Faculty Appointments
Professor of Molecular Physiology & Biophysics
Education
Ph.D., Molecular and Medical Genetics, Oregon Health & Science University, Portland, OregonB.S., Eukaryotic Genetics, Washington State University, Pullman, Washington
Office Address
2213 Garland Avenue
Nashville, TN 37232-0615
Nashville, TN 37232-0615
Research Description
Maintaining physiological blood glucose levels is a complex process critically dependent on insulin secretion. Glucose stimulation of pancreatic beta-cells results in orchestrated electrical signaling that triggers insulin secretion. Our interest is in understanding how beta-cell ion channels are regulated during glucose stimulation and how these mechanisms become perturbed in diabetes.
Research on secretagogue modulation of beta-cell ion channels has primarily focused on the ATP sensitive potassium channel, KATP, which is an essential ion channel for normal glucose stimulated insulin secretion (GSIS). However, rodents with nonfunctional KATP channels and diabetic patients treated with blockers to KATP still exhibit glucose regulated insulin secretion. Thus KATP independent glucose responsive mechanisms play an important role during GSIS in humans. The mechanism(s) for this is unknown; however, as calcium is required for insulin secretion the mechanism must in part be coupled to calcium influx. Therefore, we are investigating the ion channels and their molecular mechanisms of regulation, independent of KATP, that help modulate secretagogue induced calcium influx and insulin secretion. The focus of this research is primarily on voltage-dependent calcium channels (CaV) and leak potassium channels. This research will test hypotheses concerning glucose and G-protein dependent regulation of islet electrical activity by CaV channel phosphorylation and modulation of islet membrane potential by leak potassium channels. These studies utilize molecular biology, genetics, fluorescent microscopy, and electrophysiology techniques on pancreatic islet-cells. Understanding how secretagogues regulate islet electrical activity distinctly from KATP may help to develop new therapies for diabetic patients that target specific elements of the beta-cell excitation-secretion pathway.
Research on secretagogue modulation of beta-cell ion channels has primarily focused on the ATP sensitive potassium channel, KATP, which is an essential ion channel for normal glucose stimulated insulin secretion (GSIS). However, rodents with nonfunctional KATP channels and diabetic patients treated with blockers to KATP still exhibit glucose regulated insulin secretion. Thus KATP independent glucose responsive mechanisms play an important role during GSIS in humans. The mechanism(s) for this is unknown; however, as calcium is required for insulin secretion the mechanism must in part be coupled to calcium influx. Therefore, we are investigating the ion channels and their molecular mechanisms of regulation, independent of KATP, that help modulate secretagogue induced calcium influx and insulin secretion. The focus of this research is primarily on voltage-dependent calcium channels (CaV) and leak potassium channels. This research will test hypotheses concerning glucose and G-protein dependent regulation of islet electrical activity by CaV channel phosphorylation and modulation of islet membrane potential by leak potassium channels. These studies utilize molecular biology, genetics, fluorescent microscopy, and electrophysiology techniques on pancreatic islet-cells. Understanding how secretagogues regulate islet electrical activity distinctly from KATP may help to develop new therapies for diabetic patients that target specific elements of the beta-cell excitation-secretion pathway.
Research Keywords
Secretagogue induced mechanisms regulating pancreatic islet electrical activity and hormone secretion
Publications
Cheung R, Pizza G, Chabosseau P, Rolando D, Tomas A, Burgoyne T, Wu Z, Salowka A, Thapa A, Macklin A, Cao Y, Nguyen-Tu MS, Dickerson MT, Jacobson DA, Marchetti P, Shapiro J, Piemonti L, de Koning E, Leclerc I, Bouzakri K, Sakamoto K, Smith DM, Rutter GA, Martinez-Sanchez A. Glucose-Dependent miR-125b Is a Negative Regulator of ß-Cell Function. Diabetes. 2022 Jul 7/1/2022; 71(7): 1525-45. PMID: 35476777, PII: 145079, DOI: 10.2337/db21-0803, ISSN: 1939-327X.
Zaborska KE, Jordan KL, Thorson AS, Dadi PK, Schaub CM, Nakhe AY, Dickerson MT, Lynch JC, Weiss AJ, Dobson JR, Jacobson DA. Liraglutide increases islet Ca2+ oscillation frequency and insulin secretion by activating hyperpolarization-activated cyclic nucleotide-gated channels. Diabetes Obes Metab [print-electronic]. 2022 May 5/11/2022; PMID: 35546791, DOI: 10.1111/dom.14747, ISSN: 1463-1326.
Rahim M, Nakhe AY, Banerjee DR, Overway EM, Bosma KJ, Rosch JC, Oeser JK, Wang B, Lippmann ES, Jacobson DA, O'Brien RM, Young JD. Glucose-6-phosphatase catalytic subunit 2 negatively regulates glucose oxidation and insulin secretion in pancreatic ß-cells. J Biol Chem [print-electronic]. 2022 Apr; 298(4): 101729. PMID: 35176280, PMCID: PMC8941207, PII: S0021-9258(22)00169-7, DOI: 10.1016/j.jbc.2022.101729, ISSN: 1083-351X.
Kuo T, Du W, Miyachi Y, Dadi PK, Jacobson DA, Segrè D, Accili D. Antagonistic epistasis of Hnf4a and FoxO1 metabolic networks through enhancer interactions in ß-cell function. Mol Metab [print-electronic]. 2021 Nov; 53: 101256. PMID: 34048961, PMCID: PMC8225970, PII: S2212-8778(21)00101-0, DOI: 10.1016/j.molmet.2021.101256, ISSN: 2212-8778.
Dickerson MT, Jacobson DA. Channeling ß-cell Maturity: KATP Surface Localization Imparts Glucose Sensing. Endocrinology. 2021 Nov 11/1/2021; 162(11): PMID: 34402896, PMCID: PMC8427444, PII: 6353394, DOI: 10.1210/endocr/bqab171, ISSN: 1945-7170.
Walker EM, Cha J, Tong X, Guo M, Liu JH, Yu S, Iacovazzo D, Mauvais-Jarvis F, Flanagan SE, Korbonits M, Stafford J, Jacobson DA, Stein R. Sex-biased islet ß cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males. Cell Rep. 2021 Oct 10/12/2021; 37(2): 109813. PMID: 34644565, PMCID: PMC8845126, PII: S2211-1247(21)01277-8, DOI: 10.1016/j.celrep.2021.109813, ISSN: 2211-1247.
Altman MK, Schaub CM, Dadi PK, Dickerson MT, Zaborska KE, Nakhe AY, Graff SM, Galletta TJ, Amarnath G, Thorson AS, Gu G, Jacobson DA. TRPM7 is a crucial regulator of pancreatic endocrine development and high-fat-diet-induced ß-cell proliferation. Development [print-electronic]. 2021 Aug 8/15/2021; 148(16): PMID: 34345920, PMCID: PMC8406533, PII: 271182, DOI: 10.1242/dev.194928, ISSN: 1477-9129.
Graff SM, Johnson SR, Leo PJ, Dadi PK, Dickerson MT, Nakhe AY, McInerney-Leo AM, Marshall M, Zaborska KE, Schaub CM, Brown MA, Jacobson DA, Duncan EL. A KCNK16 mutation causing TALK-1 gain of function is associated with maturity-onset diabetes of the young. JCI Insight. 2021 Jul 7/8/2021; 6(13): PMID: 34032641, PMCID: PMC8410089, PII: 138057, DOI: 10.1172/jci.insight.138057, ISSN: 2379-3708.
West JD, Austin ED, Rizzi EM, Yan L, Tanjore H, Crabtree AL, Moore CS, Muthian G, Carrier EJ, Jacobson DA, Hamid R, Kendall PL, Majka S, Rathinasabapathy A. KCNK3 Mutation Causes Altered Immune Function in Pulmonary Arterial Hypertension Patients and Mouse Models. Int J Mol Sci. 2021 May 5/9/2021; 22(9): PMID: 34065088, PMCID: PMC8126011, PII: ijms22095014, DOI: 10.3390/ijms22095014, ISSN: 1422-0067.
Mousavy Gharavy SN, Owen BM, Millership SJ, Chabosseau P, Pizza G, Martinez-Sanchez A, Tasoez E, Georgiadou E, Hu M, Fine NHF, Jacobson DA, Dickerson MT, Idevall-Hagren O, Montoya A, Kramer H, Mehta Z, Withers DJ, Ninov N, Gadue PJ, Cardenas-Diaz FL, Cruciani-Guglielmacci C, Magnan C, Ibberson M, Leclerc I, Voz M, Rutter GA. Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis. Diabetologia [print-electronic]. 2021 Apr; 64(4): 850-64. PMID: 33492421, PMCID: PMC7829492, PII: 10.1007/s00125-020-05350-x, DOI: 10.1007/s00125-020-05350-x, ISSN: 1432-0428.
Sanavia T, Huang C, Manduchi E, Xu Y, Dadi PK, Potter LA, Jacobson DA, Di Camillo B, Magnuson MA, Stoeckert CJ, Gu G. Temporal Transcriptome Analysis Reveals Dynamic Gene Expression Patterns Driving ß-Cell Maturation. Front Cell Dev Biol. 2021; 9: 648791. PMID: 34017831, PMCID: PMC8129579, DOI: 10.3389/fcell.2021.648791, ISSN: 2296-634X.
Zaborska KE, Dadi PK, Dickerson MT, Nakhe AY, Thorson AS, Schaub CM, Graff SM, Stanley JE, Kondapavuluru RS, Denton JS, Jacobson DA. Lactate activation of a-cell KATP channels inhibits glucagon secretion by hyperpolarizing the membrane potential and reducing Ca2+ entry. Mol Metab [print-electronic]. 2020 Dec; 42: 101056. PMID: 32736089, PMCID: PMC7479281, PII: S2212-8778(20)30130-7, DOI: 10.1016/j.molmet.2020.101056, ISSN: 2212-8778.
Yang B, Maddison LA, Zaborska KE, Dai C, Yin L, Tang Z, Zang L, Jacobson DA, Powers AC, Chen W. RIPK3-mediated inflammation is a conserved ß cell response to ER stress. Sci Adv [electronic-print]. 2020 Dec; 6(51): PMID: 33355143, PII: 6/51/eabd7272, DOI: 10.1126/sciadv.abd7272, ISSN: 2375-2548.
Dickerson MT, Dadi PK, Butterworth RB, Nakhe AY, Graff SM, Zaborska KE, Schaub CM, Jacobson DA. Tetraspanin-7 regulation of L-type voltage-dependent calcium channels controls pancreatic ß-cell insulin secretion. J Physiol [print-electronic]. 2020 Nov; 598(21): 4887-905. PMID: 32790176, PMCID: PMC8095317, DOI: 10.1113/JP279941, ISSN: 1469-7793.
Lengyel M, Czirják G, Jacobson DA, Enyedi P. TRESK and TREK-2 two-pore-domain potassium channel subunits form functional heterodimers in primary somatosensory neurons. J Biol Chem [print-electronic]. 2020 Aug 8/28/2020; 295(35): 12408-25. PMID: 32641496, PMCID: PMC7458809, PII: S0021-9258(17)49482-8, DOI: 10.1074/jbc.RA120.014125, ISSN: 1083-351X.
Dai C, Walker JT, Shostak A, Bouchi Y, Poffenberger G, Hart NJ, Jacobson DA, Calcutt MW, Bottino R, Greiner DL, Shultz LD, McGuinness OP, Dean ED, Powers AC. Dapagliflozin Does Not Directly Affect Human a or ß Cells. Endocrinology. 2020 Aug 8/1/2020; 161(8): PMID: 32428240, PMCID: PMC7375801, PII: 5840747, DOI: 10.1210/endocr/bqaa080, ISSN: 1945-7170.
Georgiadou E, Haythorne E, Dickerson MT, Lopez-Noriega L, Pullen TJ, da Silva Xavier G, Davis SPX, Martinez-Sanchez A, Semplici F, Rizzuto R, McGinty JA, French PM, Cane MC, Jacobson DA, Leclerc I, Rutter GA. The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice. Diabetologia [print-electronic]. 2020 Jul; 63(7): 1368-81. PMID: 32350566, PMCID: PMC7286857, PII: 10.1007/s00125-020-05148-x, DOI: 10.1007/s00125-020-05148-x, ISSN: 1432-0428.
Yang X, Graff SM, Heiser CN, Ho KH, Chen B, Simmons AJ, Southard-Smith AN, David G, Jacobson DA, Kaverina I, Wright CVE, Lau KS, Gu G. Coregulator Sin3a Promotes Postnatal Murine ß-Cell Fitness by Regulating Genes in Ca2+ Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response. Diabetes [print-electronic]. 2020 Jun; 69(6): 1219-31. PMID: 32245798, PMCID: PMC7243292, PII: db19-0721, DOI: 10.2337/db19-0721, ISSN: 1939-327X.
Jacobson DA, Shyng SL. Ion Channels of the Islets in Type 2 Diabetes. J Mol Biol [print-electronic]. 2020 Mar 3/6/2020; 432(5): 1326-46. PMID: 31473158, PMCID: PMC7720859, PII: S0022-2836(19)30523-6, DOI: 10.1016/j.jmb.2019.08.014, ISSN: 1089-8638.
Perfitt TL, Wang X, Dickerson MT, Stephenson JR, Nakagawa T, Jacobson DA, Colbran RJ. Neuronal L-Type Calcium Channel Signaling to the Nucleus Requires a Novel CaMKIIa-Shank3 Interaction. J Neurosci [print-electronic]. 2020 Mar 3/4/2020; 40(10): 2000-14. PMID: 32019829, PMCID: PMC7055140, PII: JNEUROSCI.0893-19.2020, DOI: 10.1523/JNEUROSCI.0893-19.2020, ISSN: 1529-2401.
Dickerson MT, Dadi PK, Altman MK, Verlage KR, Thorson AS, Jordan KL, Vierra NC, Amarnath G, Jacobson DA. Glucose-mediated inhibition of calcium-activated potassium channels limits alpha-cell calcium influx and glucagon secretion. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2019 Jan 1/29/2019; PMID: 30694690, DOI: 10.1152/ajpendo.00342.2018, ISSN: 1522-1555.
Liu J, Banerjee A, Herring CA, Attalla J, Hu R, Xu Y, Shao Q, Simmons AJ, Dadi PK, Wang S, Jacobson DA, Liu B, Hodges E, Lau KS, Gu G. Neurog3-Independent Methylation Is the Earliest Detectable Mark Distinguishing Pancreatic Progenitor Identity. Dev. Cell. 2019 Jan 1/7/2019; 48(1): 49-63.e7. PMID: 30620902, PMCID: PMC6327977, PII: S1534-5807(18)31032-3, DOI: 10.1016/j.devcel.2018.11.048, ISSN: 1878-1551.
Navarro G, Allard C, Morford JJ, Xu W, Liu S, Molinas AJ, Butcher SM, Fine NHF, Blandino-Rosano M, Sure VN, Yu S, Zhang R, Münzberg H, Jacobson DA, Katakam PV, Hodson DJ, Bernal-Mizrachi E, Zsombok A, Mauvais-Jarvis F. Androgen excess in pancreatic ß cells and neurons predisposes female mice to type 2 diabetes. JCI Insight [print-electronic]. 2018 Jun 6/21/2018; 3(12): PMID: 29925687, PMCID: PMC6124401, PII: 98607, DOI: 10.1172/jci.insight.98607, ISSN: 2379-3708.
Huang C, Walker EM, Dadi PK, Hu R, Xu Y, Zhang W, Sanavia T, Mun J, Liu J, Nair GG, Tan HYA, Wang S, Magnuson MA, Stoeckert CJ, Hebrok M, Gannon M, Han W, Stein R, Jacobson DA, Gu G. Synaptotagmin 4 Regulates Pancreatic ß Cell Maturation by Modulating the Ca2+ Sensitivity of Insulin Secretion Vesicles. Dev. Cell [print-electronic]. 2018 May 5/7/2018; 45(3): 347-361.e5. PMID: 29656931, PMCID: PMC5962294, PII: S1534-5807(18)30233-8, DOI: 10.1016/j.devcel.2018.03.013, ISSN: 1878-1551.
Hart NJ, Aramandla R, Poffenberger G, Fayolle C, Thames AH, Bautista A, Spigelman AF, Babon JAB, DeNicola ME, Dadi PK, Bush WS, Balamurugan AN, Brissova M, Dai C, Prasad N, Bottino R, Jacobson DA, Drumm ML, Kent SC, MacDonald PE, Powers AC. Cystic fibrosis-related diabetes is caused by islet loss and inflammation. JCI Insight [print-electronic]. 2018 Apr 4/19/2018; 3(8): PMID: 29669939, PII: 98240, DOI: 10.1172/jci.insight.98240, ISSN: 2379-3708.
Hart NJ, Aramandla R, Poffenberger G, Fayolle C, Thames AH, Bautista A, Spigelman AF, Babon JAB, DeNicola ME, Dadi PK, Bush WS, Balamurugan AN, Brissova M, Dai C, Prasad N, Bottino R, Jacobson DA, Drumm ML, Kent SC, MacDonald PE, Powers AC. Cystic fibrosis-related diabetes is caused by islet loss and inflammation. JCI Insight [print-electronic]. 2018 Apr 4/19/2018; 3(8): PMID: 29669939, PMCID: PMC5931120, PII: 98240, DOI: 10.1172/jci.insight.98240, ISSN: 2379-3708.
Huang C, Walker EM, Dadi PK, Hu R, Xu Y, Zhang W, Sanavia T, Mun J, Liu J, Nair GG, Tan HYA, Wang S, Magnuson MA, Stoeckert CJ, Hebrok M, Gannon M, Han W, Stein R, Jacobson DA, Gu G. Synaptotagmin 4 Regulates Pancreatic ß Cell Maturation by Modulating the Ca2+ Sensitivity of Insulin Secretion Vesicles. Dev. Cell [print-electronic]. 2018 Apr 4/12/2018; PMID: 29656931, PII: S1534-5807(18)30233-8, DOI: 10.1016/j.devcel.2018.03.013, ISSN: 1878-1551.
Fine NHF, Doig CL, Elhassan YS, Vierra NC, Marchetti P, Bugliani M, Nano R, Piemonti L, Rutter GA, Jacobson DA, Lavery GG, Hodson DJ. Glucocorticoids Reprogram ß-Cell Signaling to Preserve Insulin Secretion. Diabetes [print-electronic]. 2018 Feb; 67(2): 278-90. PMID: 29203512, PMCID: PMC5780059, PII: db16-1356, DOI: 10.2337/db16-1356, ISSN: 1939-327X.
Vierra NC, Dickerson MT, Jordan KL, Dadi PK, Kadare KA, Altman MK, Milian SC, Jacobson DA. TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion. Mol Metab [print-electronic]. 2018 Jan 1/31/2018; PMID: 29402588, PII: S2212-8778(17)31084-0, DOI: 10.1016/j.molmet.2018.01.016, ISSN: 2212-8778.
Dickerson MT, Bogart AM, Altman MK, Milian SC, Jordan KL, Dadi PK, Jacobson DA. Cytokine-mediated changes in K+ channel activity promotes an adaptive Ca2+ response that sustains ß-cell insulin secretion during inflammation. Sci Rep. 2018 Jan 1/18/2018; 8(1): 1158. PMID: 29348619, PII: 10.1038/s41598-018-19600-x, DOI: 10.1038/s41598-018-19600-x, ISSN: 2045-2322.
Dickerson MT, Bogart AM, Altman MK, Milian SC, Jordan KL, Dadi PK, Jacobson DA. Cytokine-mediated changes in K+ channel activity promotes an adaptive Ca2+ response that sustains ß-cell insulin secretion during inflammation. Sci Rep. 2018 Jan 1/18/2018; 8(1): 1158. PMID: 29348619, PMCID: PMC5773563, PII: 10.1038/s41598-018-19600-x, DOI: 10.1038/s41598-018-19600-x, ISSN: 2045-2322.
Vierra NC, Dickerson MT, Philipson LH, Jacobson DA. Simultaneous Real-Time Measurement of the ß-Cell Membrane Potential and Ca2+ Influx to Assess the Role of Potassium Channels on ß-Cell Function. Methods Mol. Biol. 2018; 1684: 73-84. PMID: 29058185, DOI: 10.1007/978-1-4939-7362-0_7, ISSN: 1940-6029.
Vierra NC, Dickerson MT, Philipson LH, Jacobson DA. Simultaneous Real-Time Measurement of the ß-Cell Membrane Potential and Ca2+ Influx to Assess the Role of Potassium Channels on ß-Cell Function. Methods Mol. Biol. 2018; 1684: 73-84. PMID: 29058185, DOI: 10.1007/978-1-4939-7362-0_7, ISSN: 1940-6029.
Fine NHF, Doig CL, Elhassan YS, Vierra NC, Marchetti P, Bugliani M, Nano R, Piemonti L, Rutter GA, Jacobson DA, Lavery GG, Hodson DJ. Glucocorticoids Reprogram Beta Cell Signaling to Preserve Insulin Secretion. Diabetes [print-electronic]. 2017 Dec 12/4/2017; PMID: 29203512, PII: db16-1356, DOI: 10.2337/db16-1356, ISSN: 1939-327X.
Vierra NC, Dadi PK, Milian SC, Dickerson MT, Jordan KL, Gilon P, Jacobson DA. TALK-1 channels control ß cell endoplasmic reticulum Ca(2+) homeostasis. Sci Signal. 2017 Sep 9/19/2017; 10(497): PMID: 28928238, PII: 10/497/eaan2883, DOI: 10.1126/scisignal.aan2883, ISSN: 1937-9145.
Wang X, Marks CR, Perfitt TL, Nakagawa T, Lee A, Jacobson DA, Colbran RJ. A novel mechanism for Ca(2+)/calmodulin-dependent protein kinase II targeting to L-type Ca(2+) channels that initiates long-range signaling to the nucleus. J. Biol. Chem [print-electronic]. 2017 Sep 9/15/2017; PMID: 28916724, PII: M117.788331, DOI: 10.1074/jbc.M117.788331, ISSN: 1083-351X.
Stancill JS, Cartailler JP, Clayton HW, O'Connor JT, Dickerson MT, Dadi PK, Osipovich AB, Jacobson DA, Magnuson MA. Chronic ß-Cell Depolarization Impairs ß-Cell Identity by Disrupting a Network of Ca(2+)-Regulated Genes. Diabetes [print-electronic]. 2017 Aug; 66(8): 2175-87. PMID: 28550109, PMCID: PMC5521870, PII: db16-1355, DOI: 10.2337/db16-1355, ISSN: 1939-327X.
Stancill JS, Cartailler JP, Clayton HW, O'Connor JT, Dickerson MT, Dadi PK, Osipovich AB, Jacobson DA, Magnuson MA. Chronic ß-Cell Depolarization Impairs ß-Cell Identity by Disrupting a Network of Ca(2+)-Regulated Genes. Diabetes [print-electronic]. 2017 Aug; 66(8): 2175-87. PMID: 28550109, PMCID: PMC5521870, PII: db16-1355, DOI: 10.2337/db16-1355, ISSN: 1939-327X.
Zhu L, Almaça J, Dadi PK, Hong H, Sakamoto W, Rossi M, Lee RJ, Vierra NC, Lu H, Cui Y, McMillin SM, Perry NA, Gurevich VV, Lee A, Kuo B, Leapman RD, Matschinsky FM, Doliba NM, Urs NM, Caron MG, Jacobson DA, Caicedo A, Wess J. ß-arrestin-2 is an essential regulator of pancreatic ß-cell function under physiological and pathophysiological conditions. Nat Commun. 2017 Feb 2/1/2017; 8: 14295. PMID: 28145434, PMCID: PMC5296650, PII: ncomms14295, DOI: 10.1038/ncomms14295, ISSN: 2041-1723.
Dickerson MT, Vierra NC, Milian SC, Dadi PK, Jacobson DA. Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic ß-cells. PLoS ONE. 2017; 12(4): e0175069. PMID: 28403169, PII: PONE-D-16-40391, DOI: 10.1371/journal.pone.0175069, ISSN: 1932-6203.
Dadi PK, Vierra NC, Days EL, Dickerson M, Vinson PN, Weaver CD, Jacobson DA. Selective small molecule activators of TREK-2 channels stimulate DRG c-fiber nociceptor K2P currents and limit calcium influx. ACS Chem Neurosci [print-electronic]. 2016 Nov 11/2/2016; PMID: 27805811, DOI: 10.1021/acschemneuro.6b00301, ISSN: 1948-7193.
Boortz KA, Syring KE, Dai C, Pound LD, Oeser JK, Jacobson DA, Wang JC, McGuinness OP, Powers AC, O'Brien RM. G6PC2 Modulates Fasting Blood Glucose In Male Mice in Response to Stress. Endocrinology [print-electronic]. 2016 Aug; 157(8): 3002-8. PMID: 27300767, PMCID: PMC4967123, DOI: 10.1210/en.2016-1245, ISSN: 1945-7170.
Boortz KA, Syring KE, Dai C, Pound LD, Oeser JK, Jacobson DA, Wang JC, McGuinness OP, Powers AC, O'Brien RM. G6PC2 Modulates Fasting Blood Glucose In Male Mice in Response to Stress. Endocrinology [print-electronic]. 2016 Aug; 157(8): 3002-8. PMID: 27300767, PMCID: PMC4967123, DOI: 10.1210/en.2016-1245, ISSN: 1945-7170.
Navarro G, Xu W, Jacobson DA, Wicksteed B, Allard C, Zhang G, De Gendt K, Kim SH, Wu H, Zhang H, Verhoeven G, Katzenellenbogen JA, Mauvais-Jarvis F. Extranuclear Actions of the Androgen Receptor Enhance Glucose-Stimulated Insulin Secretion in the Male. Cell Metab [print-electronic]. 2016 Apr 4/26/2016; PMID: 27133133, PII: S1550-4131(16)30118-8, DOI: 10.1016/j.cmet.2016.03.015, ISSN: 1932-7420.
Golson ML, Dunn JC, Maulis MF, Dadi PK, Osipovich AB, Magnuson MA, Jacobson DA, Gannon M. Activation of FoxM1 Revitalizes the Replicative Potential of Aged ß-Cells in Male Mice and Enhances Insulin Secretion. Diabetes [print-electronic]. 2015 Nov; 64(11): 3829-38. PMID: 26251404, PMCID: PMC4613976, PII: db15-0465, DOI: 10.2337/db15-0465, ISSN: 1939-327X.
Vierra NC, Dadi PK, Jeong I, Dickerson M, Powell DR, Jacobson DA. Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates ß-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis. Diabetes [print-electronic]. 2015 Nov; 64(11): 3818-28. PMID: 26239056, PMCID: PMC4613978, PII: db15-0280, DOI: 10.2337/db15-0280, ISSN: 1939-327X.
Dadi PK, Luo B, Vierra NC, Jacobson DA. TASK-1 Potassium Channels Limit Pancreatic a-Cell Calcium Influx and Glucagon Secretion. Mol. Endocrinol [print-electronic]. 2015 May; 29(5): 777-87. PMID: 25849724, PMCID: PMC4415209, DOI: 10.1210/me.2014-1321, ISSN: 1944-9917.
Dadi PK, Vierra NC, Jacobson DA. Pancreatic ß-cell-specific ablation of TASK-1 channels augments glucose-stimulated calcium entry and insulin secretion, improving glucose tolerance. Endocrinology [print-electronic]. 2014 Oct; 155(10): 3757-68. PMID: 24932805, PMCID: PMC4164933, DOI: 10.1210/en.2013-2051, ISSN: 1945-7170.
Egnatchik RA, Leamy AK, Jacobson DA, Shiota M, Young JD. ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload. Mol Metab. 2014 Aug; 3(5): 544-53. PMID: 25061559, PMCID: PMC4099508, PII: S2212-8778(14)00092-1, DOI: 10.1016/j.molmet.2014.05.004, ISSN: 2212-8778.
Raphemot R, Swale DR, Dadi PK, Jacobson DA, Cooper P, Wojtovich AP, Banerjee S, Nichols CG, Denton JS. Direct activation of ß-cell KATP channels with a novel xanthine derivative. Mol. Pharmacol [print-electronic]. 2014 Jun; 85(6): 858-65. PMID: 24646456, PMCID: PMC4014665, PII: mol.114.091884, DOI: 10.1124/mol.114.091884, ISSN: 1521-0111.
Dadi PK, Vierra NC, Ustione A, Piston DW, Colbran RJ, Jacobson DA. Inhibition of pancreatic ß-cell Ca2+/calmodulin-dependent protein kinase II reduces glucose-stimulated calcium influx and insulin secretion, impairing glucose tolerance. J. Biol. Chem [print-electronic]. 2014 May 5/2/2014; 289(18): 12435-45. PMID: 24627477, PMCID: PMC4007438, PII: M114.562587, DOI: 10.1074/jbc.M114.562587, ISSN: 1083-351X.
Baerenwald DA, Bonnefond A, Bouatia-Naji N, Flemming BP, Umunakwe OC, Oeser JK, Pound LD, Conley NL, Cauchi S, Lobbens S, Eury E, Balkau B, Lantieri O, , Dadi PK, Jacobson DA, Froguel P, O'Brien RM. Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels. Diabetologia [print-electronic]. 2013 Jun; 56(6): 1306-16. PMID: 23508304, PMCID: PMC4106008, DOI: 10.1007/s00125-013-2875-3, ISSN: 1432-0428.
Kaihara KA, Dickson LM, Jacobson DA, Tamarina N, Roe MW, Philipson LH, Wicksteed B. ß-Cell-specific protein kinase A activation enhances the efficiency of glucose control by increasing acute-phase insulin secretion. Diabetes [print-electronic]. 2013 May; 62(5): 1527-36. PMID: 23349500, PMCID: PMC3636652, PII: db12-1013, DOI: 10.2337/db12-1013, ISSN: 1939-327X.
Pound LD, Oeser JK, O'Brien TP, Wang Y, Faulman CJ, Dadi PK, Jacobson DA, Hutton JC, McGuinness OP, Shiota M, O'Brien RM. G6PC2: a negative regulator of basal glucose-stimulated insulin secretion. Diabetes [print-electronic]. 2013 May; 62(5): 1547-56. PMID: 23274894, PMCID: PMC3636628, PII: db12-1067, DOI: 10.2337/db12-1067, ISSN: 1939-327X.
Fridlyand LE, Jacobson DA, Philipson LH. Ion channels and regulation of insulin secretion in human ß-cells: a computational systems analysis. Islets. 2013 Jan; 5(1): 1-15. PMID: 23624892, PMCID: PMC3662377, PII: 24166, DOI: 10.4161/isl.24166, ISSN: 1938-2022.
Pound LD, Sarkar SA, Ustione A, Dadi PK, Shadoan MK, Lee CE, Walters JA, Shiota M, McGuinness OP, Jacobson DA, Piston DW, Hutton JC, Powell DR, O'Brien RM. The physiological effects of deleting the mouse SLC30A8 gene encoding zinc transporter-8 are influenced by gender and genetic background. PLoS ONE [print-electronic]. 2012; 7(7): e40972. PMID: 22829903, PMCID: PMC3400647, PII: PONE-D-11-24034, DOI: 10.1371/journal.pone.0040972, ISSN: 1932-6203.
Denton JS, Jacobson DA. Channeling dysglycemia: ion-channel variations perturbing glucose homeostasis. Trends Endocrinol. Metab [print-electronic]. 2012 Jan; 23(1): 41-8. PMID: 22134088, PMCID: PMC3733341, PII: S1043-2760(11)00152-4, DOI: 10.1016/j.tem.2011.09.004, ISSN: 1879-3061.
Jacobson DA, Mendez F, Thompson M, Torres J, Cochet O, Philipson LH. Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and complementary roles during secretagogue induced electrical responses. J. Physiol. (Lond.) [print-electronic]. 2010 Sep 9/15/2010; 588(Pt 18): 3525-37. PMID: 20643768, PMCID: PMC2988516, PII: jphysiol.2010.190207, DOI: 10.1113/jphysiol.2010.190207, ISSN: 1469-7793.
Deriy LV, Gomez EA, Jacobson DA, Wang X, Hopson JA, Liu XY, Zhang G, Bindokas VP, Philipson LH, Nelson DJ. The granular chloride channel ClC-3 is permissive for insulin secretion. Cell Metab. 2009 Oct; 10(4): 316-23. PMID: 19808024, PMCID: PMC2778193, PII: S1550-4131(09)00262-9, DOI: 10.1016/j.cmet.2009.08.012, ISSN: 1932-7420.
Fridlyand LE, Jacobson DA, Kuznetsov A, Philipson LH. A model of action potentials and fast Ca2+ dynamics in pancreatic beta-cells. Biophys. J. 2009 Apr 4/22/2009; 96(8): 3126-39. PMID: 19383458, PMCID: PMC2718303, PII: S0006-3495(09)00502-5, DOI: 10.1016/j.bpj.2009.01.029, ISSN: 1542-0086.
Jacobson DA, Wicksteed BL, Philipson LH. The alpha-cell conundrum: ATP-sensitive K+ channels and glucose sensing. Diabetes. 2009 Feb; 58(2): 304-6. PMID: 19171747, PMCID: PMC2628601, PII: 58/2/304, DOI: 10.2337/db08-1618, ISSN: 1939-327X.
Bao S, Jacobson DA, Wohltmann M, Bohrer A, Jin W, Philipson LH, Turk J. Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta in pancreatic beta-cells and in iPLA2beta-null mice. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2008 Feb; 294(2): E217-29. PMID: 17895289, PMCID: PMC2268609, PII: 00474.2007, DOI: 10.1152/ajpendo.00474.2007, ISSN: 0193-1849.
David A. Jacobson and Louis H. Philipson. Pancreatic Beta Cells in Health and Disease. [place unknown: publisher unknown]; 2008.
Jacobson DA, Philipson LH. Action potentials and insulin secretion: new insights into the role of Kv channels. Diabetes Obes Metab. 2007 Nov; 9 Suppl 2: 89-98. PMID: 17919183, PII: DOM784, DOI: 10.1111/j.1463-1326.2007.00784.x, ISSN: 1462-8902.
Jacobson DA, Kuznetsov A, Lopez JP, Kash S, Ammälä CE, Philipson LH. Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion. Cell Metab. 2007 Sep; 6(3): 229-35. PMID: 17767909, PMCID: PMC2699758, PII: S1550-4131(07)00222-7, DOI: 10.1016/j.cmet.2007.07.010, ISSN: 1550-4131.
Jacobson DA, Weber CR, Bao S, Turk J, Philipson LH. Modulation of the pancreatic islet beta-cell-delayed rectifier potassium channel Kv2.1 by the polyunsaturated fatty acid arachidonate. J. Biol. Chem [print-electronic]. 2007 Mar 3/9/2007; 282(10): 7442-9. PMID: 17197450, PMCID: PMC2044499, PII: M607858200, DOI: 10.1074/jbc.M607858200, ISSN: 0021-9258.
Jacobson DA, Philipson LH. TRP channels of the pancreatic beta cell. Handb Exp Pharmacol. 2007; (179): 409-24. PMID: 17217070, DOI: 10.1007/978-3-540-34891-7_24, ISSN: 0171-2004.
Jacobson DA, Cho J, Landa LR, Tamarina NA, Roe MW, Buxbaum JD, Philipson LH. Downstream regulatory element antagonistic modulator regulates islet prodynorphin expression. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2006 Sep; 291(3): E587-95. PMID: 16621893, PII: 00612.2005, DOI: 10.1152/ajpendo.00612.2005, ISSN: 0193-1849.
Zaborska KE, Jordan KL, Thorson AS, Dadi PK, Schaub CM, Nakhe AY, Dickerson MT, Lynch JC, Weiss AJ, Dobson JR, Jacobson DA. Liraglutide increases islet Ca2+ oscillation frequency and insulin secretion by activating hyperpolarization-activated cyclic nucleotide-gated channels. Diabetes Obes Metab [print-electronic]. 2022 May 5/11/2022; PMID: 35546791, DOI: 10.1111/dom.14747, ISSN: 1463-1326.
Rahim M, Nakhe AY, Banerjee DR, Overway EM, Bosma KJ, Rosch JC, Oeser JK, Wang B, Lippmann ES, Jacobson DA, O'Brien RM, Young JD. Glucose-6-phosphatase catalytic subunit 2 negatively regulates glucose oxidation and insulin secretion in pancreatic ß-cells. J Biol Chem [print-electronic]. 2022 Apr; 298(4): 101729. PMID: 35176280, PMCID: PMC8941207, PII: S0021-9258(22)00169-7, DOI: 10.1016/j.jbc.2022.101729, ISSN: 1083-351X.
Kuo T, Du W, Miyachi Y, Dadi PK, Jacobson DA, Segrè D, Accili D. Antagonistic epistasis of Hnf4a and FoxO1 metabolic networks through enhancer interactions in ß-cell function. Mol Metab [print-electronic]. 2021 Nov; 53: 101256. PMID: 34048961, PMCID: PMC8225970, PII: S2212-8778(21)00101-0, DOI: 10.1016/j.molmet.2021.101256, ISSN: 2212-8778.
Dickerson MT, Jacobson DA. Channeling ß-cell Maturity: KATP Surface Localization Imparts Glucose Sensing. Endocrinology. 2021 Nov 11/1/2021; 162(11): PMID: 34402896, PMCID: PMC8427444, PII: 6353394, DOI: 10.1210/endocr/bqab171, ISSN: 1945-7170.
Walker EM, Cha J, Tong X, Guo M, Liu JH, Yu S, Iacovazzo D, Mauvais-Jarvis F, Flanagan SE, Korbonits M, Stafford J, Jacobson DA, Stein R. Sex-biased islet ß cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males. Cell Rep. 2021 Oct 10/12/2021; 37(2): 109813. PMID: 34644565, PMCID: PMC8845126, PII: S2211-1247(21)01277-8, DOI: 10.1016/j.celrep.2021.109813, ISSN: 2211-1247.
Altman MK, Schaub CM, Dadi PK, Dickerson MT, Zaborska KE, Nakhe AY, Graff SM, Galletta TJ, Amarnath G, Thorson AS, Gu G, Jacobson DA. TRPM7 is a crucial regulator of pancreatic endocrine development and high-fat-diet-induced ß-cell proliferation. Development [print-electronic]. 2021 Aug 8/15/2021; 148(16): PMID: 34345920, PMCID: PMC8406533, PII: 271182, DOI: 10.1242/dev.194928, ISSN: 1477-9129.
Graff SM, Johnson SR, Leo PJ, Dadi PK, Dickerson MT, Nakhe AY, McInerney-Leo AM, Marshall M, Zaborska KE, Schaub CM, Brown MA, Jacobson DA, Duncan EL. A KCNK16 mutation causing TALK-1 gain of function is associated with maturity-onset diabetes of the young. JCI Insight. 2021 Jul 7/8/2021; 6(13): PMID: 34032641, PMCID: PMC8410089, PII: 138057, DOI: 10.1172/jci.insight.138057, ISSN: 2379-3708.
West JD, Austin ED, Rizzi EM, Yan L, Tanjore H, Crabtree AL, Moore CS, Muthian G, Carrier EJ, Jacobson DA, Hamid R, Kendall PL, Majka S, Rathinasabapathy A. KCNK3 Mutation Causes Altered Immune Function in Pulmonary Arterial Hypertension Patients and Mouse Models. Int J Mol Sci. 2021 May 5/9/2021; 22(9): PMID: 34065088, PMCID: PMC8126011, PII: ijms22095014, DOI: 10.3390/ijms22095014, ISSN: 1422-0067.
Mousavy Gharavy SN, Owen BM, Millership SJ, Chabosseau P, Pizza G, Martinez-Sanchez A, Tasoez E, Georgiadou E, Hu M, Fine NHF, Jacobson DA, Dickerson MT, Idevall-Hagren O, Montoya A, Kramer H, Mehta Z, Withers DJ, Ninov N, Gadue PJ, Cardenas-Diaz FL, Cruciani-Guglielmacci C, Magnan C, Ibberson M, Leclerc I, Voz M, Rutter GA. Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis. Diabetologia [print-electronic]. 2021 Apr; 64(4): 850-64. PMID: 33492421, PMCID: PMC7829492, PII: 10.1007/s00125-020-05350-x, DOI: 10.1007/s00125-020-05350-x, ISSN: 1432-0428.
Sanavia T, Huang C, Manduchi E, Xu Y, Dadi PK, Potter LA, Jacobson DA, Di Camillo B, Magnuson MA, Stoeckert CJ, Gu G. Temporal Transcriptome Analysis Reveals Dynamic Gene Expression Patterns Driving ß-Cell Maturation. Front Cell Dev Biol. 2021; 9: 648791. PMID: 34017831, PMCID: PMC8129579, DOI: 10.3389/fcell.2021.648791, ISSN: 2296-634X.
Zaborska KE, Dadi PK, Dickerson MT, Nakhe AY, Thorson AS, Schaub CM, Graff SM, Stanley JE, Kondapavuluru RS, Denton JS, Jacobson DA. Lactate activation of a-cell KATP channels inhibits glucagon secretion by hyperpolarizing the membrane potential and reducing Ca2+ entry. Mol Metab [print-electronic]. 2020 Dec; 42: 101056. PMID: 32736089, PMCID: PMC7479281, PII: S2212-8778(20)30130-7, DOI: 10.1016/j.molmet.2020.101056, ISSN: 2212-8778.
Yang B, Maddison LA, Zaborska KE, Dai C, Yin L, Tang Z, Zang L, Jacobson DA, Powers AC, Chen W. RIPK3-mediated inflammation is a conserved ß cell response to ER stress. Sci Adv [electronic-print]. 2020 Dec; 6(51): PMID: 33355143, PII: 6/51/eabd7272, DOI: 10.1126/sciadv.abd7272, ISSN: 2375-2548.
Dickerson MT, Dadi PK, Butterworth RB, Nakhe AY, Graff SM, Zaborska KE, Schaub CM, Jacobson DA. Tetraspanin-7 regulation of L-type voltage-dependent calcium channels controls pancreatic ß-cell insulin secretion. J Physiol [print-electronic]. 2020 Nov; 598(21): 4887-905. PMID: 32790176, PMCID: PMC8095317, DOI: 10.1113/JP279941, ISSN: 1469-7793.
Lengyel M, Czirják G, Jacobson DA, Enyedi P. TRESK and TREK-2 two-pore-domain potassium channel subunits form functional heterodimers in primary somatosensory neurons. J Biol Chem [print-electronic]. 2020 Aug 8/28/2020; 295(35): 12408-25. PMID: 32641496, PMCID: PMC7458809, PII: S0021-9258(17)49482-8, DOI: 10.1074/jbc.RA120.014125, ISSN: 1083-351X.
Dai C, Walker JT, Shostak A, Bouchi Y, Poffenberger G, Hart NJ, Jacobson DA, Calcutt MW, Bottino R, Greiner DL, Shultz LD, McGuinness OP, Dean ED, Powers AC. Dapagliflozin Does Not Directly Affect Human a or ß Cells. Endocrinology. 2020 Aug 8/1/2020; 161(8): PMID: 32428240, PMCID: PMC7375801, PII: 5840747, DOI: 10.1210/endocr/bqaa080, ISSN: 1945-7170.
Georgiadou E, Haythorne E, Dickerson MT, Lopez-Noriega L, Pullen TJ, da Silva Xavier G, Davis SPX, Martinez-Sanchez A, Semplici F, Rizzuto R, McGinty JA, French PM, Cane MC, Jacobson DA, Leclerc I, Rutter GA. The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice. Diabetologia [print-electronic]. 2020 Jul; 63(7): 1368-81. PMID: 32350566, PMCID: PMC7286857, PII: 10.1007/s00125-020-05148-x, DOI: 10.1007/s00125-020-05148-x, ISSN: 1432-0428.
Yang X, Graff SM, Heiser CN, Ho KH, Chen B, Simmons AJ, Southard-Smith AN, David G, Jacobson DA, Kaverina I, Wright CVE, Lau KS, Gu G. Coregulator Sin3a Promotes Postnatal Murine ß-Cell Fitness by Regulating Genes in Ca2+ Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response. Diabetes [print-electronic]. 2020 Jun; 69(6): 1219-31. PMID: 32245798, PMCID: PMC7243292, PII: db19-0721, DOI: 10.2337/db19-0721, ISSN: 1939-327X.
Jacobson DA, Shyng SL. Ion Channels of the Islets in Type 2 Diabetes. J Mol Biol [print-electronic]. 2020 Mar 3/6/2020; 432(5): 1326-46. PMID: 31473158, PMCID: PMC7720859, PII: S0022-2836(19)30523-6, DOI: 10.1016/j.jmb.2019.08.014, ISSN: 1089-8638.
Perfitt TL, Wang X, Dickerson MT, Stephenson JR, Nakagawa T, Jacobson DA, Colbran RJ. Neuronal L-Type Calcium Channel Signaling to the Nucleus Requires a Novel CaMKIIa-Shank3 Interaction. J Neurosci [print-electronic]. 2020 Mar 3/4/2020; 40(10): 2000-14. PMID: 32019829, PMCID: PMC7055140, PII: JNEUROSCI.0893-19.2020, DOI: 10.1523/JNEUROSCI.0893-19.2020, ISSN: 1529-2401.
Dickerson MT, Dadi PK, Altman MK, Verlage KR, Thorson AS, Jordan KL, Vierra NC, Amarnath G, Jacobson DA. Glucose-mediated inhibition of calcium-activated potassium channels limits alpha-cell calcium influx and glucagon secretion. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2019 Jan 1/29/2019; PMID: 30694690, DOI: 10.1152/ajpendo.00342.2018, ISSN: 1522-1555.
Liu J, Banerjee A, Herring CA, Attalla J, Hu R, Xu Y, Shao Q, Simmons AJ, Dadi PK, Wang S, Jacobson DA, Liu B, Hodges E, Lau KS, Gu G. Neurog3-Independent Methylation Is the Earliest Detectable Mark Distinguishing Pancreatic Progenitor Identity. Dev. Cell. 2019 Jan 1/7/2019; 48(1): 49-63.e7. PMID: 30620902, PMCID: PMC6327977, PII: S1534-5807(18)31032-3, DOI: 10.1016/j.devcel.2018.11.048, ISSN: 1878-1551.
Navarro G, Allard C, Morford JJ, Xu W, Liu S, Molinas AJ, Butcher SM, Fine NHF, Blandino-Rosano M, Sure VN, Yu S, Zhang R, Münzberg H, Jacobson DA, Katakam PV, Hodson DJ, Bernal-Mizrachi E, Zsombok A, Mauvais-Jarvis F. Androgen excess in pancreatic ß cells and neurons predisposes female mice to type 2 diabetes. JCI Insight [print-electronic]. 2018 Jun 6/21/2018; 3(12): PMID: 29925687, PMCID: PMC6124401, PII: 98607, DOI: 10.1172/jci.insight.98607, ISSN: 2379-3708.
Huang C, Walker EM, Dadi PK, Hu R, Xu Y, Zhang W, Sanavia T, Mun J, Liu J, Nair GG, Tan HYA, Wang S, Magnuson MA, Stoeckert CJ, Hebrok M, Gannon M, Han W, Stein R, Jacobson DA, Gu G. Synaptotagmin 4 Regulates Pancreatic ß Cell Maturation by Modulating the Ca2+ Sensitivity of Insulin Secretion Vesicles. Dev. Cell [print-electronic]. 2018 May 5/7/2018; 45(3): 347-361.e5. PMID: 29656931, PMCID: PMC5962294, PII: S1534-5807(18)30233-8, DOI: 10.1016/j.devcel.2018.03.013, ISSN: 1878-1551.
Hart NJ, Aramandla R, Poffenberger G, Fayolle C, Thames AH, Bautista A, Spigelman AF, Babon JAB, DeNicola ME, Dadi PK, Bush WS, Balamurugan AN, Brissova M, Dai C, Prasad N, Bottino R, Jacobson DA, Drumm ML, Kent SC, MacDonald PE, Powers AC. Cystic fibrosis-related diabetes is caused by islet loss and inflammation. JCI Insight [print-electronic]. 2018 Apr 4/19/2018; 3(8): PMID: 29669939, PII: 98240, DOI: 10.1172/jci.insight.98240, ISSN: 2379-3708.
Hart NJ, Aramandla R, Poffenberger G, Fayolle C, Thames AH, Bautista A, Spigelman AF, Babon JAB, DeNicola ME, Dadi PK, Bush WS, Balamurugan AN, Brissova M, Dai C, Prasad N, Bottino R, Jacobson DA, Drumm ML, Kent SC, MacDonald PE, Powers AC. Cystic fibrosis-related diabetes is caused by islet loss and inflammation. JCI Insight [print-electronic]. 2018 Apr 4/19/2018; 3(8): PMID: 29669939, PMCID: PMC5931120, PII: 98240, DOI: 10.1172/jci.insight.98240, ISSN: 2379-3708.
Huang C, Walker EM, Dadi PK, Hu R, Xu Y, Zhang W, Sanavia T, Mun J, Liu J, Nair GG, Tan HYA, Wang S, Magnuson MA, Stoeckert CJ, Hebrok M, Gannon M, Han W, Stein R, Jacobson DA, Gu G. Synaptotagmin 4 Regulates Pancreatic ß Cell Maturation by Modulating the Ca2+ Sensitivity of Insulin Secretion Vesicles. Dev. Cell [print-electronic]. 2018 Apr 4/12/2018; PMID: 29656931, PII: S1534-5807(18)30233-8, DOI: 10.1016/j.devcel.2018.03.013, ISSN: 1878-1551.
Fine NHF, Doig CL, Elhassan YS, Vierra NC, Marchetti P, Bugliani M, Nano R, Piemonti L, Rutter GA, Jacobson DA, Lavery GG, Hodson DJ. Glucocorticoids Reprogram ß-Cell Signaling to Preserve Insulin Secretion. Diabetes [print-electronic]. 2018 Feb; 67(2): 278-90. PMID: 29203512, PMCID: PMC5780059, PII: db16-1356, DOI: 10.2337/db16-1356, ISSN: 1939-327X.
Vierra NC, Dickerson MT, Jordan KL, Dadi PK, Kadare KA, Altman MK, Milian SC, Jacobson DA. TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion. Mol Metab [print-electronic]. 2018 Jan 1/31/2018; PMID: 29402588, PII: S2212-8778(17)31084-0, DOI: 10.1016/j.molmet.2018.01.016, ISSN: 2212-8778.
Dickerson MT, Bogart AM, Altman MK, Milian SC, Jordan KL, Dadi PK, Jacobson DA. Cytokine-mediated changes in K+ channel activity promotes an adaptive Ca2+ response that sustains ß-cell insulin secretion during inflammation. Sci Rep. 2018 Jan 1/18/2018; 8(1): 1158. PMID: 29348619, PII: 10.1038/s41598-018-19600-x, DOI: 10.1038/s41598-018-19600-x, ISSN: 2045-2322.
Dickerson MT, Bogart AM, Altman MK, Milian SC, Jordan KL, Dadi PK, Jacobson DA. Cytokine-mediated changes in K+ channel activity promotes an adaptive Ca2+ response that sustains ß-cell insulin secretion during inflammation. Sci Rep. 2018 Jan 1/18/2018; 8(1): 1158. PMID: 29348619, PMCID: PMC5773563, PII: 10.1038/s41598-018-19600-x, DOI: 10.1038/s41598-018-19600-x, ISSN: 2045-2322.
Vierra NC, Dickerson MT, Philipson LH, Jacobson DA. Simultaneous Real-Time Measurement of the ß-Cell Membrane Potential and Ca2+ Influx to Assess the Role of Potassium Channels on ß-Cell Function. Methods Mol. Biol. 2018; 1684: 73-84. PMID: 29058185, DOI: 10.1007/978-1-4939-7362-0_7, ISSN: 1940-6029.
Vierra NC, Dickerson MT, Philipson LH, Jacobson DA. Simultaneous Real-Time Measurement of the ß-Cell Membrane Potential and Ca2+ Influx to Assess the Role of Potassium Channels on ß-Cell Function. Methods Mol. Biol. 2018; 1684: 73-84. PMID: 29058185, DOI: 10.1007/978-1-4939-7362-0_7, ISSN: 1940-6029.
Fine NHF, Doig CL, Elhassan YS, Vierra NC, Marchetti P, Bugliani M, Nano R, Piemonti L, Rutter GA, Jacobson DA, Lavery GG, Hodson DJ. Glucocorticoids Reprogram Beta Cell Signaling to Preserve Insulin Secretion. Diabetes [print-electronic]. 2017 Dec 12/4/2017; PMID: 29203512, PII: db16-1356, DOI: 10.2337/db16-1356, ISSN: 1939-327X.
Vierra NC, Dadi PK, Milian SC, Dickerson MT, Jordan KL, Gilon P, Jacobson DA. TALK-1 channels control ß cell endoplasmic reticulum Ca(2+) homeostasis. Sci Signal. 2017 Sep 9/19/2017; 10(497): PMID: 28928238, PII: 10/497/eaan2883, DOI: 10.1126/scisignal.aan2883, ISSN: 1937-9145.
Wang X, Marks CR, Perfitt TL, Nakagawa T, Lee A, Jacobson DA, Colbran RJ. A novel mechanism for Ca(2+)/calmodulin-dependent protein kinase II targeting to L-type Ca(2+) channels that initiates long-range signaling to the nucleus. J. Biol. Chem [print-electronic]. 2017 Sep 9/15/2017; PMID: 28916724, PII: M117.788331, DOI: 10.1074/jbc.M117.788331, ISSN: 1083-351X.
Stancill JS, Cartailler JP, Clayton HW, O'Connor JT, Dickerson MT, Dadi PK, Osipovich AB, Jacobson DA, Magnuson MA. Chronic ß-Cell Depolarization Impairs ß-Cell Identity by Disrupting a Network of Ca(2+)-Regulated Genes. Diabetes [print-electronic]. 2017 Aug; 66(8): 2175-87. PMID: 28550109, PMCID: PMC5521870, PII: db16-1355, DOI: 10.2337/db16-1355, ISSN: 1939-327X.
Stancill JS, Cartailler JP, Clayton HW, O'Connor JT, Dickerson MT, Dadi PK, Osipovich AB, Jacobson DA, Magnuson MA. Chronic ß-Cell Depolarization Impairs ß-Cell Identity by Disrupting a Network of Ca(2+)-Regulated Genes. Diabetes [print-electronic]. 2017 Aug; 66(8): 2175-87. PMID: 28550109, PMCID: PMC5521870, PII: db16-1355, DOI: 10.2337/db16-1355, ISSN: 1939-327X.
Zhu L, Almaça J, Dadi PK, Hong H, Sakamoto W, Rossi M, Lee RJ, Vierra NC, Lu H, Cui Y, McMillin SM, Perry NA, Gurevich VV, Lee A, Kuo B, Leapman RD, Matschinsky FM, Doliba NM, Urs NM, Caron MG, Jacobson DA, Caicedo A, Wess J. ß-arrestin-2 is an essential regulator of pancreatic ß-cell function under physiological and pathophysiological conditions. Nat Commun. 2017 Feb 2/1/2017; 8: 14295. PMID: 28145434, PMCID: PMC5296650, PII: ncomms14295, DOI: 10.1038/ncomms14295, ISSN: 2041-1723.
Dickerson MT, Vierra NC, Milian SC, Dadi PK, Jacobson DA. Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic ß-cells. PLoS ONE. 2017; 12(4): e0175069. PMID: 28403169, PII: PONE-D-16-40391, DOI: 10.1371/journal.pone.0175069, ISSN: 1932-6203.
Dadi PK, Vierra NC, Days EL, Dickerson M, Vinson PN, Weaver CD, Jacobson DA. Selective small molecule activators of TREK-2 channels stimulate DRG c-fiber nociceptor K2P currents and limit calcium influx. ACS Chem Neurosci [print-electronic]. 2016 Nov 11/2/2016; PMID: 27805811, DOI: 10.1021/acschemneuro.6b00301, ISSN: 1948-7193.
Boortz KA, Syring KE, Dai C, Pound LD, Oeser JK, Jacobson DA, Wang JC, McGuinness OP, Powers AC, O'Brien RM. G6PC2 Modulates Fasting Blood Glucose In Male Mice in Response to Stress. Endocrinology [print-electronic]. 2016 Aug; 157(8): 3002-8. PMID: 27300767, PMCID: PMC4967123, DOI: 10.1210/en.2016-1245, ISSN: 1945-7170.
Boortz KA, Syring KE, Dai C, Pound LD, Oeser JK, Jacobson DA, Wang JC, McGuinness OP, Powers AC, O'Brien RM. G6PC2 Modulates Fasting Blood Glucose In Male Mice in Response to Stress. Endocrinology [print-electronic]. 2016 Aug; 157(8): 3002-8. PMID: 27300767, PMCID: PMC4967123, DOI: 10.1210/en.2016-1245, ISSN: 1945-7170.
Navarro G, Xu W, Jacobson DA, Wicksteed B, Allard C, Zhang G, De Gendt K, Kim SH, Wu H, Zhang H, Verhoeven G, Katzenellenbogen JA, Mauvais-Jarvis F. Extranuclear Actions of the Androgen Receptor Enhance Glucose-Stimulated Insulin Secretion in the Male. Cell Metab [print-electronic]. 2016 Apr 4/26/2016; PMID: 27133133, PII: S1550-4131(16)30118-8, DOI: 10.1016/j.cmet.2016.03.015, ISSN: 1932-7420.
Golson ML, Dunn JC, Maulis MF, Dadi PK, Osipovich AB, Magnuson MA, Jacobson DA, Gannon M. Activation of FoxM1 Revitalizes the Replicative Potential of Aged ß-Cells in Male Mice and Enhances Insulin Secretion. Diabetes [print-electronic]. 2015 Nov; 64(11): 3829-38. PMID: 26251404, PMCID: PMC4613976, PII: db15-0465, DOI: 10.2337/db15-0465, ISSN: 1939-327X.
Vierra NC, Dadi PK, Jeong I, Dickerson M, Powell DR, Jacobson DA. Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates ß-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis. Diabetes [print-electronic]. 2015 Nov; 64(11): 3818-28. PMID: 26239056, PMCID: PMC4613978, PII: db15-0280, DOI: 10.2337/db15-0280, ISSN: 1939-327X.
Dadi PK, Luo B, Vierra NC, Jacobson DA. TASK-1 Potassium Channels Limit Pancreatic a-Cell Calcium Influx and Glucagon Secretion. Mol. Endocrinol [print-electronic]. 2015 May; 29(5): 777-87. PMID: 25849724, PMCID: PMC4415209, DOI: 10.1210/me.2014-1321, ISSN: 1944-9917.
Dadi PK, Vierra NC, Jacobson DA. Pancreatic ß-cell-specific ablation of TASK-1 channels augments glucose-stimulated calcium entry and insulin secretion, improving glucose tolerance. Endocrinology [print-electronic]. 2014 Oct; 155(10): 3757-68. PMID: 24932805, PMCID: PMC4164933, DOI: 10.1210/en.2013-2051, ISSN: 1945-7170.
Egnatchik RA, Leamy AK, Jacobson DA, Shiota M, Young JD. ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload. Mol Metab. 2014 Aug; 3(5): 544-53. PMID: 25061559, PMCID: PMC4099508, PII: S2212-8778(14)00092-1, DOI: 10.1016/j.molmet.2014.05.004, ISSN: 2212-8778.
Raphemot R, Swale DR, Dadi PK, Jacobson DA, Cooper P, Wojtovich AP, Banerjee S, Nichols CG, Denton JS. Direct activation of ß-cell KATP channels with a novel xanthine derivative. Mol. Pharmacol [print-electronic]. 2014 Jun; 85(6): 858-65. PMID: 24646456, PMCID: PMC4014665, PII: mol.114.091884, DOI: 10.1124/mol.114.091884, ISSN: 1521-0111.
Dadi PK, Vierra NC, Ustione A, Piston DW, Colbran RJ, Jacobson DA. Inhibition of pancreatic ß-cell Ca2+/calmodulin-dependent protein kinase II reduces glucose-stimulated calcium influx and insulin secretion, impairing glucose tolerance. J. Biol. Chem [print-electronic]. 2014 May 5/2/2014; 289(18): 12435-45. PMID: 24627477, PMCID: PMC4007438, PII: M114.562587, DOI: 10.1074/jbc.M114.562587, ISSN: 1083-351X.
Baerenwald DA, Bonnefond A, Bouatia-Naji N, Flemming BP, Umunakwe OC, Oeser JK, Pound LD, Conley NL, Cauchi S, Lobbens S, Eury E, Balkau B, Lantieri O, , Dadi PK, Jacobson DA, Froguel P, O'Brien RM. Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels. Diabetologia [print-electronic]. 2013 Jun; 56(6): 1306-16. PMID: 23508304, PMCID: PMC4106008, DOI: 10.1007/s00125-013-2875-3, ISSN: 1432-0428.
Kaihara KA, Dickson LM, Jacobson DA, Tamarina N, Roe MW, Philipson LH, Wicksteed B. ß-Cell-specific protein kinase A activation enhances the efficiency of glucose control by increasing acute-phase insulin secretion. Diabetes [print-electronic]. 2013 May; 62(5): 1527-36. PMID: 23349500, PMCID: PMC3636652, PII: db12-1013, DOI: 10.2337/db12-1013, ISSN: 1939-327X.
Pound LD, Oeser JK, O'Brien TP, Wang Y, Faulman CJ, Dadi PK, Jacobson DA, Hutton JC, McGuinness OP, Shiota M, O'Brien RM. G6PC2: a negative regulator of basal glucose-stimulated insulin secretion. Diabetes [print-electronic]. 2013 May; 62(5): 1547-56. PMID: 23274894, PMCID: PMC3636628, PII: db12-1067, DOI: 10.2337/db12-1067, ISSN: 1939-327X.
Fridlyand LE, Jacobson DA, Philipson LH. Ion channels and regulation of insulin secretion in human ß-cells: a computational systems analysis. Islets. 2013 Jan; 5(1): 1-15. PMID: 23624892, PMCID: PMC3662377, PII: 24166, DOI: 10.4161/isl.24166, ISSN: 1938-2022.
Pound LD, Sarkar SA, Ustione A, Dadi PK, Shadoan MK, Lee CE, Walters JA, Shiota M, McGuinness OP, Jacobson DA, Piston DW, Hutton JC, Powell DR, O'Brien RM. The physiological effects of deleting the mouse SLC30A8 gene encoding zinc transporter-8 are influenced by gender and genetic background. PLoS ONE [print-electronic]. 2012; 7(7): e40972. PMID: 22829903, PMCID: PMC3400647, PII: PONE-D-11-24034, DOI: 10.1371/journal.pone.0040972, ISSN: 1932-6203.
Denton JS, Jacobson DA. Channeling dysglycemia: ion-channel variations perturbing glucose homeostasis. Trends Endocrinol. Metab [print-electronic]. 2012 Jan; 23(1): 41-8. PMID: 22134088, PMCID: PMC3733341, PII: S1043-2760(11)00152-4, DOI: 10.1016/j.tem.2011.09.004, ISSN: 1879-3061.
Jacobson DA, Mendez F, Thompson M, Torres J, Cochet O, Philipson LH. Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and complementary roles during secretagogue induced electrical responses. J. Physiol. (Lond.) [print-electronic]. 2010 Sep 9/15/2010; 588(Pt 18): 3525-37. PMID: 20643768, PMCID: PMC2988516, PII: jphysiol.2010.190207, DOI: 10.1113/jphysiol.2010.190207, ISSN: 1469-7793.
Deriy LV, Gomez EA, Jacobson DA, Wang X, Hopson JA, Liu XY, Zhang G, Bindokas VP, Philipson LH, Nelson DJ. The granular chloride channel ClC-3 is permissive for insulin secretion. Cell Metab. 2009 Oct; 10(4): 316-23. PMID: 19808024, PMCID: PMC2778193, PII: S1550-4131(09)00262-9, DOI: 10.1016/j.cmet.2009.08.012, ISSN: 1932-7420.
Fridlyand LE, Jacobson DA, Kuznetsov A, Philipson LH. A model of action potentials and fast Ca2+ dynamics in pancreatic beta-cells. Biophys. J. 2009 Apr 4/22/2009; 96(8): 3126-39. PMID: 19383458, PMCID: PMC2718303, PII: S0006-3495(09)00502-5, DOI: 10.1016/j.bpj.2009.01.029, ISSN: 1542-0086.
Jacobson DA, Wicksteed BL, Philipson LH. The alpha-cell conundrum: ATP-sensitive K+ channels and glucose sensing. Diabetes. 2009 Feb; 58(2): 304-6. PMID: 19171747, PMCID: PMC2628601, PII: 58/2/304, DOI: 10.2337/db08-1618, ISSN: 1939-327X.
Bao S, Jacobson DA, Wohltmann M, Bohrer A, Jin W, Philipson LH, Turk J. Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta in pancreatic beta-cells and in iPLA2beta-null mice. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2008 Feb; 294(2): E217-29. PMID: 17895289, PMCID: PMC2268609, PII: 00474.2007, DOI: 10.1152/ajpendo.00474.2007, ISSN: 0193-1849.
David A. Jacobson and Louis H. Philipson. Pancreatic Beta Cells in Health and Disease. [place unknown: publisher unknown]; 2008.
Jacobson DA, Philipson LH. Action potentials and insulin secretion: new insights into the role of Kv channels. Diabetes Obes Metab. 2007 Nov; 9 Suppl 2: 89-98. PMID: 17919183, PII: DOM784, DOI: 10.1111/j.1463-1326.2007.00784.x, ISSN: 1462-8902.
Jacobson DA, Kuznetsov A, Lopez JP, Kash S, Ammälä CE, Philipson LH. Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion. Cell Metab. 2007 Sep; 6(3): 229-35. PMID: 17767909, PMCID: PMC2699758, PII: S1550-4131(07)00222-7, DOI: 10.1016/j.cmet.2007.07.010, ISSN: 1550-4131.
Jacobson DA, Weber CR, Bao S, Turk J, Philipson LH. Modulation of the pancreatic islet beta-cell-delayed rectifier potassium channel Kv2.1 by the polyunsaturated fatty acid arachidonate. J. Biol. Chem [print-electronic]. 2007 Mar 3/9/2007; 282(10): 7442-9. PMID: 17197450, PMCID: PMC2044499, PII: M607858200, DOI: 10.1074/jbc.M607858200, ISSN: 0021-9258.
Jacobson DA, Philipson LH. TRP channels of the pancreatic beta cell. Handb Exp Pharmacol. 2007; (179): 409-24. PMID: 17217070, DOI: 10.1007/978-3-540-34891-7_24, ISSN: 0171-2004.
Jacobson DA, Cho J, Landa LR, Tamarina NA, Roe MW, Buxbaum JD, Philipson LH. Downstream regulatory element antagonistic modulator regulates islet prodynorphin expression. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2006 Sep; 291(3): E587-95. PMID: 16621893, PII: 00612.2005, DOI: 10.1152/ajpendo.00612.2005, ISSN: 0193-1849.
Available Postdoctoral Position Details
Posted: 8/8/2015
Positions in islet biology and electrophysiology are currently available.
Positions in islet biology and electrophysiology are currently available.