Chanjuan Shi, M.D., Ph.D.

Faculty Appointments
Professor of Pathology, Microbiology and Immunology
Ph.D., Dalhousie University, Halifax, CanadaM.D., Zhejiang University, Hangzhou, China
Office Address
Vanderbilt University School of Medicine
Pathology, Microbiology, and Immunology - 3rd Fl C3321 MCN
1161 21st Avenue South
Nashville, TN 37232-2561
Wang Y, Vnencak-Jones CL, Cates JM, Shi C. Deciphering Elevated Microsatellite Alterations at Selected Tetra/Pentanucleotide Repeats, Microsatellite Instability, and Loss of Heterozygosity in Colorectal Cancers. J Mol Diagn [print-electronic]. 2018 May; 20(3): 366-72. PMID: 29474982, PII: S1525-1578(17)30446-4, DOI: 10.1016/j.jmoldx.2018.02.001, ISSN: 1943-7811.

Roberts JA, Gonzalez RS, Das S, Berlin J, Shi C. Expression of PD-1 and PD-L1 in poorly differentiated neuroendocrine carcinomas of the digestive system: a potential target for anti-PD-1/PD-L1 therapy. Hum. Pathol [print-electronic]. 2017 Dec; 70: 49-54. PMID: 29037958, PMCID: PMC5745271, PII: S0046-8177(17)30362-3, DOI: 10.1016/j.humpath.2017.10.003, ISSN: 1532-8392.

Erdogan B, Ao M, White LM, Means AL, Brewer BM, Yang L, Washington MK, Shi C, Franco OE, Weaver AM, Hayward SW, Li D, Webb DJ. Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin. J. Cell Biol [print-electronic]. 2017 Nov 11/6/2017; 216(11): 3799-816. PMID: 29021221, PMCID: PMC5674895, PII: jcb.201704053, DOI: 10.1083/jcb.201704053, ISSN: 1540-8140.

Idrees K, Padmanabhan C, Liu E, Guo Y, Gonzalez RS, Berlin J, Dahlman KB, Beauchamp RD, Shi C. Frequent BRAF mutations suggest a novel oncogenic driver in colonic neuroendocrine carcinoma. J Surg Oncol [print-electronic]. 2017 Sep 9/20/2017; PMID: 28940307, DOI: 10.1002/jso.24834, ISSN: 1096-9098.

Gonzalez RS, Salaria SN, Bohannon CD, Huber AR, Feely MM, Shi C. Immune modulator-induced changes in the gastrointestinal tract - reply [letter]. Histopathology [print-electronic]. 2017 Sep; 71(3): 496. PMID: 28387954, DOI: 10.1111/his.13233, ISSN: 1365-2559.

Pickup MW, Owens P, Gorska AE, Chytil A, Ye F, Shi C, Weaver VM, Kalluri R, Moses HL, Novitskiy SV. Development of Aggressive Pancreatic Ductal Adenocarcinomas Depends on Granulocyte Colony Stimulating Factor Secretion in Carcinoma Cells. Cancer Immunol Res [print-electronic]. 2017 Sep; 5(9): 718-29. PMID: 28775207, PMCID: PMC5581681, PII: 2326-6066.CIR-16-0311, DOI: 10.1158/2326-6066.CIR-16-0311, ISSN: 2326-6074.

Thota R, Gonzalez RS, Berlin J, Cardin DB, Shi C. Could the PD-1 Pathway Be a Potential Target for Treating Small Intestinal Adenocarcinoma?. Am. J. Clin. Pathol. 2017 Sep 9/1/2017; 148(3): 208-14. PMID: 28821192, PII: 4057091, DOI: 10.1093/AJCP/AQX070, ISSN: 1943-7722.

Charoenpitakchai M, Liu E, Zhao Z, Koyama T, Huh WJ, Berlin J, Hande K, Walker R, Shi C. In liver metastases from small intestinal neuroendocrine tumors, SSTR2A expression is heterogeneous. Virchows Arch [print-electronic]. 2017 May; 470(5): 545-52. PMID: 28213807, PMCID: PMC5623953, PII: 10.1007/s00428-017-2093-3, DOI: 10.1007/s00428-017-2093-3, ISSN: 1432-2307.

Irabor DO, Oluwasola OA, Ogunbiyi OJ, Ogun OG, Okolo CA, Melas M, Gruber SB, Shi C, Raskin L. Microsatellite Instability Is Common in Colorectal Cancer in Native Nigerians. Anticancer Res. 2017 May; 37(5): 2649-54. PMID: 28476840, PII: 37/5/2649, DOI: 10.21873/anticanres.11612, ISSN: 1791-7530.

Gonzalez RS, Huh WJ, Cates JM, Washington K, Beauchamp RD, Coffey RJ, Shi C. Micropapillary colorectal carcinoma: clinical, pathological and molecular properties, including evidence of epithelial-mesenchymal transition. Histopathology [print-electronic]. 2017 Jan; 70(2): 223-31. PMID: 27560620, DOI: 10.1111/his.13068, ISSN: 1365-2559.

Fata CR, Gonzalez RS, Liu E, Cates JM, Shi C. Mesenteric Tumor Deposits in Midgut Small Intestinal Neuroendocrine Tumors Are a Stronger Indicator Than Lymph Node Metastasis for Liver Metastasis and Poor Prognosis. Am. J. Surg. Pathol. 2017 Jan; 41(1): 128-33. PMID: 27684993, PMCID: PMC5159256, DOI: 10.1097/PAS.0000000000000751, ISSN: 1532-0979.

Wang Y, Shi C, Eisenberg R, Vnencak-Jones CL. Differences in Microsatellite Instability Profiles between Endometrioid and Colorectal Cancers: A Potential Cause for False-Negative Results?. J Mol Diagn [print-electronic]. 2017 Jan; 19(1): 57-64. PMID: 27810331, PII: S1525-1578(16)30181-7, DOI: 10.1016/j.jmoldx.2016.07.008, ISSN: 1943-7811.

Walker R, Deppen S, Smith G, Shi C, Lehman J, Clanton J, Moore B, Burns R, Grogan EL, Massion PP. 68Ga-DOTATATE PET/CT imaging of indeterminate pulmonary nodules and lung cancer. PLoS ONE. 2017; 12(2): e0171301. PMID: 28182730, PMCID: PMC5300187, PII: PONE-D-16-19765, DOI: 10.1371/journal.pone.0171301, ISSN: 1932-6203.

Salaria SN, Shi C. Pancreatic Neuroendocrine Tumors. Surg Pathol Clin [print-electronic]. 2016 Dec; 9(4): 595-617. PMID: 27926362, PII: S1875-9181(16)30030-7, DOI: 10.1016/j.path.2016.05.006, ISSN: 1875-9157.

Beeghly-Fadiel A, Luu HN, Du L, Shi C, McGavic DP, Parikh AA, Raskin L. Early onset pancreatic malignancies: Clinical characteristics and survival associations. Int. J. Cancer [print-electronic]. 2016 Nov 11/15/2016; 139(10): 2169-77. PMID: 27416564, DOI: 10.1002/ijc.30273, ISSN: 1097-0215.

Gonzalez RS, Salaria SN, Bohannon CD, Huber AR, Feely MM, Shi C. PD-1 inhibitor gastroenterocolitis: case series and appraisal of 'immunomodulatory gastroenterocolitis'. Histopathology [print-electronic]. 2016 Nov 11/7/2016; PMID: 28000302, DOI: 10.1111/his.13118, ISSN: 1365-2559.

Weiss V, Dueber J, Wright JP, Cates J, Revetta F, Parikh AA, Merchant NB, Shi C. Immunohistochemical analysis of the Wnt/ß-catenin signaling pathway in pancreatic neuroendocrine neoplasms. World J Gastrointest Oncol. 2016 Aug 8/15/2016; 8(8): 615-22. PMID: 27574554, PMCID: PMC4980652, DOI: 10.4251/wjgo.v8.i8.615.

Su Y, Li J, Shi C, Hruban RH, Radice GL. N-cadherin functions as a growth suppressor in a model of K-ras-induced PanIN. Oncogene [print-electronic]. 2016 Jun 6/23/2016; 35(25): 3335-41. PMID: 26477318, PMCID: PMC4837100, PII: onc2015382, DOI: 10.1038/onc.2015.382, ISSN: 1476-5594.

Wheeler SR, Shi C, Holt JA, Vnencak-Jones CL. Mutation profiles of synchronous colorectal cancers from a patient with Lynch syndrome suggest distinct oncogenic pathways. J Gastrointest Oncol. 2016 Jun; 7(3): E64-71. PMID: 27284491, PMCID: PMC4880766, PII: jgo-07-03-E64, DOI: 10.21037/jgo.2016.01.07, ISSN: 2078-6891.

Deppen SA, Liu E, Blume JD, Clanton J, Shi C, Jones-Jackson LB, Lakhani V, Baum RP, Berlin J, Smith GT, Graham M, Sandler MP, Delbeke D, Walker RC. Safety and Efficacy of 68Ga-DOTATATE PET/CT for Diagnosis, Staging, and Treatment Management of Neuroendocrine Tumors. J. Nucl. Med [print-electronic]. 2016 May; 57(5): 708-14. PMID: 26769865, PII: jnumed.115.163865, DOI: 10.2967/jnumed.115.163865, ISSN: 1535-5667.

Gonzalez RS, Cates JM, Washington MK, Beauchamp RD, Coffey RJ, Shi C. Adenoma-like adenocarcinoma: a subtype of colorectal carcinoma with good prognosis, deceptive appearance on biopsy and frequent KRAS mutation. Histopathology [print-electronic]. 2016 Jan; 68(2): 183-90. PMID: 25913616, PMCID: PMC4619179, DOI: 10.1111/his.12725, ISSN: 1365-2559.

Nagathihalli NS, Castellanos JA, Shi C, Beesetty Y, Reyzer ML, Caprioli R, Chen X, Walsh AJ, Skala MC, Moses HL, Merchant NB. Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer. Gastroenterology [print-electronic]. 2015 Dec; 149(7): 1932-1943.e9. PMID: 26255562, PMCID: PMC4863449, PII: S0016-5085(15)01090-2, DOI: 10.1053/j.gastro.2015.07.058, ISSN: 1528-0012.

Salaria S, Means A, Revetta F, Idrees K, Liu E, Shi C. Expression of CD24, a Stem Cell Marker, in Pancreatic and Small Intestinal Neuroendocrine Tumors. Am. J. Clin. Pathol. 2015 Oct; 144(4): 642-8. PMID: 26386086, PMCID: PMC4576728, PII: 144/4/642, DOI: 10.1309/AJCPMZY5P9TWNJJV, ISSN: 1943-7722.

Gonzalez RS, Schwartz DA, Shi C. Colestipol granules in the colon: macroscopic and microscopic findings. Histopathology [print-electronic]. 2015 Jul; 67(1): 141-2. PMID: 25406854, DOI: 10.1111/his.12618, ISSN: 1365-2559.

Wang Y, Shi C, Lu Y, Poulin EJ, Franklin JL, Coffey RJ. Loss of Lrig1 leads to expansion of Brunner glands followed by duodenal adenomas with gastric metaplasia. Am. J. Pathol. 2015 Apr; 185(4): 1123-34. PMID: 25794708, PMCID: PMC4380843, PII: S0002-9440(15)00022-X, DOI: 10.1016/j.ajpath.2014.12.014, ISSN: 1525-2191.

Sopha SC, Rosado FG, Smith JJ, Merchant NB, Shi C. Hepatic uterus-like mass misdiagnosed as hepatic abscess. Int. J. Surg. Pathol [print-electronic]. 2015 Apr; 23(2): 134-9. PMID: 24827588, PII: 1066896914534465, DOI: 10.1177/1066896914534465, ISSN: 1940-2465.

Marincola P, Gonzalez RS, Shi C, Poulose B, Parikh A. Cholangiocarcinoma arising from intraductal papillary mucinous neoplasm of the bile duct. Am Surg. 2015 Mar; 81(3): E102-3. PMID: 25760180, ISSN: 1555-9823.

Shi C, Gonzalez RS, Zhao Z, Koyama T, Cornish TC, Hande KR, Walker R, Sandler M, Berlin J, Liu EH. Liver metastases of small intestine neuroendocrine tumors: Ki-67 heterogeneity and World Health Organization grade discordance with primary tumors. Am. J. Clin. Pathol. 2015 Mar; 143(3): 398-404. PMID: 25696798, PMCID: PMC4354931, PII: 143/3/398, DOI: 10.1309/AJCPQ55SKOCYFZHN, ISSN: 1943-7722.

Johnson A, Wright JP, Zhao Z, Komaya T, Parikh A, Merchant N, Shi C. Cadherin 17 is frequently expressed by 'sclerosing variant' pancreatic neuroendocrine tumour. Histopathology [print-electronic]. 2015 Jan; 66(2): 225-33. PMID: 25307987, PMCID: PMC4302003, DOI: 10.1111/his.12535, ISSN: 1365-2559.

Wu CY, Carpenter ES, Takeuchi KK, Halbrook CJ, Peverley LV, Bien H, Hall JC, DelGiorno KE, Pal D, Song Y, Shi C, Lin RZ, Crawford HC. PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice. Gastroenterology [print-electronic]. 2014 Dec; 147(6): 1405-16.e7. PMID: 25311989, PMCID: PMC4252806, PII: S0016-5085(14)01071-3, DOI: 10.1053/j.gastro.2014.08.032, ISSN: 1528-0012.

Chmielecki J, Hutchinson KE, Frampton GM, Chalmers ZR, Johnson A, Shi C, Elvin J, Ali SM, Ross JS, Basturk O, Balasubramanian S, Lipson D, Yelensky R, Pao W, Miller VA, Klimstra DS, Stephens PJ. Comprehensive genomic profiling of pancreatic acinar cell carcinomas identifies recurrent RAF fusions and frequent inactivation of DNA repair genes. Cancer Discov [print-electronic]. 2014 Dec; 4(12): 1398-405. PMID: 25266736, PII: 2159-8290.CD-14-0617, DOI: 10.1158/2159-8290.CD-14-0617, ISSN: 2159-8290.

Shi C, Klimstra DS. Pancreatic neuroendocrine tumors: pathologic and molecular characteristics. Semin Diagn Pathol [print-electronic]. 2014 Nov; 31(6): 498-511. PMID: 25441311, PII: S0740-2570(14)00082-3, DOI: 10.1053/j.semdp.2014.08.008, ISSN: 0740-2570.

Kiernan CM, Du L, Chen X, Broome JT, Shi C, Peters MF, Solorzano CC. Predictors of hemodynamic instability during surgery for pheochromocytoma. Ann. Surg. Oncol [print-electronic]. 2014 Nov; 21(12): 3865-71. PMID: 24939623, PMCID: PMC4192065, DOI: 10.1245/s10434-014-3847-7, ISSN: 1534-4681.

Choi E, Roland JT, Barlow BJ, O'Neal R, Rich AE, Nam KT, Shi C, Goldenring JR. Cell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the gastric antrum. Gut [print-electronic]. 2014 Nov; 63(11): 1711-20. PMID: 24488499, PMCID: PMC4117823, PII: gutjnl-2013-305964, DOI: 10.1136/gutjnl-2013-305964, ISSN: 1468-3288.

James SD, Wise PE, Zuluaga-Toro T, Schwartz DA, Washington MK, Shi C. Identification of pathologic features associated with "ulcerative colitis-like" Crohn's disease. World J. Gastroenterol. 2014 Sep 9/28/2014; 20(36): 13139-45. PMID: 25278708, PMCID: PMC4177493, DOI: 10.3748/wjg.v20.i36.13139, ISSN: 2219-2840.

Gonzalez RS, Liu EH, Alvarez JR, Ayers GD, Washington MK, Shi C. Should mesenteric tumor deposits be included in staging of well-differentiated small intestine neuroendocrine tumors?. Mod. Pathol [print-electronic]. 2014 Sep; 27(9): 1288-95. PMID: 24457461, PMCID: PMC4110189, PII: modpathol2013232, DOI: 10.1038/modpathol.2013.232, ISSN: 1530-0285.

González RS, Vnencak-Jones CL, Shi C, Fadare O. Endomyometriosis ("Uterus-like mass") in an XY Male: Case Report With Molecular Confirmation and Literature Review. Int. J. Surg. Pathol [print-electronic]. 2014 Aug; 22(5): 421-6. PMID: 24651910, PII: 1066896913501385, DOI: 10.1177/1066896913501385, ISSN: 1940-2465.

Pekala KR, Ma X, Kropp PA, Petersen CP, Hudgens CW, Chung CH, Shi C, Merchant NB, Maitra A, Means AL, Gannon MA. Loss of HNF6 expression correlates with human pancreatic cancer progression. Lab. Invest [print-electronic]. 2014 May; 94(5): 517-27. PMID: 24638272, PMCID: PMC4068339, PII: labinvest201447, DOI: 10.1038/labinvest.2014.47, ISSN: 1530-0307.

Mikhitarian K, Pollen M, Zhao Z, Shyr Y, Merchant NB, Parikh A, Revetta F, Washington MK, Vnencak-Jones C, Shi C. Epidermal growth factor receptor signaling pathway is frequently altered in ampullary carcinoma at protein and genetic levels. Mod. Pathol [print-electronic]. 2014 May; 27(5): 665-74. PMID: 24186143, PMCID: PMC4007414, PII: modpathol2013185, DOI: 10.1038/modpathol.2013.185, ISSN: 1530-0285.

Catanzaro JM, Sheshadri N, Pan JA, Sun Y, Shi C, Li J, Powers RS, Crawford HC, Zong WX. Oncogenic Ras induces inflammatory cytokine production by upregulating the squamous cell carcinoma antigens SerpinB3/B4. Nat Commun. 2014 Apr 4/23/2014; 5: 3729. PMID: 24759783, PMCID: PMC4025922, PII: ncomms4729, DOI: 10.1038/ncomms4729, ISSN: 2041-1723.

Shi C, Washington MK, Chaturvedi R, Drosos Y, Revetta FL, Weaver CJ, Buzhardt E, Yull FE, Blackwell TS, Sosa-Pineda B, Whitehead RH, Beauchamp RD, Wilson KT, Means AL. Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage-stellate cell interaction. Lab. Invest [print-electronic]. 2014 Apr; 94(4): 409-21. PMID: 24535260, PMCID: PMC3992484, PII: labinvest201410, DOI: 10.1038/labinvest.2014.10, ISSN: 1530-0307.

Basturk O, Tang L, Hruban RH, Adsay V, Yang Z, Krasinskas AM, Vakiani E, La Rosa S, Jang KT, Frankel WL, Liu X, Zhang L, Giordano TJ, Bellizzi AM, Chen JH, Shi C, Allen P, Reidy DL, Wolfgang CL, Saka B, Rezaee N, Deshpande V, Klimstra DS. Poorly differentiated neuroendocrine carcinomas of the pancreas: a clinicopathologic analysis of 44 cases. Am. J. Surg. Pathol. 2014 Apr; 38(4): 437-47. PMID: 24503751, PMCID: PMC3977000, DOI: 10.1097/PAS.0000000000000169, ISSN: 1532-0979.

Matthaei H, Wu J, Dal Molin M, Shi C, Perner S, Kristiansen G, Lingohr P, Kalff JC, Wolfgang CL, Kinzler KW, Vogelstein B, Maitra A, Hruban RH. GNAS sequencing identifies IPMN-specific mutations in a subgroup of diminutive pancreatic cysts referred to as "incipient IPMNs". Am. J. Surg. Pathol. 2014 Mar; 38(3): 360-3. PMID: 24525507, PMCID: PMC3927228, PII: 00000478-201403000-00010, DOI: 10.1097/PAS.0000000000000117, ISSN: 1532-0979.

Ellison TA, Wolfgang CL, Shi C, Cameron JL, Murakami P, Mun LJ, Singhi AD, Cornish TC, Olino K, Meriden Z, Choti M, Diaz LA, Pawlik TM, Schulick RD, Hruban RH, Edil BH. A single institution's 26-year experience with nonfunctional pancreatic neuroendocrine tumors: a validation of current staging systems and a new prognostic nomogram. Ann. Surg. 2014 Feb; 259(2): 204-12. PMID: 23673766, PMCID: PMC4048026, DOI: 10.1097/SLA.0b013e31828f3174, ISSN: 1528-1140.

Shi C, Merchant N, Newsome G, Goldenberg DM, Gold DV. Differentiation of pancreatic ductal adenocarcinoma from chronic pancreatitis by PAM4 immunohistochemistry. Arch. Pathol. Lab. Med. 2014 Feb; 138(2): 220-8. PMID: 24476519, PMCID: PMC4037743, DOI: 10.5858/arpa.2013-0056-OA, ISSN: 1543-2165.

Yachimski P, Shi C, Slaughter JC, Washington MK. Endoscopic mucosal resection of Barrett's esophagus detects high prevalence of subsquamous intestinal metaplasia. World J Gastrointest Endosc. 2013 Dec 12/16/2013; 5(12): 590-4. PMID: 24368934, PMCID: PMC3870912, DOI: 10.4253/wjge.v5.i12.590.

McCall CM, Shi C, Cornish TC, Klimstra DS, Tang LH, Basturk O, Mun LJ, Ellison TA, Wolfgang CL, Choti MA, Schulick RD, Edil BH, Hruban RH. Grading of well-differentiated pancreatic neuroendocrine tumors is improved by the inclusion of both Ki67 proliferative index and mitotic rate. Am. J. Surg. Pathol. 2013 Nov; 37(11): 1671-7. PMID: 24121170, PMCID: PMC3891823, DOI: 10.1097/PAS.0000000000000089, ISSN: 1532-0979.

Ayers K, Shi C, Washington K, Yachimski P. Expert pathology review and endoscopic mucosal resection alters the diagnosis of patients referred to undergo therapy for Barrett's esophagus. Surg Endosc [print-electronic]. 2013 Aug; 27(8): 2836-40. PMID: 23389078, DOI: 10.1007/s00464-013-2830-x, ISSN: 1432-2218.

O'Neal RL, Nam KT, LaFleur BJ, Barlow B, Nozaki K, Lee HJ, Kim WH, Yang HK, Shi C, Maitra A, Montgomery E, Washington MK, El Rifai W, Drapkin RI, Goldenring JR. Human epididymis protein 4 is up-regulated in gastric and pancreatic adenocarcinomas. Hum. Pathol [print-electronic]. 2013 May; 44(5): 734-42. PMID: 23084584, PMCID: PMC3556378, PII: S0046-8177(12)00275-4, DOI: 10.1016/j.humpath.2012.07.017, ISSN: 1532-8392.

Kawamoto S, Johnson PT, Shi C, Singhi AD, Hruban RH, Wolfgang CL, Edil BH, Fishman EK. Pancreatic neuroendocrine tumor with cystlike changes: evaluation with MDCT. AJR Am J Roentgenol. 2013 Mar; 200(3): W283-90. PMID: 23436873, PMCID: PMC4048027, PII: 200/3/W283, DOI: 10.2214/AJR.12.8941, ISSN: 1546-3141.

Sopha SC, Gopal P, Merchant NB, Revetta FL, Gold DV, Washington K, Shi C. Diagnostic and therapeutic implications of a novel immunohistochemical panel detecting duodenal mucosal invasion by pancreatic ductal adenocarcinoma. Int J Clin Exp Pathol. 2013; 6(11): 2476-86. PMID: 24228110, PMCID: PMC3816817, ISSN: 1936-2625.

Singhi AD, Chu LC, Tatsas AD, Shi C, Ellison TA, Fishman EK, Kawamoto S, Schulick RD, Wolfgang CL, Hruban RH, Edil BH. Cystic pancreatic neuroendocrine tumors: a clinicopathologic study. Am. J. Surg. Pathol. 2012 Nov; 36(11): 1666-73. PMID: 23073325, PII: 00000478-201211000-00009, DOI: 10.1097/PAS.0b013e31826a0048, ISSN: 1532-0979.

Wentz SC, Zhao ZG, Shyr Y, Shi CJ, Merchant NB, Washington K, Xia F, Chakravarthy AB. Lymph node ratio and preoperative CA 19-9 levels predict overall survival and recurrence-free survival in patients with resected pancreatic adenocarcinoma. World J Gastrointest Oncol. 2012 Oct 10/15/2012; 4(10): 207-15. PMID: 23444312, PMCID: PMC3581835, DOI: 10.4251/wjgo.v4.i10.207, ISSN: 1948-5204.

Deery S, Yates R, Hata J, Shi C, Parikh AA. Gastric adenocarcinoma associated with gastritis cystica profunda in an unoperated stomach. Am Surg. 2012 Aug; 78(8): E379-80. PMID: 22856484, ISSN: 1555-9823.

McCall CM, Shi C, Klein AP, Konukiewitz B, Edil BH, Ellison TA, Wolfgang CL, Schulick RD, Klöppel G, Hruban RH. Serotonin expression in pancreatic neuroendocrine tumors correlates with a trabecular histologic pattern and large duct involvement. Hum. Pathol [print-electronic]. 2012 Aug; 43(8): 1169-76. PMID: 22221702, PMCID: PMC3323730, PII: S0046-8177(11)00405-9, DOI: 10.1016/j.humpath.2011.09.014, ISSN: 1532-8392.

Shi C, Washington K. Molecular testing in colorectal cancer: diagnosis of Lynch syndrome and personalized cancer medicine. Am. J. Clin. Pathol. 2012 Jun; 137(6): 847-59. PMID: 22586043, PII: 137/6/847, DOI: 10.1309/AJCPI83DINULUJNI, ISSN: 1943-7722.

Yachida S, Vakiani E, White CM, Zhong Y, Saunders T, Morgan R, de Wilde RF, Maitra A, Hicks J, Demarzo AM, Shi C, Sharma R, Laheru D, Edil BH, Wolfgang CL, Schulick RD, Hruban RH, Tang LH, Klimstra DS, Iacobuzio-Donahue CA. Small cell and large cell neuroendocrine carcinomas of the pancreas are genetically similar and distinct from well-differentiated pancreatic neuroendocrine tumors. Am. J. Surg. Pathol. 2012 Feb; 36(2): 173-84. PMID: 22251937, PMCID: PMC3261427, PII: 00000478-201202000-00002, DOI: 10.1097/PAS.0b013e3182417d36, ISSN: 1532-0979.

Shi C, Hruban RH. Intraductal papillary mucinous neoplasm. Hum. Pathol [print-electronic]. 2012 Jan; 43(1): 1-16. PMID: 21777948, PII: S0046-8177(11)00157-2, DOI: 10.1016/j.humpath.2011.04.003, ISSN: 1532-8392.

Jiao Y, Shi C, Edil BH, de Wilde RF, Klimstra DS, Maitra A, Schulick RD, Tang LH, Wolfgang CL, Choti MA, Velculescu VE, Diaz LA, Vogelstein B, Kinzler KW, Hruban RH, Papadopoulos N. DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science [print-electronic]. 2011 Mar 3/4/2011; 331(6021): 1199-203. PMID: 21252315, PMCID: PMC3144496, PII: science.1200609, DOI: 10.1126/science.1200609, ISSN: 1095-9203.

Xiong W, Shi C. Images in clinical medicine. Malignant pericardial effusion. N. Engl. J. Med. 2011 Mar 3/3/2011; 364(9): e18. PMID: 21366469, DOI: 10.1056/NEJMicm1009066, ISSN: 1533-4406.

Hong SM, Heaphy CM, Shi C, Eo SH, Cho H, Meeker AK, Eshleman JR, Hruban RH, Goggins M. Telomeres are shortened in acinar-to-ductal metaplasia lesions associated with pancreatic intraepithelial neoplasia but not in isolated acinar-to-ductal metaplasias. Mod. Pathol [print-electronic]. 2011 Feb; 24(2): 256-66. PMID: 20871595, PMCID: PMC3166222, PII: modpathol2010181, DOI: 10.1038/modpathol.2010.181, ISSN: 1530-0285.

Kern SE, Shi C, Hruban RH. The complexity of pancreatic ductal cancers and multidimensional strategies for therapeutic targeting. J. Pathol [print-electronic]. 2011 Jan; 223(2): 295-306. PMID: 21125682, PMCID: PMC3767138, DOI: 10.1002/path.2813, ISSN: 1096-9896.

Heaphy CM, de Wilde RF, Jiao Y, Klein AP, Edil BH, Shi C, Bettegowda C, Rodriguez FJ, Eberhart CG, Hebbar S, Offerhaus GJ, McLendon R, Rasheed BA, He Y, Yan H, Bigner DD, Oba-Shinjo SM, Marie SK, Riggins GJ, Kinzler KW, Vogelstein B, Hruban RH, Maitra A, Papadopoulos N, Meeker AK. Altered telomeres in tumors with ATRX and DAXX mutations. Science. 2011; 333((6041 Epub)): 425.

Meriden Z, Shi C, Edil BH, Ellison T, Wolfgang CL, Cornish TC, Schulick RD, Hruban RH.. Hyaline globules in neuroendocrine and solid-pseudopapillary neoplasms of the pancreas: a clue to the diagnosis. Am J Surg Pathol. 2011; 35((7)): 981-8.

Kawamoto S, Shi C, Hruban RH, Choti MA, Schulick RD, Fishman EK, Siegelman SS. Small serotonin-producing neuroendocrine tumor of the pancreas associated with pancreatic duct obstruction. AJR Am J Roentgenol. 2011; 197((3)).

Park JY, Cornish TC, Lam-Himlin D, Shi C, Montgomery E. Gastric lesions in patients with autoimmune metaplastic atrophic gastritis (AMAG) in a tertiary care setting. Am. J. Surg. Pathol. 2010 Nov; 34(11): 1591-8. PMID: 20975338, PII: 00000478-201011000-00004, DOI: 10.1097/PAS.0b013e3181f623af, ISSN: 1532-0979.

Lam-Himlin D, Park JY, Cornish TC, Shi C, Montgomery E. Morphologic characterization of syndromic gastric polyps. Am. J. Surg. Pathol. 2010 Nov; 34(11): 1656-62. PMID: 20924281, DOI: 10.1097/PAS.0b013e3181f2b1f1, ISSN: 1532-0979.

Gold DV, Goggins M, Modrak DE, Newsome G, Liu M, Shi C, Hruban RH, Goldenberg DM. Detection of early-stage pancreatic adenocarcinoma. Cancer Epidemiol. Biomarkers Prev [print-electronic]. 2010 Nov; 19(11): 2786-94. PMID: 20810605, PMCID: PMC2976815, PII: 1055-9965.EPI-10-0667, DOI: 10.1158/1055-9965.EPI-10-0667, ISSN: 1538-7755.

Shi C, Siegelman SS, Kawamoto S, Wolfgang CL, Schulick RD, Maitra A, Hruban RH. Pancreatic duct stenosis secondary to small endocrine neoplasms: a manifestation of serotonin production?. Radiology [print-electronic]. 2010 Oct; 257(1): 107-14. PMID: 20713615, PMCID: PMC2941724, PII: radiol.10100046, DOI: 10.1148/radiol.10100046, ISSN: 1527-1315.

Shi C, Scudiere JR, Cornish TC, Lam-Himlin D, Park JY, Fox MR, Montgomery EA. Clear cell change in colonic tubular adenoma and corresponding colonic clear cell adenocarcinoma is associated with an altered mucin core protein profile. Am. J. Surg. Pathol. 2010 Sep; 34(9): 1344-50. PMID: 20697252, DOI: 10.1097/PAS.0b013e3181ec0810, ISSN: 1532-0979.

Xiong W, Shi C. Images in cardiovascular medicine: Concomitant persistent left superior vena cava and agenesis of right superior vena cava: a rare congenital anomaly. Circulation. 2010 Jun 6/1/2010; 121(21): 2329-30. PMID: 20516388, PII: 121/21/2329, DOI: 10.1161/CIRCULATIONAHA.109.917336, ISSN: 1524-4539.

Kamiyama H, Kamiyama M, Hong SM, Karikari CA, Lin MT, Borges MW, Griffith M, Young A, Norris-Kirby A, Lubek C, Mizuma M, Feldmann G, Shi C, Liang H, Goggins MG, Maitra A, Hruban RH, Eshleman JR. In vivo and in vitro propagation of intraductal papillary mucinous neoplasms. Lab. Invest [print-electronic]. 2010 May; 90(5): 665-73. PMID: 20231822, PMCID: PMC2885280, PII: labinvest201051, DOI: 10.1038/labinvest.2010.51, ISSN: 1530-0307.

Scudiere JR, Shi C, Hruban RH, Herman JM, Fishman EK, Schulick RD, Wolfgang CL, Makary MA, Thornton K, Montgomery E, Horton KM. Sclerosing mesenteritis involving the pancreas: a mimicker of pancreatic cancer. Am. J. Surg. Pathol. 2010 Apr; 34(4): 447-53. PMID: 20351487, PMCID: PMC2861335, PII: 00000478-201004000-00001, DOI: 10.1097/PAS.0b013e3181d325c0, ISSN: 1532-0979.

Shi C, Klein AP, Goggins M, Maitra A, Canto M, Ali S, Schulick R, Palmisano E, Hruban RH. Increased Prevalence of Precursor Lesions in Familial Pancreatic Cancer Patients. Clin. Cancer Res [print-electronic]. 2009 Dec 12/15/2009; 15(24): 7737-43. PMID: 19996207, PMCID: PMC2795080, PII: 1078-0432.CCR-09-0004, DOI: 10.1158/1078-0432.CCR-09-0004, ISSN: 1078-0432.

Koorstra JB, Hong SM, Shi C, Meeker AK, Ryu JK, Offerhaus GJ, Goggins MG, Hruban RH, Maitra A. Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasia. Mod. Pathol [print-electronic]. 2009 Nov; 22(11): 1439-45. PMID: 19668150, PMCID: PMC2784029, PII: modpathol2009114, DOI: 10.1038/modpathol.2009.114, ISSN: 1530-0285.

Shi C, Chandrasekaran A, Thuluvath PJ, Karikari C, Argani P, Goggins M, Maitra A, Eshleman JR. Ultrasensitive detection of KRAS2 mutations in bile and serum from patients with biliary tract carcinoma using LigAmp technology. J Mol Diagn [print-electronic]. 2009 Nov; 11(6): 583-9. PMID: 19815696, PMCID: PMC2765758, PII: S1525-1578(10)60282-6, DOI: 10.2353/jmoldx.2009.090061, ISSN: 1943-7811.

Taube JM, Begum S, Shi C, Eshleman JR, Westra WH. Benign nodal nevi frequently harbor the activating V600E BRAF mutation. Am. J. Surg. Pathol. 2009 Apr; 33(4): 568-71. PMID: 19033861, DOI: 10.1097/PAS.0b013e31818a64fb, ISSN: 1532-0979.

Shi C, Hruban RH, Klein AP. Familial pancreatic cancer. Arch. Pathol. Lab. Med. 2009 Mar; 133(3): 365-74. PMID: 19260742, PII: 2008-0379-RA, DOI: 10.1043/1543-2165-133.3.365, ISSN: 1543-2165.

Shi C, Hong SM, Lim P, Kamiyama H, Khan M, Anders RA, Goggins M, Hruban RH, Eshleman JR. KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin. Mol. Cancer Res [print-electronic]. 2009 Feb; 7(2): 230-6. PMID: 19208745, PMCID: PMC2708114, PII: 1541-7786.MCR-08-0206, DOI: 10.1158/1541-7786.MCR-08-0206, ISSN: 1541-7786.

Shi C and Argani P. Synchronous primary perianal Paget’s disease and rectal adenocarcinoma: Report of a hitherto unreported phenomenon. Int J of Surg Pathol. 2009; 17((1)): 42-5.

Shi C, Daniels JA, Hruban RH. Molecular characterization of pancreatic neoplasms. Adv Anat Pathol. 2008 Jul; 15(4): 185-95. PMID: 18580095, PII: 00125480-200807000-00001, DOI: 10.1097/PAP.0b013e31817bf57d, ISSN: 1533-4031.

Shi C, Fukushima N, Abe T, Bian Y, Hua L, Wendelburg BJ, Yeo CJ, Hruban RH, Goggins MG, Eshleman JR. Sensitive and quantitative detection of KRAS2 gene mutations in pancreatic duct juice differentiates patients with pancreatic cancer from chronic pancreatitis, potential for early detection. Cancer Biol. Ther. 2008 Mar; 7(3): 353-60. PMID: 18075308, PII: 5362, ISSN: 1555-8576.

Shi C, Parker AR, Hua L, Morrell CN, Lee SC, Bandaru V, Dumler JS, Wu TC, Eshleman JR. Anti-gene padlocks eliminate Escherichia coli based on their genotype. J. Antimicrob. Chemother [print-electronic]. 2008 Feb; 61(2): 262-72. PMID: 18156610, PII: dkm482, DOI: 10.1093/jac/dkm482, ISSN: 1460-2091.

Rogers CD, Fukushima N, Sato N, Shi C, Prasad N, Hustinx SR, Matsubayashi H, Canto M, Eshleman JR, Hruban RH, Goggins M. Differentiating pancreatic lesions by microarray and QPCR analysis of pancreatic juice RNAs. Cancer Biol. Ther [print-electronic]. 2006 Oct; 5(10): 1383-9. PMID: 17012836, PII: 3323, ISSN: 1538-4047.

Church JD, Jones D, Flys T, Hoover D, Marlowe N, Chen S, Shi C, Eshleman JR, Guay LA, Jackson JB, Kumwenda N, Taha TE, Eshleman SH. Sensitivity of the ViroSeq HIV-1 genotyping system for detection of the K103N resistance mutation in HIV-1 subtypes A, C, and D. J Mol Diagn. 2006 Sep; 8(4): 430-2; quiz 527. PMID: 16931582, PMCID: PMC1867617, PII: S1525-1578(10)60325-X, DOI: 10.2353/jmoldx.2006.050148, ISSN: 1525-1578.

Bertolesi GE, Walia Da Silva R, Jollimore CA, Shi C, Barnes S, Kelly ME. Ca(v)3.1 splice variant expression during neuronal differentiation of Y-79 retinoblastoma cells. Neuroscience [print-electronic]. 2006 Aug 8/11/2006; 141(1): 259-68. PMID: 16678971, PII: S0306-4522(06)00406-4, DOI: 10.1016/j.neuroscience.2006.03.067, ISSN: 0306-4522.

Rubio-Viqueira B, Jimeno A, Cusatis G, Zhang X, Iacobuzio-Donahue C, Karikari C, Shi C, Danenberg K, Danenberg PV, Kuramochi H, Tanaka K, Singh S, Salimi-Moosavi H, Bouraoud N, Amador ML, Altiok S, Kulesza P, Yeo C, Messersmith W, Eshleman J, Hruban RH, Maitra A, Hidalgo M. An in vivo platform for translational drug development in pancreatic cancer. Clin. Cancer Res. 2006 Aug 8/1/2006; 12(15): 4652-61. PMID: 16899615, PII: 12/15/4652, DOI: 10.1158/1078-0432.CCR-06-0113, ISSN: 1078-0432.

Parker AR, Sieber OM, Shi C, Hua L, Takao M, Tomlinson IP, Eshleman JR. Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair. Carcinogenesis [print-electronic]. 2005 Nov; 26(11): 2010-8. PMID: 15987719, PII: bgi166, DOI: 10.1093/carcin/bgi166, ISSN: 0143-3334.

Flys T, Nissley DV, Claasen CW, Jones D, Shi C, Guay LA, Musoke P, Mmiro F, Strathern JN, Jackson JB, Eshleman JR, Eshleman SH. Sensitive drug-resistance assays reveal long-term persistence of HIV-1 variants with the K103N nevirapine (NVP) resistance mutation in some women and infants after the administration of single-dose NVP: HIVNET 012. J. Infect. Dis [print-electronic]. 2005 Jul 7/1/2005; 192(1): 24-9. PMID: 15942890, PII: JID34102, DOI: 10.1086/430742, ISSN: 0022-1899.

Vessey JP, Shi C, Jollimore CA, Stevens KT, Coca-Prados M, Barnes S, Kelly ME. Hyposmotic activation of ICl,swell in rabbit nonpigmented ciliary epithelial cells involves increased ClC-3 trafficking to the plasma membrane. Biochem. Cell Biol. 2004 Dec; 82(6): 708-18. PMID: 15674438, PII: o04-107, DOI: 10.1139/o04-107, ISSN: 0829-8211.

Shi C, Eshleman SH, Jones D, Fukushima N, Hua L, Parker AR, Yeo CJ, Hruban RH, Goggins MG, Eshleman JR. LigAmp for sensitive detection of single-nucleotide differences. Nat. Methods [print-electronic]. 2004 Nov; 1(2): 141-7. PMID: 15782177, PII: nmeth713, DOI: 10.1038/nmeth713, ISSN: 1548-7091.

Shi C, Szczesniak A, Mao L, Jollimore C, Coca-Prados M, Hung O, Kelly ME. A3 adenosine and CB1 receptors activate a PKC-sensitive Cl- current in human nonpigmented ciliary epithelial cells via a G beta gamma-coupled MAPK signaling pathway. Br. J. Pharmacol. 2003 Jun; 139(3): 475-86. PMID: 12788807, PMCID: PMC1573867, DOI: 10.1038/sj.bjp.0705266, ISSN: 0007-1188.

Bertolesi GE, Jollimore CA, Shi C, Elbaum L, Denovan-Wright EM, Barnes S, Kelly ME. Regulation of alpha1G T-type calcium channel gene (CACNA1G) expression during neuronal differentiation. Eur. J. Neurosci. 2003 May; 17(9): 1802-10. PMID: 12752779, PII: 2618, ISSN: 0953-816X.

Bertolesi GE, Shi C, Elbaum L, Jollimore C, Rozenberg G, Barnes S, Kelly ME. The Ca(2+) channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms. Mol. Pharmacol. 2002 Aug; 62(2): 210-9. PMID: 12130671, ISSN: 0026-895X.

Thoreson WB, Ryan JS, Shi C, Kelly ME, Bryson EJ, Toews ML, Ediger TL, Chacko DM. Lysophosphatidic acid receptor signaling in mammalian retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci. 2002 Jul; 43(7): 2450-61. PMID: 12091450, ISSN: 0146-0404.

Shi C, Barnes S, Coca-Prados M, Kelly ME. Protein tyrosine kinase and protein phosphatase signaling pathways regulate volume-sensitive chloride currents in a nonpigmented ciliary epithelial cell line. Invest. Ophthalmol. Vis. Sci. 2002 May; 43(5): 1525-32. PMID: 11980870, ISSN: 0146-0404.

Ryan JS, Shi C, Kelly ME. Patch-clamp recording methods for examining adrenergic regulation of potassium currents in ocular epithelial cells. Methods Mol. Biol. 2000; 126: 391-407. PMID: 10685425, ISSN: 1064-3745.

Shi C, Ryan JS, French AS, Coca-Prados M, Kelly ME. Hyposmotically activated chloride channels in cultured rabbit non-pigmented ciliary epithelial cells. J. Physiol. (Lond.). 1999 Nov 11/15/1999; 521 Pt 1: 57-67. PMID: 10562334, PMCID: PMC2269649, PII: PHY_9451, ISSN: 0022-3751.