Meredith Evans Pugh, M.D.

Assistant Professor
Faculty Appointments
Assistant Professor of Medicine
M.S.C.I., Clinical Investigation , Vanderbilt University, Nashville, TennesseeM.D., Virginia Commonwealth University, Richmond, VirginiaB.S., University of Richmond, Richmond, Virginia
Office Address
T1218 Medical Center North
1161 21st Avenue South
Nashville, TN 37232
Research Description
Dr. Pugh's research interest is in the area of pulmonary vascular disease and she has been involved in clinical research investigating the role of abnormal glucose metabolism and activity levels in pulmonary arterial hypertension. She continues to actively participate in early phase trials of novel therapeutic agents for pulmonary hypertension as well as ongoing studies of abnormal metabolism in PAH. Dr. Pugh also is interested in medical education and is presently studying novel strategies for teaching critical care ultrasound in the medical ICU.
Clinical Description
Dr. Pugh's clinical focus is in general pulmonary medicine and the management of pulmonary vascular disease including the evaluation and treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. She attends in the Medical Intensive Care unit and has specific interest in the use and application of critical care ultrasound in critically ill medical patients.
Research Keywords
pulmonary arterial hypertension, pulmonary hypertension, medical education
Clinical Research Keywords
pulmonary medicine, pulmonary hypertension, medical intensive care unit
Hemnes AR, Rathinasabapathy A, Austin EA, Brittain EL, Carrier EJ, Chen X, Fessel JP, Fike CD, Fong P, Fortune N, Gerszten RE, Johnson JA, Kaplowitz M, Newman JH, Piana R, Pugh ME, Rice TW, Robbins IM, Wheeler L, Yu C, Loyd JE, West J. A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension. Eur. Respir. J [electronic-print]. 2018 Jun; 51(6): PMID: 29903860, PII: 13993003.02638-2017, DOI: 10.1183/13993003.02638-2017, ISSN: 1399-3003.

Welch CE, Brittain EL, Newman AL, Robbins IM, Pugh ME, Newman JH, Hemnes AR. End-Tidal Carbon Dioxide as a Prognostic Feature in Pulmonary Arterial Hypertension. Ann Am Thorac Soc. 2017 Jun; 14(6): 896-902. PMID: 28345964, DOI: 10.1513/AnnalsATS.201612-951OC, ISSN: 2325-6621.

Matthews DT, Le CN, Robbins IM, Petracek MR, Pugh ME, Brittain EL, Hemnes AR. Severity of pulmonary hypertension and obesity are not associated with worse functional outcomes after pulmonary thromboendarterectomy. Pulm Circ. 2016 Jun; 6(2): 174-80. PMID: 27252843, PMCID: PMC4869921, PII: PC2013298, DOI: 10.1086/685736, ISSN: 2045-8932.

Robbins IM, Pugh ME, Hemnes AR. Update on chronic thromboembolic pulmonary hypertension. Trends Cardiovasc. Med [print-electronic]. 2016 May 5/25/2016; PMID: 27345156, PII: S1050-1738(16)30054-8, DOI: 10.1016/j.tcm.2016.05.010, ISSN: 1873-2615.

Brittain EL, Talati M, Fessel JP, Zhu H, Penner N, Calcutt MW, West JD, Funke M, Lewis GD, Gerszten RE, Hamid R, Pugh ME, Austin ED, Newman JH, Hemnes AR. Fatty Acid Metabolic Defects and Right Ventricular Lipotoxicity in Human Pulmonary Arterial Hypertension. Circulation [print-electronic]. 2016 May 5/17/2016; 133(20): 1936-44. PMID: 27006481, PMCID: PMC4870107, PII: CIRCULATIONAHA.115.019351, DOI: 10.1161/CIRCULATIONAHA.115.019351, ISSN: 1524-4539.

Hay BR, Pugh ME, Robbins IM, Hemnes AR. Parenteral Prostanoid Use at a Tertiary Referral Center: A Retrospective Cohort Study. Chest [print-electronic]. 2016 Mar; 149(3): 660-6. PMID: 26378379, PMCID: PMC4944766, PII: S0012-3692(15)00020-3, DOI: 10.1378/chest.15-1051, ISSN: 1931-3543.

Lewis GD, Ngo D, Hemnes AR, Farrell L, Domos C, Pappagianopoulos PP, Dhakal BP, Souza A, Shi X, Pugh ME, Beloiartsev A, Sinha S, Clish CB, Gerszten RE. Metabolic Profiling of Right Ventricular-Pulmonary Vascular Function Reveals Circulating Biomarkers of Pulmonary Hypertension. J. Am. Coll. Cardiol. 2016 Jan 1/19/2016; 67(2): 174-89. PMID: 26791065, PMCID: PMC4962613, PII: S0735-1097(15)07364-7, DOI: 10.1016/j.jacc.2015.10.072, ISSN: 1558-3597.

Robbins IM, Johnson J, Petracek M, Lambright E, Bream P, Merantz S, Pugh ME, Hemnes AR. Translocation of Microspheres into the Pulmonary Artery after Bronchial Artery Injection. Am. J. Respir. Crit. Care Med. 2015 Jun 6/15/2015; 191(12): e28-9. PMID: 26075434, DOI: 10.1164/rccm.201412-2325IM, ISSN: 1535-4970.

Trammell AW, Pugh ME, Newman JH, Hemnes AR, Robbins IM. Use of pulmonary arterial hypertension-approved therapy in the treatment of non-group 1 pulmonary hypertension at US referral centers. Pulm Circ. 2015 Jun; 5(2): 356-63. PMID: 26064462, PMCID: PMC4449248, PII: PC2013183, DOI: 10.1086/681264, ISSN: 2045-8932.

Semler MW, Keriwala RD, Clune JK, Rice TW, Pugh ME, Wheeler AP, Miller AN, Banerjee A, Terhune K, Bastarache JA. A randomized trial comparing didactics, demonstration, and simulation for teaching teamwork to medical residents. Ann Am Thorac Soc. 2015 Apr; 12(4): 512-9. PMID: 25730661, DOI: 10.1513/AnnalsATS.201501-030OC, ISSN: 2325-6621.

Halliday SJ, Hemnes AR, Robbins IM, Pugh ME, Zhao DX, Piana RN, Fong PP, Brittain EL. Prognostic value of acute vasodilator response in pulmonary arterial hypertension: beyond the "classic" responders. J. Heart Lung Transplant [print-electronic]. 2015 Mar; 34(3): 312-8. PMID: 25577565, PMCID: PMC4380573, PII: S1053-2498(14)01424-7, DOI: 10.1016/j.healun.2014.10.003, ISSN: 1557-3117.

Pugh ME, Hemnes AR, Trammell A, Newman JH, Robbins IM. Variability in hemodynamic evaluation of pulmonary hypertension at large referral centers. Pulm Circ. 2014 Dec; 4(4): 679-84. PMID: 25610603, PMCID: PMC4278627, PII: PC2013117, DOI: 10.1086/678514, ISSN: 2045-8932.

Pugh ME, Sivarajan L, Wang L, Robbins IM, Newman JH, Hemnes AR. Causes of pulmonary hypertension in the elderly. Chest. 2014 Jul; 146(1): 159-66. PMID: 24480915, PMCID: PMC4077408, PII: S0012-3692(15)48760-4, DOI: 10.1378/chest.13-1900, ISSN: 1931-3543.

Benson L, Brittain EL, Pugh ME, Austin ED, Fox K, Wheeler L, Robbins IM, Hemnes AR. Impact of diabetes on survival and right ventricular compensation in pulmonary arterial hypertension. Pulm Circ. 2014 Jun; 4(2): 311-8. PMID: 25006450, PMCID: PMC4070784, PII: PC2013057, DOI: 10.1086/675994, ISSN: 2045-8932.

Robbins IM, Hemnes AR, Pugh ME, Brittain EL, Zhao DX, Piana RN, Fong PP, Newman JH. High prevalence of occult pulmonary venous hypertension revealed by fluid challenge in pulmonary hypertension. Circ Heart Fail [print-electronic]. 2014 Jan; 7(1): 116-22. PMID: 24297689, PMCID: PMC3934572, PII: CIRCHEARTFAILURE.113.000468, DOI: 10.1161/CIRCHEARTFAILURE.113.000468, ISSN: 1941-3297.

Pugh ME, Hemnes AR, Robbins IM. Combination therapy in pulmonary arterial hypertension. Clin. Chest Med [print-electronic]. 2013 Dec; 34(4): 841-55. PMID: 24267308, PII: S0272-5231(13)00107-X, DOI: 10.1016/j.ccm.2013.08.007, ISSN: 1557-8216.

Brittain EL, Pugh ME, Wheeler LA, Robbins IM, Loyd JE, Newman JH, Larkin EK, Austin ED, Hemnes AR. Shorter survival in familial versus idiopathic pulmonary arterial hypertension is associated with hemodynamic markers of impaired right ventricular function. Pulm Circ [print-electronic]. 2013 Sep; 3(3): 589-98. PMID: 24618543, PMCID: PMC4070798, DOI: 10.1086/674326, ISSN: 2045-8932.

Brittain EL, Pugh ME, Wheeler LA, Robbins IM, Loyd JE, Newman JH, Austin ED, Hemnes AR. Prostanoids but not oral therapies improve right ventricular function in pulmonary arterial hypertension. JACC Heart Fail. 2013 Aug; 1(4): 300-7. PMID: 24015376, PMCID: PMC3763862, PII: S2213-1779(13)00189-3, DOI: 10.1016/j.jchf.2013.05.004, ISSN: 2213-1787.

West J, Niswender KD, Johnson JA, Pugh ME, Gleaves L, Fessel JP, Hemnes AR. A potential role for insulin resistance in experimental pulmonary hypertension. Eur. Respir. J [print-electronic]. 2013 Apr; 41(4): 861-71. PMID: 22936709, PMCID: PMC3746982, PII: 09031936.00030312, DOI: 10.1183/09031936.00030312, ISSN: 1399-3003.

Brittain EL, Pugh ME, Wang L, Newman AL, Robbins IM, Newman JH, Hemnes AR. Predictors of diastolic-to-wedge gradient in patients evaluated for pulmonary hypertension. PLoS ONE. 2013; 8(10): e76461. PMID: 24124561, PMCID: PMC3790694, PII: PONE-D-13-27489, DOI: 10.1371/journal.pone.0076461, ISSN: 1932-6203.

Pugh ME, Buchowski MS, Robbins IM, Newman JH, Hemnes AR. Physical activity limitation as measured by accelerometry in pulmonary arterial hypertension. Chest. 2012 Dec; 142(6): 1391-8. PMID: 22576635, PMCID: PMC3515022, PII: chest.12-0150, DOI: 10.1378/chest.12-0150, ISSN: 1931-3543.

Pettit AC, Kropski JA, Castilho JL, Schmitz JE, Rauch CA, Mobley BC, Wang XJ, Spires SS, Pugh ME. The index case for the fungal meningitis outbreak in the United States. N. Engl. J. Med [print-electronic]. 2012 Nov 11/29/2012; 367(22): 2119-25. PMID: 23083311, DOI: 10.1056/NEJMoa1212292, ISSN: 1533-4406.

Brummel NE, Pugh ME, Fessel JP. Outcomes in elderly intensive care unit patients, pulmonary hypertension in sickle cell disease, and total liquid ventilation for therapeutic hypothermia after cardiac arrest in rabbits. Am. J. Respir. Crit. Care Med. 2012 Feb 2/15/2012; 185(4): 453-4. PMID: 22336678, PMCID: PMC3297099, PII: 185/4/453, DOI: 10.1164/rccm.201109-1608RR, ISSN: 1535-4970.

Hemnes AR, Pugh ME, Newman AL, Robbins IM, Tolle J, Austin ED, Newman JH. End tidal CO(2) tension: pulmonary arterial hypertension vs pulmonary venous hypertension and response to treatment. Chest [print-electronic]. 2011 Nov; 140(5): 1267-73. PMID: 21622547, PII: chest.11-0155, DOI: 10.1378/chest.11-0155, ISSN: 1931-3543.

Pugh ME, Robbins IM, Rice TW, West J, Newman JH, Hemnes AR. Unrecognized glucose intolerance is common in pulmonary arterial hypertension. J. Heart Lung Transplant [print-electronic]. 2011 Aug; 30(8): 904-11. PMID: 21493097, PMCID: PMC3129440, PII: S1053-2498(11)00831-X, DOI: 10.1016/j.healun.2011.02.016, ISSN: 1557-3117.

Albers EL, Pugh ME, Hill KD, Wang L, Loyd JE, Doyle TP. Percutaneous vascular stent implantation as treatment for central vascular obstruction due to fibrosing mediastinitis. Circulation [print-electronic]. 2011 Apr 4/5/2011; 123(13): 1391-9. PMID: 21422386, PMCID: PMC3095436, PII: CIRCULATIONAHA.110.949180, DOI: 10.1161/CIRCULATIONAHA.110.949180, ISSN: 1524-4539.

Pugh ME, Hemnes AR. Pulmonary hypertension in women. Expert Rev Cardiovasc Ther. 2010 Nov; 8(11): 1549-58. PMID: 21090930, PMCID: PMC3077035, DOI: 10.1586/erc.10.137, ISSN: 1744-8344.

Pugh ME, Hemnes AR. Metabolic and hormonal derangements in pulmonary hypertension: from mouse to man. Int J Clin Pract Suppl. 2010 Nov; (168): 5-13. PMID: 20939841, PMCID: PMC2965027, DOI: 10.1111/j.1742-1241.2010.02523.x, ISSN: 1368-504X.

Pugh ME, Hemnes AR. Development of pulmonary arterial hypertension in women: interplay of sex hormones and pulmonary vascular disease. Womens Health (Lond Engl). 2010 Mar; 6(2): 285-96. PMID: 20187732, PMCID: PMC2853883, DOI: 10.2217/whe.09.88, ISSN: 1745-5065.