Michael L. Nickels, Ph.D.

Research Assistant Professor

Faculty Appointments
Research Assistant Professor of Radiology & Radiological Sciences
Ph.D., CHEMISTRY, University of Illinois, Urbana-Champaign, IllinoisB.S., Northern Kentucky University, Highland Heights, Kentucky
Research Description
Mike Nickels, Ph.D., earned his Ph.D. in Chemistry from the University of Illinois at Urbana-Champaign. After a one year post-doctoral appointment in an industrial setting, he went on to complete a research fellowship at the Vanderbilt University Medical Center as part of the Vanderbilt Institute of Imaging Science. During his time with the Institute he worked on the development and evaluation of molecular imaging agents and methodologies for the incorporation of complex/sensitive molecules onto imaging agents. Upon joining the Vanderbilt faculty in 2010 he was promoted to the role of Technical Director of the Radiochemistry Core Laboratory where he oversees the development of new radiochemistry techniques, production of preclinical imaging agents and the production of human research drugs. His current research focuses on the development of new and novel radiopharmaceuticals and the necessary labeling techniques used to incorporate radionuclides.

Section: Vanderbilt University Institute of Imaging Science
Li J, Schulte ML, Nickels ML, Manning HC. New structure-activity relationships of N-acetamide substituted pyrazolopyrimidines as pharmacological ligands of TSPO. Bioorg. Med. Chem. Lett [print-electronic]. 2016 Aug 8/1/2016; 26(15): 3472-7. PMID: 27353534, PII: S0960-894X(16)30652-7, DOI: 10.1016/j.bmcl.2016.06.041, ISSN: 1464-3405.

Hassanein M, Hight MR, Buck JR, Tantawy MN, Nickels ML, Hoeksema MD, Harris BK, Boyd K, Massion PP, Manning HC. Preclinical Evaluation of 4-[18F]Fluoroglutamine PET to Assess ASCT2 Expression in Lung Cancer. Mol Imaging Biol. 2016 Feb; 18(1): 18-23. PMID: 25971659, PMCID: PMC4644503, PII: 10.1007/s11307-015-0862-4, DOI: 10.1007/s11307-015-0862-4, ISSN: 1860-2002.

Cheung YY, Nickels ML, McKinley ET, Buck JR, Manning HC. High-yielding, automated production of 3'-deoxy-3'-[(18)F]fluorothymidine using a modified Bioscan Coincidence FDG reaction module. Appl Radiat Isot [print-electronic]. 2015 Mar; 97: 47-51. PMID: 25531913, PMCID: PMC4867542, PII: S0969-8043(14)00396-0, DOI: 10.1016/j.apradiso.2014.11.011, ISSN: 1872-9800.