Seth A. Smith, Ph.D.

Associate Professor

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Faculty Appointments
Associate Professor of Radiology and Radiological Sciences Associate Professor of Biomedical EngineeringChancellor Faculty FellowAssociate Professor of Ophthalmology and Visual Sciences
Ph.D., Johns Hopkins University, Baltimore, MarylandB.S., Physics, Virginia Polytechnic Institute, Blacksburg, VirginiaB.S., Mathematics, Virginia Polytechnic Institute, Blacksburg, Virginia
Office Address
1161 21st Ave South
Medical Center North, AAA-3111
Nashville, TN 37232
Research Description
Seth Smith, Ph.D., earned a B.S. in Physics and a B.S. in Mathematics from Virginia Tech and a Ph.D. in Biophysics ad Biophysical Chemistry from Johns Hopkins University. After earning his PhD, he joined the research faculty at Kennedy Krieger Institute at the F.M. Kirby Research Center where her remained until 2009. In 2009, he joined the Vanderbilt faculty as Assistant Professor of Radiology, Biomedical Engineering and Physics. In 2015 he was appointed Associate Professor in Radiology and Radiological Sciences, Biomedical Engineering, and Ophthalmology. He was named to the 2017 class of Chancellor Faculty Fellows.Since 2010, he has served as Director of the Center for Human Imaging at Vanderbilt University Institute of Imaging Science. His research is focused on translation of advanced, quantitative MRI methods into human diseases such as Multiple Sclerosis and Optic Neuropathies focusing on quantitative assessment of the spinal cord and optic nerves at both high and low field strengths.

Section: Vanderbilt University Institute of Imaging Science
Research Keywords
Magnetic Resonance Imaging, Spinal Cord, Magnetization Transfer, Diffusion Tensor Imaging, Optic Nerve
Smith SA, Jones CK, Gifford A, Belegu V, Chodkowski B, Farrell JA, Landman BA, Reich DS, Calabresi PA, McDonald JW, van Zijl PC. Reproducibility of tract-specific magnetization transfer and diffusion tensor imaging in the cervical spinal cord at 3 tesla. NMR Biomed. 2010 Feb; 23(2): 207-17. PMID: 19924726, PMCID: PMC2830283, DOI: 10.1002/nbm.1447, ISSN: 1099-1492.

Smith SA, Bulte JW, van Zijl PC. Direct saturation MRI: theory and application to imaging brain iron. Magn Reson Med. 2009 Aug; 62(2): 384-93. PMID: 19526497, PMCID: PMC2766589, DOI: 10.1002/mrm.21980, ISSN: 1522-2594.

Zackowski KM, Smith SA, Reich DS, Gordon-Lipkin E, Chodkowski BA, Sambandan DR, Shteyman M, Bastian AJ, van Zijl PC, Calabresi PA. Sensorimotor dysfunction in multiple sclerosis and column-specific magnetization transfer-imaging abnormalities in the spinal cord. Brain [print-electronic]. 2009 May; 132(Pt 5): 1200-9. PMID: 19297508, PMCID: PMC2677795, PII: awp032, DOI: 10.1093/brain/awp032, ISSN: 1460-2156.

Smith SA, Golay X, Fatemi A, Mahmood A, Raymond GV, Moser HW, van Zijl PC, Stanisz GJ. Quantitative magnetization transfer characteristics of the human cervical spinal cord in vivo: application to adrenomyeloneuropathy. Magn Reson Med. 2009 Jan; 61(1): 22-7. PMID: 19097204, PMCID: PMC2632947, DOI: 10.1002/mrm.21827, ISSN: 1522-2594.

Smith SA, Edden RA, Farrell JA, Barker PB, Van Zijl PC. Measurement of T1 and T2 in the cervical spinal cord at 3 tesla. Magn Reson Med. 2008 Jul; 60(1): 213-9. PMID: 18581383, PMCID: PMC2887301, DOI: 10.1002/mrm.21596, ISSN: 0740-3194.

Farrell JA, Smith SA, Gordon-Lipkin EM, Reich DS, Calabresi PA, van Zijl PC. High b-value q-space diffusion-weighted MRI of the human cervical spinal cord in vivo: feasibility and application to multiple sclerosis. Magn Reson Med. 2008 May; 59(5): 1079-89. PMID: 18429023, PMCID: PMC2849312, DOI: 10.1002/mrm.21563, ISSN: 0740-3194.

Reich DS, Zackowski KM, Gordon-Lipkin EM, Smith SA, Chodkowski BA, Cutter GR, Calabresi PA. Corticospinal tract abnormalities are associated with weakness in multiple sclerosis. AJNR Am J Neuroradiol [print-electronic]. 2008 Feb; 29(2): 333-9. PMID: 17974617, PMCID: PMC2802714, PII: ajnr.A0788, DOI: 10.3174/ajnr.A0788, ISSN: 1936-959X.

Reich DS, Smith SA, Zackowski KM, Gordon-Lipkin EM, Jones CK, Farrell JA, Mori S, van Zijl PC, Calabresi PA. Multiparametric magnetic resonance imaging analysis of the corticospinal tract in multiple sclerosis. Neuroimage [print-electronic]. 2007 Nov 11/1/2007; 38(2): 271-9. PMID: 17870615, PMCID: PMC2082136, PII: S1053-8119(07)00678-7, DOI: 10.1016/j.neuroimage.2007.07.049, ISSN: 1053-8119.

Gordon-Lipkin E, Chodkowski B, Reich DS, Smith SA, Pulicken M, Balcer LJ, Frohman EM, Cutter G, Calabresi PA. Retinal nerve fiber layer is associated with brain atrophy in multiple sclerosis. Neurology. 2007 Oct 10/16/2007; 69(16): 1603-9. PMID: 17938370, PII: 69/16/1603, DOI: 10.1212/, ISSN: 1526-632X.

Hua J, Jones CK, Blakeley J, Smith SA, van Zijl PC, Zhou J. Quantitative description of the asymmetry in magnetization transfer effects around the water resonance in the human brain. Magn Reson Med. 2007 Oct; 58(4): 786-93. PMID: 17899597, PMCID: PMC3707117, DOI: 10.1002/mrm.21387, ISSN: 0740-3194.

Farrell JA, Landman BA, Jones CK, Smith SA, Prince JL, van Zijl PC, Mori S. Effects of signal-to-noise ratio on the accuracy and reproducibility of diffusion tensor imaging-derived fractional anisotropy, mean diffusivity, and principal eigenvector measurements at 1.5 T. J Magn Reson Imaging. 2007 Sep; 26(3): 756-67. PMID: 17729339, PMCID: PMC2862967, DOI: 10.1002/jmri.21053, ISSN: 1053-1807.

Reich DS, Smith SA, Jones CK, Zackowski KM, van Zijl PC, Calabresi PA, Mori S. Quantitative characterization of the corticospinal tract at 3T. AJNR Am J Neuroradiol. 2006 Nov; 27(10): 2168-78. PMID: 17110689, PMCID: PMC2802715, PII: 27/10/2168, ISSN: 0195-6108.

Smith SA, Farrell JA, Jones CK, Reich DS, Calabresi PA, van Zijl PC. Pulsed magnetization transfer imaging with body coil transmission at 3 Tesla: feasibility and application. Magn Reson Med. 2006 Oct; 56(4): 866-75. PMID: 16964602, DOI: 10.1002/mrm.21035, ISSN: 0740-3194.

Smith SA, Golay X, Fatemi A, Jones CK, Raymond GV, Moser HW, van Zijl PC. Magnetization transfer weighted imaging in the upper cervical spinal cord using cerebrospinal fluid as intersubject normalization reference (MTCSF imaging). Magn Reson Med. 2005 Jul; 54(1): 201-6. PMID: 15968676, DOI: 10.1002/mrm.20553, ISSN: 0740-3194.

Fatemi A, Smith SA, Dubey P, Zackowski KM, Bastian AJ, van Zijl PC, Moser HW, Raymond GV, Golay X. Magnetization transfer MRI demonstrates spinal cord abnormalities in adrenomyeloneuropathy. Neurology. 2005 May 5/24/2005; 64(10): 1739-45. PMID: 15911801, PII: 64/10/1739, DOI: 10.1212/01.WNL.0000164458.02141.06, ISSN: 1526-632X.