Bret C. Mobley, M.D.

Associate Professor
Faculty Appointments
Associate Professor of Pathology, Microbiology and Immunology
M.D., Medicine, University of Michigan, Ann Arbor, MichiganM.S., Neuroscience, University of Michigan, Ann Arbor, MichiganA.B., Stanford University, Stanford, California
Research Description
Currently working in the Rebecca Ihrie laboratory (Department of Cancer Biology) on projects exploring heterogeneity and tumor propagating cells in glioblastoma and IDH-mutated gliomas.
Research Keywords
Glioblastoma, Glioma, IDH mutation
Georgescu MM, Olar A, Mobley BC, Faust PL, Raisanen JM. Epithelial differentiation with microlumen formation in meningioma: diagnostic utility of NHERF1/EBP50 immunohistochemistry. Oncotarget. 2018 Jun 6/19/2018; 9(47): 28652-65. PMID: 29983887, PMCID: PMC6033365, PII: 25595, DOI: 10.18632/oncotarget.25595, ISSN: 1949-2553.

Hu B, Mccollum M, Ravi V, Arpag S, Moiseev D, Castoro R, Mobley BC, Burnette BW, Siskind C, Day JW, Yawn R, Feely S, Li Y, Yan Q, Shy ME, Li J. Myelin Abnormality in CMT4J Recapitulates Features of Acquired Demyelination. Ann. Neurol [print-electronic]. 2018 Mar 3/8/2018; PMID: 29518270, DOI: 10.1002/ana.25198, ISSN: 1531-8249.

Mistry AM, Vnencak-Jones CL, Mobley BC. Clinical prognostic value of the isocitrate dehydrogenase 1 single-nucleotide polymorphism rs11554137 in glioblastoma. J. Neurooncol [print-electronic]. 2018 Feb 2/8/2018; PMID: 29423539, PII: 10.1007/s11060-018-2796-6, DOI: 10.1007/s11060-018-2796-6, ISSN: 1573-7373.

Sinnaeve J, Mobley BC, Ihrie RA. Space Invaders: Brain Tumor Exploitation of the Stem Cell Niche. Am. J. Pathol [print-electronic]. 2018 Jan; 188(1): 29-38. PMID: 29024634, PMCID: PMC5745521, PII: S0002-9440(17)30315-2, DOI: 10.1016/j.ajpath.2017.08.029, ISSN: 1525-2191.

Paul P, Rellinger EJ, Qiao J, Lee S, Volny N, Padmanabhan C, Romain CV, Mobley B, Correa H, Chung DH. Elevated TIMP-1 expression is associated with a prometastatic phenotype, disease relapse, and poor survival in neuroblastoma. Oncotarget. 2017 Oct 10/10/2017; 8(47): 82609-20. PMID: 29137288, PMCID: PMC5669914, PII: 19664, DOI: 10.18632/oncotarget.19664, ISSN: 1949-2553.

Leelatian N, Doxie DB, Greenplate AR, Mobley BC, Lehman JM, Sinnaeve J, Kauffmann RM, Werkhaven JA, Mistry AM, Weaver KD, Thompson RC, Massion PP, Hooks MA, Kelley MC, Chambless LB, Ihrie RA, Irish JM. Single cell analysis of human tissues and solid tumors with mass cytometry. Cytometry B Clin Cytom [print-electronic]. 2016 Sep 9/6/2016; PMID: 27598832, DOI: 10.1002/cyto.b.21481, ISSN: 1552-4957.

Lehman NL, Hattab EM, Mobley BC, Usubalieva A, Schniederjan MJ, McLendon RE, Paulus W, Rushing EJ, Georgescu MM, Couce M, Dulai MS, Cohen ML, Pierson CR, Raisanen JM, Martin SE, Lehman TD, Lipp ES, Bonnin JM, Al-Abbadi MA, Kenworthy K, Zhao K, Mohamed N, Zhang G, Zhao W. Morphological and molecular features of astroblastoma, including BRAFV600E mutations, suggest an ontological relationship to other cortical-based gliomas of children and young adults. Neuro-oncology [print-electronic]. 2016 Jul 7/14/2016; PMID: 27416954, PII: now118, DOI: 10.1093/neuonc/now118, ISSN: 1523-5866.

Ma Y, Tang N, Thompson RC, Mobley BC, Clark SW, Sarkaria JN, Wang J. InsR/IGF1R Pathway Mediates Resistance to EGFR Inhibitors in Glioblastoma. Clin. Cancer Res [print-electronic]. 2016 Apr 4/1/2016; 22(7): 1767-76. PMID: 26561558, PMCID: PMC4818693, PII: 1078-0432.CCR-15-1677, DOI: 10.1158/1078-0432.CCR-15-1677, ISSN: 1078-0432.

Bradshaw MJ, Mobley BC, Zwerner JP, Sriram S. Autopsy-proven demyelination associated with infliximab treatment. Neurol Neuroimmunol Neuroinflamm. 2016 Apr; 3(2): e205. PMID: 26894207, PMCID: PMC4747476, PII: NEURIMMINFL2015008300, DOI: 10.1212/NXI.0000000000000205, ISSN: 2332-7812.

Sturm D, Orr BA, Toprak UH, Hovestadt V, Jones DT, Capper D, Sill M, Buchhalter I, Northcott PA, Leis I, Ryzhova M, Koelsche C, Pfaff E, Allen SJ, Balasubramanian G, Worst BC, Pajtler KW, Brabetz S, Johann PD, Sahm F, Reimand J, Mackay A, Carvalho DM, Remke M, Phillips JJ, Perry A, Cowdrey C, Drissi R, Fouladi M, Giangaspero F, Lastowska M, Grajkowska W, Scheurlen W, Pietsch T, Hagel C, Gojo J, Lötsch D, Berger W, Slavc I, Haberler C, Jouvet A, Holm S, Hofer S, Prinz M, Keohane C, Fried I, Mawrin C, Scheie D, Mobley BC, Schniederjan MJ, Santi M, Buccoliero AM, Dahiya S, Kramm CM, von Bueren AO, von Hoff K, Rutkowski S, Herold-Mende C, Frühwald MC, Milde T, Hasselblatt M, Wesseling P, Rößler J, Schüller U, Ebinger M, Schittenhelm J, Frank S, Grobholz R, Vajtai I, Hans V, Schneppenheim R, Zitterbart K, Collins VP, Aronica E, Varlet P, Puget S, Dufour C, Grill J, Figarella-Branger D, Wolter M, Schuhmann MU, Shalaby T, Grotzer M, van Meter T, Monoranu CM, Felsberg J, Reifenberger G, Snuderl M, Forrester LA, Koster J, Versteeg R, Volckmann R, van Sluis P, Wolf S, Mikkelsen T, Gajjar A, Aldape K, Moore AS, Taylor MD, Jones C, Jabado N, Karajannis MA, Eils R, Schlesner M, Lichter P, von Deimling A, Pfister SM, Ellison DW, Korshunov A, Kool M. New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs. Cell. 2016 Feb 2/25/2016; 164(5): 1060-72. PMID: 26919435, PII: S0092-8674(16)00055-6, DOI: 10.1016/j.cell.2016.01.015, ISSN: 1097-4172.

Peng C, Wang J, Tanksley JP, Mobley BC, Ayers GD, Moots PL, Clark SW. Valganciclovir and bevacizumab for recurrent glioblastoma: A single-institution experience. Mol Clin Oncol [print-electronic]. 2016 Feb; 4(2): 154-8. PMID: 26893852, PMCID: PMC4734189, PII: MCO-0-0-692, DOI: 10.3892/mco.2015.692, ISSN: 2049-9450.

Gong Y, Ma Y, Sinyuk M, Loganathan S, Thompson RC, Sarkaria JN, Chen W, Lathia JD, Mobley BC, Clark SW, Wang J. Insulin-mediated signaling promotes proliferation and survival of glioblastoma through Akt activation. Neuro-oncology [print-electronic]. 2016 Jan; 18(1): 48-57. PMID: 26136493, PMCID: PMC4677408, PII: nov096, DOI: 10.1093/neuonc/nov096, ISSN: 1523-5866.

Georgescu MM, Mobley BC, Orr BA, Shang P, Lehman NL, Zhu X, O'Neill TJ, Rajaram V, Hatanpaa KJ, Timmons CF, Raisanen JM. NHERF1/EBP50 and NF2 as diagnostic markers for choroid plexus tumors. Acta Neuropathol Commun. 2016; 4(1): 55. PMID: 27229317, PMCID: PMC4882843, PII: 10.1186/s40478-016-0329-0, DOI: 10.1186/s40478-016-0329-0, ISSN: 2051-5960.

Ho CY, Mobley BC, Gordish-Dressman H, VandenBussche CJ, Mason GE, Bornhorst M, Esbenshade AJ, Tehrani M, Orr BA, LaFrance DR, Devaney JM, Meltzer BW, Hofherr SE, Burger PC, Packer RJ, Rodriguez FJ. A clinicopathologic study of diencephalic pediatric low-grade gliomas with BRAF V600 mutation. Acta Neuropathol [print-electronic]. 2015 Oct; 130(4): 575-85. PMID: 26264609, PII: 10.1007/s00401-015-1467-3, DOI: 10.1007/s00401-015-1467-3, ISSN: 1432-0533.

Shelton JS, Davis LT, Peebles RS, Tillman BF, Mobley BC. Cerebral Amyloid Angiopathy Presenting with Synchronous Bilateral Intracerebral Macrohemorrhages. Case Rep Neurol. 2015 Sep; 7(3): 233-7. PMID: 26955333, PMCID: PMC4777955, PII: crn-0007-0233, DOI: 10.1159/000442085, ISSN: 1662-680X.

Mobley BC, Kumar M, Sanger WG, Nelson M, Nickols HH, Chambless LB, Gokden M. Papillary tumor of the pineal region with synchronous suprasellar focus and novel cytogenetic features. Hum. Pathol [print-electronic]. 2015 Aug; 46(8): 1232-6. PMID: 26068071, PII: S0046-8177(15)00156-2, DOI: 10.1016/j.humpath.2015.04.014, ISSN: 1532-8392.

Hata JL, Correa H, Krishnan C, Esbenshade AJ, Black JO, Chung DH, Mobley BC. Diagnostic utility of PHOX2B in primary and treated neuroblastoma and in neuroblastoma metastatic to the bone marrow. Arch. Pathol. Lab. Med. 2015 Apr; 139(4): 543-6. PMID: 25822764, DOI: 10.5858/arpa.2014-0255-OA, ISSN: 1543-2165.

Georgescu MM, Yell P, Mobley BC, Shang P, Georgescu T, Wang SH, Canoll P, Hatanpaa KJ, White CL, Raisanen JM. NHERF1/EBP50 is an organizer of polarity structures and a diagnostic marker in ependymoma. Acta Neuropathol Commun. 2015; 3: 11. PMID: 25775275, PMCID: PMC4352254, PII: s40478-015-0197-z, DOI: 10.1186/s40478-015-0197-z, ISSN: 2051-5960.

Mobley BC, Kwon M, Kraemer BR, Hickman FE, Qiao J, Chung DH, Carter BD. Expression of MYCN in Multipotent Sympathoadrenal Progenitors Induces Proliferation and Neural Differentiation, but Is Not Sufficient for Tumorigenesis. PLoS ONE. 2015; 10(7): e0133897. PMID: 26222553, PMCID: PMC4519318, PII: PONE-D-15-06683, DOI: 10.1371/journal.pone.0133897, ISSN: 1932-6203.

Daniels BH, McComb RD, Mobley BC, Gultekin SH, Lee HS, Margeta M. LC3 and p62 as diagnostic markers of drug-induced autophagic vacuolar cardiomyopathy: a study of 3 cases. Am. J. Surg. Pathol. 2013 Jul; 37(7): 1014-21. PMID: 23681079, DOI: 10.1097/PAS.0b013e3182863fa8, ISSN: 1532-0979.

Yeom KW, Lober RM, Mobley BC, Harsh G, Vogel H, Allagio R, Pearson M, Edwards MS, Fischbein NJ. Diffusion-weighted MRI: distinction of skull base chordoma from chondrosarcoma. AJNR Am J Neuroradiol [print-electronic]. 2013 May; 34(5): 1056-61, S1. PMID: 23124635, PII: ajnr.A3333, DOI: 10.3174/ajnr.A3333, ISSN: 1936-959X.

Yeom KW, Mobley BC, Lober RM, Andre JB, Partap S, Vogel H, Barnes PD. Distinctive MRI features of pediatric medulloblastoma subtypes. AJR Am J Roentgenol. 2013 Apr; 200(4): 895-903. PMID: 23521467, DOI: 10.2214/AJR.12.9249, ISSN: 1546-3141.

Kleinfeld K, Mobley B, Hedera P, Wegner A, Sriram S, Pawate S. Adult-onset leukoencephalopathy with neuroaxonal spheroids and pigmented glia: report of five cases and a new mutation. J. Neurol [print-electronic]. 2013 Feb; 260(2): 558-71. PMID: 23052599, DOI: 10.1007/s00415-012-6680-6, ISSN: 1432-1459.

Paul P, Qiao J, Kim KW, Romain C, Lee S, Volny N, Mobley B, Correa H, Chung DH. Targeting gastrin-releasing peptide suppresses neuroblastoma progression via upregulation of PTEN signaling. PLoS ONE. 2013; 8(9): e72570. PMID: 24039782, PMCID: PMC3767701, PII: PONE-D-13-06094, DOI: 10.1371/journal.pone.0072570, ISSN: 1932-6203.

Pettit AC, Kropski JA, Castilho JL, Schmitz JE, Rauch CA, Mobley BC, Wang XJ, Spires SS, Pugh ME. The index case for the fungal meningitis outbreak in the United States. N. Engl. J. Med [print-electronic]. 2012 Nov 11/29/2012; 367(22): 2119-25. PMID: 23083311, DOI: 10.1056/NEJMoa1212292, ISSN: 1533-4406.

Azimian M, Gultekin SH, Hata JL, Atkinson JB, Ely KA, Fuchs HA, Mobley BC. Fatal antimalarial-induced cardiomyopathy: report of 2 cases. J Clin Rheumatol. 2012 Oct; 18(7): 363-6. PMID: 23047537, PII: 00124743-201210000-00010, DOI: 10.1097/RHU.0b013e31826852db, ISSN: 1536-7355.

Ghazi SO, Stark M, Zhao Z, Mobley BC, Munden A, Hover L, Abel TW. Cell of origin determines tumor phenotype in an oncogenic Ras/p53 knockout transgenic model of high-grade glioma. J. Neuropathol. Exp. Neurol. 2012 Aug; 71(8): 729-40. PMID: 22805776, PMCID: PMC3407564, DOI: 10.1097/NEN.0b013e3182625c02, ISSN: 1554-6578.

Forbes JA, Mobley BC, O'Lynnger TM, Cooper CM, Ghiassi M, Hanif R, Pearson MM. Pediatric cerebellar pilomyxoid-spectrum astrocytomas. J Neurosurg Pediatr. 2011 Jul; 8(1): 90-6. PMID: 21721894, PMCID: PMC3779306, DOI: 10.3171/2011.4.PEDS1115, ISSN: 1933-0715.

Bredel M, Scholtens DM, Yadav AK, Alvarez AA, Renfrow JJ, Chandler JP, Yu IL, Carro MS, Dai F, Tagge MJ, Ferrarese R, Bredel C, Phillips HS, Lukac PJ, Robe PA, Weyerbrock A, Vogel H, Dubner S, Mobley B, He X, Scheck AC, Sikic BI, Aldape KD, Chakravarti A, Harsh GR. NFKBIA deletion in glioblastomas. N. Engl. J. Med [print-electronic]. 2011 Feb 2/17/2011; 364(7): 627-37. PMID: 21175304, PMCID: PMC3652611, DOI: 10.1056/NEJMoa1006312, ISSN: 1533-4406.

Mobley BC, McKenney JK, Bangs CD, Callahan K, Yeom KW, Schneppenheim R, Hayden MG, Cherry AM, Gokden M, Edwards MS, Fisher PG, Vogel H. Loss of SMARCB1/INI1 expression in poorly differentiated chordomas. Acta Neuropathol [print-electronic]. 2010 Dec; 120(6): 745-53. PMID: 21057957, DOI: 10.1007/s00401-010-0767-x, ISSN: 1432-0533.

Mobley B, Kalani MY, Harsh GR, Edwards MS, Vogel H. Papillary tumor of the spinal cord: report of 2 cases. Am. J. Surg. Pathol. 2009 Aug; 33(8): 1191-7. PMID: 19417584, DOI: 10.1097/PAS.0b013e31819c45ca, ISSN: 1532-0979.

Boyd SD, Mobley BC, Regula DP, Arber DA. Features of hemolysis due to Clostridium perfringens infection. Int J Lab Hematol [print-electronic]. 2009 Jun; 31(3): 364-7. PMID: 18177433, PII: CLH1018, DOI: 10.1111/j.1751-553X.2007.01018.x, ISSN: 1751-553X.

Hayden MG, Guzman R, Dulai MS, Mobley BC, Edwards MS. Recurring osteoma within a calcium phosphate bone cement cranioplasty: case report. Neurosurgery. 2009 Apr; 64(4): E775-6; discussion E776. PMID: 19349808, PII: 00006123-200904000-00031, DOI: 10.1227/01.NEU.0000339126.47870.43, ISSN: 1524-4040.

Mobley BC, Enns GM, Wong LJ, Vogel H. A novel homozygous SCO2 mutation, p.G193S, causing fatal infantile cardioencephalomyopathy. Clin. Neuropathol. 2009 Mar; 28(2): 143-9. PMID: 19353847, PII: 5603, ISSN: 0722-5091.

Murovic JA, Gibbs IC, Chang SD, Mobley BC, Park J, Adler JR. Foraminal nerve sheath tumors: intermediate follow-up after cyberknife radiosurgery. Neurosurgery. 2009 Feb; 64(2 Suppl): A33-43. PMID: 19165072, PII: 00006123-200902001-00007, DOI: 10.1227/01.NEU.0000341632.39692.9E, ISSN: 1524-4040.

Tsao GJ, Tsang MW, Mobley BC, Cheng WW. Foramen magnum meningioma: Dysphagia of atypical etiology. J Gen Intern Med [print-electronic]. 2008 Feb; 23(2): 206-9. PMID: 18080720, PMCID: PMC2359174, DOI: 10.1007/s11606-007-0474-z, ISSN: 1525-1497.

Mobley BC, Roulston D, Shah GV, Bijwaard KE, McKeever PE. Peripheral primitive neuroectodermal tumor/Ewing's sarcoma of the craniospinal vault: case reports and review. Hum. Pathol [print-electronic]. 2006 Jul; 37(7): 845-53. PMID: 16784984, PII: S0046-8177(06)00087-6, DOI: 10.1016/j.humpath.2006.02.011, ISSN: 0046-8177.

Vincent AM, Mobley BC, Hiller A, Feldman EL. IGF-I prevents glutamate-induced motor neuron programmed cell death. Neurobiol. Dis. 2004 Jul; 16(2): 407-16. PMID: 15193297, PII: S0969996104000658, DOI: 10.1016/j.nbd.2004.03.001, ISSN: 0969-9961.

Rubin A, Mobley B, Hogikyan N, Bell K, Sullivan K, Boulis N, Feldman E. Delivery of an adenoviral vector to the crushed recurrent laryngeal nerve. Laryngoscope. 2003 Jun; 113(6): 985-9. PMID: 12782809, DOI: 10.1097/00005537-200306000-00013, ISSN: 0023-852X.

Minor DL, Lin YF, Mobley BC, Avelar A, Jan YN, Jan LY, Berger JM. The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel. Cell. 2000 Sep 9/1/2000; 102(5): 657-70. PMID: 11007484, PII: S0092-8674(00)00088-X, ISSN: 0092-8674.