Faculty Appointments
Research Assistant Professor of Medicine
Education
Ph.D., Medical College of Wisconsin, Milwaukee, WisconsinB.S., Guilford College, Greensboro, North Carolina
Publications
Hemnes AR, Rathinasabapathy A, Austin EA, Brittain EL, Carrier EJ, Chen X, Fessel JP, Fike CD, Fong P, Fortune N, Gerszten RE, Johnson JA, Kaplowitz M, Newman JH, Piana R, Pugh ME, Rice TW, Robbins IM, Wheeler L, Yu C, Loyd JE, West J. A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension. Eur. Respir. J [electronic-print]. 2018 Jun; 51(6): PMID: 29903860, PII: 13993003.02638-2017, DOI: 10.1183/13993003.02638-2017, ISSN: 1399-3003.
West JD, Carrier EJ. Precision Modeling of Pulmonary Hypertension Pathology with iPSC-derived Cells. Am. J. Respir. Crit. Care Med [print-electronic]. 2018 Mar 3/29/2018; PMID: 29596760, DOI: 10.1164/rccm.201803-0480ED, ISSN: 1535-4970.
Suzuki T, Carrier EJ, Talati MH, Rathinasabapathy A, Chen X, Nishimura R, Tada Y, Tatsumi K, West J. Isolation and characterization of endothelial-to-mesenchymal transition cells in pulmonary arterial hypertension. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2018 Jan 1/1/2018; 314(1): L118-L126. PMID: 28935639, PMCID: PMC5866427, PII: ajplung.00296.2017, DOI: 10.1152/ajplung.00296.2017, ISSN: 1522-1504.
Rathinasabapathy A, Bryant AJ, Suzuki T, Moore C, Shay S, Gladson S, West JD, Carrier EJ. RhACE2 Therapy Modifies Bleomycin-Induced Pulmonary Hypertension via Rescue of Vascular Remodeling. Front Physiol. 2018; 9: 271. PMID: 29731719, PMCID: PMC5922219, DOI: 10.3389/fphys.2018.00271, ISSN: 1664-042X.
Gaskill CF, Carrier EJ, Kropski JA, Bloodworth NC, Menon S, Foronjy RF, Taketo MM, Hong CC, Austin ED, West JD, Means AL, Loyd JE, Merryman WD, Hemnes AR, De Langhe S, Blackwell TS, Klemm DJ, Majka SM. Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction. J. Clin. Invest [print-electronic]. 2017 Jun 6/1/2017; 127(6): 2262-76. PMID: 28463231, PMCID: PMC5451236, PII: 88629, DOI: 10.1172/JCI88629, ISSN: 1558-8238.
West JD, Voss BM, Pavliv L, de Caestecker M, Hemnes AR, Carrier EJ. Antagonism of the thromboxane-prostanoid receptor is cardioprotective against right ventricular pressure overload. Pulm Circ. 2016 Jun; 6(2): 211-23. PMID: 27252848, PMCID: PMC4869926, PII: PC2013314, DOI: 10.1086/686140, ISSN: 2045-8932.
Bryant AJ, Carrick RP, McConaha ME, Jones BR, Shay SD, Moore CS, Blackwell TR, Gladson S, Penner NL, Burman A, Tanjore H, Hemnes AR, Karwandyar AK, Polosukhin VV, Talati MA, Dong HJ, Gleaves LA, Carrier EJ, Gaskill C, Scott EW, Majka SM, Fessel JP, Haase VH, West JD, Blackwell TS, Lawson WE. Endothelial HIF signaling regulates pulmonary fibrosis-associated pulmonary hypertension. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2016 Feb 2/1/2016; 310(3): L249-62. PMID: 26637636, PMCID: PMC4838140, PII: ajplung.00258.2015, DOI: 10.1152/ajplung.00258.2015, ISSN: 1522-1504.
West JD, Carrier EJ, Bloodworth NC, Schroer AK, Chen P, Ryzhova LM, Gladson S, Shay S, Hutcheson JD, Merryman WD. Serotonin 2B Receptor Antagonism Prevents Heritable Pulmonary Arterial Hypertension. PLoS ONE. 2016; 11(2): e0148657. PMID: 26863209, PMCID: PMC4749293, PII: PONE-D-15-46627, DOI: 10.1371/journal.pone.0148657, ISSN: 1932-6203.
Marriott S, Baskir RS, Gaskill C, Menon S, Carrier EJ, Williams J, Talati M, Helm K, Alford CE, Kropski JA, Loyd J, Wheeler L, Johnson J, Austin E, Nozik-Grayck E, Meyrick B, West JD, Klemm DJ, Majka SM. ABCG2pos lung mesenchymal stem cells are a novel pericyte subpopulation that contributes to fibrotic remodeling. Am. J. Physiol., Cell Physiol. 2014 Oct 10/15/2014; 307(8): C684-98. PMID: 25122876, PMCID: PMC4200000, PII: ajpcell.00114.2014, DOI: 10.1152/ajpcell.00114.2014, ISSN: 1522-1563.
Carrier EJ, Zagol-Ikapitte I, Amarnath V, Boutaud O, Oates JA. Levuglandin forms adducts with histone h4 in a cyclooxygenase-2-dependent manner, altering its interaction with DNA. Biochemistry [print-electronic]. 2014 Apr 4/22/2014; 53(15): 2436-41. PMID: 24684440, PMCID: PMC4004227, DOI: 10.1021/bi401673b, ISSN: 1520-4995.
Carrier EJ, Amarnath V, Oates JA, Boutaud O. Characterization of covalent adducts of nucleosides and DNA formed by reaction with levuglandin. Biochemistry. 2009 Nov 11/17/2009; 48(45): 10775-81. PMID: 19824699, PMCID: PMC2824920, DOI: 10.1021/bi9015132, ISSN: 1520-4995.
West JD, Carrier EJ. Precision Modeling of Pulmonary Hypertension Pathology with iPSC-derived Cells. Am. J. Respir. Crit. Care Med [print-electronic]. 2018 Mar 3/29/2018; PMID: 29596760, DOI: 10.1164/rccm.201803-0480ED, ISSN: 1535-4970.
Suzuki T, Carrier EJ, Talati MH, Rathinasabapathy A, Chen X, Nishimura R, Tada Y, Tatsumi K, West J. Isolation and characterization of endothelial-to-mesenchymal transition cells in pulmonary arterial hypertension. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2018 Jan 1/1/2018; 314(1): L118-L126. PMID: 28935639, PMCID: PMC5866427, PII: ajplung.00296.2017, DOI: 10.1152/ajplung.00296.2017, ISSN: 1522-1504.
Rathinasabapathy A, Bryant AJ, Suzuki T, Moore C, Shay S, Gladson S, West JD, Carrier EJ. RhACE2 Therapy Modifies Bleomycin-Induced Pulmonary Hypertension via Rescue of Vascular Remodeling. Front Physiol. 2018; 9: 271. PMID: 29731719, PMCID: PMC5922219, DOI: 10.3389/fphys.2018.00271, ISSN: 1664-042X.
Gaskill CF, Carrier EJ, Kropski JA, Bloodworth NC, Menon S, Foronjy RF, Taketo MM, Hong CC, Austin ED, West JD, Means AL, Loyd JE, Merryman WD, Hemnes AR, De Langhe S, Blackwell TS, Klemm DJ, Majka SM. Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction. J. Clin. Invest [print-electronic]. 2017 Jun 6/1/2017; 127(6): 2262-76. PMID: 28463231, PMCID: PMC5451236, PII: 88629, DOI: 10.1172/JCI88629, ISSN: 1558-8238.
West JD, Voss BM, Pavliv L, de Caestecker M, Hemnes AR, Carrier EJ. Antagonism of the thromboxane-prostanoid receptor is cardioprotective against right ventricular pressure overload. Pulm Circ. 2016 Jun; 6(2): 211-23. PMID: 27252848, PMCID: PMC4869926, PII: PC2013314, DOI: 10.1086/686140, ISSN: 2045-8932.
Bryant AJ, Carrick RP, McConaha ME, Jones BR, Shay SD, Moore CS, Blackwell TR, Gladson S, Penner NL, Burman A, Tanjore H, Hemnes AR, Karwandyar AK, Polosukhin VV, Talati MA, Dong HJ, Gleaves LA, Carrier EJ, Gaskill C, Scott EW, Majka SM, Fessel JP, Haase VH, West JD, Blackwell TS, Lawson WE. Endothelial HIF signaling regulates pulmonary fibrosis-associated pulmonary hypertension. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2016 Feb 2/1/2016; 310(3): L249-62. PMID: 26637636, PMCID: PMC4838140, PII: ajplung.00258.2015, DOI: 10.1152/ajplung.00258.2015, ISSN: 1522-1504.
West JD, Carrier EJ, Bloodworth NC, Schroer AK, Chen P, Ryzhova LM, Gladson S, Shay S, Hutcheson JD, Merryman WD. Serotonin 2B Receptor Antagonism Prevents Heritable Pulmonary Arterial Hypertension. PLoS ONE. 2016; 11(2): e0148657. PMID: 26863209, PMCID: PMC4749293, PII: PONE-D-15-46627, DOI: 10.1371/journal.pone.0148657, ISSN: 1932-6203.
Marriott S, Baskir RS, Gaskill C, Menon S, Carrier EJ, Williams J, Talati M, Helm K, Alford CE, Kropski JA, Loyd J, Wheeler L, Johnson J, Austin E, Nozik-Grayck E, Meyrick B, West JD, Klemm DJ, Majka SM. ABCG2pos lung mesenchymal stem cells are a novel pericyte subpopulation that contributes to fibrotic remodeling. Am. J. Physiol., Cell Physiol. 2014 Oct 10/15/2014; 307(8): C684-98. PMID: 25122876, PMCID: PMC4200000, PII: ajpcell.00114.2014, DOI: 10.1152/ajpcell.00114.2014, ISSN: 1522-1563.
Carrier EJ, Zagol-Ikapitte I, Amarnath V, Boutaud O, Oates JA. Levuglandin forms adducts with histone h4 in a cyclooxygenase-2-dependent manner, altering its interaction with DNA. Biochemistry [print-electronic]. 2014 Apr 4/22/2014; 53(15): 2436-41. PMID: 24684440, PMCID: PMC4004227, DOI: 10.1021/bi401673b, ISSN: 1520-4995.
Carrier EJ, Amarnath V, Oates JA, Boutaud O. Characterization of covalent adducts of nucleosides and DNA formed by reaction with levuglandin. Biochemistry. 2009 Nov 11/17/2009; 48(45): 10775-81. PMID: 19824699, PMCID: PMC2824920, DOI: 10.1021/bi9015132, ISSN: 1520-4995.