James A. S. Muldowney, M.D.

Assistant Professor

Faculty Appointments
Assistant Professor of Medicine
M.D., Medicine , Vanderbilt University, Nashville, TennesseeA.B., Chemistry, Princeton University, Princeton, New Jersey
Office Address
383 Preston Research Building
Division of Cardiovascular Medicine
2220 Pierce Avenue
Nashville, TN 37232-6300
Gregory JM, Muldowney JA, Engelhardt BG, Tyree R, Marks-Shulman P, Silver HJ, Donahue EP, Edgerton DS, Winnick JJ. Aerobic exercise training improves hepatic and muscle insulin sensitivity, but reduces splanchnic glucose uptake in obese humans with type 2 diabetes. Nutr Diabetes. 2019 Sep 9/2/2019; 9(1): 25. PMID: 31474750, PMCID: PMC6717736, PII: 10.1038/s41387-019-0090-0, DOI: 10.1038/s41387-019-0090-0, ISSN: 2044-4052.

McDonell KE, Preheim BA, Diedrich A, Muldowney JAS, Peltier AC, Robertson D, Biaggioni I, Shibao CA. Initiation of droxidopa during hospital admission for management of refractory neurogenic orthostatic hypotension in severely ill patients. J Clin Hypertens (Greenwich) [print-electronic]. 2019 Sep; 21(9): 1308-14. PMID: 31368635, DOI: 10.1111/jch.13619, ISSN: 1751-7176.

Lenihan DJ, Anderson SA, Lenneman CG, Brittain E, Muldowney JAS, Mendes L, Zhao PZ, Iaci J, Frohwein S, Zolty R, Eisen A, Sawyer DB, Caggiano AO. A Phase I, Single Ascending Dose Study of Cimaglermin Alfa (Neuregulin 1ß3) in Patients With Systolic Dysfunction and Heart Failure. JACC Basic Transl Sci. 2016 Dec; 1(7): 576-86. PMID: 30167542, PMCID: PMC6113538, PII: S2452-302X(16)30161-9, DOI: 10.1016/j.jacbts.2016.09.005, ISSN: 2452-302X.

Silver HJ, Kang H, Keil CD, Muldowney JA, Kocalis H, Fazio S, Vaughan DE, Niswender KD. Consuming a balanced high fat diet for 16 weeks improves body composition, inflammation and vascular function parameters in obese premenopausal women. Metab. Clin. Exp [print-electronic]. 2014 Apr; 63(4): 562-73. PMID: 24559846, PMCID: PMC4306330, PII: S0026-0495(14)00017-1, DOI: 10.1016/j.metabol.2014.01.004, ISSN: 1532-8600.

Bagai K, Muldowney JA, Song Y, Wang L, Bagai J, Artibee KJ, Vaughan DE, Malow BA. Circadian variability of fibrinolytic markers and endothelial function in patients with obstructive sleep apnea. Sleep. 2014 Feb 2/1/2014; 37(2): 359-67. PMID: 24497664, PMCID: PMC3900618, DOI: 10.5665/sleep.3414, ISSN: 1550-9109.

Muldowney JA, Chen Q, Blakemore DL, Vaughan DE. Pentoxifylline lowers plasminogen activator inhibitor 1 levels in obese individuals: a pilot study. Angiology [print-electronic]. 2012 Aug; 63(6): 429-34. PMID: 22345157, PII: 0003319712436755, DOI: 10.1177/0003319712436755, ISSN: 1940-1574.

Pecot CV, Fuller M, Muldowney JA, Misra S. A very late stent thrombosis in a patient with diabetes: a call for lifelong dual anti-platelet therapy. Tenn Med. 2009 May; 102(5): 37-9. PMID: 19456028, ISSN: 1088-6222.

Muldowney JA, Schoenhard JA, Benge CD. The clinical pharmacology of eplerenone. Expert Opin Drug Metab Toxicol. 2009 Apr; 5(4): 425-32. PMID: 19379127, DOI: 10.1517/17425250902837973, ISSN: 1744-7607.

Schoenhard JA, Muldowney JA, Emens JS, Lewy AJ, Vaughan DE. Plasminogen activator inhibitor-1 has a circadian rhythm in blind individuals [letter]. Thromb. Haemost. 2007 Aug; 98(2): 479-81. PMID: 17721638, PII: 07080479, ISSN: 0340-6245.

Muldowney JA, Painter CA, Sanders-Bush E, Brown NJ, Vaughan DE. Acute tissue-type plasminogen activator release in human microvascular endothelial cells: the roles of Galphaq, PLC-beta, IP3 and 5,6-epoxyeicosatrienoic acid. Thromb. Haemost. 2007 Feb; 97(2): 263-71. PMID: 17264956, PII: 07020263, ISSN: 0340-6245.

Muldowney JA, Stringham JR, Levy SE, Gleaves LA, Eren M, Piana RN, Vaughan DE. Antiproliferative agents alter vascular plasminogen activator inhibitor-1 expression: a potential prothrombotic mechanism of drug-eluting stents. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2007 Feb; 27(2): 400-6. PMID: 17158352, PII: 01.ATV.0000254677.12861.b8, DOI: 10.1161/01.ATV.0000254677.12861.b8, ISSN: 1524-4636.

Brown NJ, Muldowney JA, Vaughan DE. Endogenous NO regulates plasminogen activator inhibitor-1 during angiotensin-converting enzyme inhibition. Hypertension [print-electronic]. 2006 Mar; 47(3): 441-8. PMID: 16432054, PII: 01.HYP.0000202478.79587.1a, DOI: 10.1161/01.HYP.0000202478.79587.1a, ISSN: 1524-4563.

McLaughlin JN, Mazzoni MR, Cleator JH, Earls L, Perdigoto AL, Brooks JD, Muldowney JA, Vaughan DE, Hamm HE. Thrombin modulates the expression of a set of genes including thrombospondin-1 in human microvascular endothelial cells. J. Biol. Chem [print-electronic]. 2005 Jun 6/10/2005; 280(23): 22172-80. PMID: 15817447, PII: M500721200, DOI: 10.1074/jbc.M500721200, ISSN: 0021-9258.

Shaklee JF, Talbot TR, Muldowney JA, Vaughan DE, Butler J, House F, Crowe JE, Smith LH, Edwards KM. Smallpox vaccination does not elevate systemic levels of prothrombotic proteins associated with ischemic cardiac events. J. Infect. Dis [print-electronic]. 2005 Mar 3/1/2005; 191(5): 724-30. PMID: 15688286, PII: JID33581, DOI: 10.1086/427831, ISSN: 0022-1899.

Muldowney JA, Davis SN, Vaughan DE, Brown NJ. NO synthase inhibition increases aldosterone in humans. Hypertension [print-electronic]. 2004 Nov; 44(5): 739-45. PMID: 15381675, PII: 01.HYP.0000143852.48258.f1, DOI: 10.1161/01.HYP.0000143852.48258.f1, ISSN: 1524-4563.

Levy SE, Muldowney JA. Microarray analysis of neointima: flowing toward a clear future [editorial]. Arterioscler. Thromb. Vasc. Biol. 2002 Dec 12/1/2002; 22(12): 1946-7. PMID: 12482816, ISSN: 1524-4636.

Muldowney JA, Vaughan DE. Tissue-type plasminogen activator release: new frontiers in endothelial function [editorial]. J. Am. Coll. Cardiol. 2002 Sep 9/4/2002; 40(5): 967-9. PMID: 12225724, PII: S0735109702020600, ISSN: 0735-1097.

Spickard A, Ryan SP, Muldowney JA, Farnham L. Outpatient morning report: a new conference for internal medicine residency programs. J Gen Intern Med. 2000 Nov; 15(11): 822-4. PMID: 11119176, PMCID: PMC1495611, PII: jgi91109, ISSN: 0884-8734.

Gainer JV, Hunley TE, Kon V, Nadeau JH, Muldowney JA, Brown NJ. Angiotensin II type I receptor polymorphism in African Americans lower frequency of the C1166 variant. Biochem. Mol. Biol. Int. 1997 Sep; 43(1): 227-31. PMID: 9315301, ISSN: 1039-9712.