Faculty Appointments
Assistant Professor of Medicine
Education
M.S., Clinical Invstigation, Vanderbilt University, Nashville, TennesseeM.D., Duke University, Durham, North CarolinaB.S., North Carolina State University, Raleigh, North Carolina
Publications
Iwuchukwu OF, Ramirez AH, Shi Y, Bowton EA, Kawai VK, Schildcrout JS, Roden DM, Denny JC, Stein CM. Genetic determinants of variability in warfarin response after the dose-titration phase. Pharmacogenet. Genomics. 2016 Nov; 26(11): 510-6. PMID: 27632229, DOI: 10.1097/FPC.0000000000000244, ISSN: 1744-6880.
Williams VS, Cresswell CJ, Ruspi G, Yang T, Atak TC, McLoughlin M, Ingram CD, Ramirez AH, Roden D, Armstrong M. Multiplex ligation-dependent probe amplification copy number variant analysis in patients with acquired long QT syndrome. Europace [print-electronic]. 2015 Apr; 17(4): 635-41. PMID: 25564553, PII: euu288, DOI: 10.1093/europace/euu288, ISSN: 1532-2092.
Weeke P, Mosley JD, Hanna D, Delaney JT, Shaffer C, Wells QS, Van Driest S, Karnes JH, Ingram C, Guo Y, Shyr Y, Norris K, Kannankeril PJ, Ramirez AH, Smith JD, Mardis ER, Nickerson D, George AL, Roden DM. Exome sequencing implicates an increased burden of rare potassium channel variants in the risk of drug-induced long QT interval syndrome. J. Am. Coll. Cardiol [print-electronic]. 2014 Apr 4/15/2014; 63(14): 1430-7. PMID: 24561134, PMCID: PMC4018823, PII: S0735-1097(14)00446-X, DOI: 10.1016/j.jacc.2014.01.031, ISSN: 1558-3597.
Ritchie MD, Verma SS, Hall MA, Goodloe RJ, Berg RL, Carrell DS, Carlson CS, Chen L, Crosslin DR, Denny JC, Jarvik G, Li R, Linneman JG, Pathak J, Peissig P, Rasmussen LV, Ramirez AH, Wang X, Wilke RA, Wolf WA, Torstenson ES, Turner SD, McCarty CA. Electronic medical records and genomics (eMERGE) network exploration in cataract: several new potential susceptibility loci. Mol. Vis. 2014; 20: 1281-95. PMID: 25352737, PMCID: PMC4168835, ISSN: 1090-0535.
Wells QS, Becker JR, Su YR, Mosley JD, Weeke P, D'Aoust L, Ausborn NL, Ramirez AH, Pfotenhauer JP, Naftilan AJ, Markham L, Exil V, Roden DM, Hong CC. Whole exome sequencing identifies a causal RBM20 mutation in a large pedigree with familial dilated cardiomyopathy. Circ Cardiovasc Genet [print-electronic]. 2013 Aug; 6(4): 317-26. PMID: 23861363, PMCID: PMC3895490, PII: CIRCGENETICS.113.000011, DOI: 10.1161/CIRCGENETICS.113.000011, ISSN: 1942-3268.
Ramirez AH, Shaffer CM, Delaney JT, Sexton DP, Levy SE, Rieder MJ, Nickerson DA, George AL, Roden DM. Novel rare variants in congenital cardiac arrhythmia genes are frequent in drug-induced torsades de pointes. Pharmacogenomics J [print-electronic]. 2013 Aug; 13(4): 325-9. PMID: 22584458, PMCID: PMC3422407, PII: tpj201214, DOI: 10.1038/tpj.2012.14, ISSN: 1473-1150.
Jeff JM, Ritchie MD, Denny JC, Kho AN, Ramirez AH, Crosslin D, Armstrong L, Basford MA, Wolf WA, Pacheco JA, Chisholm RL, Roden DM, Hayes MG, Crawford DC. Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans. Ann. Hum. Genet [print-electronic]. 2013 Jul; 77(4): 321-32. PMID: 23534349, PMCID: PMC3743946, DOI: 10.1111/ahg.12023, ISSN: 1469-1809.
Schildcrout JS, Denny JC, Bowton E, Gregg W, Pulley JM, Basford MA, Cowan JD, Xu H, Ramirez AH, Crawford DC, Ritchie MD, Peterson JF, Masys DR, Wilke RA, Roden DM. Optimizing drug outcomes through pharmacogenetics: a case for preemptive genotyping. Clin. Pharmacol. Ther [print-electronic]. 2012 Aug; 92(2): 235-42. PMID: 22739144, PMCID: PMC3785311, PII: clpt201266, DOI: 10.1038/clpt.2012.66, ISSN: 1532-6535.
Pulley JM, Denny JC, Peterson JF, Bernard GR, Vnencak-Jones CL, Ramirez AH, Delaney JT, Bowton E, Brothers K, Johnson K, Crawford DC, Schildcrout J, Masys DR, Dilks HH, Wilke RA, Clayton EW, Shultz E, Laposata M, McPherson J, Jirjis JN, Roden DM. Operational implementation of prospective genotyping for personalized medicine: the design of the Vanderbilt PREDICT project. Clin. Pharmacol. Ther [print-electronic]. 2012 Jul; 92(1): 87-95. PMID: 22588608, PMCID: PMC3581305, PII: clpt2011371, DOI: 10.1038/clpt.2011.371, ISSN: 1532-6535.
Ramirez AH, Shi Y, Schildcrout JS, Delaney JT, Xu H, Oetjens MT, Zuvich RL, Basford MA, Bowton E, Jiang M, Speltz P, Zink R, Cowan J, Pulley JM, Ritchie MD, Masys DR, Roden DM, Crawford DC, Denny JC. Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record. Pharmacogenomics [print-electronic]. 2012 Mar; 13(4): 407-18. PMID: 22329724, PMCID: PMC3361510, DOI: 10.2217/pgs.11.164, ISSN: 1744-8042.
Delaney JT, Ramirez AH, Bowton E, Pulley JM, Basford MA, Schildcrout JS, Shi Y, Zink R, Oetjens M, Xu H, Cleator JH, Jahangir E, Ritchie MD, Masys DR, Roden DM, Crawford DC, Denny JC. Predicting clopidogrel response using DNA samples linked to an electronic health record. Clin. Pharmacol. Ther [print-electronic]. 2012 Feb; 91(2): 257-63. PMID: 22190063, PMCID: PMC3621954, PII: clpt2011221, DOI: 10.1038/clpt.2011.221, ISSN: 1532-6535.
Denny JC, Crawford DC, Ritchie MD, Bielinski SJ, Basford MA, Bradford Y, Chai HS, Bastarache L, Zuvich R, Peissig P, Carrell D, Ramirez AH, Pathak J, Wilke RA, Rasmussen L, Wang X, Pacheco JA, Kho AN, Hayes MG, Weston N, Matsumoto M, Kopp PA, Newton KM, Jarvik GP, Li R, Manolio TA, Kullo IJ, Chute CG, Chisholm RL, Larson EB, McCarty CA, Masys DR, Roden DM, de Andrade M. Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies. Am. J. Hum. Genet. 2011 Oct 10/7/2011; 89(4): 529-42. PMID: 21981779, PMCID: PMC3188836, PII: S0002-9297(11)00398-3, DOI: 10.1016/j.ajhg.2011.09.008, ISSN: 1537-6605.
Ramirez AH, Delaney JT, Shuldiner AR. Carrying one or two reduced-function CYP2C19 alleles is associated with an increased risk of major adverse cardiovascular events in people undergoing percutaneous coronary intervention and treated with clopidogrel. Evid Based Med [print-electronic]. 2011 Aug; 16(4): 124-5. PMID: 21705400, PII: ebm1203, DOI: 10.1136/ebm1203, ISSN: 1473-6810.
Xu H, Jiang M, Oetjens M, Bowton EA, Ramirez AH, Jeff JM, Basford MA, Pulley JM, Cowan JD, Wang X, Ritchie MD, Masys DR, Roden DM, Crawford DC, Denny JC. Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin. J Am Med Inform Assoc. 2011 Jul; 18(4): 387-91. PMID: 21672908, PMCID: PMC3128409, PII: amiajnl-2011-000208, DOI: 10.1136/amiajnl-2011-000208, ISSN: 1527-974X.
Ramirez AH, Schildcrout JS, Blakemore DL, Masys DR, Pulley JM, Basford MA, Roden DM, Denny JC. Modulators of normal electrocardiographic intervals identified in a large electronic medical record. Heart Rhythm [print-electronic]. 2011 Feb; 8(2): 271-7. PMID: 21044898, PMCID: PMC3057498, PII: S1547-5271(10)01139-2, DOI: 10.1016/j.hrthm.2010.10.034, ISSN: 1556-3871.
Denny JC, Ritchie MD, Crawford DC, Schildcrout JS, Ramirez AH, Pulley JM, Basford MA, Masys DR, Haines JL, Roden DM. Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science. Circulation [print-electronic]. 2010 Nov 11/16/2010; 122(20): 2016-21. PMID: 21041692, PMCID: PMC2991609, PII: CIRCULATIONAHA.110.948828, DOI: 10.1161/CIRCULATIONAHA.110.948828, ISSN: 1524-4539.
Ritchie MD, Denny JC, Crawford DC, Ramirez AH, Weiner JB, Pulley JM, Basford MA, Brown-Gentry K, Balser JR, Masys DR, Haines JL, Roden DM. Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record. Am. J. Hum. Genet [print-electronic]. 2010 Apr 4/9/2010; 86(4): 560-72. PMID: 20362271, PMCID: PMC2850440, PII: S0002-9297(10)00146-1, DOI: 10.1016/j.ajhg.2010.03.003, ISSN: 1537-6605.
Williams VS, Cresswell CJ, Ruspi G, Yang T, Atak TC, McLoughlin M, Ingram CD, Ramirez AH, Roden D, Armstrong M. Multiplex ligation-dependent probe amplification copy number variant analysis in patients with acquired long QT syndrome. Europace [print-electronic]. 2015 Apr; 17(4): 635-41. PMID: 25564553, PII: euu288, DOI: 10.1093/europace/euu288, ISSN: 1532-2092.
Weeke P, Mosley JD, Hanna D, Delaney JT, Shaffer C, Wells QS, Van Driest S, Karnes JH, Ingram C, Guo Y, Shyr Y, Norris K, Kannankeril PJ, Ramirez AH, Smith JD, Mardis ER, Nickerson D, George AL, Roden DM. Exome sequencing implicates an increased burden of rare potassium channel variants in the risk of drug-induced long QT interval syndrome. J. Am. Coll. Cardiol [print-electronic]. 2014 Apr 4/15/2014; 63(14): 1430-7. PMID: 24561134, PMCID: PMC4018823, PII: S0735-1097(14)00446-X, DOI: 10.1016/j.jacc.2014.01.031, ISSN: 1558-3597.
Ritchie MD, Verma SS, Hall MA, Goodloe RJ, Berg RL, Carrell DS, Carlson CS, Chen L, Crosslin DR, Denny JC, Jarvik G, Li R, Linneman JG, Pathak J, Peissig P, Rasmussen LV, Ramirez AH, Wang X, Wilke RA, Wolf WA, Torstenson ES, Turner SD, McCarty CA. Electronic medical records and genomics (eMERGE) network exploration in cataract: several new potential susceptibility loci. Mol. Vis. 2014; 20: 1281-95. PMID: 25352737, PMCID: PMC4168835, ISSN: 1090-0535.
Wells QS, Becker JR, Su YR, Mosley JD, Weeke P, D'Aoust L, Ausborn NL, Ramirez AH, Pfotenhauer JP, Naftilan AJ, Markham L, Exil V, Roden DM, Hong CC. Whole exome sequencing identifies a causal RBM20 mutation in a large pedigree with familial dilated cardiomyopathy. Circ Cardiovasc Genet [print-electronic]. 2013 Aug; 6(4): 317-26. PMID: 23861363, PMCID: PMC3895490, PII: CIRCGENETICS.113.000011, DOI: 10.1161/CIRCGENETICS.113.000011, ISSN: 1942-3268.
Ramirez AH, Shaffer CM, Delaney JT, Sexton DP, Levy SE, Rieder MJ, Nickerson DA, George AL, Roden DM. Novel rare variants in congenital cardiac arrhythmia genes are frequent in drug-induced torsades de pointes. Pharmacogenomics J [print-electronic]. 2013 Aug; 13(4): 325-9. PMID: 22584458, PMCID: PMC3422407, PII: tpj201214, DOI: 10.1038/tpj.2012.14, ISSN: 1473-1150.
Jeff JM, Ritchie MD, Denny JC, Kho AN, Ramirez AH, Crosslin D, Armstrong L, Basford MA, Wolf WA, Pacheco JA, Chisholm RL, Roden DM, Hayes MG, Crawford DC. Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans. Ann. Hum. Genet [print-electronic]. 2013 Jul; 77(4): 321-32. PMID: 23534349, PMCID: PMC3743946, DOI: 10.1111/ahg.12023, ISSN: 1469-1809.
Schildcrout JS, Denny JC, Bowton E, Gregg W, Pulley JM, Basford MA, Cowan JD, Xu H, Ramirez AH, Crawford DC, Ritchie MD, Peterson JF, Masys DR, Wilke RA, Roden DM. Optimizing drug outcomes through pharmacogenetics: a case for preemptive genotyping. Clin. Pharmacol. Ther [print-electronic]. 2012 Aug; 92(2): 235-42. PMID: 22739144, PMCID: PMC3785311, PII: clpt201266, DOI: 10.1038/clpt.2012.66, ISSN: 1532-6535.
Pulley JM, Denny JC, Peterson JF, Bernard GR, Vnencak-Jones CL, Ramirez AH, Delaney JT, Bowton E, Brothers K, Johnson K, Crawford DC, Schildcrout J, Masys DR, Dilks HH, Wilke RA, Clayton EW, Shultz E, Laposata M, McPherson J, Jirjis JN, Roden DM. Operational implementation of prospective genotyping for personalized medicine: the design of the Vanderbilt PREDICT project. Clin. Pharmacol. Ther [print-electronic]. 2012 Jul; 92(1): 87-95. PMID: 22588608, PMCID: PMC3581305, PII: clpt2011371, DOI: 10.1038/clpt.2011.371, ISSN: 1532-6535.
Ramirez AH, Shi Y, Schildcrout JS, Delaney JT, Xu H, Oetjens MT, Zuvich RL, Basford MA, Bowton E, Jiang M, Speltz P, Zink R, Cowan J, Pulley JM, Ritchie MD, Masys DR, Roden DM, Crawford DC, Denny JC. Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record. Pharmacogenomics [print-electronic]. 2012 Mar; 13(4): 407-18. PMID: 22329724, PMCID: PMC3361510, DOI: 10.2217/pgs.11.164, ISSN: 1744-8042.
Delaney JT, Ramirez AH, Bowton E, Pulley JM, Basford MA, Schildcrout JS, Shi Y, Zink R, Oetjens M, Xu H, Cleator JH, Jahangir E, Ritchie MD, Masys DR, Roden DM, Crawford DC, Denny JC. Predicting clopidogrel response using DNA samples linked to an electronic health record. Clin. Pharmacol. Ther [print-electronic]. 2012 Feb; 91(2): 257-63. PMID: 22190063, PMCID: PMC3621954, PII: clpt2011221, DOI: 10.1038/clpt.2011.221, ISSN: 1532-6535.
Denny JC, Crawford DC, Ritchie MD, Bielinski SJ, Basford MA, Bradford Y, Chai HS, Bastarache L, Zuvich R, Peissig P, Carrell D, Ramirez AH, Pathak J, Wilke RA, Rasmussen L, Wang X, Pacheco JA, Kho AN, Hayes MG, Weston N, Matsumoto M, Kopp PA, Newton KM, Jarvik GP, Li R, Manolio TA, Kullo IJ, Chute CG, Chisholm RL, Larson EB, McCarty CA, Masys DR, Roden DM, de Andrade M. Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies. Am. J. Hum. Genet. 2011 Oct 10/7/2011; 89(4): 529-42. PMID: 21981779, PMCID: PMC3188836, PII: S0002-9297(11)00398-3, DOI: 10.1016/j.ajhg.2011.09.008, ISSN: 1537-6605.
Ramirez AH, Delaney JT, Shuldiner AR. Carrying one or two reduced-function CYP2C19 alleles is associated with an increased risk of major adverse cardiovascular events in people undergoing percutaneous coronary intervention and treated with clopidogrel. Evid Based Med [print-electronic]. 2011 Aug; 16(4): 124-5. PMID: 21705400, PII: ebm1203, DOI: 10.1136/ebm1203, ISSN: 1473-6810.
Xu H, Jiang M, Oetjens M, Bowton EA, Ramirez AH, Jeff JM, Basford MA, Pulley JM, Cowan JD, Wang X, Ritchie MD, Masys DR, Roden DM, Crawford DC, Denny JC. Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin. J Am Med Inform Assoc. 2011 Jul; 18(4): 387-91. PMID: 21672908, PMCID: PMC3128409, PII: amiajnl-2011-000208, DOI: 10.1136/amiajnl-2011-000208, ISSN: 1527-974X.
Ramirez AH, Schildcrout JS, Blakemore DL, Masys DR, Pulley JM, Basford MA, Roden DM, Denny JC. Modulators of normal electrocardiographic intervals identified in a large electronic medical record. Heart Rhythm [print-electronic]. 2011 Feb; 8(2): 271-7. PMID: 21044898, PMCID: PMC3057498, PII: S1547-5271(10)01139-2, DOI: 10.1016/j.hrthm.2010.10.034, ISSN: 1556-3871.
Denny JC, Ritchie MD, Crawford DC, Schildcrout JS, Ramirez AH, Pulley JM, Basford MA, Masys DR, Haines JL, Roden DM. Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science. Circulation [print-electronic]. 2010 Nov 11/16/2010; 122(20): 2016-21. PMID: 21041692, PMCID: PMC2991609, PII: CIRCULATIONAHA.110.948828, DOI: 10.1161/CIRCULATIONAHA.110.948828, ISSN: 1524-4539.
Ritchie MD, Denny JC, Crawford DC, Ramirez AH, Weiner JB, Pulley JM, Basford MA, Brown-Gentry K, Balser JR, Masys DR, Haines JL, Roden DM. Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record. Am. J. Hum. Genet [print-electronic]. 2010 Apr 4/9/2010; 86(4): 560-72. PMID: 20362271, PMCID: PMC2850440, PII: S0002-9297(10)00146-1, DOI: 10.1016/j.ajhg.2010.03.003, ISSN: 1537-6605.