Ginger Lohr Milne, Ph.D.

Research Associate Professor

ginger.milne@vanderbilt.edu

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Faculty Appointments
Research Associate Professor of Medicine Research Associate Professor of Pharmacology
Education
Ph.D., Chemistry , Vanderbilt University, Nashville, TennesseeB.S., Wake Forest University, Winston-Salem, North Carolina
Office Address
502-A RRB
23rd Avenue South at Pierce Avenue
Nashville, TN 37232-6602
Publications
Anderson C, Milne GL, Sandler DP, Nichols HB. Oxidative stress in relation to diet and physical activity among premenopausal women. Br. J. Nutr [print-electronic]. 2016 Oct; 116(8): 1416-24. PMID: 27725001, PII: S0007114516003226, DOI: 10.1017/S0007114516003226, ISSN: 1475-2662.

Matthews MA, Aschner JL, Stark AR, Moore PE, Slaughter JC, Steele S, Beller A, Milne GL, Settles O, Chorna O, Maitre NL. Increasing F2-isoprostanes in the first month after birth predicts poor respiratory and neurodevelopmental outcomes in very preterm infants. J Perinatol [print-electronic]. 2016 Sep; 36(9): 779-83. PMID: 27171764, PII: jp201674, DOI: 10.1038/jp.2016.74, ISSN: 1476-5543.

Murff HJ, Tindle HA, Shrubsole MJ, Cai Q, Smalley W, Milne GL, Swift LL, Ness RM, Zheng W. Smoking and red blood cell phospholipid membrane fatty acids. Prostaglandins Leukot. Essent. Fatty Acids [print-electronic]. 2016 Sep; 112: 24-31. PMID: 27637337, PMCID: PMC5028119, PII: S0952-3278(16)30119-3, DOI: 10.1016/j.plefa.2016.08.004, ISSN: 1532-2823.

Boutaud O, Sosa IR, Amin T, Oram D, Adler D, Hwang HS, Crews B, Milne GL, Harris BK, Hoeksema MD, Knowllmann BC, Lammers PE, Marnett LJ, Massion PP, Oates JA. Inhibition of the biosynthesis of prostaglandin E2 by low dose aspirin: implications for adenocarcinoma metastasis. Cancer Prev Res (Phila) [print-electronic]. 2016 Aug 8/23/2016; PMID: 27554763, PII: 1940-6207.CAPR-16-0094, DOI: 10.1158/1940-6207.CAPR-16-0094, ISSN: 1940-6215.

Kekatpure VD, Bs N, Wang H, Zhou XK, Kandasamy C, Sunny SP, Suresh A, Milne GL, Kuriakose MA, Dannenberg AJ. Elevated Levels of Urinary PGE-M Are Found in Tobacco Users and Indicate a Poor Prognosis for Oral Squamous Cell Carcinoma Patients. Cancer Prev Res (Phila) [print-electronic]. 2016 Jun; 9(6): 428-36. PMID: 27045033, PII: 1940-6207.CAPR-15-0412, DOI: 10.1158/1940-6207.CAPR-15-0412, ISSN: 1940-6215.

Navarro SL, Kantor ED, Song X, Milne GL, Lampe JW, Kratz M, White E. Factors Associated with Multiple Biomarkers of Systemic Inflammation. Cancer Epidemiol. Biomarkers Prev [print-electronic]. 2016 Mar; 25(3): 521-31. PMID: 26908433, PMCID: PMC4779684, PII: 1055-9965.EPI-15-0956, DOI: 10.1158/1055-9965.EPI-15-0956, ISSN: 1538-7755.

Toth P, Tarantini S, Ashpole NM, Tucsek Z, Milne GL, Valcarcel-Ares NM, Menyhart A, Farkas E, Sonntag WE, Csiszar A, Ungvari Z. IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging. Aging Cell [print-electronic]. 2015 Dec; 14(6): 1034-44. PMID: 26172407, PMCID: PMC4693458, DOI: 10.1111/acel.12372, ISSN: 1474-9726.

Joe AK, Schnoll-Sussman F, Bresalier RS, Abrams JA, Hibshoosh H, Cheung K, Friedman RA, Yang CS, Milne GL, Liu DD, Lee JJ, Abdul K, Bigg M, Foreman J, Su T, Wang X, Ahmed A, Neugut AI, Akpa E, Lippman SM, Perloff M, Brown PH, Lightdale CJ. Phase Ib Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Patients with Barrett's Esophagus. Cancer Prev Res (Phila) [print-electronic]. 2015 Dec; 8(12): 1131-7. PMID: 26471236, PMCID: PMC4670789, PII: 1940-6207.CAPR-14-0274-T, DOI: 10.1158/1940-6207.CAPR-14-0274-T, ISSN: 1940-6215.

Fedirko V, Bradshaw PT, Figueiredo JC, Sandler RS, Barry EL, Ahnen DJ, Milne GL, Bresalier RS, Baron JA. Urinary metabolites of prostanoids and risk of recurrent colorectal adenomas in the Aspirin/Folate Polyp Prevention Study (AFPPS). Cancer Prev Res (Phila) [print-electronic]. 2015 Nov; 8(11): 1061-8. PMID: 26304466, PMCID: PMC4633350, PII: 1940-6207.CAPR-15-0212, DOI: 10.1158/1940-6207.CAPR-15-0212, ISSN: 1940-6215.

Kirkby NS, Reed DM, Edin ML, Rauzi F, Mataragka S, Vojnovic I, Bishop-Bailey D, Milne GL, Longhurst H, Zeldin DC, Mitchell JA, Warner TD. Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation. FASEB J [print-electronic]. 2015 Nov; 29(11): 4568-78. PMID: 26183771, PMCID: PMC4608906, PII: fj.15-275065, DOI: 10.1096/fj.15-275065, ISSN: 1530-6860.

Frederiksen BN, Seifert J, Kroehl M, Lamb MM, Milne GL, Rewers M, Norris JM. Timing of solid food introduction is associated with urinary F2-isoprostane concentrations in childhood. Pediatr. Res [print-electronic]. 2015 Oct; 78(4): 451-6. PMID: 26083762, PMCID: PMC4589419, PII: pr2015116, DOI: 10.1038/pr.2015.116, ISSN: 1530-0447.

Reckamp KL, Koczywas M, Cristea MC, Dowell JE, Wang HJ, Gardner BK, Milne GL, Figlin RA, Fishbein MC, Elashoff RM, Dubinett SM. Randomized phase 2 trial of erlotinib in combination with high-dose celecoxib or placebo in patients with advanced non-small cell lung cancer. Cancer [print-electronic]. 2015 Sep 9/15/2015; 121(18): 3298-306. PMID: 26033830, PMCID: PMC4864011, DOI: 10.1002/cncr.29480, ISSN: 1097-0142.

Zhang Y, Desai A, Yang SY, Bae KB, Antczak MI, Fink SP, Tiwari S, Willis JE, Williams NS, Dawson DM, Wald D, Chen WD, Wang Z, Kasturi L, Larusch GA, He L, Cominelli F, Di Martino L, Djuric Z, Milne GL, Chance M, Sanabria J, Dealwis C, Mikkola D, Naidoo J, Wei S, Tai HH, Gerson SL, Ready JM, Posner B, Willson JK, Markowitz SD. TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration. Science. 2015 Jun 6/12/2015; 348(6240): aaa2340. PMID: 26068857, PMCID: PMC4481126, PII: 348/6240/aaa2340, DOI: 10.1126/science.aaa2340, ISSN: 1095-9203.

Wu JH, Marchioli R, Silletta MG, Masson S, Sellke FW, Libby P, Milne GL, Brown NJ, Lombardi F, Damiano RJ, Marsala J, Rinaldi M, Domenech A, Simon C, Tavazzi L, Mozaffarian D. Oxidative Stress Biomarkers and Incidence of Postoperative Atrial Fibrillation in the Omega-3 Fatty Acids for Prevention of Postoperative Atrial Fibrillation (OPERA) Trial. J Am Heart Assoc. 2015 May; 4(5): PMID: 25994442, PMCID: PMC4599415, PII: JAHA.115.001886, DOI: 10.1161/JAHA.115.001886, ISSN: 2047-9980.

Andreyev AY, Tsui HS, Milne GL, Shmanai VV, Bekish AV, Fomich MA, Pham MN, Nong Y, Murphy AN, Clarke CF, Shchepinov MS. Isotope-reinforced polyunsaturated fatty acids protect mitochondria from oxidative stress. Free Radic. Biol. Med [print-electronic]. 2015 May; 82: 63-72. PMID: 25578654, PII: S0891-5849(15)00003-9, DOI: 10.1016/j.freeradbiomed.2014.12.023, ISSN: 1873-4596.

Milne GL, Dai Q, Roberts LJ. The isoprostanes--25 years later. Biochim. Biophys. Acta [print-electronic]. 2015 Apr; 1851(4): 433-45. PMID: 25449649, PII: S1388-1981(14)00216-9, DOI: 10.1016/j.bbalip.2014.10.007, ISSN: 0006-3002.

Navarro SL, White E, Kantor ED, Zhang Y, Rho J, Song X, Milne GL, Lampe PD, Lampe JW. Randomized trial of glucosamine and chondroitin supplementation on inflammation and oxidative stress biomarkers and plasma proteomics profiles in healthy humans. PLoS ONE. 2015; 10(2): e0117534. PMID: 25719429, PMCID: PMC4342228, PII: PONE-D-14-46797, DOI: 10.1371/journal.pone.0117534, ISSN: 1932-6203.

Ramirez CE, Shuey MM, Milne GL, Gilbert K, Hui N, Yu C, Luther JM, Brown NJ. Arg287Gln variant of EPHX2 and epoxyeicosatrienoic acids are associated with insulin sensitivity in humans. Prostaglandins Other Lipid Mediat [print-electronic]. 2014 Oct; 113-115: 38-44. PMID: 25173047, PMCID: PMC4253976, PII: S1098-8823(14)00032-X, DOI: 10.1016/j.prostaglandins.2014.08.001, ISSN: 1098-8823.

Zhou W, Goleniewska K, Zhang J, Dulek DE, Toki S, Lotz MT, Newcomb DC, Boswell MG, Polosukhin VV, Milne GL, Wu P, Moore ML, FitzGerald GA, Peebles RS. Cyclooxygenase inhibition abrogates aeroallergen-induced immune tolerance by suppressing prostaglandin I2 receptor signaling. J. Allergy Clin. Immunol [print-electronic]. 2014 Sep; 134(3): 698-705.e5. PMID: 25042746, PMCID: PMC4358822, PII: S0091-6749(14)00806-9, DOI: 10.1016/j.jaci.2014.06.004, ISSN: 1097-6825.

El-Khuffash A, Jain A, Corcoran D, Shah PS, Hooper CW, Brown N, Poole SD, Shelton EL, Milne GL, Reese J, McNamara PJ. Efficacy of paracetamol on patent ductus arteriosus closure may be dose dependent: evidence from human and murine studies. Pediatr. Res [print-electronic]. 2014 Sep; 76(3): 238-44. PMID: 24941212, PMCID: PMC4321957, PII: pr201482, DOI: 10.1038/pr.2014.82, ISSN: 1530-0447.

Guda K, Fink SP, Milne GL, Molyneaux N, Ravi L, Lewis SM, Dannenberg AJ, Montgomery CG, Zhang S, Willis J, Wiesner GL, Markowitz SD. Inactivating mutation in the prostaglandin transporter gene, SLCO2A1, associated with familial digital clubbing, colon neoplasia, and NSAID resistance. Cancer Prev Res (Phila) [print-electronic]. 2014 Aug; 7(8): 805-12. PMID: 24838973, PMCID: PMC4125515, PII: 1940-6207.CAPR-14-0108, DOI: 10.1158/1940-6207.CAPR-14-0108, ISSN: 1940-6215.

Bezawada N, Song M, Wu K, Mehta RS, Milne GL, Ogino S, Fuchs CS, Giovannucci EL, Chan AT. Urinary PGE-M levels are associated with risk of colorectal adenomas and chemopreventive response to anti-inflammatory drugs. Cancer Prev Res (Phila) [print-electronic]. 2014 Jul; 7(7): 758-65. PMID: 24824037, PMCID: PMC4085181, PII: 1940-6207.CAPR-14-0120, DOI: 10.1158/1940-6207.CAPR-14-0120, ISSN: 1940-6215.

Nechuta S, Cai Q, Zheng Y, Milne GL, Cai H, Dai Q, Yang G, Zheng W, Lu W, Shu XO. Urinary biomarkers of oxidative stress and breast cancer survival. Cancer Causes Control [print-electronic]. 2014 Jun; 25(6): 701-7. PMID: 24820618, PMCID: PMC4031460, DOI: 10.1007/s10552-014-0373-7, ISSN: 1573-7225.

Savage WJ, Hamilton RG, Tobian AA, Milne GL, Kaufman RM, Savage JH, Borge PD, Ness PM. Defining risk factors and presentations of allergic reactions to platelet transfusion [letter]. J. Allergy Clin. Immunol [print-electronic]. 2014 Jun; 133(6): 1772-5.e9. PMID: 24794681, PMCID: PMC4040306, PII: S0091-6749(14)00454-0, DOI: 10.1016/j.jaci.2014.03.030, ISSN: 1097-6825.

Clayton DB, Stephany HA, Ching CB, Rahman SA, Tanaka ST, Thomas JC, Pope JC, Adams MC, Brock JW, Clark PE, Hayward SW, Matusik RJ, Milne GL. F2-isoprostanes as a biomarker of oxidative stress in the mouse bladder. J. Urol [print-electronic]. 2014 May; 191(5 Suppl): 1597-601. PMID: 24679873, PII: S0022-5347(13)05466-9, DOI: 10.1016/j.juro.2013.09.027, ISSN: 1527-3792.

Kawai VK, Avalos I, Oeser A, Oates JA, Milne GL, Solus JF, Chung CP, Stein CM. Suboptimal inhibition of platelet cyclooxygenase 1 by aspirin in systemic lupus erythematosus: association with metabolic syndrome. Arthritis Care Res (Hoboken). 2014 Feb; 66(2): 285-92. PMID: 24022862, PMCID: PMC3946810, DOI: 10.1002/acr.22169, ISSN: 2151-4658.

Timmons BC, Reese J, Socrate S, Ehinger N, Paria BC, Milne GL, Akins ML, Auchus RJ, McIntire D, House M, Mahendroo M. Prostaglandins are essential for cervical ripening in LPS-mediated preterm birth but not term or antiprogestin-driven preterm ripening. Endocrinology [print-electronic]. 2014 Jan; 155(1): 287-98. PMID: 24189143, PMCID: PMC3868800, PII: en.2013-1304, DOI: 10.1210/en.2013-1304, ISSN: 1945-7170.

Hulgan T, Boger MS, Liao DH, McComsey GA, Wanke CA, Mangili A, Walmsley SL, McCreath H, Milne GL, Sanchez SC, Currier JS, Lake JE. Urinary eicosanoid metabolites in HIV-infected women with central obesity switching to raltegravir: an analysis from the women, integrase, and fat accumulation trial. Mediators Inflamm [print-electronic]. 2014; 2014: 803095. PMID: 24991090, PMCID: PMC4058804, DOI: 10.1155/2014/803095, ISSN: 1466-1861.

Crist MB, Melekhin VV, Bian A, Shintani A, Milne GL, Kallianpur AR, Dageforde LA, Haas DW, Hulgan T. Higher serum iron is associated with increased oxidant stress in HIV-infected men. J. Acquir. Immune Defic. Syndr. 2013 Dec 12/1/2013; 64(4): 367-73. PMID: 24169121, PMCID: PMC3816092, PII: 00126334-201312010-00007, DOI: 10.1097/QAI.0b013e3182a60f36, ISSN: 1944-7884.

Stephany HA, Strand DW, Ching CB, Tanaka ST, Milne GL, Cajaiba MM, Thomas JC, Pope JC, Adams MC, Brock JW, Hayward SW, Matusik RJ, Clayton DB. Chronic cyclic bladder over distention up-regulates hypoxia dependent pathways. J. Urol [print-electronic]. 2013 Oct; 190(4 Suppl): 1603-9. PMID: 23429070, PMCID: PMC4085185, PII: S0022-5347(13)00295-4, DOI: 10.1016/j.juro.2013.02.026, ISSN: 1527-3792.

Grelli KN, Palubinsky AM, Kale AC, Lizama-Manibusan BN, Stankowski JN, Milne GL, Singer R, McLaughlin B. Alteration of isocitrate dehydrogenase following acute ischemic injury as a means to improve cellular energetic status in neuroadaptation. CNS Neurol Disord Drug Targets. 2013 Sep; 12(6): 849-60. PMID: 23469839, PMCID: PMC3770751, PII: CDTCNSND-EPUB-20130227-4, ISSN: 1996-3181.

Milne GL, Gao B, Terry ES, Zackert WE, Sanchez SC. Measurement of F2- isoprostanes and isofurans using gas chromatography-mass spectrometry. Free Radic. Biol. Med [print-electronic]. 2013 Jun; 59: 36-44. PMID: 23044261, PMCID: PMC4306329, PII: S0891-5849(12)01164-1, DOI: 10.1016/j.freeradbiomed.2012.09.030, ISSN: 1873-4596.

Kozak KR, Milne GL, Bentzen SM, Yock TI. Elevation of prostaglandin E2 in lung cancer patients with digital clubbing. J Thorac Oncol. 2012 Dec; 7(12): 1877-8. PMID: 22024643, PMCID: PMC3371124, DOI: 10.1097/JTO.0b013e3181fc76a9, ISSN: 1556-1380.

Brantley MA, Osborn MP, Sanders BJ, Rezaei KA, Lu P, Li C, Milne GL, Cai J, Sternberg P. The short-term effects of antioxidant and zinc supplements on oxidative stress biomarker levels in plasma: a pilot investigation. Am. J. Ophthalmol [print-electronic]. 2012 Jun; 153(6): 1104-9.e2. PMID: 22381365, PMCID: PMC3358482, PII: S0002-9394(11)00990-1, DOI: 10.1016/j.ajo.2011.12.010, ISSN: 1879-1891.

Hoskins A, Roberts JL, Milne G, Choi L, Dworski R. Natural-source d-a-tocopheryl acetate inhibits oxidant stress and modulates atopic asthma in humans in vivo. Allergy [print-electronic]. 2012 May; 67(5): 676-82. PMID: 22435735, PMCID: PMC3476459, DOI: 10.1111/j.1398-9995.2012.02810.x, ISSN: 1398-9995.

Albers E, Donahue BS, Milne G, Saville BR, Wang W, Bichell D, McLaughlin B. Perioperative plasma F(2)-Isoprostane levels correlate with markers of impaired ventilation in infants with single-ventricle physiology undergoing stage 2 surgical palliation on the cardiopulmonary bypass. Pediatr Cardiol [print-electronic]. 2012 Apr; 33(4): 562-8. PMID: 22327227, PMCID: PMC3641818, DOI: 10.1007/s00246-012-0166-2, ISSN: 1432-1971.

Murff HJ, Shrubsole MJ, Cai Q, Smalley WE, Dai Q, Milne GL, Ness RM, Zheng W. Dietary intake of PUFAs and colorectal polyp risk. Am. J. Clin. Nutr [print-electronic]. 2012 Mar; 95(3): 703-12. PMID: 22277551, PMCID: PMC3278245, PII: ajcn.111.024000, DOI: 10.3945/ajcn.111.024000, ISSN: 1938-3207.

Brantley MA, Osborn MP, Sanders BJ, Rezaei KA, Lu P, Li C, Milne GL, Cai J, Sternberg P. Plasma biomarkers of oxidative stress and genetic variants in age-related macular degeneration. Am. J. Ophthalmol [print-electronic]. 2012 Mar; 153(3): 460-467.e1. PMID: 22035603, PMCID: PMC3288635, PII: S0002-9394(11)00675-1, DOI: 10.1016/j.ajo.2011.08.033, ISSN: 1879-1891.

Shrubsole MJ, Cai Q, Wen W, Milne G, Smalley WE, Chen Z, Ness RM, Zheng W. Urinary prostaglandin E2 metabolite and risk for colorectal adenoma. Cancer Prev Res (Phila) [print-electronic]. 2012 Feb; 5(2): 336-42. PMID: 22166248, PMCID: PMC3273609, PII: 1940-6207.CAPR-11-0426, DOI: 10.1158/1940-6207.CAPR-11-0426, ISSN: 1940-6215.

Brooks JD, Musiek ES, Koestner TR, Stankowski JN, Howard JR, Brunoldi EM, Porta A, Zanoni G, Vidari G, Morrow JD, Milne GL, McLaughlin B. The fatty acid oxidation product 15-A3t-isoprostane is a potent inhibitor of NF¿B transcription and macrophage transformation. J. Neurochem [print-electronic]. 2011 Nov; 119(3): 604-16. PMID: 21838782, PMCID: PMC3640263, DOI: 10.1111/j.1471-4159.2011.07422.x, ISSN: 1471-4159.

Milne GL, Yin H, Hardy KD, Davies SS, Roberts LJ. Isoprostane generation and function. Chem. Rev [print-electronic]. 2011 Oct 10/12/2011; 111(10): 5973-96. PMID: 21848345, PMCID: PMC3192249, DOI: 10.1021/cr200160h, ISSN: 1520-6890.

Dorjgochoo T, Gao YT, Chow WH, Shu XO, Yang G, Cai Q, Rothman N, Cai H, Li H, Deng X, Shrubsole MJ, Murff H, Milne G, Zheng W, Dai Q. Obesity, age, and oxidative stress in middle-aged and older women. Antioxid. Redox Signal [print-electronic]. 2011 Jun 6/15/2011; 14(12): 2453-60. PMID: 21043829, PMCID: PMC3096497, DOI: 10.1089/ars.2010.3337, ISSN: 1557-7716.

Barocas DA, Motley S, Cookson MS, Chang SS, Penson DF, Dai Q, Milne G, Roberts LJ, Morrow J, Concepcion RS, Smith JA, Fowke JH. Oxidative stress measured by urine F2-isoprostane level is associated with prostate cancer. J. Urol [print-electronic]. 2011 Jun; 185(6): 2102-7. PMID: 21496850, PMCID: PMC3093434, PII: S0022-5347(11)00255-2, DOI: 10.1016/j.juro.2011.02.020, ISSN: 1527-3792.

Hardy KD, Cox BE, Milne GL, Yin H, Roberts LJ. Nonenzymatic free radical-catalyzed generation of 15-deoxy-¿(12,14)-prostaglandin J2-like compounds (deoxy-J2-isoprostanes) in vivo. J. Lipid Res [print-electronic]. 2011 Jan; 52(1): 113-24. PMID: 20944061, PMCID: PMC2999919, PII: jlr.M010264, DOI: 10.1194/jlr.M010264, ISSN: 0022-2275.

Kleman AM, Brown JE, Zeiger SL, Hettinger JC, Brooks JD, Holt B, Morrow JD, Musiek ES, Milne GL, McLaughlin B. P66(shc)'s role as an essential mitophagic molecule in controlling neuronal redox and energetic tone. Autophagy [print-electronic]. 2010 Oct; 6(7): 948-9. PMID: 20724835, PMCID: PMC3679093, PII: 13007, DOI: 10.1523/j.neurosci.6366-09.2010, ISSN: 1554-8635.

Rho YH, Chung CP, Oeser A, Solus JF, Gebretsadik T, Shintani A, Raggi P, Milne GL, Stein CM. Interaction between oxidative stress and high-density lipoprotein cholesterol is associated with severity of coronary artery calcification in rheumatoid arthritis. Arthritis Care Res (Hoboken). 2010 Oct; 62(10): 1473-80. PMID: 20506360, PMCID: PMC2933413, DOI: 10.1002/acr.20237, ISSN: 2151-4658.

Brown JE, Zeiger SL, Hettinger JC, Brooks JD, Holt B, Morrow JD, Musiek ES, Milne G, McLaughlin B. Essential role of the redox-sensitive kinase p66shc in determining energetic and oxidative status and cell fate in neuronal preconditioning. J. Neurosci. 2010 Apr 4/14/2010; 30(15): 5242-52. PMID: 20392947, PMCID: PMC2869196, PII: 30/15/5242, DOI: 10.1523/JNEUROSCI.6366-09.2010, ISSN: 1529-2401.

Wu X, Cai H, Xiang YB, Cai Q, Yang G, Liu D, Sanchez S, Zheng W, Milne G, Shu XO. Intra-person variation of urinary biomarkers of oxidative stress and inflammation. Cancer Epidemiol. Biomarkers Prev [print-electronic]. 2010 Apr; 19(4): 947-52. PMID: 20332256, PMCID: PMC2874066, PII: 1055-9965.EPI-10-0046, DOI: 10.1158/1055-9965.EPI-10-0046, ISSN: 1538-7755.

Li J, Solus J, Chen Q, Rho YH, Milne G, Stein CM, Darbar D. Role of inflammation and oxidative stress in atrial fibrillation. Heart Rhythm [print-electronic]. 2010 Apr; 7(4): 438-44. PMID: 20153266, PMCID: PMC2843774, PII: S1547-5271(09)01380-0, DOI: 10.1016/j.hrthm.2009.12.009, ISSN: 1556-3871.

Norman KG, Canter JA, Shi M, Milne GL, Morrow JD, Sligh JE. Cyclosporine A suppresses keratinocyte cell death through MPTP inhibition in a model for skin cancer in organ transplant recipients. Mitochondrion [print-electronic]. 2010 Mar; 10(2): 94-101. PMID: 19836469, PII: S1567-7249(09)00155-X, DOI: 10.1016/j.mito.2009.10.001, ISSN: 1872-8278.

Zeiger SL, Musiek ES, Zanoni G, Vidari G, Morrow JD, Milne GJ, McLaughlin B. Neurotoxic lipid peroxidation species formed by ischemic stroke increase injury. Free Radic. Biol. Med [print-electronic]. 2009 Nov 11/15/2009; 47(10): 1422-31. PMID: 19699297, PMCID: PMC2767385, PII: S0891-5849(09)00496-1, DOI: 10.1016/j.freeradbiomed.2009.08.011, ISSN: 1873-4596.

Rho YH, Oeser A, Chung CP, Milne GL, Stein CM. Drugs Used in the Treatment of Rheumatoid Arthritis: Relationship between Current Use and Cardiovascular Risk Factors. Arch Drug Inf. 2009 Jun; 2(2): 34-40. PMID: 19684849, PMCID: PMC2721969, DOI: 10.1111/j.1753-5174.2009.00019.x, ISSN: 1753-5174.

Yin H, Cox BE, Liu W, Porter NA, Morrow JD, Milne GL. Identification of intact oxidation products of glycerophospholipids in vitro and in vivo using negative ion electrospray iontrap mass spectrometry. J Mass Spectrom. 2009 May; 44(5): 672-80. PMID: 19125398, PMCID: PMC2715274, DOI: 10.1002/jms.1542, ISSN: 1096-9888.

Chung CP, Titova D, Oeser A, Randels M, Avalos I, Milne GL, Morrow JD, Stein CM. Oxidative stress in fibromyalgia and its relationship to symptoms. Clin. Rheumatol [print-electronic]. 2009 Apr; 28(4): 435-8. PMID: 19089486, PMCID: PMC2654204, DOI: 10.1007/s10067-008-1072-0, ISSN: 1434-9949.

Roberts LJ, Milne GL. Isoprostanes. J. Lipid Res [print-electronic]. 2009 Apr; 50 Suppl: S219-23. PMID: 18957694, PMCID: PMC2674741, PII: R800037-JLR200, DOI: 10.1194/jlr.R800037-JLR200, ISSN: 0022-2275.

Adler DH, Phillips JA, Cogan JD, Iverson TM, Schnetz-Boutaud N, Stein JA, Brenner DA, Milne GL, Morrow JD, Boutaud O, Oates JA. The enteropathy of prostaglandin deficiency. J. Gastroenterol [print-electronic]. 2009; 44 Suppl 19: 1-7. PMID: 19148786, PMCID: PMC2799331, DOI: 10.1007/s00535-008-2253-y, ISSN: 0944-1174.

Chen J, Zhao M, He W, Milne GL, Howard JR, Morrow J, Hébert RL, Breyer RM, Chen J, Hao CM. Increased dietary NaCl induces renal medullary PGE2 production and natriuresis via the EP2 receptor. Am. J. Physiol. Renal Physiol [print-electronic]. 2008 Sep; 295(3): F818-25. PMID: 18632796, PMCID: PMC2653111, PII: 90253.2008, DOI: 10.1152/ajprenal.90253.2008, ISSN: 1931-857X.

Musiek ES, Brooks JD, Joo M, Brunoldi E, Porta A, Zanoni G, Vidari G, Blackwell TS, Montine TJ, Milne GL, McLaughlin B, Morrow JD. Electrophilic cyclopentenone neuroprostanes are anti-inflammatory mediators formed from the peroxidation of the omega-3 polyunsaturated fatty acid docosahexaenoic acid. J. Biol. Chem [print-electronic]. 2008 Jul 7/18/2008; 283(29): 19927-35. PMID: 18490445, PMCID: PMC2459280, PII: M803625200, DOI: 10.1074/jbc.M803625200, ISSN: 0021-9258.

Dostalek M, Hardy KD, Milne GL, Morrow JD, Chen C, Gonzalez FJ, Gu J, Ding X, Johnson DA, Johnson JA, Martin MV, Guengerich FP. Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems. J. Biol. Chem [print-electronic]. 2008 Jun 6/20/2008; 283(25): 17147-57. PMID: 18442974, PMCID: PMC2427356, PII: M802447200, DOI: 10.1074/jbc.M802447200, ISSN: 0021-9258.

Milne GL, Yin H, Morrow JD. Human biochemistry of the isoprostane pathway. J. Biol. Chem [print-electronic]. 2008 Jun 6/6/2008; 283(23): 15533-7. PMID: 18285331, PMCID: PMC2414280, PII: R700047200, DOI: 10.1074/jbc.R700047200, ISSN: 0021-9258.

Adler DH, Cogan JD, Phillips JA, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA, Brenner DA, Morrow JD, Boutaud O, Oates JA. Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. J. Clin. Invest. 2008 Jun; 118(6): 2121-31. PMID: 18451993, PMCID: PMC2350426, DOI: 10.1172/JCI30473, ISSN: 0021-9738.

Brooks JD, Milne GL, Yin H, Sanchez SC, Porter NA, Morrow JD. Formation of highly reactive cyclopentenone isoprostane compounds (A3/J3-isoprostanes) in vivo from eicosapentaenoic acid. J. Biol. Chem [print-electronic]. 2008 May 5/2/2008; 283(18): 12043-55. PMID: 18263929, PMCID: PMC2335341, PII: M800122200, DOI: 10.1074/jbc.M800122200, ISSN: 0021-9258.

Dostalek M, Brooks JD, Hardy KD, Milne GL, Moore MM, Sharma S, Morrow JD, Guengerich FP. In vivo oxidative damage in rats is associated with barbiturate response but not other cytochrome P450 inducers. Mol. Pharmacol [print-electronic]. 2007 Dec; 72(6): 1419-24. PMID: 17898314, PII: mol.107.040238, DOI: 10.1124/mol.107.040238, ISSN: 1521-0111.

Brunoldi EM, Zanoni G, Vidari G, Sasi S, Freeman ML, Milne GL, Morrow JD. Cyclopentenone prostaglandin, 15-deoxy-Delta12,14-PGJ2, is metabolized by HepG2 cells via conjugation with glutathione. Chem. Res. Toxicol [print-electronic]. 2007 Oct; 20(10): 1528-35. PMID: 17854155, DOI: 10.1021/tx700231a, ISSN: 0893-228X.

Avalos I, Chung CP, Oeser A, Milne GL, Borntrager H, Morrow JD, Raggi P, Solus J, Stein CM. Aspirin therapy and thromboxane biosynthesis in systemic lupus erythematosus. Lupus. 2007; 16(12): 981-6. PMID: 18042592, PII: 16/12/981, DOI: 10.1177/0961203307083313, ISSN: 0961-2033.

Avalos I, Chung CP, Oeser A, Milne GL, Morrow JD, Gebretsadik T, Shintani A, Yu C, Stein CM. Oxidative stress in systemic lupus erythematosus: relationship to disease activity and symptoms. Lupus. 2007; 16(3): 195-200. PMID: 17432105, ISSN: 0961-2033.

Milne GL, Yin H, Brooks JD, Sanchez S, Jackson Roberts L, Morrow JD. Quantification of F2-isoprostanes in biological fluids and tissues as a measure of oxidant stress. Meth. Enzymol. 2007; 433: 113-26. PMID: 17954231, PII: S0076-6879(07)33006-1, DOI: 10.1016/S0076-6879(07)33006-1, ISSN: 0076-6879.

Milne GL, Sanchez SC, Musiek ES, Morrow JD. Quantification of F2-isoprostanes as a biomarker of oxidative stress. Nat Protoc. 2007; 2(1): 221-6. PMID: 17401357, PII: nprot.2006.375, DOI: 10.1038/nprot.2006.375, ISSN: 1750-2799.

Milne GL, Morrow JD, Picklo MJ. Elevated oxidation of docosahexaenoic acid, 22:6 (n-3), in brain regions of rats undergoing ethanol withdrawal. Neurosci. Lett [print-electronic]. 2006 Sep 9/25/2006; 405(3): 172-4. PMID: 16875780, PII: S0304-3940(06)00656-2, DOI: 10.1016/j.neulet.2006.06.058, ISSN: 0304-3940.

Milne GL, Morrow JD. Isoprostanes and related compounds: update 2006. Antioxid. Redox Signal. 2006 Jul; 8(7-8): 1379-84. PMID: 16910785, DOI: 10.1089/ars.2006.8.1379, ISSN: 1523-0864.

Reckamp KL, Krysan K, Morrow JD, Milne GL, Newman RA, Tucker C, Elashoff RM, Dubinett SM, Figlin RA. A phase I trial to determine the optimal biological dose of celecoxib when combined with erlotinib in advanced non-small cell lung cancer. Clin. Cancer Res. 2006 Jun 6/1/2006; 12(11 Pt 1): 3381-8. PMID: 16740761, PII: 12/11/3381, DOI: 10.1158/1078-0432.CCR-06-0112, ISSN: 1078-0432.

Musiek ES, Breeding RS, Milne GL, Zanoni G, Morrow JD, McLaughlin B. Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration. J. Neurochem [print-electronic]. 2006 Jun; 97(5): 1301-13. PMID: 16638022, PMCID: PMC2881557, PII: JNC3797, DOI: 10.1111/j.1471-4159.2006.03797.x, ISSN: 0022-3042.

Gao L, Yin H, Milne GL, Porter NA, Morrow JD. Formation of F-ring isoprostane-like compounds (F3-isoprostanes) in vivo from eicosapentaenoic acid. J. Biol. Chem [print-electronic]. 2006 May 5/19/2006; 281(20): 14092-9. PMID: 16569632, PII: M601035200, DOI: 10.1074/jbc.M601035200, ISSN: 0021-9258.

Sergeant A, Milne G, Shaffrali F. Lichenoid eruption associated with orlistat. Br. J. Dermatol. 2006 May; 154(5): 1020-1. PMID: 16634924, PII: BJD7220, DOI: 10.1111/j.1365-2133.2006.07220.x, ISSN: 0007-0963.

Landar A, Zmijewski JW, Dickinson DA, Le Goffe C, Johnson MS, Milne GL, Zanoni G, Vidari G, Morrow JD, Darley-Usmar VM. Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2006 May; 290(5): H1777-87. PMID: 16387790, PII: 01087.2005, DOI: 10.1152/ajpheart.01087.2005, ISSN: 0363-6135.

Milne GA, Shennan I, Youngs BA, Waugh AI, Teferle FN, Bingley RM, Bassett SE, Cuthbert-Brown C, Bradley SL. Modelling the glacial isostatic adjustment of the UK region. Philos Trans A Math Phys Eng Sci. 2006 Apr 4/15/2006; 364(1841): 931-48. PMID: 16537149, PII: GR73515417115303, DOI: 10.1098/rsta.2006.1747, ISSN: 1364-503X.

Milne GL, Musiek ES, Morrow JD. F2-isoprostanes as markers of oxidative stress in vivo: an overview. Biomarkers. 2005 Nov; 10 Suppl 1: S10-23. PMID: 16298907, PII: N5816208U2747672, DOI: 10.1080/13547500500216546, ISSN: 1354-750X.

Musiek ES, Gao L, Milne GL, Han W, Everhart MB, Wang D, Backlund MG, DuBois RN, Zanoni G, Vidari G, Blackwell TS, Morrow JD. Cyclopentenone isoprostanes inhibit the inflammatory response in macrophages. J. Biol. Chem [print-electronic]. 2005 Oct 10/21/2005; 280(42): 35562-70. PMID: 16100121, PII: M504785200, DOI: 10.1074/jbc.M504785200, ISSN: 0021-9258.

Musiek ES, Yin H, Milne GL, Morrow JD. Recent advances in the biochemistry and clinical relevance of the isoprostane pathway. Lipids. 2005 Oct; 40(10): 987-94. PMID: 16382569, ISSN: 0024-4201.

Bassett SE, Milne GA, Mitrovica JX, Clark PU. Ice sheet and solid Earth influences on far-field sea-level histories. Science [print-electronic]. 2005 Aug 8/5/2005; 309(5736): 925-8. PMID: 15976270, PII: 1111575, DOI: 10.1126/science.1111575, ISSN: 1095-9203.

Milne GL, Gao L, Porta A, Zanoni G, Vidari G, Morrow JD. Identification of the major urinary metabolite of the highly reactive cyclopentenone isoprostane 15-A(2t)-isoprostane in vivo. J. Biol. Chem [print-electronic]. 2005 Jul 7/1/2005; 280(26): 25178-84. PMID: 15878849, PII: M502891200, DOI: 10.1074/jbc.M502891200, ISSN: 0021-9258.

Musiek ES, Milne GL, McLaughlin B, Morrow JD. Cyclopentenone eicosanoids as mediators of neurodegeneration: a pathogenic mechanism of oxidative stress-mediated and cyclooxygenase-mediated neurotoxicity. Brain Pathol. 2005 Apr; 15(2): 149-58. PMID: 15912888, PMCID: PMC2881556, ISSN: 1015-6305.

Backlund MG, Mann JR, Holla VR, Buchanan FG, Tai HH, Musiek ES, Milne GL, Katkuri S, DuBois RN. 15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer. J. Biol. Chem [print-electronic]. 2005 Feb 2/4/2005; 280(5): 3217-23. PMID: 15542609, PMCID: PMC1847633, PII: M411221200, DOI: 10.1074/jbc.M411221200, ISSN: 0021-9258.

Milne GL, Seal JR, Havrilla CM, Wijtmans M, Porter NA. Identification and analysis of products formed from phospholipids in the free radical oxidation of human low density lipoproteins. J. Lipid Res [print-electronic]. 2005 Feb; 46(2): 307-19. PMID: 15547297, PII: M400311-JLR200, DOI: 10.1194/jlr.M400311-JLR200, ISSN: 0022-2275.

Milne GL, Musiek ES, Morrow JD. The cyclopentenone (A2/J2) isoprostanes--unique, highly reactive products of arachidonate peroxidation. Antioxid. Redox Signal. 2005 Jan; 7(1-2): 210-20. PMID: 15650409, DOI: 10.1089/ars.2005.7.210, ISSN: 1523-0864.

Arbic BK, Macayeal DR, Mitrovica JX, Milne GA. Palaeoclimate: ocean tides and Heinrich events. Nature. 2004 Nov 11/25/2004; 432(7016): 460. PMID: 15565143, PII: 432460a, DOI: 10.1038/432460a, ISSN: 1476-4687.

Milne GL, Zanoni G, Porta A, Sasi S, Vidari G, Musiek ES, Freeman ML, Morrow JD. The cyclopentenone product of lipid peroxidation, 15-A2t-isoprostane, is efficiently metabolized by HepG2 cells via conjugation with glutathione. Chem. Res. Toxicol. 2004 Jan; 17(1): 17-25. PMID: 14727915, DOI: 10.1021/tx034213o, ISSN: 0893-228X.

Gao L, Zackert WE, Hasford JJ, Danekis ME, Milne GL, Remmert C, Reese J, Yin H, Tai HH, Dey SK, Porter NA, Morrow JD. Formation of prostaglandins E2 and D2 via the isoprostane pathway: a mechanism for the generation of bioactive prostaglandins independent of cyclooxygenase. J. Biol. Chem [print-electronic]. 2003 Aug 8/1/2003; 278(31): 28479-89. PMID: 12746435, PII: M303984200, DOI: 10.1074/jbc.M303984200, ISSN: 0021-9258.

Fam SS, Murphey LJ, Terry ES, Zackert WE, Chen Y, Gao L, Pandalai S, Milne GL, Roberts LJ, Porter NA, Montine TJ, Morrow JD. Formation of highly reactive A-ring and J-ring isoprostane-like compounds (A4/J4-neuroprostanes) in vivo from docosahexaenoic acid. J. Biol. Chem [print-electronic]. 2002 Sep 9/27/2002; 277(39): 36076-84. PMID: 12133837, PII: M205638200, DOI: 10.1074/jbc.M205638200, ISSN: 0021-9258.

Culbertson SM, Antunes F, Havrilla CM, Milne GL, Porter NA. Determination of the alpha-tocopherol inhibition rate constant for peroxidation in low-density lipoprotein. Chem. Res. Toxicol. 2002 Jun; 15(6): 870-6. PMID: 12067255, PII: tx020012t, ISSN: 0893-228X.

Milne GL, Porter NA. Separation and identification of phospholipid peroxidation products. Lipids. 2001 Nov; 36(11): 1265-75. PMID: 11795860, ISSN: 0024-4201.