Rachel Kuchtey, M.D., Ph.D.

Associate Professor

rachel.w.kuchtey@vanderbilt.edu

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Faculty Appointments
Associate Professor of Ophthalmology and Visual Sciences Associate Professor of Molecular Physiology & Biophysics
Education
Ph.D., Cornell University, Ithaca, New YorkM.D., West China University of Medical Sciences, Chengdu, China
Office Address
Vanderbilt Eye Institute
2133 Pierce Ave.
Nashville, TN 37232
Research Description
Glaucoma is a major public global health problem accounting for vision loss and blindness in millions of people world-wide. Although glaucoma can be treated by lowering intraocular pressure with medications, laser treatments or surgery, most patients are unaware of decreased vision until advanced stages of the disease. Improved treatment for glaucoma patients requires better understanding of the disease mechanisms and development of early detection strategies. Our broad long term goals are to understand the disease pathophysiology and to identify genetic markers for early detection and better treatment of glaucoma.
Research Keywords
glaucoma
Publications
Lalezary M, Shah RJ, Reddy RK, Kammer JA, Kuchtey RW, Joos KM, Cherney EF, Recchia FM, Kim SJ. Prospective Retinal and Optic Nerve Vitrectomy Evaluation (PROVE) study: twelve-month findings. Ophthalmology [print-electronic]. 2014 Oct; 121(10): 1983-9. PMID: 24907063, PII: S0161-6420(14)00344-3, DOI: 10.1016/j.ophtha.2014.04.008, ISSN: 1549-4713.

Kuchtey J, Kunkel J, Burgess LG, Parks MB, Brantley MA, Kuchtey RW. Elevated transforming growth factor ß1 in plasma of primary open-angle glaucoma patients. Invest. Ophthalmol. Vis. Sci. 2014 Aug; 55(8): 5291-7. PMID: 25061114, PMCID: PMC4142830, PII: iovs.14-14578, DOI: 10.1167/iovs.14-14578, ISSN: 1552-5783.

Kuchtey J, Kuchtey RW. The microfibril hypothesis of glaucoma: implications for treatment of elevated intraocular pressure. J Ocul Pharmacol Ther [print-electronic]. 2014 Mar; 30(2-3): 170-80. PMID: 24521159, PMCID: PMC3991966, DOI: 10.1089/jop.2013.0184, ISSN: 1557-7732.

Rapoport Y, Benegas N, Kuchtey RW, Joos KM. Acute myopia and angle closure glaucoma from topiramate in a seven-year-old: a case report and review of the literature. BMC Pediatr. 2014; 14: 96. PMID: 24712825, PMCID: PMC3991910, PII: 1471-2431-14-96, DOI: 10.1186/1471-2431-14-96, ISSN: 1471-2431.

Kuchtey J, Chowdhury UR, Uptegraft CC, Fautsch MP, Kuchtey RW. A de novo MYOC mutation detected in juvenile open angle glaucoma associated with reduced myocilin protein in aqueous humor. Eur J Med Genet [print-electronic]. 2013 Jun; 56(6): 292-6. PMID: 23517641, PMCID: PMC3672363, PII: S1769-7212(13)00062-1, DOI: 10.1016/j.ejmg.2013.03.002, ISSN: 1878-0849.

Kuchtey J, Chang TC, Panagis L, Kuchtey RW. Marfan syndrome caused by a novel FBN1 mutation with associated pigmentary glaucoma. Am. J. Med. Genet. A [print-electronic]. 2013 Apr; 161A(4): 880-3. PMID: 23444230, PMCID: PMC3638319, DOI: 10.1002/ajmg.a.35838, ISSN: 1552-4833.

Kuchtey J, Kunkel J, Esson D, Sapienza JS, Ward DA, Plummer CE, Gelatt KN, Kuchtey RW. Screening ADAMTS10 in dog populations supports Gly661Arg as the glaucoma-causing variant in beagles. Invest. Ophthalmol. Vis. Sci. 2013 Mar; 54(3): 1881-6. PMID: 23422823, PMCID: PMC3604907, PII: iovs.12-10796, DOI: 10.1167/iovs.12-10796, ISSN: 1552-5783.

Reddy RK, Lalezary M, Kim SJ, Kammer JA, Kuchtey RW, Cherney EF, Recchia FM, Joos KM, Agarwal A, Law JC. Prospective Retinal and Optic Nerve Vitrectomy Evaluation (PROVE) study: findings at 3 months. Clin Ophthalmol [print-electronic]. 2013; 7: 1761-9. PMID: 24039396, PMCID: PMC3770890, PII: opth-7-1761, DOI: 10.2147/OPTH.S49375, ISSN: 1177-5467.

Thinda S, Melson MR, Kuchtey RW. Worsening angle closure glaucoma and choroidal detachments subsequent to closure of a carotid cavernous fistula. BMC Ophthalmol. 2012; 12: 28. PMID: 22839357, PMCID: PMC3412712, PII: 1471-2415-12-28, DOI: 10.1186/1471-2415-12-28, ISSN: 1471-2415.

Kuchtey J, Olson LM, Rinkoski T, Mackay EO, Iverson TM, Gelatt KN, Haines JL, Kuchtey RW. Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open angle glaucoma. PLoS Genet [print-electronic]. 2011 Feb; 7(2): e1001306. PMID: 21379321, PMCID: PMC3040645, DOI: 10.1371/journal.pgen.1001306, ISSN: 1553-7404.

Kuchtey J, Rezaei KA, Jaru-Ampornpan P, Sternberg P, Kuchtey RW. Multiplex cytokine analysis reveals elevated concentration of interleukin-8 in glaucomatous aqueous humor. Invest. Ophthalmol. Vis. Sci [print-electronic]. 2010 Dec; 51(12): 6441-7. PMID: 20592224, PMCID: PMC3055764, PII: iovs.10-5216, DOI: 10.1167/iovs.10-5216, ISSN: 1552-5783.

Jaru-Ampornpan P, Kuchtey J, Dev VG, Kuchtey R. Primary congenital glaucoma associated with Patau syndrome with long survival. J Pediatr Ophthalmol Strabismus. 2010; 47 Online: e1-4. PMID: 21080618, DOI: 10.3928/01913913-20100618-09, ISSN: 1938-2405.

Kuchtey J, Källberg ME, Gelatt KN, Rinkoski T, Komàromy AM, Kuchtey RW. Angiopoietin-like 7 secretion is induced by glaucoma stimuli and its concentration is elevated in glaucomatous aqueous humor. Invest. Ophthalmol. Vis. Sci [print-electronic]. 2008 Aug; 49(8): 3438-48. PMID: 18421092, PMCID: PMC2814173, PII: iovs.07-1347, DOI: 10.1167/iovs.07-1347, ISSN: 1552-5783.

Kukekova AV, Nelson J, Kuchtey RW, Lowe JK, Johnson JL, Ostrander EA, Aguirre GD, Acland GM. Linkage mapping of canine rod cone dysplasia type 2 (rcd2) to CFA7, the canine orthologue of human 1q32. Invest. Ophthalmol. Vis. Sci. 2006 Mar; 47(3): 1210-5. PMID: 16505060, PII: 47/3/1210, DOI: 10.1167/iovs.05-0861, ISSN: 0146-0404.

Kuchtey RW, Lowder CY, Smith SD. Glaucoma in patients with ocular inflammatory disease. Ophthalmol Clin North Am. 2005 Sep; 18(3): 421-30, vii. PMID: 16054999, PII: S0896-1549(05)00046-5, DOI: 10.1016/j.ohc.2005.05.004, ISSN: 0896-1549.

Bhattacharya SK, Annangudi SP, Salomon RG, Kuchtey RW, Peachey NS, Crabb JW. Cochlin deposits in the trabecular meshwork of the glaucomatous DBA/2J mouse [letter]. Exp. Eye Res. 2005 May; 80(5): 741-4. PMID: 15862180, PII: S0014-4835(05)00032-1, DOI: 10.1016/j.exer.2005.01.028, ISSN: 0014-4835.

Bhattacharya SK, Rockwood EJ, Smith SD, Bonilha VL, Crabb JS, Kuchtey RW, Robertson NG, Peachey NS, Morton CC, Crabb JW. Proteomics reveal Cochlin deposits associated with glaucomatous trabecular meshwork. J. Biol. Chem [print-electronic]. 2005 Feb 2/18/2005; 280(7): 6080-4. PMID: 15579465, PMCID: PMC1483217, PII: M411233200, DOI: 10.1074/jbc.M411233200, ISSN: 0021-9258.

Perry JD, Aguilar CL, Kuchtey R. Modified vertical mattress technique for eyelid margin repair. Dermatol Surg. 2004 Dec; 30(12 Pt 2): 1580-2. PMID: 15606846, PII: DSU30570, DOI: 10.1111/j.1524-4725.2004.30570.x, ISSN: 1076-0512.

Kuchtey R, Perry JD, Lerner L. Buccal fat pad hemorrhage after retrobulbar injection. Am. J. Ophthalmol. 2004 Jun; 137(6): 1131-2. PMID: 15183805, PII: S0002939403015368, DOI: 10.1016/j.ajo.2003.12.015, ISSN: 0002-9394.

Kuchtey RW, Kosmorsky GS, Martin D, Lee MS. Uveitis associated with West Nile virus infection. Arch. Ophthalmol. 2003 Nov; 121(11): 1648-9. PMID: 14609930, PII: 121/11/1648, DOI: 10.1001/archopht.121.11.1648, ISSN: 0003-9950.

Wang W, Acland GM, Ray K, Aguirre GD. Evaluation of cGMP-phosphodiesterase (PDE) subunits for causal association with rod-cone dysplasia 2 (rcd2), a canine model of abnormal retinal cGMP metabolism. Exp. Eye Res. 1999 Oct; 69(4): 445-53. PMID: 10504278, PII: S0014-4835(99)90720-0, DOI: 10.1006/exer.1999.0720, ISSN: 0014-4835.

Wang W, Zhang Q, Acland GM, Mellersh C, Ostrander EA, Ray K, Aguirre GD. Molecular characterization and mapping of canine cGMP-phosphodiesterase delta subunit (PDE6D). Gene. 1999 Aug 8/20/1999; 236(2): 325-32. PMID: 10452952, PII: S0378111999002462, ISSN: 0378-1119.

Ray K, Wang W, Czarnecki J, Zhang Q, Acland GM, Aguirre GD. Strategies for identification of mutations causing hereditary retinal diseases in dogs: evaluation of opsin as a candidate gene. J. Hered. 1999 Jan; 90(1): 133-7. PMID: 9987920, ISSN: 0022-1503.

Wang W, Aguirre GD, Ray K. PCR/RFLP marker in the canine transducin-gamma gene (GNGT1). Anim. Genet. 1997 Aug; 28(4): 319-20. PMID: 9345745, ISSN: 0268-9146.

Wang W, Acland GM, Aguirre GD, Ray K. Cloning and characterization of the cDNA and gene encoding the gamma-subunit of cGMP-phosphodiesterase in canine retinal rod photoreceptor cells. Gene. 1996 Nov 11/28/1996; 181(1-2): 1-5. PMID: 8973300, ISSN: 0378-1119.

Wang W, Acland GM, Aguirre GD, Ray K. Cloning and characterization of the cDNA encoding the alpha-subunit of cGMP-phosphodiesterase in canine retinal rod photoreceptor cells. Mol. Vis. 1996 May 5/9/1996; 2: 3. PMID: 9233984, ISSN: 1090-0535.

Wang W, Zheng W, Pang G, Wang Z, Sun Y, Jin Y, Li W. Excimer laser photorefractive keratectomy for myopia in China. A report of 750 eyes with a 6-month follow-up. Chin. Med. J. 1995 Aug; 108(8): 601-5. PMID: 7587492, ISSN: 0366-6999.

Wang W, Li B, Wang Z, Li W. An empirical model of hyperopic shift with corticosteroid modulation and refractive power prediction after photorefractive keratectomy. J Refract Surg. 1995 May; 11(3 Suppl): S314-8. PMID: 7553114, ISSN: 1081-597X.

Wang Z, Pang G, Zheng W, Wang W, Sun Y, Jin Y, Li W. An analysis on follow-up results of photoreactive keratectomy for treatment of myopia. Zhonghua Yan Ke Za Zhi. 1995 May; 31(3): 172-80. PMID: 7555398, ISSN: 0412-4081.

Pang G, Wang Z, Zheng W, Wang W, Sun Y. [Glucocorticoid-induced ocular hypertension after photorefractive keratectomy]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1995 Apr; 17(2): 115-9. PMID: 7656390, ISSN: 1000-503X.

Zheng W, Wang W, Pang G, Wang Z, Li W. [Photorefractive keratectomy for myopia: 6 month results]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1995 Feb; 17(1): 20-4. PMID: 7781123, ISSN: 1000-503X.

Available Postdoctoral Position Details
Posted: 5/11/2015
A postdoctoral position is available at the Vanderbilt Eye Institute in Nashville, TN, in the laboratory of Dr. Rachel Kuchtey. This position involves investigation of a novel mouse model of low tension glaucoma with reduced aqueous humor outflow facility but not elevated intraocular pressure. One aspect of the project focuses on aqueous humor outflow physiology using a state of the art perfusion system. The other aspect focuses on degeneration of retinal ganglion cell bodies and axons by techniques such as anteriograde and retrograde labeling. The project has a translational component investigating protective effects of a drug used to treat systemic hypertension. Vanderbilt Eye institute offers a highly collaborative and well-equipped environment. The ideal candidate would have training in eye research and possess excellent communication skills, though training could be provided to highly motivated candidates. Recent PhDs or advanced postdocs are welcome to apply. For further information, please email rachel.kuchtey@vanderbilt.edu.