Lance R. Thomas, Ph.D.

Research Assistant Professor
Faculty Appointments
Research Assistant Professor in Cell and Developmental Biology
Ph.D., CANCER BIOLOGY, Wake Forest University, Winston-Salem, North CarolinaB.S., University of Utah, Salt Lake City, Utah
Research Keywords
Regulatory Protein Modifications in Immunoreceptor Signaling
Thomas LR, Cobb RM, Oltz EM. Dynamic regulation of antigen receptor gene assembly. Adv. Exp. Med. Biol. 2009; 650: 103-15. PMID: 19731805, ISSN: 0065-2598.

Thomas LR, Miyashita H, Cobb RM, Pierce S, Tachibana M, Hobeika E, Reth M, Shinkai Y, Oltz EM. Functional analysis of histone methyltransferase g9a in B and T lymphocytes. J. Immunol. 2008 Jul 7/1/2008; 181(1): 485-93. PMID: 18566414, PMCID: PMC2497432, PII: 181/1/485, ISSN: 0022-1767.

Bin L, Thorburn J, Thomas LR, Clark PE, Humphreys R, Thorburn A. Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through the DR4 receptor by competing for ligand binding. J. Biol. Chem [print-electronic]. 2007 Sep 9/21/2007; 282(38): 28189-94. PMID: 17666396, PII: M704210200, DOI: 10.1074/jbc.M704210200, ISSN: 0021-9258.

Zhang F, Thomas LR, Oltz EM, Aune TM. Control of thymocyte development and recombination-activating gene expression by the zinc finger protein Zfp608. Nat. Immunol [print-electronic]. 2006 Dec; 7(12): 1309-16. PMID: 17057722, PII: ni1397, DOI: 10.1038/ni1397, ISSN: 1529-2908.

Thomas LR, Bender LM, Morgan MJ, Thorburn A. Extensive regions of the FADD death domain are required for binding to the TRAIL receptor DR5 [letter]. Cell Death Differ. 2006 Jan; 13(1): 160-2. PMID: 16003390, PII: 4401714, DOI: 10.1038/sj.cdd.4401714, ISSN: 1350-9047.

O'Flaherty JT, Rogers LC, Paumi CM, Hantgan RR, Thomas LR, Clay CE, High K, Chen YQ, Willingham MC, Smitherman PK, Kute TE, Rao A, Cramer SD, Morrow CS. 5-Oxo-ETE analogs and the proliferation of cancer cells. Biochim. Biophys. Acta [print-electronic]. 2005 Oct 10/1/2005; 1736(3): 228-36. PMID: 16154383, PII: S1388-1981(05)00198-8, DOI: 10.1016/j.bbalip.2005.08.009, ISSN: 0006-3002.

Bender LM, Morgan MJ, Thomas LR, Liu ZG, Thorburn A. The adaptor protein TRADD activates distinct mechanisms of apoptosis from the nucleus and the cytoplasm. Cell Death Differ. 2005 May; 12(5): 473-81. PMID: 15761471, PII: 4401578, DOI: 10.1038/sj.cdd.4401578, ISSN: 1350-9047.

Thorburn J, Moore F, Rao A, Barclay WW, Thomas LR, Grant KW, Cramer SD, Thorburn A. Selective inactivation of a Fas-associated death domain protein (FADD)-dependent apoptosis and autophagy pathway in immortal epithelial cells. Mol. Biol. Cell [print-electronic]. 2005 Mar; 16(3): 1189-99. PMID: 15635090, PMCID: PMC551484, PII: E04-10-0906, DOI: 10.1091/mbc.E04-10-0906, ISSN: 1059-1524.

Thomas LR, Johnson RL, Reed JC, Thorburn A. The C-terminal tails of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas receptors have opposing functions in Fas-associated death domain (FADD) recruitment and can regulate agonist-specific mechanisms of receptor activation. J. Biol. Chem [print-electronic]. 2004 Dec 12/10/2004; 279(50): 52479-86. PMID: 15452120, PII: M409578200, DOI: 10.1074/jbc.M409578200, ISSN: 0021-9258.

Thomas LR, Henson A, Reed JC, Salsbury FR, Thorburn A. Direct binding of Fas-associated death domain (FADD) to the tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 is regulated by the death effector domain of FADD. J. Biol. Chem [print-electronic]. 2004 Jul 7/30/2004; 279(31): 32780-5. PMID: 15173180, PII: M401680200, DOI: 10.1074/jbc.M401680200, ISSN: 0021-9258.

Eriksson P, Thomas LR, Thorburn A, Stillman DJ. PRS yeast vectors with a LYS2 marker. BioTechniques. 2004 Feb; 36(2): 212-3. PMID: 14989082, ISSN: 0736-6205.

Bhoite LT, Allen JM, Garcia E, Thomas LR, Gregory ID, Voth WP, Whelihan K, Rolfes RJ, Stillman DJ. Mutations in the pho2 (bas2) transcription factor that differentially affect activation with its partner proteins bas1, pho4, and swi5. J. Biol. Chem [print-electronic]. 2002 Oct 10/4/2002; 277(40): 37612-8. PMID: 12145299, PII: M206125200, DOI: 10.1074/jbc.M206125200, ISSN: 0021-9258.

Thomas LR, Stillman DJ, Thorburn A. Regulation of Fas-associated death domain interactions by the death effector domain identified by a modified reverse two-hybrid screen. J. Biol. Chem [print-electronic]. 2002 Sep 9/13/2002; 277(37): 34343-8. PMID: 12107169, PII: M204169200, DOI: 10.1074/jbc.M204169200, ISSN: 0021-9258.

Morgan MJ, Thorburn J, Thomas L, Maxwell T, Brothman AR, Thorburn A. An apoptosis signaling pathway induced by the death domain of FADD selectively kills normal but not cancerous prostate epithelial cells. Cell Death Differ. 2001 Jul; 8(7): 696-705. PMID: 11464214, DOI: 10.1038/sj.cdd.4400866, ISSN: 1350-9047.