Cyndya A. Shibao, M.D.

Associate Professor
Faculty Appointments
Associate Professor of Medicine
M.S.C.I., Clinical Investigation, Vanderbilt University, Nashville, TennesseeM.D., Universidad Peruana Cayetano Heredia, Lima, PeruB.Sc., Human Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru
Office Address
MCN AA3228
1161 21 Ave Avenue South AA3228
Nashville, TN 37232
Clinical Research Keywords
blood pressure regulation, rare autonomic disorders, obesity hypertension
Norcliffe-Kaufmann L, Kaufmann H, Palma JA, Shibao CA, Biaggioni I, Peltier AC, Singer W, Low PA, Goldstein DS, Gibbons CH, Freeman R, Robertson D, . Orthostatic Heart Rate Changes in Patients with Autonomic Failure caused by Neurodegenerative Synucleinopathies. Ann. Neurol [print-electronic]. 2018 Feb 2/5/2018; PMID: 29405350, DOI: 10.1002/ana.25170, ISSN: 1531-8249.

Marinos A, Gamboa A, Celedonio JE, Preheim BA, Okamoto LE, Ramirez CE, Arnold AC, Diedrich A, Biaggioni I, Shibao CA. Hypertension in Obese Black Women is Not Caused by Increased Sympathetic Vascular Tone. J Am Heart Assoc. 2017 Nov 11/18/2017; 6(11): PMID: 29151035, PMCID: PMC5721777, PII: JAHA.117.006971, DOI: 10.1161/JAHA.117.006971, ISSN: 2047-9980.

Shibao CA, Kaufmann H. Pharmacotherapy of Cardiovascular Autonomic Dysfunction in Parkinson Disease. CNS Drugs. 2017 Nov; 31(11): 975-89. PMID: 29076058, PMCID: PMC5809001, PII: 10.1007/s40263-017-0473-5, DOI: 10.1007/s40263-017-0473-5, ISSN: 1179-1934.

Grijalva CG, Biaggioni I, Griffin MR, Shibao CA. Fludrocortisone Is Associated With a Higher Risk of All-Cause Hospitalizations Compared With Midodrine in Patients With Orthostatic Hypotension. J Am Heart Assoc. 2017 Oct 10/12/2017; 6(10): PMID: 29025750, PII: JAHA.117.006848, DOI: 10.1161/JAHA.117.006848, ISSN: 2047-9980.

Shaw BH, Garland EM, Black BK, Paranjape SY, Shibao CA, Okamoto LE, Gamboa A, Diedrich A, Plummer WD, Dupont WD, Biaggioni I, Robertson D, Raj SR. Optimal diagnostic thresholds for diagnosis of orthostatic hypotension with a 'sit-to-stand test'. J. Hypertens. 2017 May; 35(5): 1019-25. PMID: 28129252, PMCID: PMC5542884, DOI: 10.1097/HJH.0000000000001265, ISSN: 1473-5598.

Kaufmann H, Norcliffe-Kaufmann L, Palma JA, Biaggioni I, Low PA, Singer W, Goldstein DS, Peltier AC, Shibao CA, Gibbons CH, Freeman R, Robertson D, . Natural history of pure autonomic failure: A United States prospective cohort. Ann. Neurol. 2017 Feb; 81(2): 287-97. PMID: 28093795, PMCID: PMC5323269, DOI: 10.1002/ana.24877, ISSN: 1531-8249.

Arnold AC, Garland EM, Celedonio JE, Raj SR, Abumrad NN, Biaggioni I, Robertson D, Luther JM, Shibao CA. Hyperinsulinemia and Insulin Resistance in Dopamine ß-Hydroxylase Deficiency. J. Clin. Endocrinol. Metab [print-electronic]. 2016 Oct 10/25/2016; jc20163274. PMID: 27778639, DOI: 10.1210/jc.2016-3274, ISSN: 1945-7197.

Okamoto LE, Diedrich A, Baudenbacher FJ, Harder R, Whitfield JS, Iqbal F, Gamboa A, Shibao CA, Black BK, Raj SR, Robertson D, Biaggioni I. Efficacy of Servo-Controlled Splanchnic Venous Compression in the Treatment of Orthostatic Hypotension: A Randomized Comparison With Midodrine. Hypertension [print-electronic]. 2016 Aug; 68(2): 418-26. PMID: 27271310, PMCID: PMC4945429, PII: HYPERTENSIONAHA.116.07199, DOI: 10.1161/HYPERTENSIONAHA.116.07199, ISSN: 1524-4563.

Shibao CA, Celedonio JE, Ramirez CE, Love-Gregory L, Arnold AC, Choi L, Okamoto LE, Gamboa A, Biaggioni I, Abumrad NN, Abumrad NA. A Common CD36 Variant Influences Endothelial Function and Response to Treatment with Phosphodiesterase 5 Inhibition. J. Clin. Endocrinol. Metab [print-electronic]. 2016 Jul; 101(7): 2751-8. PMID: 27144937, PMCID: PMC4929841, DOI: 10.1210/jc.2016-1294, ISSN: 1945-7197.

Shah SS, Ramirez CE, Powers AC, Yu C, Shibao CA, Luther JM. Hyperglycemic clamp-derived disposition index is negatively associated with metabolic syndrome severity in obese subjects. Metab. Clin. Exp [print-electronic]. 2016 Jun; 65(6): 835-42. PMID: 27173462, PMCID: PMC4867079, PII: S0026-0495(16)00050-0, DOI: 10.1016/j.metabol.2016.02.011, ISSN: 1532-8600.

Bagai K, Peltier AC, Malow BA, Diedrich A, Shibao CA, Black BK, Paranjape SY, Orozco C, Biaggioni I, Robertson D, Raj SR. Objective Sleep Assessments in Patients with Postural Tachycardia Syndrome using Overnight Polysomnograms. J Clin Sleep Med. 2016 May 5/15/2016; 12(5): 727-33. PMID: 26951415, PMCID: PMC4865560, PII: jc-00367-15, DOI: 10.5664/jcsm.5806, ISSN: 1550-9397.

Arnold AC, Okamoto LE, Gamboa A, Black BK, Raj SR, Elijovich F, Robertson D, Shibao CA, Biaggioni I. Mineralocorticoid Receptor Activation Contributes to the Supine Hypertension of Autonomic Failure. Hypertension [print-electronic]. 2016 Feb; 67(2): 424-9. PMID: 26644241, PMCID: PMC4748950, PII: HYPERTENSIONAHA.115.06617, DOI: 10.1161/HYPERTENSIONAHA.115.06617, ISSN: 1524-4563.

Okamoto LE, Raj SR, Gamboa A, Shibao CA, Arnold AC, Garland EM, Black BK, Farley G, Diedrich A, Biaggioni I. Sympathetic activation is associated with increased IL-6, but not CRP in the absence of obesity: lessons from postural tachycardia syndrome and obesity. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2015 Dec 12/15/2015; 309(12): H2098-107. PMID: 26453329, PMCID: PMC4698423, PII: ajpheart.00409.2015, DOI: 10.1152/ajpheart.00409.2015, ISSN: 1522-1539.

McDonell KE, Shibao CA, Claassen DO. Clinical Relevance of Orthostatic Hypotension in Neurodegenerative Disease. Curr Neurol Neurosci Rep. 2015 Dec; 15(12): 78. PMID: 26486792, PII: 10.1007/s11910-015-0599-0, DOI: 10.1007/s11910-015-0599-0, ISSN: 1534-6293.

Ramirez CE, Nian H, Yu C, Gamboa JL, Luther JM, Brown NJ, Shibao CA. Treatment with Sildenafil Improves Insulin Sensitivity in Prediabetes: A Randomized, Controlled Trial. J. Clin. Endocrinol. Metab [print-electronic]. 2015 Dec; 100(12): 4533-40. PMID: 26580240, PMCID: PMC4667163, DOI: 10.1210/jc.2015-3415, ISSN: 1945-7197.

Marinos A, Celedonio JE, Ramirez CE, Gottlieb J, Gamboa A, Hui N, Yu C, Stein CM, Biaggioni I, Shibao CA. Time-Course Analysis of Flow Mediated Dilation for the Evaluation of Endothelial Function After a High-Fat Meal in African Americans. J Am Heart Assoc. 2015 Nov 11/5/2015; 4(11): PMID: 26541392, PMCID: PMC4845211, PII: JAHA.115.002388, DOI: 10.1161/JAHA.115.002388, ISSN: 2047-9980.

Celedonio JE, Arnold AC, Dupont WD, Ramirez CE, Diedrich A, Okamoto LE, Raj SR, Robertson D, Peltier AC, Biaggioni I, Shibao CA. Residual sympathetic tone is associated with reduced insulin sensitivity in patients with autonomic failure. Clin. Auton. Res [print-electronic]. 2015 Oct; 25(5): 309-15. PMID: 26359268, PMCID: PMC4785595, PII: 10.1007/s10286-015-0307-9, DOI: 10.1007/s10286-015-0307-9, ISSN: 0959-9851.

Johnson DA, Joosten YA, Wilkins CH, Shibao CA. Case Study: Community Engagement and Clinical Trial Success: Outreach to African American Women. Clin Transl Sci [print-electronic]. 2015 Aug; 8(4): 388-90. PMID: 25752995, PMCID: PMC4553110, DOI: 10.1111/cts.12264, ISSN: 1752-8062.

Mar PL, Shibao CA, Garland EM, Black BK, Biaggioni I, Diedrich A, Paranjape SY, Robertson D, Raj SR. Neurogenic hyperadrenergic orthostatic hypotension: a newly recognized variant of orthostatic hypotension in older adults with elevated norepinephrine (noradrenaline). Clin. Sci. 2015 Jul; 129(2): 107-16. PMID: 25706983, PMCID: PMC4417057, PII: CS20140766, DOI: 10.1042/CS20140766, ISSN: 1470-8736.

Ramirez CE, Okamoto LE, Arnold AC, Gamboa A, Diedrich A, Choi L, Raj SR, Robertson D, Biaggioni I, Shibao CA. Efficacy of atomoxetine versus midodrine for the treatment of orthostatic hypotension in autonomic failure. Hypertension [print-electronic]. 2014 Dec; 64(6): 1235-40. PMID: 25185131, PMCID: PMC4231172, PII: HYPERTENSIONAHA.114.04225, DOI: 10.1161/HYPERTENSIONAHA.114.04225, ISSN: 1524-4563.

Kpaeyeh J, Mar PL, Raj V, Black BK, Arnold AC, Biaggioni I, Shibao CA, Paranjape SY, Dupont WD, Robertson D, Raj SR. Hemodynamic profiles and tolerability of modafinil in the treatment of postural tachycardia syndrome: a randomized, placebo-controlled trial. J Clin Psychopharmacol. 2014 Dec; 34(6): 738-41. PMID: 25222185, PMCID: PMC4239166, DOI: 10.1097/JCP.0000000000000221, ISSN: 1533-712X.

Okamoto LE, Gamboa A, Shibao CA, Arnold AC, Choi L, Black BK, Raj SR, Robertson D, Biaggioni I. Nebivolol, but not metoprolol, lowers blood pressure in nitric oxide-sensitive human hypertension. Hypertension [print-electronic]. 2014 Dec; 64(6): 1241-7. PMID: 25267802, PMCID: PMC4230998, PII: HYPERTENSIONAHA.114.04116, DOI: 10.1161/HYPERTENSIONAHA.114.04116, ISSN: 1524-4563.

Ferguson MC, Garland EM, Hedges L, Womack-Nunley B, Hamid R, Phillips JA, Shibao CA, Raj SR, Biaggioni I, Robertson D. SHC2 gene copy number in multiple system atrophy (MSA). Clin. Auton. Res [print-electronic]. 2014 Feb; 24(1): 25-30. PMID: 24170347, PMCID: PMC3946192, DOI: 10.1007/s10286-013-0216-8, ISSN: 1619-1560.

Mar PL, Raj V, Black BK, Biaggioni I, Shibao CA, Paranjape SY, Dupont WD, Robertson D, Raj SR. Acute hemodynamic effects of a selective serotonin reuptake inhibitor in postural tachycardia syndrome: a randomized, crossover trial. J. Psychopharmacol. (Oxford) [print-electronic]. 2014 Feb; 28(2): 155-61. PMID: 24227635, PMCID: PMC3956655, PII: 0269881113512911, DOI: 10.1177/0269881113512911, ISSN: 1461-7285.

Arnold AC, Ramirez CE, Choi L, Okamoto LE, Gamboa A, Diedrich A, Raj SR, Robertson D, Biaggioni I, Shibao CA. Combination ergotamine and caffeine improves seated blood pressure and presyncopal symptoms in autonomic failure. Front Physiol. 2014; 5: 270. PMID: 25104940, PMCID: PMC4109567, DOI: 10.3389/fphys.2014.00270.

Green EA, Raj V, Shibao CA, Biaggioni I, Black BK, Dupont WD, Robertson D, Raj SR. Effects of norepinephrine reuptake inhibition on postural tachycardia syndrome. J Am Heart Assoc. 2013 Sep 9/3/2013; 2(5): e000395. PMID: 24002370, PMCID: PMC3835251, PII: jah3299, DOI: 10.1161/JAHA.113.000395, ISSN: 2047-9980.

Gamboa A, Okamoto LE, Raj SR, Diedrich A, Shibao CA, Robertson D, Biaggioni I. Nitric oxide and regulation of heart rate in patients with postural tachycardia syndrome and healthy subjects. Hypertension [print-electronic]. 2013 Feb; 61(2): 376-81. PMID: 23283362, PMCID: PMC3621717, PII: HYPERTENSIONAHA.111.00203, DOI: 10.1161/HYPERTENSIONAHA.111.00203, ISSN: 1524-4563.

Brewster JA, Garland EM, Biaggioni I, Black BK, Ling JF, Shibao CA, Robertson D, Raj SR. Diurnal variability in orthostatic tachycardia: implications for the postural tachycardia syndrome. Clin. Sci. 2012 Jan; 122(1): 25-31. PMID: 21751966, PMCID: PMC3172399, PII: CS20110077, DOI: 10.1042/CS20110077, ISSN: 1470-8736.

Okamoto LE, Gamboa A, Shibao C, Black BK, Diedrich A, Raj SR, Robertson D, Biaggioni I. Nocturnal blood pressure dipping in the hypertension of autonomic failure. Hypertension [print-electronic]. 2009 Feb; 53(2): 363-9. PMID: 19047577, PMCID: PMC2665259, PII: HYPERTENSIONAHA.108.124552, DOI: 10.1161/HYPERTENSIONAHA.108.124552, ISSN: 1524-4563.

Gamboa A, Shibao C, Diedrich A, Paranjape SY, Farley G, Christman B, Raj SR, Robertson D, Biaggioni I. Excessive nitric oxide function and blood pressure regulation in patients with autonomic failure. Hypertension [print-electronic]. 2008 Jun; 51(6): 1531-6. PMID: 18426998, PMCID: PMC2497433, PII: HYPERTENSIONAHA.107.105171, DOI: 10.1161/HYPERTENSIONAHA.107.105171, ISSN: 1524-4563.

Shibao C, Garland EM, Gamboa A, Vnencak-Jones CL, Van Woeltz M, Haines JL, Yu C, Biaggioni I. PRNP M129V homozygosity in multiple system atrophy vs. Parkinson's disease. Clin. Auton. Res [print-electronic]. 2008 Feb; 18(1): 13-9. PMID: 18236005, DOI: 10.1007/s10286-007-0447-7, ISSN: 0959-9851.

Shibao C, Grijalva CG, Raj SR, Biaggioni I, Griffin MR. Orthostatic hypotension-related hospitalizations in the United States. Am. J. Med. 2007 Nov; 120(11): 975-80. PMID: 17976425, PII: S0002-9343(07)00655-9, DOI: 10.1016/j.amjmed.2007.05.009, ISSN: 1555-7162.

Shibao C, Raj SR, Gamboa A, Diedrich A, Choi L, Black BK, Robertson D, Biaggioni I. Norepinephrine transporter blockade with atomoxetine induces hypertension in patients with impaired autonomic function. Hypertension [print-electronic]. 2007 Jul; 50(1): 47-53. PMID: 17515448, PII: HYPERTENSIONAHA.107.089961, DOI: 10.1161/HYPERTENSIONAHA.107.089961, ISSN: 1524-4563.

Shibao C, Gamboa A, Diedrich A, Dossett C, Choi L, Farley G, Biaggioni I. Acarbose, an alpha-glucosidase inhibitor, attenuates postprandial hypotension in autonomic failure. Hypertension [print-electronic]. 2007 Jul; 50(1): 54-61. PMID: 17515447, PII: HYPERTENSIONAHA.107.091355, DOI: 10.1161/HYPERTENSIONAHA.107.091355, ISSN: 1524-4563.

Gamboa A, Shibao C, Diedrich A, Choi L, Pohar B, Jordan J, Paranjape S, Farley G, Biaggioni I. Contribution of endothelial nitric oxide to blood pressure in humans. Hypertension [print-electronic]. 2007 Jan; 49(1): 170-7. PMID: 17130304, PII: 01.HYP.0000252425.06216.26, DOI: 10.1161/01.HYP.0000252425.06216.26, ISSN: 1524-4563.

Shibao C, Gamboa A, Diedrich A, Ertl AC, Chen KY, Byrne DW, Farley G, Paranjape SY, Davis SN, Biaggioni I. Autonomic contribution to blood pressure and metabolism in obesity. Hypertension [print-electronic]. 2007 Jan; 49(1): 27-33. PMID: 17116758, PII: 01.HYP.0000251679.87348.05, DOI: 10.1161/01.HYP.0000251679.87348.05, ISSN: 1524-4563.

Shibao C, Gamboa A, Diedrich A, Biaggioni I. Management of hypertension in the setting of autonomic dysfunction. Curr Treat Options Cardiovasc Med. 2006 Apr; 8(2): 105-9. PMID: 16533484, ISSN: 1092-8464.

Shibao C, Gamboa A, Abraham R, Raj SR, Diedrich A, Black B, Robertson D, Biaggioni I. Clonidine for the treatment of supine hypertension and pressure natriuresis in autonomic failure. Hypertension [print-electronic]. 2006 Mar; 47(3): 522-6. PMID: 16391172, PII: 01.HYP.0000199982.71858.11, DOI: 10.1161/01.HYP.0000199982.71858.11, ISSN: 1524-4563.

Gamboa A, Abraham R, Diedrich A, Shibao C, Paranjape SY, Farley G, Biaggioni I. Role of adenosine and nitric oxide on the mechanisms of action of dipyridamole. Stroke [print-electronic]. 2005 Oct; 36(10): 2170-5. PMID: 16141426, PII: 01.STR.0000179044.37760.9d, DOI: 10.1161/01.STR.0000179044.37760.9d, ISSN: 1524-4628.

Shibao C, Gamboa A, Diedrich A, Biaggioni I. Management of hypertension in the setting of autonomic failure: a pathophysiological approach. Hypertension [print-electronic]. 2005 Apr; 45(4): 469-76. PMID: 15738343, PII: 01.HYP.0000158835.94916.0c, DOI: 10.1161/01.HYP.0000158835.94916.0c, ISSN: 1524-4563.

Shibao C, Arzubiaga C, Roberts LJ, Raj S, Black B, Harris P, Biaggioni I. Hyperadrenergic postural tachycardia syndrome in mast cell activation disorders. Hypertension [print-electronic]. 2005 Mar; 45(3): 385-90. PMID: 15710782, PII: 01.HYP.0000158259.68614.40, DOI: 10.1161/01.HYP.0000158259.68614.40, ISSN: 1524-4563.