Jamie P. Dwyer, M.D.


Faculty Appointments
Professor of Medicine
M.D., Medicine, Brown University, Providence, Rhode IslandSc.B., CLASSICS: LATIN, MATHEMATICS, Brown University, Providence, Rhode Island
Office Address
Division of Nephrology / Hypertension
1161 21st Ave S
S-3223 MCN
Nashville, TN 37232
Clinical Research Keywords
Diabetic nephropathy Non-proteinuric diabetic kidney disease Safety in clinical trials Renal safety of non-renal drugs Renal safety in non-renal clinical trials Clinical trial design Clinical trial analysis Clinical trial conduct
Drawz PE, Pajewski NM, Bates JT, Bello NA, Cushman WC, Dwyer JP, Fine LJ, Goff DC, Haley WE, Krousel-Wood M, McWilliams A, Rifkin DE, Slinin Y, Taylor A, Townsend R, Wall B, Wright JT, Rahman M. Effect of Intensive Versus Standard Clinic-Based Hypertension Management on Ambulatory Blood Pressure: Results From the SPRINT (Systolic Blood Pressure Intervention Trial) Ambulatory Blood Pressure Study. Hypertension [print-electronic]. 2017 Jan; 69(1): 42-50. PMID: 27849563, PMCID: PMC5145774, PII: HYPERTENSIONAHA.116.08076, DOI: 10.1161/HYPERTENSIONAHA.116.08076, ISSN: 1524-4563.

van der Sande NG, Dorresteijn JA, Visseren FL, Dwyer JP, Blankestijn PJ, van der Graaf Y, Heerspink HL. Individualized prediction of the effect of angiotensin receptor blockade on renal and cardiovascular outcomes in patients with diabetic nephropathy. Diabetes Obes Metab [print-electronic]. 2016 Nov; 18(11): 1120-7. PMID: 27337598, DOI: 10.1111/dom.12708, ISSN: 1463-1326.

Jalal D, McFadden M, Dwyer JP, Umanath K, Aguilar E, Yagil Y, Greco B, Sika M, Lewis JB, Greene T, Goral S. Adherence rates to ferric citrate as compared to active control in patients with end stage kidney disease on dialysis. Hemodial Int [print-electronic]. 2016 Sep 9/12/2016; PMID: 27615161, DOI: 10.1111/hdi.12487, ISSN: 1542-4758.

Dwyer JP. We Give Too Much Intravenous Iron. Semin Dial [print-electronic]. 2016 May 5/7/2016; PMID: 27153768, DOI: 10.1111/sdi.12509, ISSN: 1525-139X.

Chang TI, Evans G, Cheung AK, Cushman WC, Diamond MJ, Dwyer JP, Huan Y, Kitzman D, Kostis JB, Oparil S, Rastogi A, Roumie CL, Sahay R, Stafford RS, Taylor AA, Wright JT, Chertow GM, . Patterns and Correlates of Baseline Thiazide-Type Diuretic Prescription in the Systolic Blood Pressure Intervention Trial. Hypertension [print-electronic]. 2016 Mar; 67(3): 550-5. PMID: 26865200, PMCID: PMC4755350, PII: HYPERTENSIONAHA.115.06851, DOI: 10.1161/HYPERTENSIONAHA.115.06851, ISSN: 1524-4563.

Schievink B, Kröpelin T, Mulder S, Parving HH, Remuzzi G, Dwyer J, Vemer P, de Zeeuw D, Lambers Heerspink HJ. Early renin-angiotensin system intervention is more beneficial than late intervention in delaying end-stage renal disease in patients with type 2 diabetes. Diabetes Obes Metab [print-electronic]. 2016 Jan; 18(1): 64-71. PMID: 26434564, DOI: 10.1111/dom.12583, ISSN: 1463-1326.

Umanath K, Jalal DI, Greco BA, Umeukeje EM, Reisin E, Manley J, Zeig S, Negoi DG, Hiremath AN, Blumenthal SS, Sika M, Niecestro R, Koury MJ, Ma KN, Greene T, Lewis JB, Dwyer JP, . Ferric Citrate Reduces Intravenous Iron and Erythropoiesis-Stimulating Agent Use in ESRD. J. Am. Soc. Nephrol [print-electronic]. 2015 Oct; 26(10): 2578-87. PMID: 25736045, PMCID: PMC4587699, PII: ASN.2014080842, DOI: 10.1681/ASN.2014080842, ISSN: 1533-3450.

Van Buren PN, Lewis JB, Dwyer JP, Greene T, Middleton J, Sika M, Umanath K, Abraham JD, Arfeen SS, Bowline IG, Chernin G, Fadem SZ, Goral S, Koury M, Sinsakul MV, Weiner DE, . The Phosphate Binder Ferric Citrate and Mineral Metabolism and Inflammatory Markers in Maintenance Dialysis Patients: Results From Prespecified Analyses of a Randomized Clinical Trial. Am. J. Kidney Dis [print-electronic]. 2015 Sep; 66(3): 479-88. PMID: 25958079, PMCID: PMC4868355, PII: S0272-6386(15)00541-7, DOI: 10.1053/j.ajkd.2015.03.013, ISSN: 1523-6838.

Lewis JB, Sika M, Koury MJ, Chuang P, Schulman G, Smith MT, Whittier FC, Linfert DR, Galphin CM, Athreya BP, Nossuli AK, Chang IJ, Blumenthal SS, Manley J, Zeig S, Kant KS, Olivero JJ, Greene T, Dwyer JP, . Ferric citrate controls phosphorus and delivers iron in patients on dialysis. J. Am. Soc. Nephrol [print-electronic]. 2015 Feb; 26(2): 493-503. PMID: 25060056, PMCID: PMC4310662, PII: ASN.2014020212, DOI: 10.1681/ASN.2014020212, ISSN: 1533-3450.

Coffin ST, Waguespack DR, Haglund NA, Maltais S, Dwyer JP, Keebler ME. Kidney dysfunction and left ventricular assist device support: a comprehensive perioperative review. Cardiorenal Med [print-electronic]. 2015 Feb; 5(1): 48-60. PMID: 25759700, PMCID: PMC4327330, PII: crm-0005-0048, DOI: 10.1159/000369589, ISSN: 1664-3828.

McMullan CJ, Lambers Heerspink HJ, Parving HH, Dwyer JP, Forman JP, de Zeeuw D. Visit-to-visit variability in blood pressure and kidney and cardiovascular outcomes in patients with type 2 diabetes and nephropathy: a post hoc analysis from the RENAAL study and the Irbesartan Diabetic Nephropathy Trial. Am. J. Kidney Dis [print-electronic]. 2014 Nov; 64(5): 714-22. PMID: 25064674, PII: S0272-6386(14)00909-3, DOI: 10.1053/j.ajkd.2014.06.008, ISSN: 1523-6838.

Haglund NA, Feurer ID, Dwyer JP, Stulak JM, DiSalvo TG, Keebler ME, Schlendorf KH, Wigger MA, Maltais S. Does renal dysfunction and method of bridging support influence heart transplant graft survival?. Ann. Thorac. Surg [print-electronic]. 2014 Sep; 98(3): 835-41. PMID: 25069689, PII: S0003-4975(14)01179-5, DOI: 10.1016/j.athoracsur.2014.05.059, ISSN: 1552-6259.

Umanath K, Burgner A, Lewis JB, Dwyer JP. Guidelines and Straitjackets: blood pressure targets in the era of the Eighth Joint National Committee [editorial]. Am. J. Kidney Dis [print-electronic]. 2014 Jun; 63(6): 895-9. PMID: 24721220, PII: S0272-6386(14)00621-0, DOI: 10.1053/j.ajkd.2014.03.009, ISSN: 1523-6838.

Umanath K, Lewis JB, Dwyer JP. Optimizing blood pressure control in patients with nondiabetic glomerular disease. Adv Chronic Kidney Dis. 2014 Mar; 21(2): 200-4. PMID: 24602469, PII: S1548-5595(14)00009-3, DOI: 10.1053/j.ackd.2014.01.006, ISSN: 1548-5609.

Lambers Heerspink HJ, Weldegiorgis M, Inker LA, Gansevoort R, Parving HH, Dwyer JP, Mondal H, Coresh J, Greene T, Levey AS, de Zeeuw D. Estimated GFR decline as a surrogate end point for kidney failure: a post hoc analysis from the Reduction of End Points in Non-Insulin-Dependent Diabetes With the Angiotensin II Antagonist Losartan (RENAAL) study and Irbesartan Diabetic Nephropathy Trial (IDNT). Am. J. Kidney Dis [print-electronic]. 2014 Feb; 63(2): 244-50. PMID: 24210590, PII: S0272-6386(13)01289-4, DOI: 10.1053/j.ajkd.2013.09.016, ISSN: 1523-6838.

Hartle PM, Carlo ME, Dwyer JP, Fogo AB. AKI in an HIV patient. J. Am. Soc. Nephrol [print-electronic]. 2013 Jul; 24(8): 1204-8. PMID: 23559580, PMCID: PMC3736712, PII: ASN.2012070665, DOI: 10.1681/ASN.2012070665, ISSN: 1533-3450.

Dwyer JP, Sika M, Schulman G, Chang IJ, Anger M, Smith M, Kaplan M, Zeig S, Koury MJ, Blumenthal SS, Lewis JB, . Dose-response and efficacy of ferric citrate to treat hyperphosphatemia in hemodialysis patients: a short-term randomized trial. Am. J. Kidney Dis [print-electronic]. 2013 May; 61(5): 759-66. PMID: 23369827, PII: S0272-6386(12)01506-5, DOI: 10.1053/j.ajkd.2012.11.041, ISSN: 1523-6838.

Umanath K, Morrison RS, Christopher Wilbeck J, Schulman G, Bream P, Dwyer JP. In-center thrombolysis for clotted AV access: a cohort review. Semin Dial [print-electronic]. 2013 Jan; 26(1): 124-9. PMID: 22784240, DOI: 10.1111/j.1525-139X.2012.01105.x, ISSN: 1525-139X.

Umanath K, Sika M, Niecestro R, Connelly C, Schulman G, Koury MJ, Lewis JB, Dwyer JP, . Rationale and study design of a three-period, 58-week trial of ferric citrate as a phosphate binder in patients with ESRD on dialysis. Hemodial Int [print-electronic]. 2013 Jan; 17(1): 67-74. PMID: 22702490, DOI: 10.1111/j.1542-4758.2012.00711.x, ISSN: 1542-4758.

Dwyer JP, Lewis JB. Nonproteinuric diabetic nephropathy: when diabetics don't read the textbook. Med. Clin. North Am [print-electronic]. 2013 Jan; 97(1): 53-8. PMID: 23290729, PII: S0025-7125(12)00191-5, DOI: 10.1016/j.mcna.2012.10.006, ISSN: 1557-9859.

Fatima H, Siew ED, Dwyer JP, Paueksakon P. Membranous glomerulopathy with superimposed pauci-immune necrotizing crescentic glomerulonephritis. Clin Kidney J. 2012 Dec; 5(6): 587-90. PMID: 26069808, PMCID: PMC4400567, PII: sfs145, DOI: 10.1093/ckj/sfs145, ISSN: 2048-8505.

Siew ED, Ikizler TA, Matheny ME, Shi Y, Schildcrout JS, Danciu I, Dwyer JP, Srichai M, Hung AM, Smith JP, Peterson JF. Estimating baseline kidney function in hospitalized patients with impaired kidney function. Clin J Am Soc Nephrol [print-electronic]. 2012 May; 7(5): 712-9. PMID: 22422536, PMCID: PMC3338282, PII: CJN.10821011, DOI: 10.2215/CJN.10821011, ISSN: 1555-905X.

Dwyer JP, Parving HH, Hunsicker LG, Ravid M, Remuzzi G, Lewis JB. Renal Dysfunction in the Presence of Normoalbuminuria in Type 2 Diabetes: Results from the DEMAND Study. Cardiorenal Med [print-electronic]. 2012 Feb; 2(1): 1-10. PMID: 22493597, PMCID: PMC3318932, PII: crm-0002-0001, DOI: 000333249, ISSN: 1664-3828.

Packham DK, Alves TP, Dwyer JP, Atkins R, de Zeeuw D, Cooper M, Shahinfar S, Lewis JB, Lambers Heerspink HJ. Relative incidence of ESRD versus cardiovascular mortality in proteinuric type 2 diabetes and nephropathy: results from the DIAMETRIC (Diabetes Mellitus Treatment for Renal Insufficiency Consortium) database. Am. J. Kidney Dis [print-electronic]. 2012 Jan; 59(1): 75-83. PMID: 22051245, PII: S0272-6386(11)01406-5, DOI: 10.1053/j.ajkd.2011.09.017, ISSN: 1523-6838.

Dwyer JP, Lewis JB. Olmesartan to prevent the development of microalbuminuria: is it new? Is it true? Is it important?. Am. J. Kidney Dis [print-electronic]. 2011 Nov; 58(5): 700-3. PMID: 21802806, PII: S0272-6386(11)01055-9, DOI: 10.1053/j.ajkd.2011.07.001, ISSN: 1523-6838.

Basford AW, Lewis J, Dwyer JP, Fogo AB. Membranous nephropathy with crescents. J. Am. Soc. Nephrol [print-electronic]. 2011 Oct; 22(10): 1804-8. PMID: 21903992, PII: ASN.2010090923, DOI: 10.1681/ASN.2010090923, ISSN: 1533-3450.

Packham DK, Ivory SE, Reutens AT, Wolfe R, Rohde R, Lambers Heerspink H, Dwyer JP, Atkins RC, Lewis J, . Proteinuria in type 2 diabetic patients with renal impairment: the changing face of diabetic nephropathy. Nephron Clin Pract [print-electronic]. 2011; 118(4): c331-8. PMID: 21293156, PII: 000323139, DOI: 10.1159/000323139, ISSN: 1660-2110.

Elliott MR, Cortese C, Moreno-Aspitia A, Dwyer JP. Plasma cell dyscrasia causing light chain tubulopathy without Fanconi syndrome. Am. J. Kidney Dis [print-electronic]. 2010 Jun; 55(6): 1136-41. PMID: 19850387, PII: S0272-6386(09)01142-1, DOI: 10.1053/j.ajkd.2009.08.010, ISSN: 1523-6838.

Choma DP, Cavanaugh KL, Dwyer JP. Is it always wrong to perform futile CPR? [letter]. N. Engl. J. Med. 2010 May 5/27/2010; 362(21): 2036; author reply 2036-7. PMID: 20518111, ISSN: 1533-4406.

Dwyer JP, Greco BA, Lewis JB. Evaluation of renal artery stenosis in dialysis patients. Semin Dial [print-electronic]. 2009 Sep; 22(5): 519-23. PMID: 19558627, PII: SDI618, DOI: 10.1111/j.1525-139X.2009.00618.x, ISSN: 1525-139X.

Bridges MD, St Amant BS, McNeil RB, Cernigliaro JG, Dwyer JP, Fitzpatrick PM. High-dose gadodiamide for catheter angiography and CT in patients with varying degrees of renal insufficiency: Prevalence of subsequent nephrogenic systemic fibrosis and decline in renal function. AJR Am J Roentgenol. 2009 Jun; 192(6): 1538-43. PMID: 19457816, PII: 192/6/1538, DOI: 10.2214/AJR.07.3895, ISSN: 1546-3141.

Irizarry-Alvarado JM, Dwyer JP, Brumble LM, Alvarez S, Mendez JC. Proximal tubular dysfunction associated with tenofovir and didanosine causing Fanconi syndrome and diabetes insipidus: a report of 3 cases. AIDS Read. 2009 Mar; 19(3): 114-21. PMID: 19334328, ISSN: 1053-0894.

Umana IE, Dwyer JP. Vicarious contrast excretion by the gallbladder in contrast nephropathy. Kidney Int. 2009 Feb; 75(4): 446. PMID: 19180157, PII: ki2008259, DOI: 10.1038/ki.2008.259, ISSN: 1523-1755.

Lette F, Dwyer JP. The fluid craze. Lancet. 2008 Sep 9/6/2008; 372(9641): 782-4. PMID: 18774404, PII: S0140-6736(08)61316-1, DOI: 10.1016/S0140-6736(08)61316-1, ISSN: 1474-547X.

Dwyer JP, Yates KM, Sumner EL, Stone WJ, Wang Y, Koury MJ, Fogo AB, Zent R. Chronic myeloid leukemia-associated membranoproliferative glomerulonephritis that responded to imatinib mesylate therapy. Clin. Nephrol. 2007 Mar; 67(3): 176-81. PMID: 17390742, ISSN: 0301-0430.

Dwyer JP, Cohen MD. Musculoskeletal Manifestations of Chronic Kidney Disease. Bull Rheum Dis. 2003; 52((9)).