Alexander J. Langerman, M.D.

Associate Professor
Faculty Appointments
Associate Professor of Otolaryngology - Head and Neck Surgery Associate Professor of Radiology & Radiological Sciences
S.M., Clinical and Administrative Data Science, University of Chicago, Chicago, IllinoisM.D., University of Chicago Pritzker School of Medicine, Chicago, IllinoisB.A., Cornell College, Mt Vernon, Iowa
Research Description
Dr. Langerman focuses on the intersection of ethics, data science, and management in the operating room, and he has faculty positions in the Vanderbilt Center for Biomedical Ethics and Society and the Vanderbilt Institute for Surgery and Engineering. Dr. Langerman holds a masters degree in clinical and administrative data science and is a fellowship-trained clinical medical ethicist. He is also Chief Medical Officer of ExplORer Surgical, a startup he co-founded that specializes in real-time surgical data acquisition.
Clinical Description
Dr. Langerman is a fellowship-trained head and neck cancer and microvascular reconstructive surgeon. He has a diverse surgical practice, with special interest in parapharyngeal and infratemporal fossa lesions, complex airway reconstruction, and advanced cutaneous and parotid neoplasms. He has innovated novel endoscopic procedures for pharyngoceles and novel reconstructive procedures for long-segment tracheal stenosis. Dr. Langerman also manages the head and neck cancer data research enterprise at Vanderbilt.
Still BR, Christianson LW, Mhlaba JM, O'Malley IP, Song DH, Langerman AJ. Standardization of Disposable Instruments in Microvascular Breast Reconstruction: A Case Study in Cost Reduction. J Reconstr Microsurg [print-electronic]. 2017 Feb; 33(2): 92-6. PMID: 27733003, DOI: 10.1055/s-0036-1592427, ISSN: 1098-8947.

Davidson SJ, Rojnica M, Matthews JB, Langerman AJ. Variation and Acquisition of Complex Techniques: Pancreaticoduodenectomy. Surg Innov [print-electronic]. 2016 Dec; 23(6): 586-92. PMID: 27507575, PII: 1553350616663322, DOI: 10.1177/1553350616663322, ISSN: 1553-3514.

Pariser JJ, Diamond AJ, Christianson LW, Mitchell BA, Langerman A. Operating Room Inefficiencies Attributable to Errors in Surgical Case Scheduling and Surgeon Procedure Heterogeneity. Am J Med Qual [print-electronic]. 2016 Nov; 31(6): 584-8. PMID: 26395127, PII: 1062860615606517, DOI: 10.1177/1062860615606517, ISSN: 1555-824X.

Fidai SS, Ginat DT, Langerman AJ, Cipriani NA. Dedifferentiated Chondrosarcoma of the Larynx. Head Neck Pathol [print-electronic]. 2016 Sep; 10(3): 345-8. PMID: 26718693, PMCID: PMC4972750, PII: 10.1007/s12105-015-0676-3, DOI: 10.1007/s12105-015-0676-3, ISSN: 1936-0568.

Fong AJ, Smith M, Langerman A. Efficiency improvement in the operating room. J. Surg. Res [print-electronic]. 2016 Aug; 204(2): 371-83. PMID: 27565073, PII: S0022-4804(16)30054-3, DOI: 10.1016/j.jss.2016.04.054, ISSN: 1095-8673.

Smith CS, Guyton K, Pariser JJ, Siegler M, Schindler N, Langerman A. Surgeon-patient communication during awake procedures. Am. J. Surg [print-electronic]. 2016 Jul 7/29/2016; PMID: 27567112, PII: S0002-9610(16)30369-5, DOI: 10.1016/j.amjsurg.2016.06.017, ISSN: 1879-1883.

Maldonado AA, Langerman A. Fibula osteofascial flap with proximal skin paddle for intraoral reconstruction. Microsurgery [print-electronic]. 2016 Jul 7/29/2016; PMID: 27471008, DOI: 10.1002/micr.30084, ISSN: 1098-2752.

Nocon CC, Cohen MA, Langerman AJ. Quality of neck dissection operative reports. Am J Otolaryngol [print-electronic]. 2016 Jul; 37(4): 330-3. PMID: 27037006, PII: S0196-0709(16)00053-3, DOI: 10.1016/j.amjoto.2016.02.006, ISSN: 1532-818X.

Langerman A. Concurrent Surgery and Informed Consent. JAMA Surg. 2016 Jul 7/1/2016; 151(7): 601-2. PMID: 26987099, PII: 2504500, DOI: 10.1001/jamasurg.2016.0511, ISSN: 2168-6262.

Langerman A, Thisted R, Hohmann S, Howell M. Antibiotic and Duration of Perioperative Prophylaxis Predicts Surgical Site Infection in Head and Neck Surgery. Otolaryngol Head Neck Surg [print-electronic]. 2016 Jun; 154(6): 1054-63. PMID: 26932957, PII: 0194599816634303, DOI: 10.1177/0194599816634303, ISSN: 1097-6817.

Langerman A, Siegler M, Angelos P. Intraoperative Decision Making: The Decision to Perform Additional, Unplanned Procedures on Anesthetized Patients. J. Am. Coll. Surg [print-electronic]. 2016 May; 222(5): 956-60. PMID: 27113519, PII: S1072-7515(16)00166-6, DOI: 10.1016/j.jamcollsurg.2016.02.011, ISSN: 1879-1190.

Villaflor VM, Melotek JM, Karrison TG, Brisson RJ, Blair EA, Portugal L, De Souza JA, Ginat DT, Stenson KM, Langerman A, Kocherginsky M, Spiotto MT, Hannigan N, Seiwert TY, Cohen EE, Vokes EE, Haraf DJ. Response-adapted volume de-escalation (RAVD) in locally advanced head and neck cancer. Ann. Oncol [print-electronic]. 2016 May; 27(5): 908-13. PMID: 26884588, PII: mdw051, DOI: 10.1093/annonc/mdw051, ISSN: 1569-8041.

Spear TT, Callender GG, Roszkowski JJ, Moxley KM, Simms PE, Foley KC, Murray DC, Scurti GM, Li M, Thomas JT, Langerman A, Garrett-Mayer E, Zhang Y, Nishimura MI. TCR gene-modified T cells can efficiently treat established hepatitis C-associated hepatocellular carcinoma tumors. Cancer Immunol. Immunother [print-electronic]. 2016 Mar; 65(3): 293-304. PMID: 26842125, PMCID: PMC4887146, PII: 10.1007/s00262-016-1800-2, DOI: 10.1007/s00262-016-1800-2, ISSN: 1432-0851.

Sur MD, Schindler N, Singh P, Angelos P, Langerman A. Young surgeons on speaking up: when and how surgical trainees voice concerns about supervisors' clinical decisions. Am. J. Surg [print-electronic]. 2016 Feb; 211(2): 437-44. PMID: 26691924, PII: S0002-9610(15)00612-1, DOI: 10.1016/j.amjsurg.2015.10.006, ISSN: 1879-1883.

Xiao H, Langerman A, Zhang Y, Khalid O, Hu S, Cao CX, Lingen MW, Wong DT. Quantitative proteomic analysis of microdissected oral epithelium for cancer biomarker discovery. Oral Oncol [print-electronic]. 2015 Nov; 51(11): 1011-9. PMID: 26321370, PII: S1368-8375(15)00298-5, DOI: 10.1016/j.oraloncology.2015.08.008, ISSN: 1879-0593.

Langerman A, Carlton DA. In response to A systematic review of the quality of randomized controlled trials in head and neck oncology surgery [letter]. Laryngoscope [print-electronic]. 2015 Oct; 125(10): E353. PMID: 25727191, DOI: 10.1002/lary.25225, ISSN: 1531-4995.

Silas MR, Grassia P, Langerman A. Video recording of the operating room--is anonymity possible?. J. Surg. Res [print-electronic]. 2015 Aug; 197(2): 272-6. PMID: 25972314, PII: S0022-4804(15)00362-5, DOI: 10.1016/j.jss.2015.03.097, ISSN: 1095-8673.

Langerman A, Ham SA, Pisano J, Pariser J, Hohmann SF, Meltzer DO. Laryngectomy Complications Are Associated with Perioperative Antibiotic Choice. Otolaryngol Head Neck Surg [print-electronic]. 2015 Jul; 153(1): 60-8. PMID: 25944348, PII: 0194599815583641, DOI: 10.1177/0194599815583641, ISSN: 1097-6817.

Ginat DT, Bolotin D, Langerman AJ. Perineural spread of cutaneous squamous cell carcinoma along the great auricular nerve [corrected]. Ear Nose Throat J. 2015 Apr; 94(4-5): 150-2. PMID: 25923271, ISSN: 1942-7522.

Graves SN, Shenaq DS, Langerman AJ, Song DH. Video Capture of Plastic Surgery Procedures Using the GoPro HERO 3+. Plast Reconstr Surg Glob Open. 2015 Feb; 3(2): e312. PMID: 25750851, PMCID: PMC4350318, DOI: 10.1097/GOX.0000000000000242.

Seiwert TY, Zuo Z, Keck MK, Khattri A, Pedamallu CS, Stricker T, Brown C, Pugh TJ, Stojanov P, Cho J, Lawrence MS, Getz G, Brägelmann J, DeBoer R, Weichselbaum RR, Langerman A, Portugal L, Blair E, Stenson K, Lingen MW, Cohen EE, Vokes EE, White KP, Hammerman PS. Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas. Clin. Cancer Res [print-electronic]. 2015 Feb 2/1/2015; 21(3): 632-41. PMID: 25056374, PMCID: PMC4305034, PII: 1078-0432.CCR-13-3310, DOI: 10.1158/1078-0432.CCR-13-3310, ISSN: 1078-0432.

Carlton DA, Kocherginsky M, Langerman AJ. A systematic review of the quality of randomized controlled trials in head and neck oncology surgery. Laryngoscope [print-electronic]. 2015 Jan; 125(1): 146-52. PMID: 24729155, DOI: 10.1002/lary.24718, ISSN: 1531-4995.

Langerman A, Angelos P, Siegler M. The "call for help": intraoperative consultation and the surgeon-patient relationship. J. Am. Coll. Surg [print-electronic]. 2014 Dec; 219(6): 1181-6. PMID: 25283740, PII: S1072-7515(14)01467-7, DOI: 10.1016/j.jamcollsurg.2014.07.931, ISSN: 1879-1190.

Jordan AL, Rojnica M, Siegler M, Angelos P, Langerman A. Surgeon-family perioperative communication: surgeons' self-reported approaches to the "surgeon-family relationship". J. Am. Coll. Surg [print-electronic]. 2014 Nov; 219(5): 958-67. PMID: 25256372, PII: S1072-7515(14)00539-0, DOI: 10.1016/j.jamcollsurg.2014.05.019, ISSN: 1879-1190.

Stockert EW, Langerman A. Assessing the magnitude and costs of intraoperative inefficiencies attributable to surgical instrument trays. J. Am. Coll. Surg [print-electronic]. 2014 Oct; 219(4): 646-55. PMID: 25154669, PII: S1072-7515(14)00510-9, DOI: 10.1016/j.jamcollsurg.2014.06.019, ISSN: 1879-1190.

Tower JI, Lingen MW, Seiwert TY, Langerman A. Impact of warm ischemia on phosphorylated biomarkers in head and neck squamous cell carcinoma. Am J Transl Res. 2014; 6(5): 548-57. PMID: 25360219, PMCID: PMC4212929.

Plein CT, Langerman AJ, Redleaf MI. Bilateral middle cranial fossa encephaloceles presenting as conductive hearing loss. Ear Nose Throat J. 2013 Dec; 92(12): E14-6. PMID: 24366708, ISSN: 1942-7522.

Naunheim M, Langerman A. Pharyngoceles: a photo-anatomic study and novel management. Laryngoscope [print-electronic]. 2013 Jul; 123(7): 1632-8. PMID: 23371264, DOI: 10.1002/lary.23971, ISSN: 1531-4995.

Langerman A, Rangarajan SV, Athavale SM, Pham MQ, Sinard RJ, Netterville JL. Tumors of the cervical sympathetic chain--diagnosis and management. Head Neck [print-electronic]. 2013 Jul; 35(7): 930-3. PMID: 23002012, DOI: 10.1002/hed.23050, ISSN: 1097-0347.

Saloura V, Langerman A, Rudra S, Chin R, Cohen EE. Multidisciplinary care of the patient with head and neck cancer. Surg. Oncol. Clin. N. Am [print-electronic]. 2013 Apr; 22(2): 179-215. PMID: 23453331, PII: S1055-3207(12)00112-3, DOI: 10.1016/j.soc.2012.12.001, ISSN: 1558-5042.

Langerman A, Naslund TC, Netterville JL. Skull base approach to carotid artery lesions: technique, indications, and outcomes. J Neurol Surg B Skull Base. 2012 Jun; 73(3): 163-7. PMID: 23730544, PMCID: PMC3424011, PII: 73163, DOI: 10.1055/s-0032-1301401, ISSN: 2193-6331.

Langerman A, Athavale SM, Rangarajan SV, Sinard RJ, Netterville JL. Natural history of cervical paragangliomas: outcomes of observation of 43 patients. Arch. Otolaryngol. Head Neck Surg [print-electronic]. 2012 Apr; 138(4): 341-5. PMID: 22431860, PII: archoto.2012.37, DOI: 10.1001/archoto.2012.37, ISSN: 1538-361X.

Langerman A, Patel RM, Cohen EE, Blair EA, Stenson KM. Airway management before chemoradiation for advanced head and neck cancer. Head Neck [print-electronic]. 2012 Feb; 34(2): 254-9. PMID: 21384461, DOI: 10.1002/hed.21729, ISSN: 1097-0347.

Doçi CL, Mankame TP, Langerman A, Ostler KR, Kanteti R, Best T, Onel K, Godley LA, Salgia R, Lingen MW. Characterization of NOL7 gene point mutations, promoter methylation, and protein expression in cervical cancer. Int. J. Gynecol. Pathol. 2012 Jan; 31(1): 15-24. PMID: 22123719, PMCID: PMC3237951, DOI: 10.1097/PGP.0b013e318220ba16, ISSN: 1538-7151.

Villaflor VM, Haraf D, Salama JK, Kocherginsky M, Langerman A, Gomez-Abuin G, Beniwal P, Blair EA, Stenson KM, Portugal L, Seiwert T, Williams RD, Dekker AJ, Witt ME, Vokes EE, Cohen EE. Phase II trial of pemetrexed-based induction chemotherapy followed by concomitant chemoradiotherapy in previously irradiated patients with squamous cell carcinoma of the head and neck. Ann. Oncol [print-electronic]. 2011 Nov; 22(11): 2501-7. PMID: 21385883, PII: mdq785, DOI: 10.1093/annonc/mdq785, ISSN: 1569-8041.

Langerman A, Stenson KM, Ferguson MK. Retrograde endoscopic-assisted esophageal dilation. J. Gastrointest. Surg [print-electronic]. 2010 Jul; 14(7): 1186-9. PMID: 20440656, DOI: 10.1007/s11605-010-1205-z, ISSN: 1873-4626.

Langerman A, Sigari F, Naclerio R. Calcified maxillary cyst secondary to a foreign-body reaction at the site of a remote tooth extraction. Ear Nose Throat J. 2010 Jan; 89(1): 42-3. PMID: 20155700, ISSN: 1942-7522.

Langerman A, Plein C, Vokes EE, Salama JK, Haraf DJ, Blair EA, Stenson KM. Neck response to chemoradiotherapy: complete radiographic response correlates with pathologic complete response in locoregionally advanced head and neck cancer. Arch. Otolaryngol. Head Neck Surg. 2009 Nov; 135(11): 1133-6. PMID: 19917927, PII: 135/11/1133, DOI: 10.1001/archoto.2009.154, ISSN: 1538-361X.

Bamba R, Sweiss NJ, Langerman AJ, Taxy JB, Blair EA. The minor salivary gland biopsy as a diagnostic tool for Sjogren syndrome. Laryngoscope. 2009 Oct; 119(10): 1922-6. PMID: 19650134, DOI: 10.1002/lary.20292, ISSN: 1531-4995.

Langerman A, Comstock R, Konda S, Abramovitch A, Kasza K, Vokes EE, Stenson KM. Neck dissection planning based on postchemoradiation computed tomography in patients with head and neck cancer. Arch. Otolaryngol. Head Neck Surg. 2009 Sep; 135(9): 876-80. PMID: 19770419, PII: 135/9/876, DOI: 10.1001/archoto.2009.119, ISSN: 1538-361X.

Taxy JB, El-Zayaty S, Langerman A. Acute fungal sinusitis: natural history and the role of frozen section. Am. J. Clin. Pathol. 2009 Jul; 132(1): 86-93. PMID: 19864238, PII: 132/1/86, DOI: 10.1309/AJCP9HTH9NRPMYCT, ISSN: 1943-7722.

Mohyuddin N, Langerman A, LeHew C, Kaste L, Pytynia K. Knowledge of head and neck cancer among medical students at 2 Chicago universities. Arch. Otolaryngol. Head Neck Surg. 2008 Dec; 134(12): 1294-8. PMID: 19075125, PII: 134/12/1294, DOI: 10.1001/archotol.134.12.1294, ISSN: 1538-361X.

Langerman A, Maccracken E, Kasza K, Haraf DJ, Vokes EE, Stenson KM. Aspiration in chemoradiated patients with head and neck cancer. Arch. Otolaryngol. Head Neck Surg. 2007 Dec; 133(12): 1289-95. PMID: 18086974, PII: 133/12/1289, DOI: 10.1001/archotol.133.12.1289, ISSN: 0886-4470.

Langerman AJ, Blair EA, Sweiss NJ, Taxy JB. Utility of lip biopsy in the diagnosis and treatment of Sjogren's syndrome. Laryngoscope. 2007 Jun; 117(6): 1004-8. PMID: 17417107, DOI: 10.1097/MLG.0b013e31804654f7, ISSN: 0023-852X.

Klemens JJ, Thompson K, Langerman A, Naclerio RM. Persistent inflammation and hyperresponsiveness following viral rhinosinusitis. Laryngoscope. 2006 Jul; 116(7): 1236-40. PMID: 16826067, PII: 00005537-200607000-00030, DOI: 10.1097/01.mlg.0000224526.43698.52, ISSN: 0023-852X.

Langerman A, Callender GG, Nishimura MI. Retroviral transduction of peptide stimulated t cells can generate dual t cell receptor-expressing (bifunctional) t cells reactive with two defined antigens. J Transl Med. 2004 Dec 12/8/2004; 2(1): 42. PMID: 15588290, PMCID: PMC544585, PII: 1479-5876-2-42, DOI: 10.1186/1479-5876-2-42, ISSN: 1479-5876.

Hasson HM, Galanopoulos C, Langerman A. Ischemic necrosis of small bowel following laparoscopic surgery. JSLS. 2004 Apr; 8(2): 159-63. PMID: 15119662, PMCID: PMC3015534, ISSN: 1086-8089.

Klyushnenkova EN, Ponniah S, Rodriguez A, Kodak J, Mann DL, Langerman A, Nishimura MI, Alexander RB. CD4 and CD8 T-lymphocyte recognition of prostate specific antigen in granulomatous prostatitis. J. Immunother. 2004 Mar; 27(2): 136-46. PMID: 14770085, PII: 00002371-200403000-00007, ISSN: 1524-9557.

Langerman A, Schneider JA, Ward RP. Pheochromocytoma storm presenting as cardiovascular collapse at term pregnancy. Rev Cardiovasc Med. 2004; 5(4): 226-30. PMID: 15580162, ISSN: 1530-6550.

Wu PC, Langerman A, Ryan CW, Hart J, Swiger S, Posner MC. Surgical treatment of gastrointestinal stromal tumors in the imatinib (STI-571) era. Surgery. 2003 Oct; 134(4): 656-65; discussion 665. PMID: 14605627, PII: S0039606003003143, DOI: 10.1016/S0039, ISSN: 0039-6060.

Staradub VL, Hsieh YC, Clauson J, Langerman A, Rademaker AW, Morrow M. Factors that influence surgical choices in women with breast carcinoma. Cancer. 2002 Sep 9/15/2002; 95(6): 1185-90. PMID: 12216083, DOI: 10.1002/cncr.10824, ISSN: 0008-543X.

Langerman A, Angelos P, Johnston C. Opinions and use of advance directives by physicians at a tertiary care hospital. Qual Manag Health Care. 2000; 8(3): 14-8. PMID: 10947380, ISSN: 1063-8628.