10.1086/427831, ISSN: 0022-1899.

Muldowney JA, Davis SN, Vaughan DE, Brown NJ. NO synthase inhibition increases aldosterone in humans. Hypertension [print-electronic]. 2004 Nov; 44(5): 739-45. PMID: 15381675, PII: 01.HYP.0000143852.48258.f1, DOI: 10.1161/01.HYP.0000143852.48258.f1, ISSN: 1524-4563.

Levy SE, Muldowney JA. Microarray analysis of neointima: flowing toward a clear future [editorial]. Arterioscler. Thromb. Vasc. Biol. 2002 Dec 12/1/2002; 22(12): 1946-7. PMID: 12482816, ISSN: 1524-4636.

Muldowney JA, Vaughan DE. Tissue-type plasminogen activator release: new frontiers in endothelial function [editorial]. J. Am. Coll. Cardiol. 2002 Sep 9/4/2002; 40(5): 967-9. PMID: 12225724, PII: S0735109702020600, ISSN: 0735-1097.

Spickard A, Ryan SP, Muldowney JA, Farnham L. Outpatient morning report: a new conference for internal medicine residency programs. J Gen Intern Med. 2000 Nov; 15(11): 822-4. PMID: 11119176, PMCID: PMC1495611, PII: jgi91109, ISSN: 0884-8734.

Gainer JV, Hunley TE, Kon V, Nadeau JH, Muldowney JA, Brown NJ. Angiotensin II type I receptor polymorphism in African Americans lower frequency of the C1166 variant. Biochem. Mol. Biol. Int. 1997 Sep; 43(1): 227-31. PMID: 9315301, ISSN: 1039-9712.