Eric Tatsuo Shinohara, M.D.

Associate Professor

eric.t.shinohara@vanderbilt.edu
Faculty Appointments
Associate Professor of Radiation Oncology
Education
M.S.C.I., Clinical Investigation, Vanderbilt University, Nashville, TennesseeM.D., Medicine, Vanderbilt University, Nashville, TennesseeB.S., University of Maryland, College Park, Maryland
Publications
Shinohara ET, Guo M, Mitra N, Metz JM. Brachytherapy in the treatment of cholangiocarcinoma. Int. J. Radiat. Oncol. Biol. Phys [print-electronic]. 2010 Nov 11/1/2010; 78(3): 722-8. PMID: 20207503, PII: S0360-3016(09)03044-2, DOI: 10.1016/j.ijrobp.2009.08.070, ISSN: 1879-355X.

Fernandes AT, Shinohara ET, Guo M, Mitra N, Wilson LD, Rengan R, Metz JM. The role of radiation therapy in malignant thymoma: a Surveillance, Epidemiology, and End Results database analysis. J Thorac Oncol. 2010 Sep; 5(9): 1454-60. PMID: 20651611, DOI: 10.1097/JTO.0b013e3181e8f345, ISSN: 1556-1380.

Shinohara ET, Maity A. Increasing sensitivity to radiotherapy and chemotherapy by using novel biological agents that alter the tumor microenvironment. Curr. Mol. Med. 2009 Dec; 9(9): 1034-45. PMID: 19938317, ISSN: 1875-5666.

Shinohara ET, Mitra N, Guo M, Metz JM. Radiotherapy is associated with improved survival in adjuvant and palliative treatment of extrahepatic cholangiocarcinomas. Int. J. Radiat. Oncol. Biol. Phys [print-electronic]. 2009 Jul 7/15/2009; 74(4): 1191-8. PMID: 19201549, PII: S0360-3016(08)03469-X, DOI: 10.1016/j.ijrobp.2008.09.017, ISSN: 1879-355X.

Shinohara ET, Maity A, Jha N, Lustig RA. Sirolimus as a potential radiosensitizer in squamous cell cancer of the head and neck. Head Neck. 2009 Mar; 31(3): 406-11. PMID: 18704962, PMCID: PMC2737255, DOI: 10.1002/hed.20898, ISSN: 1097-0347.

Shinohara ET, Mitra N, Guo M, Metz JM. Radiation therapy is associated with improved survival in the adjuvant and definitive treatment of intrahepatic cholangiocarcinoma. Int. J. Radiat. Oncol. Biol. Phys [print-electronic]. 2008 Dec 12/1/2008; 72(5): 1495-501. PMID: 18472359, PII: S0360-3016(08)00480-X, DOI: 10.1016/j.ijrobp.2008.03.018, ISSN: 1879-355X.

Jaboin JJ, Shinohara ET, Moretti L, Yang ES, Kaminski JM, Lu B. The role of mTOR inhibition in augmenting radiation induced autophagy. Technol. Cancer Res. Treat. 2007 Oct; 6(5): 443-7. PMID: 17877432, PII: d=3029&c=4241&p=16188&do=detail, ISSN: 1533-0346.

Shinohara ET, Kaminski JM, Segal DJ, Pelczar P, Kolhe R, Ryan T, Coates CJ, Fraser MJ, Handler AM, Yanagimachi R, Moisyadi S. Active integration: new strategies for transgenesis. Transgenic Res [print-electronic]. 2007 Jun; 16(3): 333-9. PMID: 17340207, DOI: 10.1007/s11248-007-9077-z, ISSN: 0962-8819.

Kim KW, Mutter RW, Willey CD, Subhawong TK, Shinohara ET, Albert JM, Ling G, Cao C, Gi YJ, Lu B. Inhibition of survivin and aurora B kinase sensitizes mesothelioma cells by enhancing mitotic arrests. Int. J. Radiat. Oncol. Biol. Phys. 2007 Apr 4/1/2007; 67(5): 1519-25. PMID: 17394948, PII: S0360-3016(06)03665-0, DOI: 10.1016/j.ijrobp.2006.12.018, ISSN: 0360-3016.

Shinohara ET, Gonzalez A, Massion PP, Olson SJ, Albert JM, Shyr Y, Carbone DP, Johnson DH, Hallahan DE, Lu B. PDGFR-beta expression in small cell lung cancer patients. Int. J. Radiat. Oncol. Biol. Phys. 2007 Feb 2/1/2007; 67(2): 431-7. PMID: 17236966, PII: S0360-3016(06)02807-0, DOI: 10.1016/j.ijrobp.2006.08.060, ISSN: 0360-3016.

Shinohara ET, Swisher-McClure S, Husson M, Sun W, Metz JM. Esophageal cancer in a young woman with bulimia nervosa: a case report. J Med Case Rep. 2007; 1: 160. PMID: 18047676, PMCID: PMC2213673, PII: 1752-1947-1-160, DOI: 10.1186/1752-1947-1-160, ISSN: 1752-1947.

Yazlovitskaya EM, Edwards E, Thotala D, Fu A, Osusky KL, Whetsell WO, Boone B, Shinohara ET, Hallahan DE. Lithium treatment prevents neurocognitive deficit resulting from cranial irradiation. Cancer Res. 2006 Dec 12/1/2006; 66(23): 11179-86. PMID: 17145862, PII: 66/23/11179, DOI: 10.1158/0008-5472.CAN-06-2740, ISSN: 0008-5472.

Li HC, Albert JM, Shinohara ET, Cai Q, Freyer A, Cai H, Cao C, Wang Z, Kataoka N, Teng M, Zheng W, Lu B. E-cadherin promoter polymorphisms are not associated with the aggressiveness of prostate cancer in Caucasian patients. Urol. Oncol. 2006 Nov; 24(6): 496-502. PMID: 17138130, PII: S1078-1439(06)00062-7, DOI: 10.1016/j.urolonc.2006.02.018, ISSN: 1078-1439.

Kim KW, Mutter RW, Cao C, Albert JM, Shinohara ET, Sekhar KR, Lu B. Inhibition of signal transducer and activator of transcription 3 activity results in down-regulation of Survivin following irradiation. Mol. Cancer Ther. 2006 Nov; 5(11): 2659-65. PMID: 17121912, PII: 5/11/2659, DOI: 10.1158/1535-7163.MCT-06-0261, ISSN: 1535-7163.

Browning RE, Li H, Shinohara ET, Cai Q, Chen H, Courtney R, Cao C, Zheng W, Lu B. ATM polymorphism IVS62+60G>A is not associated with disease aggressiveness in prostate cancer. Urology. 2006 Jun; 67(6): 1320-3. PMID: 16765197, PII: S0090-4295(05)01766-8, DOI: 10.1016/j.urology.2005.12.012, ISSN: 1527-9995.

Li H, Shinohara ET, Cai Q, Chen H, Courtney R, Cao C, Wang Z, Teng M, Zheng W, Lu B. Plasminogen activator inhibitor-1 promoter polymorphism is not associated with the aggressiveness of disease in prostate cancer. Clin Oncol (R Coll Radiol). 2006 May; 18(4): 333-7. PMID: 16703752, ISSN: 0936-6555.

Cuneo KC, Geng L, Tan J, Brousal J, Shinohara ET, Osusky K, Fu A, Shyr Y, Wu H, Hallahan DE. SRC family kinase inhibitor SU6656 enhances antiangiogenic effect of irradiation. Int. J. Radiat. Oncol. Biol. Phys. 2006 Mar 3/15/2006; 64(4): 1197-203. PMID: 16504759, PII: S0360-3016(05)02974-3, DOI: 10.1016/j.ijrobp.2005.11.014, ISSN: 0360-3016.

Cao C, Shinohara ET, Subhawong TK, Geng L, Kim KW, Albert JM, Hallahan DE, Lu B. Radiosensitization of lung cancer by nutlin, an inhibitor of murine double minute 2. Mol. Cancer Ther. 2006 Feb; 5(2): 411-7. PMID: 16505116, PII: 5/2/411, DOI: 10.1158/1535-7163.MCT-05-0356, ISSN: 1535-7163.

Geng L, Shinohara ET, Kim D, Tan J, Osusky K, Shyr Y, Hallahan DE. STI571 (Gleevec) improves tumor growth delay and survival in irradiated mouse models of glioblastoma. Int. J. Radiat. Oncol. Biol. Phys [print-electronic]. 2006 Jan 1/1/2006; 64(1): 263-71. PMID: 16274936, PII: S0360-3016(05)02387-4, DOI: 10.1016/j.ijrobp.2005.08.025, ISSN: 0360-3016.

Lu B, Shinohara ET, Edwards E, Geng L, Tan J, Hallahan DE. The use of tyrosine kinase inhibitors in modifying the response of tumor microvasculature to radiotherapy. Technol. Cancer Res. Treat. 2005 Dec; 4(6): 691-8. PMID: 16292890, PII: d=3022&c=4191&p=13211&do=detail, ISSN: 1533-0346.

Cao C, Shinohara ET, Li H, Niermann KJ, Kim KW, Sekhar KR, Gleave M, Freeman M, Lu B. Clusterin as a therapeutic target for radiation sensitization in a lung cancer model. Int. J. Radiat. Oncol. Biol. Phys. 2005 Nov 11/15/2005; 63(4): 1228-36. PMID: 16253777, PII: S0360-3016(05)02143-7, DOI: 10.1016/j.ijrobp.2005.07.956, ISSN: 0360-3016.

Cao C, Shinohara ET, Niermann KJ, Donnelly EF, Chen X, Hallahan DE, Lu B. Murine double minute 2 as a therapeutic target for radiation sensitization of lung cancer. Mol. Cancer Ther. 2005 Aug; 4(8): 1137-45. PMID: 16093429, PII: 4/8/1137, DOI: 10.1158/1535-7163.MCT-04-0327, ISSN: 1535-7163.