Brian G. Engelhardt, M.D.

Associate Professor
Faculty Appointments
Associate Professor of Medicine
M.S.C.I., Clinical Investigation , Vanderbilt University, Nashville, TennesseeM.D., Medicine, Case Western Reserve University, Cleveland, OhioB.S., University of Michigan, Dearborn, Michigan
Office Address
2665 TVC
Nashville, TN 37232-5505
McDonald MK, Culos KA, Gatwood KS, Prow C, Chen H, Savani BN, Byrne M, Kassim AA, Engelhardt BG, Jagasia M, Satyanarayana G. Defining Incidence and Risk Factors for Catheter-Associated Bloodstream Infections in an Outpatient Adult Hematopoietic Cell Transplantation Program. Biol. Blood Marrow Transplant [print-electronic]. 2018 May 5/9/2018; PMID: 29753159, PII: S1083-8791(18)30253-2, DOI: 10.1016/j.bbmt.2018.04.031, ISSN: 1523-6536.

Huang J, Phillips S, Byrne M, Chinratanalab W, Engelhardt BG, Goodman SA, Harrell SL, Jagasia M, Kassim A, Rawling KT, Savani BN, Sengsayadeth S, Cornell RF. Lenalidomide vs bortezomib maintenance choice post-autologous hematopoietic cell transplantation for multiple myeloma. Bone Marrow Transplant [print-electronic]. 2018 Apr 4/27/2018; PMID: 29703965, PII: 10.1038/s41409-018-0177-6, DOI: 10.1038/s41409-018-0177-6, ISSN: 1476-5365.

Gatwood KS, Culos KA, Binari LA, Engelhardt BG, Kassim A, Byrne MT, Goodman SA, Chinratanalab W, Sengsayadeth SM, Greer JP, Jagasia M, Savani BN. Outcomes of a novel rituximab-based non-myeloablative conditioning regimen for hematopoietic cell transplantation in severe aplastic anemia [letter]. Bone Marrow Transplant [print-electronic]. 2018 Mar 3/14/2018; PMID: 29540851, PII: 10.1038/s41409-018-0124-6, DOI: 10.1038/s41409-018-0124-6, ISSN: 1476-5365.

Kennedy VE, Chen H, Savani BN, Greer J, Kassim AA, Engelhardt BG, Goodman S, Sengsayadeth S, Chinratanalab W, Jagasia M. Optimizing Antithymocyte Globulin Dosing for Unrelated Donor Allogeneic Hematopoietic Cell Transplantation Based on Recipient Absolute Lymphocyte Count. Biol. Blood Marrow Transplant [print-electronic]. 2018 Jan; 24(1): 150-5. PMID: 28864139, PII: S1083-8791(17)30682-1, DOI: 10.1016/j.bbmt.2017.08.029, ISSN: 1523-6536.

Abana CO, Pilkinton MA, Gaudieri S, Chopra A, McDonnell WJ, Wanjalla C, Barnett L, Gangula R, Hager C, Jung DK, Engelhardt BG, Jagasia MH, Klenerman P, Phillips EJ, Koelle DM, Kalams SA, Mallal SA. Cytomegalovirus (CMV) Epitope-Specific CD4+ T Cells Are Inflated in HIV+ CMV+ Subjects. J. Immunol [print-electronic]. 2017 Nov 11/1/2017; 199(9): 3187-201. PMID: 28972094, PMCID: PMC5679304, PII: jimmunol.1700851, DOI: 10.4049/jimmunol.1700851, ISSN: 1550-6606.

Johnpulle RA, Paczesny S, Jung DK, Daguindau E, Jagasia MH, Savani BN, Chinratanalab W, Cornell RF, Goodman S, Greer JP, Kassim AA, Sengsayadeth S, Byrne MT, Engelhardt BG. Metabolic Complications Precede Alloreactivity and Are Characterized by Changes in Suppression of Tumorigenicity 2 Signaling. Biol. Blood Marrow Transplant [print-electronic]. 2017 Mar; 23(3): 529-32. PMID: 28013014, PMCID: PMC5321545, PII: S1083-8791(16)31186-7, DOI: 10.1016/j.bbmt.2016.12.627, ISSN: 1523-6536.

Rapoport Y, Freeman T, Koyama T, Engelhardt BG, Jagasia M, Savani BN, Tran U, Kassim AA. Validation of International Chronic Ocular Graft-Versus-Host Disease (GVHD) Group Diagnostic Criteria as a Chronic Ocular GVHD-Specific Metric. Cornea. 2017 Feb; 36(2): 258-63. PMID: 28060078, PII: 00003226-201702000-00022, DOI: 10.1097/ICO.0000000000001109, ISSN: 1536-4798.

Rapoport Y, Freeman T, Koyama T, Engelhardt BG, Jagasia M, Savani BN, Tran U, Kassim AA. Validation of International Chronic Ocular Graft-Versus-Host Disease (GVHD) Group Diagnostic Criteria as a Chronic Ocular GVHD-Specific Metric. Cornea [print-electronic]. 2016 Dec 12/14/2016; PMID: 27984363, DOI: 10.1097/ICO.0000000000001109, ISSN: 1536-4798.

Kennedy VE, Savani BN, Greer JP, Kassim AA, Engelhardt BG, Goodman SA, Sengsayadeth S, Chinratanalab W, Jagasia M. Reduced-Intensity Conditioning with Fludarabine, Cyclophosphamide, and Rituximab Is Associated with Improved Outcomes Compared with Fludarabine and Busulfan after Allogeneic Stem Cell Transplantation for B Cell Malignancies. Biol. Blood Marrow Transplant [print-electronic]. 2016 Oct; 22(10): 1801-7. PMID: 27377900, PII: S1083-8791(16)30202-6, DOI: 10.1016/j.bbmt.2016.06.029, ISSN: 1523-6536.

Fuji S, Rovó A, Ohashi K, Griffith M, Einsele H, Kapp M, Mohty M, Majhail NS, Engelhardt BG, Tichelli A, Savani BN. How do I manage hyperglycemia/post-transplant diabetes mellitus after allogeneic HSCT. Bone Marrow Transplant [print-electronic]. 2016 Aug; 51(8): 1041-9. PMID: 27042848, PII: bmt201681, DOI: 10.1038/bmt.2016.81, ISSN: 1476-5365.

Engelhardt BG, Paczesny S, Jung DK, Daguindau E, Jagasia M, Savani BN, Chinratanalab W, Cornell RF, Goodman S, Greer JP, Kassim AA, Sengsayadeth S, Yoder SM, Rock MT, Crowe JE. Early Th1 immunity promotes immune tolerance and may impair graft-versus-leukemia effect after allogeneic hematopoietic cell transplantation [letter]. Haematologica [print-electronic]. 2016 May; 101(5): e204-8. PMID: 26819055, PMCID: PMC5004357, PII: haematol.2015.139501, DOI: 10.3324/haematol.2015.139501, ISSN: 1592-8721.

Das-Gupta E, Greinix H, Jacobs R, Zhou L, Savani BN, Engelhardt BG, Kassim A, Worel N, Knobler R, Russell N, Jagasia M. Extracorporeal photopheresis as second-line treatment for acute graft-versus-host disease: impact on six-month freedom from treatment failure. Haematologica [print-electronic]. 2014 Nov; 99(11): 1746-52. PMID: 25150260, PMCID: PMC4222474, PII: haematol.2014.108217, DOI: 10.3324/haematol.2014.108217, ISSN: 1592-8721.

Sengsayadeth S, Savani BN, Jagasia M, Goodman S, Greer JP, Chen H, Chinratanalab W, Kassim AA, Engelhardt BG. Six-month freedom from treatment failure is an important end point for acute GVHD clinical trials. Bone Marrow Transplant [print-electronic]. 2014 Feb; 49(2): 236-40. PMID: 24096824, PMCID: PMC3946331, PII: bmt2013157, DOI: 10.1038/bmt.2013.157, ISSN: 1476-5365.

Ragon BK, Clifton C, Chen H, Savani BN, Engelhardt BG, Kassim AA, Vaughan LA, Lucid C, Jagasia M. Geographic distance is not associated with inferior outcome when using long-term transplant clinic strategy. Biol. Blood Marrow Transplant [print-electronic]. 2014 Jan; 20(1): 53-7. PMID: 24120525, PII: S1083-8791(13)00450-3, DOI: 10.1016/j.bbmt.2013.10.004, ISSN: 1523-6536.

Reddy NM, Oluwole O, Greer JP, Engelhardt BG, Jagasia MH, Savani BN. Outcomes of autologous or allogeneic stem cell transplantation for non-Hodgkin lymphoma. Exp. Hematol [print-electronic]. 2014 Jan; 42(1): 39-45. PMID: 24096123, PII: S0301-472X(13)00747-9, DOI: 10.1016/j.exphem.2013.09.012, ISSN: 1873-2399.

Vaughan LA, Vu M, Sengsayadeth S, Lucid C, Clifton C, McCarty K, Hagaman D, Domm J, Kassim A, Chinratanalab W, Goodman S, Greer J, Frangoul H, Engelhardt BG, Jagasia M, Savani BN. New allergies after cord blood transplantation. Cytotherapy. 2013 Oct; 15(10): 1259-65. PMID: 23993300, PII: S1465-3249(13)00550-1, DOI: 10.1016/j.jcyt.2013.05.018, ISSN: 1477-2566.

Jagasia M, Greinix H, Robin M, Das-Gupta E, Jacobs R, Savani BN, Engelhardt BG, Kassim A, Worel N, Knobler R, Russell N, Socie G. Extracorporeal photopheresis versus anticytokine therapy as a second-line treatment for steroid-refractory acute GVHD: a multicenter comparative analysis. Biol. Blood Marrow Transplant [print-electronic]. 2013 Jul; 19(7): 1129-33. PMID: 23623892, PII: S1083-8791(13)00186-9, DOI: 10.1016/j.bbmt.2013.04.018, ISSN: 1523-6536.

Weitkamp JH, Koyama T, Rock MT, Correa H, Goettel JA, Matta P, Oswald-Richter K, Rosen MJ, Engelhardt BG, Moore DJ, Polk DB. Necrotising enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory (FOXP3)/effector (CD4, CD8) T cell ratios. Gut [print-electronic]. 2013 Jan; 62(1): 73-82. PMID: 22267598, PMCID: PMC3606820, PII: gutjnl-2011-301551, DOI: 10.1136/gutjnl-2011-301551, ISSN: 1468-3288.

Engelhardt BG, Sengsayadeth SM, Jagasia M, Savani BN, Kassim AA, Lu P, Shyr Y, Yoder SM, Rock MT, Crowe JE. Tissue-specific regulatory T cells: biomarker for acute graft-vs-host disease and survival. Exp. Hematol [print-electronic]. 2012 Dec; 40(12): 974-982.e1. PMID: 22885125, PMCID: PMC3611587, PII: S0301-472X(12)00343-8, DOI: 10.1016/j.exphem.2012.08.002, ISSN: 1873-2399.

Sengsayadeth SM, Jagasia M, Engelhardt BG, Kassim A, Strickland SA, Goodman S, Lucid C, Vnencak-Jones CL, Greer JP, Savani BN. Allo-SCT for high-risk AML-CR1 in the molecular era: impact of FLT3/ITD outweighs the conventional markers. Bone Marrow Transplant [print-electronic]. 2012 Dec; 47(12): 1535-7. PMID: 22659680, PII: bmt201288, DOI: 10.1038/bmt.2012.88, ISSN: 1476-5365.

Jacobs R, Tran U, Chen H, Kassim A, Engelhardt BG, Greer JP, Goodman SG, Clifton C, Lucid C, Vaughan LA, Savani BN, Jagasia M. Prevalence and risk factors associated with development of ocular GVHD defined by NIH consensus criteria. Bone Marrow Transplant [print-electronic]. 2012 Nov; 47(11): 1470-3. PMID: 22484321, PII: bmt201256, DOI: 10.1038/bmt.2012.56, ISSN: 1476-5365.

Jagasia M, Clark WB, Brown-Gentry KD, Crawford DC, Fan KH, Chen H, Kassim A, Greer JP, Engelhardt BG, Savani BN. Genetic variation in donor CTLA-4 regulatory region is a strong predictor of outcome after allogeneic hematopoietic cell transplantation for hematologic malignancies. Biol. Blood Marrow Transplant [print-electronic]. 2012 Jul; 18(7): 1069-75. PMID: 22178694, PII: S1083-8791(11)01080-9, DOI: 10.1016/j.bbmt.2011.12.518, ISSN: 1523-6536.

Engelhardt BG, Jagasia SM, Crowe JE, Griffith ML, Savani BN, Kassim AA, Lu P, Weitkamp JH, Moore DJ, Yoder SM, Rock MT, Jagasia M. Predicting posttransplantation diabetes mellitus by regulatory T-cell phenotype: implications for metabolic intervention to modulate alloreactivity. Blood [print-electronic]. 2012 Mar 3/8/2012; 119(10): 2417-21. PMID: 22262764, PMCID: PMC3311262, PII: blood-2011-10-384750, DOI: 10.1182/blood-2011-10-384750, ISSN: 1528-0020.

Clark WB, Brown-Gentry KD, Crawford DC, Fan KH, Snavely J, Chen H, Savani BN, Kassim A, Greer JP, Schuening FG, Engelhardt BG, Jagasia MH. Genetic variation in recipient B-cell activating factor modulates phenotype of GVHD. Blood [print-electronic]. 2011 Jul 7/28/2011; 118(4): 1140-4. PMID: 21628416, PII: blood-2010-09-310011, DOI: 10.1182/blood-2010-09-310011, ISSN: 1528-0020.

Lucid CE, Savani BN, Engelhardt BG, Shah P, Clifton C, Greenhut SL, Vaughan LA, Kassim A, Schuening F, Jagasia M. Extracorporeal photopheresis in patients with refractory bronchiolitis obliterans developing after allo-SCT. Bone Marrow Transplant [print-electronic]. 2011 Mar; 46(3): 426-9. PMID: 20581885, PII: bmt2010152, DOI: 10.1038/bmt.2010.152, ISSN: 1476-5365.

Engelhardt BG, Jagasia M, Savani BN, Bratcher NL, Greer JP, Jiang A, Kassim AA, Lu P, Schuening F, Yoder SM, Rock MT, Crowe JE. Regulatory T cell expression of CLA or a(4)ß(7) and skin or gut acute GVHD outcomes. Bone Marrow Transplant [print-electronic]. 2011 Mar; 46(3): 436-42. PMID: 20577222, PMCID: PMC3217583, PII: bmt2010127, DOI: 10.1038/bmt.2010.127, ISSN: 1476-5365.

Tedeschi SK, Jagasia M, Engelhardt BG, Domm J, Kassim AA, Chinratanalab W, Greenhut SL, Goodman S, Greer JP, Schuening F, Frangoul H, Savani BN. Early lymphocyte reconstitution is associated with improved transplant outcome after cord blood transplantation. Cytotherapy [print-electronic]. 2011 Jan; 13(1): 78-82. PMID: 20586668, DOI: 10.3109/14653249.2010.495114, ISSN: 1477-2566.

Griffith ML, Jagasia MH, Misfeldt AA, Chen H, Engelhardt BG, Kassim A, Savani BN, Survant M, Jagasia SM. Pretransplantation C-Peptide level predicts early posttransplantation diabetes mellitus and has an impact on survival after allogeneic stem cell transplantation. Biol. Blood Marrow Transplant [print-electronic]. 2011 Jan; 17(1): 86-92. PMID: 20561594, PII: S1083-8791(10)00254-5, DOI: 10.1016/j.bbmt.2010.06.010, ISSN: 1523-6536.

Engelhardt BG, Crowe JE. Homing in on acute graft vs. host disease: tissue-specific T regulatory and Th17 cells. Curr. Top. Microbiol. Immunol. 2010; 341: 121-46. PMID: 20563712, PMCID: PMC3793903, DOI: 10.1007/82_2010_24, ISSN: 0070-217X.

Engelhardt BG, Holland DW, Brandt SJ, Chinratanalab W, Goodman SA, Greer JP, Jagasia MH, Kassim AA, Morgan DS, Ruffner KL, Schuening FG, Wolff S, Bitting R, Sulur P, Stein RS. High-dose chemotherapy followed by autologous stem cell transplantation for relapsed or refractory Hodgkin lymphoma: prognostic features and outcomes. Leuk. Lymphoma. 2007 Sep; 48(9): 1728-35. PMID: 17786708, PII: 781802102, DOI: 10.1080/10428190701534374, ISSN: 1042-8194.