Roberto M. Vanacore, Ph.D.

Assistant Professor

roberto.vanacore@vanderbilt.edu

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Faculty Appointments
Assistant Professor of Medicine
Education
Ph.D., Biochemistry, University of Kansas, Kansas City, KansasM.S., Biochemistry, Universidad Austral de Chile, Valdivia, Chile
Office Address
S-3223 MCN
1161 21st Ave South
Nashville, TN 37232-2372
Research Keywords
Biochemistry, Protein Structure, Post-translational Modifications, Mass Spectrometry, Proteomics, Basement Membrane, Extracellular Matrix, Matrix Biology, Diabetic Nephropathy, Glomeruosclerosis and Kidney Disease
Publications
Fidler AL, Vanacore RM, Chetyrkin SV, Pedchenko VK, Bhave G, Yin VP, Stothers CL, Rose KL, McDonald WH, Clark TA, Borza DB, Steele RE, Ivy MT, , Hudson JK, Hudson BG. A unique covalent bond in basement membrane is a primordial innovation for tissue evolution. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2014 Jan 1/7/2014; 111(1): 331-6. PMID: 24344311, PMCID: PMC3890831, PII: 1318499111, DOI: 10.1073/pnas.1318499111, ISSN: 1091-6490.

McCall AS*, Cummings CF*, Bhave G*, Vanacore RM, Page-McCaw A, and Hudson BG. ¿¿¿Bromine is an essential trace element for assembly of collagen IV scaffolds in tissue development and architecture¿¿¿. 2014.

Chen X, Wang H, Liao H, Hu W, Gewin L, Mernaugh G, Zhang S, Zhang S-Y, Vega-Montoto L, Vanacore RM, F¿¿ssler R, Zent R, Pozzi A.. ¿¿¿Integrin ¿¿1¿¿1-mediated tyrosine dephosphorylation of the type II TGF-¿¿ receptor controls Smad-dependent pro-fibrotic signaling¿¿¿. 2014.

Robertson WE, Rose KL, Hudson BG, Vanacore RM. ¿¿¿Supramolecular Organization of the ¿¿121-¿¿565 Collagen IV Network¿¿¿. 2014.

Bhave G, Cummings CF, Vanacore RM, Kumagai-Cresse C, Ero-Tolliver IA, Rafi M, Kang JS, Pedchenko V, Fessler LI, Fessler JH, Hudson BG. Peroxidasin forms sulfilimine chemical bonds using hypohalous acids in tissue genesis. Nat. Chem. Biol [print-electronic]. 2012 Sep; 8(9): 784-90. PMID: 22842973, PMCID: PMC4128002, PII: nchembio.1038, DOI: 10.1038/nchembio.1038, ISSN: 1552-4469.

Steenhard BM, Vanacore R, Friedman D, Zelenchuk A, Stroganova L, Isom K, St John PL, Hudson BG, Abrahamson DR. Upregulated expression of integrin a1 in mesangial cells and integrin a3 and vimentin in podocytes of Col4a3-null (Alport) mice. PLoS ONE [print-electronic]. 2012; 7(12): e50745. PMID: 23236390, PMCID: PMC3517557, PII: PONE-D-12-29453, DOI: 10.1371/journal.pone.0050745, ISSN: 1932-6203.

Vanacore R, Pedchenko V, Bhave G, Hudson BG. Sulphilimine cross-links in Goodpasture's disease. Clin. Exp. Immunol. 2011 May; 164 Suppl 1: 4-6. PMID: 21447121, PMCID: PMC3095855, DOI: 10.1111/j.1365-2249.2011.04356.x, ISSN: 1365-2249.

Pedchenko V, Vanacore R, Hudson B. Goodpasture's disease: molecular architecture of the autoantigen provides clues to etiology and pathogenesis. Curr. Opin. Nephrol. Hypertens. 2011 May; 20(3): 290-6. PMID: 21378566, PMCID: PMC3159420, DOI: 10.1097/MNH.0b013e328344ff20, ISSN: 1473-6543.

Pedchenko V, Bondar O, Fogo AB, Vanacore R, Voziyan P, Kitching AR, Wieslander J, Kashtan C, Borza DB, Neilson EG, Wilson CB, Hudson BG. Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis. N. Engl. J. Med. 2010 Jul 7/22/2010; 363(4): 343-54. PMID: 20660402, PMCID: PMC4144421, PII: 363/4/343, DOI: 10.1056/NEJMoa0910500, ISSN: 1533-4406.

Vanacore R, Ham AJ, Voehler M, Sanders CR, Conrads TP, Veenstra TD, Sharpless KB, Dawson PE, Hudson BG. A sulfilimine bond identified in collagen IV. Science. 2009 Sep 9/4/2009; 325(5945): 1230-4. PMID: 19729652, PMCID: PMC2876822, PII: 325/5945/1230, DOI: 10.1126/science.1176811, ISSN: 1095-9203.

Vanacore RM, Ham AJ, Cartailler JP, Sundaramoorthy M, Todd P, Pedchenko V, Sado Y, Borza DB, Hudson BG. A role for collagen IV cross-links in conferring immune privilege to the Goodpasture autoantigen: structural basis for the crypticity of B cell epitopes. J. Biol. Chem [print-electronic]. 2008 Aug 8/15/2008; 283(33): 22737-48. PMID: 18499662, PMCID: PMC2504875, PII: M803451200, DOI: 10.1074/jbc.M803451200, ISSN: 0021-9258.

Vanacore RM, Friedman DB, Ham AJ, Sundaramoorthy M, Hudson BG. Identification of S-hydroxylysyl-methionine as the covalent cross-link of the noncollagenous (NC1) hexamer of the alpha1alpha1alpha2 collagen IV network: a role for the post-translational modification of lysine 211 to hydroxylysine 211 in hexamer assembly. J. Biol. Chem [print-electronic]. 2005 Aug 8/12/2005; 280(32): 29300-10. PMID: 15951440, PII: M502752200, DOI: 10.1074/jbc.M502752200, ISSN: 0021-9258.

Vanacore RM, Shanmugasundararaj S, Friedman DB, Bondar O, Hudson BG, Sundaramoorthy M. The alpha1.alpha2 network of collagen IV. Reinforced stabilization of the noncollagenous domain-1 by noncovalent forces and the absence of Met-Lys cross-links. J. Biol. Chem [print-electronic]. 2004 Oct 10/22/2004; 279(43): 44723-30. PMID: 15299013, PII: M406344200, DOI: 10.1074/jbc.M406344200, ISSN: 0021-9258.

Vanacore RM, Eskew JD, Morales PJ, Sung L, Smith A. Role for copper in transient oxidation and nuclear translocation of MTF-1, but not of NF-kappa B, by the heme-hemopexin transport system. Antioxid. Redox Signal. 2000; 2(4): 739-52. PMID: 11213479, ISSN: 1523-0864.

Eskew JD, Vanacore RM, Sung L, Morales PJ, Smith A. Cellular protection mechanisms against extracellular heme. heme-hemopexin, but not free heme, activates the N-terminal c-jun kinase. J. Biol. Chem. 1999 Jan 1/8/1999; 274(2): 638-48. PMID: 9872997, ISSN: 0021-9258.

Available Postdoctoral Position Details
Posted: 9/29/2014
Research fellow (Postdoctoral) - Center for Matrix Biology
Division of Nephrology - Vanderbilt University, Nashville TN

Job Description
A NIH- funded postdoctoral fellow position is available immediately in the Center for Matrix Biology to investigate the role of lysyl oxidases in normal kidney function and renal fibrosis.

We are looking for a highly motivated ambitious young scientist (recent PhD graduate) who can work independently and proven ability for critical thinking, method development and problem solving while delivering timely research. The ideal candidate will have extensive experience in protein biochemistry, molecular biology and renal biology. A strong background in enzymology, molecular cloning, and recombinant protein expression will be preferred. Preference will be given to academic career oriented individuals pursuing first author peer-reviewed publication(s).

Basic Requirements:
This position requires a PhD degree (Biochemistry, Molecular/Cell Biology, or related fields)
Excellent written and verbal communication skills including the ability to publish the results of scientific research in scientific journals

Additional Information:
This is a full-time position; 40 hours per week which includes NIH-based salary and all Vanderbilt staff benefits including health and dental insurance, retirement plan, etc.

Qualified applicants will need to submit a cover letter, current CV, publications reprints and at least 3 references via e-mail to debbie.scott@vanderbilt.edu , with the subject line of "Postdoc Position RV"