Gautam Bhave, Ph.D., M.D.

Assistant Professor

gautam.bhave@vanderbilt.edu
Faculty Appointments
Assistant Professor of Medicine Assistant Professor of Cell and Developmental Biology
Education
M.D., Medicine, Baylor College of Medicine, Houston, TexasPh.D., Neuroscience, Baylor College of Medicine, Houston, TexasB.G.S., Cornell University, Ithaca, New York
Office Address
1161 21st Avenue South
Nashville, TN 37232
Research Description
I am interested in the assembly and function of basement membranes and extracellular matrix particularly in renal disease. By studying matrix biochemistry at a fundamental level, I hope to gain insight into renal glomerular and tubulointerstitial fibrosis which represents the common final pathway to injury in nearly all kidney diseases. My group utilizes cell culture systems, molecular biology, biochemistry, mass spectrometry, and mouse genetics to answer questions of interest.
Research Keywords
Renal Biology, Matrix Biology
Publications
Colon S, Bhave G. Proprotein Convertase Processing Enhances Peroxidasin Activity to Reinforce Collagen IV. J. Biol. Chem [print-electronic]. 2016 Oct 10/3/2016; PMID: 27697841, PII: M116.745935, DOI: 10.1074/jbc.M116.745935, ISSN: 1083-351X.

Jones-Paris CR, Paria S, Berg T, Saus J, Bhave G, Paria BC, Hudson BG. Embryo implantation triggers dynamic spatiotemporal expression of the basement membrane toolkit during uterine reprogramming. Matrix Biol [print-electronic]. 2016 Sep 9/10/2016; PMID: 27619726, PII: S0945-053X(16)30074-9, DOI: 10.1016/j.matbio.2016.09.005, ISSN: 1569-1802.

Cummings CF, Pedchenko V, Brown KL, Colon S, Rafi M, Jones-Paris C, Pokydeshava E, Liu M, Pastor-Pareja JC, Stothers C, Ero-Tolliver IA, McCall AS, Vanacore R, Bhave G, Santoro S, Blackwell TS, Zent R, Pozzi A, Hudson BG. Extracellular chloride signals collagen IV network assembly during basement membrane formation. J. Cell Biol. 2016 May 5/23/2016; 213(4): 479-94. PMID: 27216258, PMCID: PMC4878091, PII: jcb.201510065, DOI: 10.1083/jcb.201510065, ISSN: 1540-8140.

Ero-Tolliver IA, Hudson BG, Bhave G. The Ancient Immunoglobulin Domains of Peroxidasin Are Required to Form Sulfilimine Cross-links in Collagen IV. J. Biol. Chem [print-electronic]. 2015 Aug 8/28/2015; 290(35): 21741-8. PMID: 26178375, PMCID: PMC4571896, PII: M115.673996, DOI: 10.1074/jbc.M115.673996, ISSN: 1083-351X.

McCall AS, Cummings CF, Bhave G, Vanacore R, Page-McCaw A, Hudson BG. Bromine is an essential trace element for assembly of collagen IV scaffolds in tissue development and architecture. Cell. 2014 Jun 6/5/2014; 157(6): 1380-92. PMID: 24906154, PMCID: PMC4144415, PII: S0092-8674(14)00598-4, DOI: 10.1016/j.cell.2014.05.009, ISSN: 1097-4172.

Fidler AL, Vanacore RM, Chetyrkin SV, Pedchenko VK, Bhave G, Yin VP, Stothers CL, Rose KL, McDonald WH, Clark TA, Borza DB, Steele RE, Ivy MT, , Hudson JK, Hudson BG. A unique covalent bond in basement membrane is a primordial innovation for tissue evolution. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2014 Jan 1/7/2014; 111(1): 331-6. PMID: 24344311, PMCID: PMC3890831, PII: 1318499111, DOI: 10.1073/pnas.1318499111, ISSN: 1091-6490.

Cox ZL, McCoy AB, Matheny ME, Bhave G, Peterson NB, Siew ED, Lewis J, Danciu I, Bian A, Shintani A, Ikizler TA, Neal EB, Peterson JF. Adverse drug events during AKI and its recovery. Clin J Am Soc Nephrol [print-electronic]. 2013 Jul; 8(7): 1070-8. PMID: 23539228, PMCID: PMC3700703, PII: CJN.11921112, DOI: 10.2215/CJN.11921112, ISSN: 1555-905X.

Bhave G, Cummings CF, Vanacore RM, Kumagai-Cresse C, Ero-Tolliver IA, Rafi M, Kang JS, Pedchenko V, Fessler LI, Fessler JH, Hudson BG. Peroxidasin forms sulfilimine chemical bonds using hypohalous acids in tissue genesis. Nat. Chem. Biol [print-electronic]. 2012 Sep; 8(9): 784-90. PMID: 22842973, PMCID: PMC4128002, PII: nchembio.1038, DOI: 10.1038/nchembio.1038, ISSN: 1552-4469.

McCoy AB, Cox ZL, Neal EB, Waitman LR, Peterson NB, Bhave G, Siew ED, Danciu I, Lewis JB, Peterson JF. Real-time pharmacy surveillance and clinical decision support to reduce adverse drug events in acute kidney injury: a randomized, controlled trial. Appl Clin Inform [print-electronic]. 2012 Jan 1/1/2012; 3(2): 221-38. PMID: 22719796, PMCID: PMC3377180, DOI: 10.4338/ACI-2012-03-RA-0009, ISSN: 1869-0327.

Bhave G, Neilson EG. Body fluid dynamics: back to the future. J. Am. Soc. Nephrol [print-electronic]. 2011 Dec; 22(12): 2166-81. PMID: 22034644, PMCID: PMC4096826, PII: ASN.2011080865, DOI: 10.1681/ASN.2011080865, ISSN: 1533-3450.

Bhave G, Neilson EG. Volume depletion versus dehydration: how understanding the difference can guide therapy. Am. J. Kidney Dis [print-electronic]. 2011 Aug; 58(2): 302-9. PMID: 21705120, PMCID: PMC4096820, PII: S0272-6386(11)00813-4, DOI: 10.1053/j.ajkd.2011.02.395, ISSN: 1523-6838.

Vanacore R, Pedchenko V, Bhave G, Hudson BG. Sulphilimine cross-links in Goodpasture's disease. Clin. Exp. Immunol. 2011 May; 164 Suppl 1: 4-6. PMID: 21447121, PMCID: PMC3095855, DOI: 10.1111/j.1365-2249.2011.04356.x, ISSN: 1365-2249.

Bhave G, Chauder BA, Liu W, Dawson ES, Kadakia R, Nguyen TT, Lewis LM, Meiler J, Weaver CD, Satlin LM, Lindsley CW, Denton JS. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol. Pharmacol [print-electronic]. 2011 Jan; 79(1): 42-50. PMID: 20926757, PMCID: PMC3014278, PII: mol.110.066928, DOI: 10.1124/mol.110.066928, ISSN: 1521-0111.

Bhave G, Lonergan D, Chauder BA, Denton JS. Small-molecule modulators of inward rectifier K+ channels: recent advances and future possibilities. Future Med Chem. 2010 May; 2(5): 757-74. PMID: 20543968, PMCID: PMC2883187, DOI: 10.4155/fmc.10.179, ISSN: 1756-8927.

Lewis LM, Bhave G, Chauder BA, Banerjee S, Lornsen KA, Redha R, Fallen K, Lindsley CW, Weaver CD, Denton JS. High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1. Mol. Pharmacol [print-electronic]. 2009 Nov; 76(5): 1094-103. PMID: 19706730, PMCID: PMC2774996, PII: mol.109.059840, DOI: 10.1124/mol.109.059840, ISSN: 1521-0111.

Bhave G, Lewis JB, Chang SS. Association of gadolinium based magnetic resonance imaging contrast agents and nephrogenic systemic fibrosis. J. Urol [print-electronic]. 2008 Sep; 180(3): 830-5; discussion 835. PMID: 18635232, PMCID: PMC4128001, PII: S0022-5347(08)01225-1, DOI: 10.1016/j.juro.2008.05.005, ISSN: 1527-3792.

Bhave G, Gereau RW. Posttranslational mechanisms of peripheral sensitization. J. Neurobiol. 2004 Oct; 61(1): 88-106. PMID: 15362155, DOI: 10.1002/neu.20083, ISSN: 0022-3034.

Bhave G, Hu HJ, Glauner KS, Zhu W, Wang H, Brasier DJ, Oxford GS, Gereau RW. Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2003 Oct 10/14/2003; 100(21): 12480-5. PMID: 14523239, PMCID: PMC218783, PII: 2032100100, DOI: 10.1073/pnas.2032100100, ISSN: 0027-8424.

Bhave G, Gereau RW. Growing pains: the cytoskeleton as a critical regulator of pain plasticity. Neuron. 2003 Aug 8/14/2003; 39(4): 577-9. PMID: 12925270, PII: S0896627303005002, ISSN: 0896-6273.

Bhave G, Nadin BM, Brasier DJ, Glauner KS, Shah RD, Heinemann SF, Karim F, Gereau RW. Membrane topology of a metabotropic glutamate receptor. J. Biol. Chem [print-electronic]. 2003 Aug 8/8/2003; 278(32): 30294-301. PMID: 12764131, PII: M303258200, DOI: 10.1074/jbc.M303258200, ISSN: 0021-9258.

Neugebauer V, Li W, Bird GC, Bhave G, Gereau RW. Synaptic plasticity in the amygdala in a model of arthritic pain: differential roles of metabotropic glutamate receptors 1 and 5. J. Neurosci. 2003 Jan 1/1/2003; 23(1): 52-63. PMID: 12514201, PII: 23/1/52, ISSN: 1529-2401.

Hu HJ, Bhave G, Gereau RW. Prostaglandin and protein kinase A-dependent modulation of vanilloid receptor function by metabotropic glutamate receptor 5: potential mechanism for thermal hyperalgesia. J. Neurosci. 2002 Sep 9/1/2002; 22(17): 7444-52. PMID: 12196566, PII: 22/17/7444, ISSN: 1529-2401.

Bhave G, Zhu W, Wang H, Brasier DJ, Oxford GS, Gereau RW. CAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation. Neuron. 2002 Aug 8/15/2002; 35(4): 721-31. PMID: 12194871, PII: S0896627302008024, ISSN: 0896-6273.

Karim F, Bhave G, Gereau RW. Metabotropic glutamate receptors on peripheral sensory neuron terminals as targets for the development of novel analgesics. Mol. Psychiatry. 2001 Nov; 6(6): 615-7. PMID: 11673787, DOI: 10.1038/sj.mp.4000961, ISSN: 1359-4184.

Bhave G, Karim F, Carlton SM, Gereau RW. Peripheral group I metabotropic glutamate receptors modulate nociception in mice. Nat. Neurosci. 2001 Apr; 4(4): 417-23. PMID: 11276233, PII: 86075, DOI: 10.1038/86075, ISSN: 1097-6256.