Padmini Komalavilas, Ph.D.

Research Associate Professor

padmini.komalavilas@vanderbilt.edu
Faculty Appointments
Research Associate Professor of Surgery
Education
Ph.D., Oklahoma State University, Stillwater, OklahomaM.S., University of Madras, Chennai, IndiaB.S., University of Madras, Chennai, India
Office Address
CC 2306 MCN
Nashville, TN 2730
Publications
Pedigo SL, Guth CM, Hocking KM, Banathy A, Li FD, Cheung-Flynn J, Brophy CM, Guzman RJ, Komalavilas P. Calcification of Human Saphenous Vein Associated with Endothelial Dysfunction: A Pilot Histopathophysiological and Demographical Study. Front Surg. 2017; 4: 6. PMID: 28232909, PMCID: PMC5298955, DOI: 10.3389/fsurg.2017.00006.

Wise ES, Hocking KM, Luo W, Feldman DL, Song J, Komalavilas P, Cheung-Flynn J, Brophy CM. Traditional graft preparation decreases physiologic responses, diminishes viscoelasticity, and reduces cellular viability of the conduit: A porcine saphenous vein model. Vasc Med [print-electronic]. 2016 Oct; 21(5): 413-21. PMID: 27216870, PMCID: PMC5115945, PII: 1358863X16649040, DOI: 10.1177/1358863X16649040, ISSN: 1477-0377.

Banathy A, Cheung-Flynn J, Goleniewska K, Boyd KL, Newcomb DC, Peebles RS, Komalavilas P. Heat Shock-Related Protein 20 Peptide Decreases Human Airway Constriction Downstream of ß2-Adrenergic Receptor. Am. J. Respir. Cell Mol. Biol. 2016 Aug; 55(2): 225-33. PMID: 26909644, PMCID: PMC4979360, DOI: 10.1165/rcmb.2015-0139OC, ISSN: 1535-4989.

Osgood MJ, Sexton K, Voskresensky I, Hocking K, Song J, Komalavilas P, Brophy C, Cheung-Flynn J. Use of Brilliant Blue FCF during vein graft preparation inhibits intimal hyperplasia. J. Vasc. Surg. 2016 Aug; 64(2): 471-8. PMID: 27763268, PII: S0741-5214(15)00278-5, DOI: 10.1016/j.jvs.2015.02.028, ISSN: 1097-6809.

Hocking KM, Luo W, Li FD, Komalavilas P, Brophy C, Cheung-Flynn J. Brilliant blue FCF is a nontoxic dye for saphenous vein graft marking that abrogates response to injury. J. Vasc. Surg [print-electronic]. 2016 Jul; 64(1): 210-8. PMID: 25704409, PMCID: PMC4544660, PII: S0741-5214(15)00061-0, DOI: 10.1016/j.jvs.2014.12.059, ISSN: 1097-6809.

Hocking KM, Putumbaka G, Wise ES, Cheung-Flynn J, Brophy CM, Komalavilas P. Papaverine Prevents Vasospasm by Regulation of Myosin Light Chain Phosphorylation and Actin Polymerization in Human Saphenous Vein. PLoS ONE. 2016; 11(5): e0154460. PMID: 27136356, PMCID: PMC4852981, PII: PONE-D-15-27329, DOI: 10.1371/journal.pone.0154460, ISSN: 1932-6203.

Wise ES, Hocking KM, Eagle S, Absi T, Komalavilas P, Cheung-Flynn J, Brophy CM. Preservation solution impacts physiologic function and cellular viability of human saphenous vein graft. Surgery [print-electronic]. 2015 Aug; 158(2): 537-46. PMID: 26003912, PMCID: PMC4492846, PII: S0039-6060(15)00243-3, DOI: 10.1016/j.surg.2015.03.036, ISSN: 1532-7361.

Wise ES, Hocking KM, Feldman D, Komalavilas P, Cheung-Flynn J, Brophy CM. An Optimized Preparation Technique for Saphenous Vein Graft. Am Surg. 2015 Jul; 81(7): E274-6. PMID: 26140874, PMCID: PMC4635024, ISSN: 1555-9823.

Voskresensky IV, Wise ES, Hocking KM, Li FD, Osgood MJ, Komalavilas P, Brophy C, Cheung-Flynn J. Brilliant blue FCF as an alternative dye for saphenous vein graft marking: effect on conduit function. JAMA Surg. 2014 Nov; 149(11): 1176-81. PMID: 25251505, PMCID: PMC4237645, PII: 1906151, DOI: 10.1001/jamasurg.2014.2029, ISSN: 2168-6262.

Li FD, Eagle S, Brophy C, Hocking KM, Osgood M, Komalavilas P, Cheung-Flynn J. Pressure control during preparation of saphenous veins. JAMA Surg. 2014 Jul; 149(7): 655-62. PMID: 24759942, PMCID: PMC4102634, PII: 1862292, DOI: 10.1001/jamasurg.2013.5067, ISSN: 2168-6262.

Osgood MJ, Hocking KM, Voskresensky IV, Li FD, Komalavilas P, Cheung-Flynn J, Brophy CM. Surgical vein graft preparation promotes cellular dysfunction, oxidative stress, and intimal hyperplasia in human saphenous vein. J. Vasc. Surg [print-electronic]. 2014 Jul; 60(1): 202-11. PMID: 23911244, PMCID: PMC3926896, PII: S0741-5214(13)01145-2, DOI: 10.1016/j.jvs.2013.06.004, ISSN: 1097-6809.

Li FD, Sexton KW, Hocking KM, Osgood MJ, Eagle S, Cheung-Flynn J, Brophy CM, Komalavilas P. Intimal thickness associated with endothelial dysfunction in human vein grafts. J. Surg. Res [print-electronic]. 2013 Mar; 180(1): e55-62. PMID: 22763213, PMCID: PMC3515722, PII: S0022-4804(12)00548-3, DOI: 10.1016/j.jss.2012.06.017, ISSN: 1095-8673.

Osgood MJ, Flynn CR, Komalavilas P, Brophy C. Cell-permeant peptide inhibitors of vasospasm and intimal hyperplasia. Vascular [print-electronic]. 2013 Feb; 21(1): 46-53. PMID: 23104826, PMCID: PMC4180429, PII: vasc.2011.201203, DOI: 10.1258/vasc.2011.201203, ISSN: 1708-5381.

Hocking KM, Baudenbacher FJ, Putumbaka G, Venkatraman S, Cheung-Flynn J, Brophy CM, Komalavilas P. Role of cyclic nucleotide-dependent actin cytoskeletal dynamics:Ca(2+)](i) and force suppression in forskolin-pretreated porcine coronary arteries. PLoS ONE [electronic-print]. 2013; 8(4): e60986. PMID: 23593369, PMCID: PMC3625185, PII: PONE-D-12-33807, DOI: 10.1371/journal.pone.0060986, ISSN: 1932-6203.

Osgood MJ, Harrison DG, Sexton KW, Hocking KM, Voskresensky IV, Komalavilas P, Cheung-Flynn J, Guzman RJ, Brophy CM. Role of the renin-angiotensin system in the pathogenesis of intimal hyperplasia: therapeutic potential for prevention of vein graft failure?. Ann Vasc Surg [print-electronic]. 2012 Nov; 26(8): 1130-44. PMID: 22445245, PMCID: PMC4189806, PII: S0890-5096(12)00052-0, DOI: 10.1016/j.avsg.2011.12.001, ISSN: 1615-5947.

Sexton KW, Hocking KM, Wise E, Osgood MJ, Cheung-Flynn J, Komalavilas P, Campbell KE, Dattilo JB, Brophy CM. Women in academic surgery: the pipeline is busted. J Surg Educ [print-electronic]. 2012 Jan; 69(1): 84-90. PMID: 22208838, PMCID: PMC3458116, PII: S1931-7204(11)00229-7, DOI: 10.1016/j.jsurg.2011.07.008, ISSN: 1878-7452.

Eagle S, Brophy CM, Komalavilas P, Hocking K, Putumbaka G, Osgood M, Sexton K, Leacche M, Cheung-Flynn J. Surgical skin markers impair human saphenous vein graft smooth muscle and endothelial function. Am Surg. 2011 Jul; 77(7): 922-8. PMID: 21944360, PMCID: PMC3957273, ISSN: 1555-9823.

Hocking KM, Brophy C, Rizvi SZ, Komalavilas P, Eagle S, Leacche M, Balaguer JM, Cheung-Flynn J. Detrimental effects of mechanical stretch on smooth muscle function in saphenous veins. J. Vasc. Surg [print-electronic]. 2011 Feb; 53(2): 454-60. PMID: 21146345, PMCID: PMC3053010, PII: S0741-5214(10)02184-1, DOI: 10.1016/j.jvs.2010.09.010, ISSN: 1097-6809.