Faculty Appointments
Associate Professor of Biomedical Informatics
Associate Professor of Computer Science
Education
Ph.D., Electrical Engineering & Computer Science, Massachusetts Institute of Technology, Cambridge, MassachusettsM.D., University of California, San Diego, CaliforniaB.S., University of California, San Diego, California
Research Keywords
machine learning, computational medicine, unsupervised learning, deep learning, phenotype discovery, EHR data
Publications
Xu K, Khan MS, Li TZ, Gao R, Terry JG, Huo Y, Lasko TA, Carr JJ, Maldonado F, Landman BA, Sandler KL. AI Body Composition in Lung Cancer Screening: Added Value Beyond Lung Cancer Detection. Radiology. 2023 Jul; 308(1): e222937. PMID: 37489991, PMCID: PMC10374937, DOI: 10.1148/radiol.222937, ISSN: 1527-1315.
Xu K, Khan MS, Li TZ, Gao R, Terry JG, Huo Y, Lasko TA, Carr JJ, Maldonado F, Landman BA, Sandler KL. AI Body Composition in Lung Cancer Screening: Added Value Beyond Lung Cancer Detection. Radiology. 2023 Jul; 308(1): e222937. PMID: 37489991, PMCID: PMC10374937, DOI: 10.1148/radiol.222937, ISSN: 1527-1315.
Li TZ, Xu K, Gao R, Tang Y, Lasko TA, Maldonado F, Sandler KL, Landman BA. Time-distance vision transformers in lung cancer diagnosis from longitudinal computed tomography. Proc SPIE Int Soc Opt Eng [print-electronic]. 2023 Feb; 12464: PMID: 37465096, PMCID: PMC10353776, PII: 1246412, DOI: 10.1117/12.2653911, ISSN: 0277-786X.
Li TZ, Xu K, Gao R, Tang Y, Lasko TA, Maldonado F, Sandler KL, Landman BA. Time-distance vision transformers in lung cancer diagnosis from longitudinal computed tomography. Proc SPIE Int Soc Opt Eng [print-electronic]. 2023 Feb; 12464: PMID: 37465096, PMCID: PMC10353776, PII: 1246412, DOI: 10.1117/12.2653911, ISSN: 0277-786X.
Gao R, Li T, Tang Y, Xu K, Khan M, Kammer M, Antic SL, Deppen S, Huo Y, Lasko TA, Sandler KL, Maldonado F, Landman BA. Reducing uncertainty in cancer risk estimation for patients with indeterminate pulmonary nodules using an integrated deep learning model. Comput Biol Med [print-electronic]. 2022 Sep 9/29/2022; 150: 106113. PMID: 36198225, PMCID: PMC10050219, PII: S0010-4825(22)00821-6, DOI: 10.1016/j.compbiomed.2022.106113, ISSN: 1879-0534.
Gao R, Li T, Tang Y, Xu K, Khan M, Kammer M, Antic SL, Deppen S, Huo Y, Lasko TA, Sandler KL, Maldonado F, Landman BA. Reducing uncertainty in cancer risk estimation for patients with indeterminate pulmonary nodules using an integrated deep learning model. Comput Biol Med [print-electronic]. 2022 Sep 9/29/2022; 150: 106113. PMID: 36198225, PMCID: PMC10050219, PII: S0010-4825(22)00821-6, DOI: 10.1016/j.compbiomed.2022.106113, ISSN: 1879-0534.
Kerley CI, Chaganti S, Nguyen TQ, Bermudez C, Cutting LE, Beason-Held LL, Lasko T, Landman BA. PyPheWAS: A Phenome-Disease Association Tool for Electronic Medical Record Analysis. Neuroinformatics [print-electronic]. 2022 Apr; 20(2): 483-505. PMID: 34981404, PMCID: PMC9250547, PII: 10.1007/s12021-021-09553-4, DOI: 10.1007/s12021-021-09553-4, ISSN: 1559-0089.
McNaughton CD, Adams NM, Hirschie Johnson C, Ward MJ, Schmitz JE, Lasko TA. Diurnal Variation in SARS-CoV-2 PCR Test Results: Test Accuracy May Vary by Time of Day [letter]. J Biol Rhythms [print-electronic]. 2021 Dec; 36(6): 595-601. PMID: 34696614, PMCID: PMC8599649, DOI: 10.1177/07487304211051841, ISSN: 1552-4531.
McNaughton CD, Adams NM, Hirschie Johnson C, Ward MJ, Schmitz JE, Lasko TA. Diurnal Variation in SARS-CoV-2 PCR Test Results: Test Accuracy May Vary by Time of Day [letter]. J Biol Rhythms [print-electronic]. 2021 Dec; 36(6): 595-601. PMID: 34696614, PMCID: PMC8599649, DOI: 10.1177/07487304211051841, ISSN: 1552-4531.
Levinson RT, Vaitinidin NS, Farber-Eger E, Roden DM, Lasko TA, Wells QS, Mosley JD. Heart failure clinical care analysis uncovers risk reduction opportunities for preserved ejection fraction subtype. Sci Rep. 2021 Sep 9/20/2021; 11(1): 18618. PMID: 34545125, PMCID: PMC8452678, PII: 10.1038/s41598-021-97831-1, DOI: 10.1038/s41598-021-97831-1, ISSN: 2045-2322.
Levinson RT, Vaitinidin NS, Farber-Eger E, Roden DM, Lasko TA, Wells QS, Mosley JD. Heart failure clinical care analysis uncovers risk reduction opportunities for preserved ejection fraction subtype. Sci Rep. 2021 Sep 9/20/2021; 11(1): 18618. PMID: 34545125, PMCID: PMC8452678, PII: 10.1038/s41598-021-97831-1, DOI: 10.1038/s41598-021-97831-1, ISSN: 2045-2322.
Zhang Z, Yan C, Lasko TA, Sun J, Malin BA. SynTEG: a framework for temporal structured electronic health data simulation. J Am Med Inform Assoc. 2021 Mar 3/1/2021; 28(3): 596-604. PMID: 33277896, PMCID: PMC7936402, PII: 6024632, DOI: 10.1093/jamia/ocaa262, ISSN: 1527-974X.
Zhang Z, Yan C, Lasko TA, Sun J, Malin BA. SynTEG: a framework for temporal structured electronic health data simulation. J Am Med Inform Assoc. 2021 Mar 3/1/2021; 28(3): 596-604. PMID: 33277896, PMCID: PMC7936402, PII: 6024632, DOI: 10.1093/jamia/ocaa262, ISSN: 1527-974X.
Wanderer JP, Lasko TA, Coco JR, Fowler LC, McEvoy MD, Feng X, Shotwell MS, Li G, Gelfand BJ, Novak LL, Owens DA, Fabbri DV. Visualization of aggregate perioperative data improves anesthesia case planning: A randomized, cross-over trial. J Clin Anesth [print-electronic]. 2021 Feb; 68: 110114. PMID: 33142248, PMCID: PMC7750268, PII: S0952-8180(20)32209-1, DOI: 10.1016/j.jclinane.2020.110114, ISSN: 1873-4529.
Wanderer JP, Lasko TA, Coco JR, Fowler LC, McEvoy MD, Feng X, Shotwell MS, Li G, Gelfand BJ, Novak LL, Owens DA, Fabbri DV. Visualization of aggregate perioperative data improves anesthesia case planning: A randomized, cross-over trial. J Clin Anesth [print-electronic]. 2021 Feb; 68: 110114. PMID: 33142248, PMCID: PMC7750268, PII: S0952-8180(20)32209-1, DOI: 10.1016/j.jclinane.2020.110114, ISSN: 1873-4529.
Novak LL, Wanderer J, Owens DA, Fabbri D, Genkins JZ, Lasko TA. A Perioperative Care Display for Understanding High Acuity Patients. Appl Clin Inform [print-electronic]. 2021 Jan; 12(1): 164-9. PMID: 33657635, PMCID: PMC7929715, DOI: 10.1055/s-0041-1723023, ISSN: 1869-0327.
Novak LL, Wanderer J, Owens DA, Fabbri D, Genkins JZ, Lasko TA. A Perioperative Care Display for Understanding High Acuity Patients. Appl Clin Inform [print-electronic]. 2021 Jan; 12(1): 164-9. PMID: 33657635, PMCID: PMC7929715, DOI: 10.1055/s-0041-1723023, ISSN: 1869-0327.
Davis SE, Greevy RA, Lasko TA, Walsh CG, Matheny ME. Detection of calibration drift in clinical prediction models to inform model updating. J Biomed Inform [print-electronic]. 2020 Dec; 112: 103611. PMID: 33157313, PMCID: PMC8627243, PII: S1532-0464(20)30239-2, DOI: 10.1016/j.jbi.2020.103611, ISSN: 1532-0480.
Davis SE, Greevy RA, Lasko TA, Walsh CG, Matheny ME. Detection of calibration drift in clinical prediction models to inform model updating. J Biomed Inform [print-electronic]. 2020 Dec; 112: 103611. PMID: 33157313, PMCID: PMC8627243, PII: S1532-0464(20)30239-2, DOI: 10.1016/j.jbi.2020.103611, ISSN: 1532-0480.
Lasko TA, Owens DA, Fabbri D, Wanderer JP, Genkins JZ, Novak LL. User-Centered Clinical Display Design Issues for Inpatient Providers. Appl Clin Inform [print-electronic]. 2020 Oct; 11(5): 700-9. PMID: 33086396, PMCID: PMC7595798, DOI: 10.1055/s-0040-1716746, ISSN: 1869-0327.
Lasko TA, Owens DA, Fabbri D, Wanderer JP, Genkins JZ, Novak LL. User-Centered Clinical Display Design Issues for Inpatient Providers. Appl Clin Inform [print-electronic]. 2020 Oct; 11(5): 700-9. PMID: 33086396, PMCID: PMC7595798, DOI: 10.1055/s-0040-1716746, ISSN: 1869-0327.
Nelson SD, Walsh CG, Olsen CA, McLaughlin AJ, LeGrand JR, Schutz N, Lasko TA. Demystifying artificial intelligence in pharmacy. Am J Health Syst Pharm. 2020 Sep 9/18/2020; 77(19): 1556-70. PMID: 32620944, PII: 5867281, DOI: 10.1093/ajhp/zxaa218, ISSN: 1535-2900.
Nelson SD, Walsh CG, Olsen CA, McLaughlin AJ, LeGrand JR, Schutz N, Lasko TA. Demystifying artificial intelligence in pharmacy. Am J Health Syst Pharm. 2020 Sep 9/18/2020; 77(19): 1556-70. PMID: 32620944, PII: 5867281, DOI: 10.1093/ajhp/zxaa218, ISSN: 1535-2900.
Hansen CB, Nath V, Gao R, Bermudez C, Huo Y, Sandler KL, Massion PP, Blume JD, Lasko TA, Landman BA. Semi-supervised Machine Learning with MixMatch and Equivalence Classes. Lect Notes Monogr Ser [print-electronic]. 2020; 12446: 112-21. PMID: 34456459, PMCID: PMC8388309, ISSN: 0749-2170.
Hansen CB, Nath V, Gao R, Bermudez C, Huo Y, Sandler KL, Massion PP, Blume JD, Lasko TA, Landman BA. Semi-supervised Machine Learning with MixMatch and Equivalence Classes. Lect Notes Monogr Ser [print-electronic]. 2020; 12446: 112-21. PMID: 34456459, PMCID: PMC8388309, ISSN: 0749-2170.
Davis SE, Greevy RA, Fonnesbeck C, Lasko TA, Walsh CG, Matheny ME. A nonparametric updating method to correct clinical prediction model drift. J Am Med Inform Assoc. 2019 Dec 12/1/2019; 26(12): 1448-57. PMID: 31397478, PMCID: PMC6857513, PII: 5545426, DOI: 10.1093/jamia/ocz127, ISSN: 1527-974X.
Davis SE, Greevy RA, Fonnesbeck C, Lasko TA, Walsh CG, Matheny ME. A nonparametric updating method to correct clinical prediction model drift. J Am Med Inform Assoc. 2019 Dec 12/1/2019; 26(12): 1448-57. PMID: 31397478, PMCID: PMC6857513, PII: 5545426, DOI: 10.1093/jamia/ocz127, ISSN: 1527-974X.
Wei Q, Chen Y, Salimi M, Denny JC, Mei Q, Lasko TA, Chen Q, Wu S, Franklin A, Cohen T, Xu H. Cost-aware active learning for named entity recognition in clinical text. J Am Med Inform Assoc. 2019 Nov 11/1/2019; 26(11): 1314-22. PMID: 31294792, PMCID: PMC6798575, PII: 5531148, DOI: 10.1093/jamia/ocz102, ISSN: 1527-974X.
Wei Q, Chen Y, Salimi M, Denny JC, Mei Q, Lasko TA, Chen Q, Wu S, Franklin A, Cohen T, Xu H. Cost-aware active learning for named entity recognition in clinical text. J Am Med Inform Assoc. 2019 Nov 11/1/2019; 26(11): 1314-22. PMID: 31294792, PMCID: PMC6798575, PII: 5531148, DOI: 10.1093/jamia/ocz102, ISSN: 1527-974X.
Chaganti S, Bermudez C, Mawn LA, Lasko T, Landman BA. Contextual Deep Regression Network for Volume Estimation in Orbital CT. Med Image Comput Comput Assist Interv [print-electronic]. 2019 Oct; 11769: 104-11. PMID: 35098262, PMCID: PMC8796819, DOI: 10.1007/978-3-030-32226-7_12.
Huo Y, Terry JG, Wang J, Nair S, Lasko TA, Freedman BI, Carr JJ, Landman BA. Fully automatic liver attenuation estimation combing CNN segmentation and morphological operations. Med Phys [print-electronic]. 2019 Aug; 46(8): 3508-19. PMID: 31228267, PMCID: PMC6692233, DOI: 10.1002/mp.13675, ISSN: 2473-4209.
Huo Y, Terry JG, Wang J, Nair S, Lasko TA, Freedman BI, Carr JJ, Landman BA. Fully automatic liver attenuation estimation combing CNN segmentation and morphological operations. Med Phys [print-electronic]. 2019 Aug; 46(8): 3508-19. PMID: 31228267, PMCID: PMC6692233, DOI: 10.1002/mp.13675, ISSN: 2473-4209.
Davis SE, Greevy RA, Lasko TA, Walsh CG, Matheny ME. Comparison of Prediction Model Performance Updating Protocols: Using a Data-Driven Testing Procedure to Guide Updating. AMIA Annu Symp Proc. 2019; 2019: 1002-10. PMID: 32308897, PMCID: PMC7153129, ISSN: 1942-597X.
Chaganti S, Welty VF, Taylor W, Albert K, Failla MD, Cascio C, Smith S, Mawn L, Resnick SM, Beason-Held LL, Bagnato F, Lasko T, Blume JD, Landman BA. Discovering novel disease comorbidities using electronic medical records. PLoS One. 2019; 14(11): e0225495. PMID: 31774837, PMCID: PMC6880990, PII: PONE-D-19-15594, DOI: 10.1371/journal.pone.0225495, ISSN: 1932-6203.
Shi Y, Graves JA, Garbett SP, Zhou Z, Marathi R, Wang X, Harrell FE, Lasko TA, Denny JC, Roden DM, Peterson JF, Schildcrout JS. A Decision-Theoretic Approach to Panel-Based, Preemptive Genotyping. MDM Policy Pract. 2019; 4(2): 2381468319864337. PMID: 31453360, PMCID: PMC6699004, PII: 10.1177_2381468319864337, DOI: 10.1177/2381468319864337, ISSN: 2381-4683.
Shi Y, Graves JA, Garbett SP, Zhou Z, Marathi R, Wang X, Harrell FE, Lasko TA, Denny JC, Roden DM, Peterson JF, Schildcrout JS. A Decision-Theoretic Approach to Panel-Based, Preemptive Genotyping. MDM Policy Pract. 2019; 4(2): 2381468319864337. PMID: 31453360, PMCID: PMC6699004, PII: 10.1177_2381468319864337, DOI: 10.1177/2381468319864337, ISSN: 2381-4683.
Davis SE, Greevy RA, Lasko TA, Walsh CG, Matheny ME. Comparison of Prediction Model Performance Updating Protocols: Using a Data-Driven Testing Procedure to Guide Updating. AMIA Annu Symp Proc. 2019; 2019: 1002-10. PMID: 32308897, PMCID: PMC7153129, ISSN: 1942-597X.
Parr SK, Shotwell MS, Jeffery AD, Lasko TA, Matheny ME. Automated mapping of laboratory tests to LOINC codes using noisy labels in a national electronic health record system database. J Am Med Inform Assoc. 2018 Oct 10/1/2018; 25(10): 1292-300. PMID: 30137378, PMCID: PMC7646911, PII: 5075874, DOI: 10.1093/jamia/ocy110, ISSN: 1527-974X.
Parr SK, Shotwell MS, Jeffery AD, Lasko TA, Matheny ME. Automated mapping of laboratory tests to LOINC codes using noisy labels in a national electronic health record system database. J Am Med Inform Assoc. 2018 Oct 10/1/2018; 25(10): 1292-300. PMID: 30137378, PMCID: PMC7646911, PII: 5075874, DOI: 10.1093/jamia/ocy110, ISSN: 1527-974X.
Zhang L, Fabbri D, Lasko TA, Ehrenfeld JM, Wanderer JP. A System for Automated Determination of Perioperative Patient Acuity. J Med Syst. 2018 May 5/30/2018; 42(7): 123. PMID: 29846806, PMCID: PMC7265800, PII: 10.1007/s10916-018-0977-7, DOI: 10.1007/s10916-018-0977-7, ISSN: 1573-689X.
Zhang L, Fabbri D, Lasko TA, Ehrenfeld JM, Wanderer JP. A System for Automated Determination of Perioperative Patient Acuity. J Med Syst. 2018 May 5/30/2018; 42(7): 123. PMID: 29846806, PMCID: PMC7265800, PII: 10.1007/s10916-018-0977-7, DOI: 10.1007/s10916-018-0977-7, ISSN: 1573-689X.
Ye C, Coco J, Epishova A, Hajaj C, Bogardus H, Novak L, Denny J, Vorobeychik Y, Lasko T, Malin B, Fabbri D. A Crowdsourcing Framework for Medical Data Sets. AMIA Jt Summits Transl Sci Proc. 2018; 2017: 273-80. PMID: 29888085, PMCID: PMC5961774, ISSN: 2153-4063.
Lasko TA, Walsh CG, Malin B. Benefits and Risks of Machine Learning Decision Support Systems [letter]. JAMA. 2017 Dec 12/19/2017; 318(23): 2355. PMID: 29260218, PII: 2666495, DOI: 10.1001/jama.2017.16623, ISSN: 1538-3598.
Davis SE, Lasko TA, Chen G, Siew ED, Matheny ME. Calibration drift in regression and machine learning models for acute kidney injury. J Am Med Inform Assoc. 2017 Nov 11/1/2017; 24(6): 1052-61. PMID: 28379439, PII: 3096776, DOI: 10.1093/jamia/ocx030, ISSN: 1527-974X.
Teixeira PL, Wei WQ, Cronin RM, Mo H, VanHouten JP, Carroll RJ, LaRose E, Bastarache LA, Rosenbloom ST, Edwards TL, Roden DM, Lasko TA, Dart RA, Nikolai AM, Peissig PL, Denny JC. Evaluating electronic health record data sources and algorithmic approaches to identify hypertensive individuals. J Am Med Inform Assoc [print-electronic]. 2017 Jan; 24(1): 162-71. PMID: 27497800, PMCID: PMC5201185, PII: ocw071, DOI: 10.1093/jamia/ocw071, ISSN: 1527-974X.
Chaganti S, Robinson JR, Bermudez C, Lasko T, Mawn LA, Landman BA. EMR-Radiological Phenotypes in Diseases of the Optic Nerve and their Association with Visual Function. Deep Learn Med Image Anal Multimodal Learn Clin Decis Support (2017) [print-electronic]. 2017; 2017: 373-81. PMID: 29392245, PMCID: PMC5790176, DOI: 10.1007/978-3-319-67558-9_43.
Davis SE, Lasko TA, Chen G, Matheny ME. Calibration Drift Among Regression and Machine Learning Models for Hospital Mortality. AMIA Annu Symp Proc. 2017; 2017: 625-34. PMID: 29854127, PMCID: PMC5977580, ISSN: 1942-597X.
Davis SE, Lasko TA, Chen G, Matheny ME. Calibration Drift Among Regression and Machine Learning Models for Hospital Mortality. AMIA Annu Symp Proc. 2017; 2017: 625-34. PMID: 29854127, PMCID: PMC5977580, ISSN: 1942-597X.
Chen Y, Lasko TA, Mei Q, Denny JC, Xu H. A study of active learning methods for named entity recognition in clinical text. J Biomed Inform [print-electronic]. 2015 Dec; 58: 11-8. PMID: 26385377, PMCID: PMC4934373, PII: S1532-0464(15)00203-8, DOI: 10.1016/j.jbi.2015.09.010, ISSN: 1532-0480.
Lasko TA. Nonstationary Gaussian Process Regression for Evaluating Clinical Laboratory Test Sampling Strategies. Proc Conf AAAI Artif Intell. 2015 Jan; 2015: 1777-83. PMID: 26097785, PMCID: PMC4472307, ISSN: 2159-5399.
Lasko TA. Efficient Inference of Gaussian-Process-Modulated Renewal Processes with Application to Medical Event Data. Uncertain Artif Intell. 2014 Jul; 2014: 469-76. PMID: 25552936, PMCID: PMC4278374, ISSN: 1525-3384.
VanHouten JP, Starmer JM, Lorenzi NM, Maron DJ, Lasko TA. Machine learning for risk prediction of acute coronary syndrome. AMIA Annu Symp Proc. 2014; 2014: 1940-9. PMID: 25954467, PMCID: PMC4419888, ISSN: 1942-597X.
Wei WQ, Cronin RM, Xu H, Lasko TA, Bastarache L, Denny JC. Development and evaluation of an ensemble resource linking medications to their indications. J Am Med Inform Assoc [print-electronic]. 2013 Sep; 20(5): 954-61. PMID: 23576672, PMCID: PMC3756263, PII: amiajnl-2012-001431, DOI: 10.1136/amiajnl-2012-001431, ISSN: 1527-974X.
Wei WQ, Cronin RM, Xu H, Lasko TA, Bastarache L, Denny JC. Development of an ensemble resource linking MEDications to their Indications (MEDI). AMIA Jt Summits Transl Sci Proc. 2013; 2013: 172. PMID: 24303333, ISSN: 2153-4063.
Lasko TA, Denny JC, Levy MA. Scalable Data-driven Phenotypes via Unsupervised Feature Learning. AMIA Jt Summits Transl Sci Proc. 2013; 2013: 106. PMID: 24303314, ISSN: 2153-4063.
Lasko TA, Denny JC, Levy MA. Computational phenotype discovery using unsupervised feature learning over noisy, sparse, and irregular clinical data. PLoS ONE [electronic-print]. 2013; 8(6): e66341. PMID: 23826094, PMCID: PMC3691199, PII: PONE-D-12-40629, DOI: 10.1371/journal.pone.0066341, ISSN: 1932-6203.
Carroll RJ, Thompson WK, Eyler AE, Mandelin AM, Cai T, Zink RM, Pacheco JA, Boomershine CS, Lasko TA, Xu H, Karlson EW, Perez RG, Gainer VS, Murphy SN, Ruderman EM, Pope RM, Plenge RM, Kho AN, Liao KP, Denny JC. Portability of an algorithm to identify rheumatoid arthritis in electronic health records. J Am Med Inform Assoc [print-electronic]. 2012 Jun; 19(e1): e162-9. PMID: 22374935, PMCID: PMC3392871, PII: amiajnl-2011-000583, DOI: 10.1136/amiajnl-2011-000583, ISSN: 1527-974X.
Xu K, Khan MS, Li TZ, Gao R, Terry JG, Huo Y, Lasko TA, Carr JJ, Maldonado F, Landman BA, Sandler KL. AI Body Composition in Lung Cancer Screening: Added Value Beyond Lung Cancer Detection. Radiology. 2023 Jul; 308(1): e222937. PMID: 37489991, PMCID: PMC10374937, DOI: 10.1148/radiol.222937, ISSN: 1527-1315.
Li TZ, Xu K, Gao R, Tang Y, Lasko TA, Maldonado F, Sandler KL, Landman BA. Time-distance vision transformers in lung cancer diagnosis from longitudinal computed tomography. Proc SPIE Int Soc Opt Eng [print-electronic]. 2023 Feb; 12464: PMID: 37465096, PMCID: PMC10353776, PII: 1246412, DOI: 10.1117/12.2653911, ISSN: 0277-786X.
Li TZ, Xu K, Gao R, Tang Y, Lasko TA, Maldonado F, Sandler KL, Landman BA. Time-distance vision transformers in lung cancer diagnosis from longitudinal computed tomography. Proc SPIE Int Soc Opt Eng [print-electronic]. 2023 Feb; 12464: PMID: 37465096, PMCID: PMC10353776, PII: 1246412, DOI: 10.1117/12.2653911, ISSN: 0277-786X.
Gao R, Li T, Tang Y, Xu K, Khan M, Kammer M, Antic SL, Deppen S, Huo Y, Lasko TA, Sandler KL, Maldonado F, Landman BA. Reducing uncertainty in cancer risk estimation for patients with indeterminate pulmonary nodules using an integrated deep learning model. Comput Biol Med [print-electronic]. 2022 Sep 9/29/2022; 150: 106113. PMID: 36198225, PMCID: PMC10050219, PII: S0010-4825(22)00821-6, DOI: 10.1016/j.compbiomed.2022.106113, ISSN: 1879-0534.
Gao R, Li T, Tang Y, Xu K, Khan M, Kammer M, Antic SL, Deppen S, Huo Y, Lasko TA, Sandler KL, Maldonado F, Landman BA. Reducing uncertainty in cancer risk estimation for patients with indeterminate pulmonary nodules using an integrated deep learning model. Comput Biol Med [print-electronic]. 2022 Sep 9/29/2022; 150: 106113. PMID: 36198225, PMCID: PMC10050219, PII: S0010-4825(22)00821-6, DOI: 10.1016/j.compbiomed.2022.106113, ISSN: 1879-0534.
Kerley CI, Chaganti S, Nguyen TQ, Bermudez C, Cutting LE, Beason-Held LL, Lasko T, Landman BA. PyPheWAS: A Phenome-Disease Association Tool for Electronic Medical Record Analysis. Neuroinformatics [print-electronic]. 2022 Apr; 20(2): 483-505. PMID: 34981404, PMCID: PMC9250547, PII: 10.1007/s12021-021-09553-4, DOI: 10.1007/s12021-021-09553-4, ISSN: 1559-0089.
McNaughton CD, Adams NM, Hirschie Johnson C, Ward MJ, Schmitz JE, Lasko TA. Diurnal Variation in SARS-CoV-2 PCR Test Results: Test Accuracy May Vary by Time of Day [letter]. J Biol Rhythms [print-electronic]. 2021 Dec; 36(6): 595-601. PMID: 34696614, PMCID: PMC8599649, DOI: 10.1177/07487304211051841, ISSN: 1552-4531.
McNaughton CD, Adams NM, Hirschie Johnson C, Ward MJ, Schmitz JE, Lasko TA. Diurnal Variation in SARS-CoV-2 PCR Test Results: Test Accuracy May Vary by Time of Day [letter]. J Biol Rhythms [print-electronic]. 2021 Dec; 36(6): 595-601. PMID: 34696614, PMCID: PMC8599649, DOI: 10.1177/07487304211051841, ISSN: 1552-4531.
Levinson RT, Vaitinidin NS, Farber-Eger E, Roden DM, Lasko TA, Wells QS, Mosley JD. Heart failure clinical care analysis uncovers risk reduction opportunities for preserved ejection fraction subtype. Sci Rep. 2021 Sep 9/20/2021; 11(1): 18618. PMID: 34545125, PMCID: PMC8452678, PII: 10.1038/s41598-021-97831-1, DOI: 10.1038/s41598-021-97831-1, ISSN: 2045-2322.
Levinson RT, Vaitinidin NS, Farber-Eger E, Roden DM, Lasko TA, Wells QS, Mosley JD. Heart failure clinical care analysis uncovers risk reduction opportunities for preserved ejection fraction subtype. Sci Rep. 2021 Sep 9/20/2021; 11(1): 18618. PMID: 34545125, PMCID: PMC8452678, PII: 10.1038/s41598-021-97831-1, DOI: 10.1038/s41598-021-97831-1, ISSN: 2045-2322.
Zhang Z, Yan C, Lasko TA, Sun J, Malin BA. SynTEG: a framework for temporal structured electronic health data simulation. J Am Med Inform Assoc. 2021 Mar 3/1/2021; 28(3): 596-604. PMID: 33277896, PMCID: PMC7936402, PII: 6024632, DOI: 10.1093/jamia/ocaa262, ISSN: 1527-974X.
Zhang Z, Yan C, Lasko TA, Sun J, Malin BA. SynTEG: a framework for temporal structured electronic health data simulation. J Am Med Inform Assoc. 2021 Mar 3/1/2021; 28(3): 596-604. PMID: 33277896, PMCID: PMC7936402, PII: 6024632, DOI: 10.1093/jamia/ocaa262, ISSN: 1527-974X.
Wanderer JP, Lasko TA, Coco JR, Fowler LC, McEvoy MD, Feng X, Shotwell MS, Li G, Gelfand BJ, Novak LL, Owens DA, Fabbri DV. Visualization of aggregate perioperative data improves anesthesia case planning: A randomized, cross-over trial. J Clin Anesth [print-electronic]. 2021 Feb; 68: 110114. PMID: 33142248, PMCID: PMC7750268, PII: S0952-8180(20)32209-1, DOI: 10.1016/j.jclinane.2020.110114, ISSN: 1873-4529.
Wanderer JP, Lasko TA, Coco JR, Fowler LC, McEvoy MD, Feng X, Shotwell MS, Li G, Gelfand BJ, Novak LL, Owens DA, Fabbri DV. Visualization of aggregate perioperative data improves anesthesia case planning: A randomized, cross-over trial. J Clin Anesth [print-electronic]. 2021 Feb; 68: 110114. PMID: 33142248, PMCID: PMC7750268, PII: S0952-8180(20)32209-1, DOI: 10.1016/j.jclinane.2020.110114, ISSN: 1873-4529.
Novak LL, Wanderer J, Owens DA, Fabbri D, Genkins JZ, Lasko TA. A Perioperative Care Display for Understanding High Acuity Patients. Appl Clin Inform [print-electronic]. 2021 Jan; 12(1): 164-9. PMID: 33657635, PMCID: PMC7929715, DOI: 10.1055/s-0041-1723023, ISSN: 1869-0327.
Novak LL, Wanderer J, Owens DA, Fabbri D, Genkins JZ, Lasko TA. A Perioperative Care Display for Understanding High Acuity Patients. Appl Clin Inform [print-electronic]. 2021 Jan; 12(1): 164-9. PMID: 33657635, PMCID: PMC7929715, DOI: 10.1055/s-0041-1723023, ISSN: 1869-0327.
Davis SE, Greevy RA, Lasko TA, Walsh CG, Matheny ME. Detection of calibration drift in clinical prediction models to inform model updating. J Biomed Inform [print-electronic]. 2020 Dec; 112: 103611. PMID: 33157313, PMCID: PMC8627243, PII: S1532-0464(20)30239-2, DOI: 10.1016/j.jbi.2020.103611, ISSN: 1532-0480.
Davis SE, Greevy RA, Lasko TA, Walsh CG, Matheny ME. Detection of calibration drift in clinical prediction models to inform model updating. J Biomed Inform [print-electronic]. 2020 Dec; 112: 103611. PMID: 33157313, PMCID: PMC8627243, PII: S1532-0464(20)30239-2, DOI: 10.1016/j.jbi.2020.103611, ISSN: 1532-0480.
Lasko TA, Owens DA, Fabbri D, Wanderer JP, Genkins JZ, Novak LL. User-Centered Clinical Display Design Issues for Inpatient Providers. Appl Clin Inform [print-electronic]. 2020 Oct; 11(5): 700-9. PMID: 33086396, PMCID: PMC7595798, DOI: 10.1055/s-0040-1716746, ISSN: 1869-0327.
Lasko TA, Owens DA, Fabbri D, Wanderer JP, Genkins JZ, Novak LL. User-Centered Clinical Display Design Issues for Inpatient Providers. Appl Clin Inform [print-electronic]. 2020 Oct; 11(5): 700-9. PMID: 33086396, PMCID: PMC7595798, DOI: 10.1055/s-0040-1716746, ISSN: 1869-0327.
Nelson SD, Walsh CG, Olsen CA, McLaughlin AJ, LeGrand JR, Schutz N, Lasko TA. Demystifying artificial intelligence in pharmacy. Am J Health Syst Pharm. 2020 Sep 9/18/2020; 77(19): 1556-70. PMID: 32620944, PII: 5867281, DOI: 10.1093/ajhp/zxaa218, ISSN: 1535-2900.
Nelson SD, Walsh CG, Olsen CA, McLaughlin AJ, LeGrand JR, Schutz N, Lasko TA. Demystifying artificial intelligence in pharmacy. Am J Health Syst Pharm. 2020 Sep 9/18/2020; 77(19): 1556-70. PMID: 32620944, PII: 5867281, DOI: 10.1093/ajhp/zxaa218, ISSN: 1535-2900.
Hansen CB, Nath V, Gao R, Bermudez C, Huo Y, Sandler KL, Massion PP, Blume JD, Lasko TA, Landman BA. Semi-supervised Machine Learning with MixMatch and Equivalence Classes. Lect Notes Monogr Ser [print-electronic]. 2020; 12446: 112-21. PMID: 34456459, PMCID: PMC8388309, ISSN: 0749-2170.
Hansen CB, Nath V, Gao R, Bermudez C, Huo Y, Sandler KL, Massion PP, Blume JD, Lasko TA, Landman BA. Semi-supervised Machine Learning with MixMatch and Equivalence Classes. Lect Notes Monogr Ser [print-electronic]. 2020; 12446: 112-21. PMID: 34456459, PMCID: PMC8388309, ISSN: 0749-2170.
Davis SE, Greevy RA, Fonnesbeck C, Lasko TA, Walsh CG, Matheny ME. A nonparametric updating method to correct clinical prediction model drift. J Am Med Inform Assoc. 2019 Dec 12/1/2019; 26(12): 1448-57. PMID: 31397478, PMCID: PMC6857513, PII: 5545426, DOI: 10.1093/jamia/ocz127, ISSN: 1527-974X.
Davis SE, Greevy RA, Fonnesbeck C, Lasko TA, Walsh CG, Matheny ME. A nonparametric updating method to correct clinical prediction model drift. J Am Med Inform Assoc. 2019 Dec 12/1/2019; 26(12): 1448-57. PMID: 31397478, PMCID: PMC6857513, PII: 5545426, DOI: 10.1093/jamia/ocz127, ISSN: 1527-974X.
Wei Q, Chen Y, Salimi M, Denny JC, Mei Q, Lasko TA, Chen Q, Wu S, Franklin A, Cohen T, Xu H. Cost-aware active learning for named entity recognition in clinical text. J Am Med Inform Assoc. 2019 Nov 11/1/2019; 26(11): 1314-22. PMID: 31294792, PMCID: PMC6798575, PII: 5531148, DOI: 10.1093/jamia/ocz102, ISSN: 1527-974X.
Wei Q, Chen Y, Salimi M, Denny JC, Mei Q, Lasko TA, Chen Q, Wu S, Franklin A, Cohen T, Xu H. Cost-aware active learning for named entity recognition in clinical text. J Am Med Inform Assoc. 2019 Nov 11/1/2019; 26(11): 1314-22. PMID: 31294792, PMCID: PMC6798575, PII: 5531148, DOI: 10.1093/jamia/ocz102, ISSN: 1527-974X.
Chaganti S, Bermudez C, Mawn LA, Lasko T, Landman BA. Contextual Deep Regression Network for Volume Estimation in Orbital CT. Med Image Comput Comput Assist Interv [print-electronic]. 2019 Oct; 11769: 104-11. PMID: 35098262, PMCID: PMC8796819, DOI: 10.1007/978-3-030-32226-7_12.
Huo Y, Terry JG, Wang J, Nair S, Lasko TA, Freedman BI, Carr JJ, Landman BA. Fully automatic liver attenuation estimation combing CNN segmentation and morphological operations. Med Phys [print-electronic]. 2019 Aug; 46(8): 3508-19. PMID: 31228267, PMCID: PMC6692233, DOI: 10.1002/mp.13675, ISSN: 2473-4209.
Huo Y, Terry JG, Wang J, Nair S, Lasko TA, Freedman BI, Carr JJ, Landman BA. Fully automatic liver attenuation estimation combing CNN segmentation and morphological operations. Med Phys [print-electronic]. 2019 Aug; 46(8): 3508-19. PMID: 31228267, PMCID: PMC6692233, DOI: 10.1002/mp.13675, ISSN: 2473-4209.
Davis SE, Greevy RA, Lasko TA, Walsh CG, Matheny ME. Comparison of Prediction Model Performance Updating Protocols: Using a Data-Driven Testing Procedure to Guide Updating. AMIA Annu Symp Proc. 2019; 2019: 1002-10. PMID: 32308897, PMCID: PMC7153129, ISSN: 1942-597X.
Chaganti S, Welty VF, Taylor W, Albert K, Failla MD, Cascio C, Smith S, Mawn L, Resnick SM, Beason-Held LL, Bagnato F, Lasko T, Blume JD, Landman BA. Discovering novel disease comorbidities using electronic medical records. PLoS One. 2019; 14(11): e0225495. PMID: 31774837, PMCID: PMC6880990, PII: PONE-D-19-15594, DOI: 10.1371/journal.pone.0225495, ISSN: 1932-6203.
Shi Y, Graves JA, Garbett SP, Zhou Z, Marathi R, Wang X, Harrell FE, Lasko TA, Denny JC, Roden DM, Peterson JF, Schildcrout JS. A Decision-Theoretic Approach to Panel-Based, Preemptive Genotyping. MDM Policy Pract. 2019; 4(2): 2381468319864337. PMID: 31453360, PMCID: PMC6699004, PII: 10.1177_2381468319864337, DOI: 10.1177/2381468319864337, ISSN: 2381-4683.
Shi Y, Graves JA, Garbett SP, Zhou Z, Marathi R, Wang X, Harrell FE, Lasko TA, Denny JC, Roden DM, Peterson JF, Schildcrout JS. A Decision-Theoretic Approach to Panel-Based, Preemptive Genotyping. MDM Policy Pract. 2019; 4(2): 2381468319864337. PMID: 31453360, PMCID: PMC6699004, PII: 10.1177_2381468319864337, DOI: 10.1177/2381468319864337, ISSN: 2381-4683.
Davis SE, Greevy RA, Lasko TA, Walsh CG, Matheny ME. Comparison of Prediction Model Performance Updating Protocols: Using a Data-Driven Testing Procedure to Guide Updating. AMIA Annu Symp Proc. 2019; 2019: 1002-10. PMID: 32308897, PMCID: PMC7153129, ISSN: 1942-597X.
Parr SK, Shotwell MS, Jeffery AD, Lasko TA, Matheny ME. Automated mapping of laboratory tests to LOINC codes using noisy labels in a national electronic health record system database. J Am Med Inform Assoc. 2018 Oct 10/1/2018; 25(10): 1292-300. PMID: 30137378, PMCID: PMC7646911, PII: 5075874, DOI: 10.1093/jamia/ocy110, ISSN: 1527-974X.
Parr SK, Shotwell MS, Jeffery AD, Lasko TA, Matheny ME. Automated mapping of laboratory tests to LOINC codes using noisy labels in a national electronic health record system database. J Am Med Inform Assoc. 2018 Oct 10/1/2018; 25(10): 1292-300. PMID: 30137378, PMCID: PMC7646911, PII: 5075874, DOI: 10.1093/jamia/ocy110, ISSN: 1527-974X.
Zhang L, Fabbri D, Lasko TA, Ehrenfeld JM, Wanderer JP. A System for Automated Determination of Perioperative Patient Acuity. J Med Syst. 2018 May 5/30/2018; 42(7): 123. PMID: 29846806, PMCID: PMC7265800, PII: 10.1007/s10916-018-0977-7, DOI: 10.1007/s10916-018-0977-7, ISSN: 1573-689X.
Zhang L, Fabbri D, Lasko TA, Ehrenfeld JM, Wanderer JP. A System for Automated Determination of Perioperative Patient Acuity. J Med Syst. 2018 May 5/30/2018; 42(7): 123. PMID: 29846806, PMCID: PMC7265800, PII: 10.1007/s10916-018-0977-7, DOI: 10.1007/s10916-018-0977-7, ISSN: 1573-689X.
Ye C, Coco J, Epishova A, Hajaj C, Bogardus H, Novak L, Denny J, Vorobeychik Y, Lasko T, Malin B, Fabbri D. A Crowdsourcing Framework for Medical Data Sets. AMIA Jt Summits Transl Sci Proc. 2018; 2017: 273-80. PMID: 29888085, PMCID: PMC5961774, ISSN: 2153-4063.
Lasko TA, Walsh CG, Malin B. Benefits and Risks of Machine Learning Decision Support Systems [letter]. JAMA. 2017 Dec 12/19/2017; 318(23): 2355. PMID: 29260218, PII: 2666495, DOI: 10.1001/jama.2017.16623, ISSN: 1538-3598.
Davis SE, Lasko TA, Chen G, Siew ED, Matheny ME. Calibration drift in regression and machine learning models for acute kidney injury. J Am Med Inform Assoc. 2017 Nov 11/1/2017; 24(6): 1052-61. PMID: 28379439, PII: 3096776, DOI: 10.1093/jamia/ocx030, ISSN: 1527-974X.
Teixeira PL, Wei WQ, Cronin RM, Mo H, VanHouten JP, Carroll RJ, LaRose E, Bastarache LA, Rosenbloom ST, Edwards TL, Roden DM, Lasko TA, Dart RA, Nikolai AM, Peissig PL, Denny JC. Evaluating electronic health record data sources and algorithmic approaches to identify hypertensive individuals. J Am Med Inform Assoc [print-electronic]. 2017 Jan; 24(1): 162-71. PMID: 27497800, PMCID: PMC5201185, PII: ocw071, DOI: 10.1093/jamia/ocw071, ISSN: 1527-974X.
Chaganti S, Robinson JR, Bermudez C, Lasko T, Mawn LA, Landman BA. EMR-Radiological Phenotypes in Diseases of the Optic Nerve and their Association with Visual Function. Deep Learn Med Image Anal Multimodal Learn Clin Decis Support (2017) [print-electronic]. 2017; 2017: 373-81. PMID: 29392245, PMCID: PMC5790176, DOI: 10.1007/978-3-319-67558-9_43.
Davis SE, Lasko TA, Chen G, Matheny ME. Calibration Drift Among Regression and Machine Learning Models for Hospital Mortality. AMIA Annu Symp Proc. 2017; 2017: 625-34. PMID: 29854127, PMCID: PMC5977580, ISSN: 1942-597X.
Davis SE, Lasko TA, Chen G, Matheny ME. Calibration Drift Among Regression and Machine Learning Models for Hospital Mortality. AMIA Annu Symp Proc. 2017; 2017: 625-34. PMID: 29854127, PMCID: PMC5977580, ISSN: 1942-597X.
Chen Y, Lasko TA, Mei Q, Denny JC, Xu H. A study of active learning methods for named entity recognition in clinical text. J Biomed Inform [print-electronic]. 2015 Dec; 58: 11-8. PMID: 26385377, PMCID: PMC4934373, PII: S1532-0464(15)00203-8, DOI: 10.1016/j.jbi.2015.09.010, ISSN: 1532-0480.
Lasko TA. Nonstationary Gaussian Process Regression for Evaluating Clinical Laboratory Test Sampling Strategies. Proc Conf AAAI Artif Intell. 2015 Jan; 2015: 1777-83. PMID: 26097785, PMCID: PMC4472307, ISSN: 2159-5399.
Lasko TA. Efficient Inference of Gaussian-Process-Modulated Renewal Processes with Application to Medical Event Data. Uncertain Artif Intell. 2014 Jul; 2014: 469-76. PMID: 25552936, PMCID: PMC4278374, ISSN: 1525-3384.
VanHouten JP, Starmer JM, Lorenzi NM, Maron DJ, Lasko TA. Machine learning for risk prediction of acute coronary syndrome. AMIA Annu Symp Proc. 2014; 2014: 1940-9. PMID: 25954467, PMCID: PMC4419888, ISSN: 1942-597X.
Wei WQ, Cronin RM, Xu H, Lasko TA, Bastarache L, Denny JC. Development and evaluation of an ensemble resource linking medications to their indications. J Am Med Inform Assoc [print-electronic]. 2013 Sep; 20(5): 954-61. PMID: 23576672, PMCID: PMC3756263, PII: amiajnl-2012-001431, DOI: 10.1136/amiajnl-2012-001431, ISSN: 1527-974X.
Wei WQ, Cronin RM, Xu H, Lasko TA, Bastarache L, Denny JC. Development of an ensemble resource linking MEDications to their Indications (MEDI). AMIA Jt Summits Transl Sci Proc. 2013; 2013: 172. PMID: 24303333, ISSN: 2153-4063.
Lasko TA, Denny JC, Levy MA. Scalable Data-driven Phenotypes via Unsupervised Feature Learning. AMIA Jt Summits Transl Sci Proc. 2013; 2013: 106. PMID: 24303314, ISSN: 2153-4063.
Lasko TA, Denny JC, Levy MA. Computational phenotype discovery using unsupervised feature learning over noisy, sparse, and irregular clinical data. PLoS ONE [electronic-print]. 2013; 8(6): e66341. PMID: 23826094, PMCID: PMC3691199, PII: PONE-D-12-40629, DOI: 10.1371/journal.pone.0066341, ISSN: 1932-6203.
Carroll RJ, Thompson WK, Eyler AE, Mandelin AM, Cai T, Zink RM, Pacheco JA, Boomershine CS, Lasko TA, Xu H, Karlson EW, Perez RG, Gainer VS, Murphy SN, Ruderman EM, Pope RM, Plenge RM, Kho AN, Liao KP, Denny JC. Portability of an algorithm to identify rheumatoid arthritis in electronic health records. J Am Med Inform Assoc [print-electronic]. 2012 Jun; 19(e1): e162-9. PMID: 22374935, PMCID: PMC3392871, PII: amiajnl-2011-000583, DOI: 10.1136/amiajnl-2011-000583, ISSN: 1527-974X.