David G. Harrison, M.D.


Faculty Appointments
Director, Division of Clinical Pharmacology Professor of Medicine Betty and Jack Bailey Chair in CardiologyProfessor of Molecular Physiology & BiophysicsProfessor of Pharmacology
M.D., University of Oklahoma Health Science Center, Oklahoma City, OklahomaB.S., Oklahoma State University, Stillwater, Oklahoma
Office Address
2200 Pierce Avenue
536 RRB
Nashville, TN 37232-6602
Research Description
Our laboratory has been focused on understanding how inflammation, and in particular, the adaptive immune response contributes to hypertension. Several years ago, we found that T cells are essential for the development of hypertension. We have shown that various hypertensive stimuli, including angiotensin II, norepinephrine and DOCA-salt cause activation of T cells and leads to their accumulation in the perivascular fat and kidneys. Our data indicate that T cell-derived cytokines such as IL-17 and TNF-a enhance vasoconstriction and sodium retention, leading to the hypertensive phenotype. Central signals derived from the circumventricular organs contribute to T cell activation, and manipulation of signals from this region affect T cell activation and the eventual elevation in blood pressure caused by angiotensin II. We are attempting to understand mechanisms involved in T cell activation in response to hypertensive stimuli. We have recently shown that gamma-ketoaldehydes, or isoketals adduct to proteins in hypertensive mice and humans, and that these are immunogenic. These modified proteins seem to act as "auto-antigens" that promote dendritic cell and ultimately T cell activation in hypertension.

Research Keywords
Inflammation, hypertension, immune activation
Clinical Research Keywords
Internal Medicine; Cardiology
Montaniel KR, Harrison DG. Is Hypertension a Bone Marrow Disease?. Circulation [print-electronic]. 2016 Sep 9/27/2016; PMID: 27678263, PII: CIRCULATIONAHA.116.024520, DOI: 10.1161/CIRCULATIONAHA.116.024520, ISSN: 1524-4539.

Grome HN, Barnett L, Hagar CC, Harrison DG, Kalams SA, Koethe JR. Association of T Cell and Macrophage Activation with Arterial Vascular Health in HIV. AIDS Res. Hum. Retroviruses [print-electronic]. 2016 Sep 9/14/2016; PMID: 27527002, DOI: 10.1089/AID.2016.0113, ISSN: 1931-8405.

Oh YS, Appel LJ, Galis ZS, Hafler DA, He J, Hernandez AL, Joe B, Karumanchi SA, Maric-Bilkan C, Mattson D, Mehta NN, Randolph G, Ryan M, Sandberg K, Titze J, Tolunay E, Toney GM, Harrison DG. National Heart, Lung, and Blood Institute Working Group Report on Salt in Human Health and Sickness: Building on the Current Scientific Evidence. Hypertension [print-electronic]. 2016 Aug; 68(2): 281-8. PMID: 27324228, PMCID: PMC4945367, PII: HYPERTENSIONAHA.116.07415, DOI: 10.1161/HYPERTENSIONAHA.116.07415, ISSN: 1524-4563.

Sanders LN, Schoenhard JA, Saleh MA, Mukherjee A, Ryzhov S, McMaster WG, Nolan K, Gumina RJ, Thompson TB, Magnuson MA, Harrison DG, Hatzopoulos AK. BMP Antagonist Gremlin 2 Limits Inflammation After Myocardial Infarction. Circ. Res [print-electronic]. 2016 Jul 7/22/2016; 119(3): 434-49. PMID: 27283840, PMCID: PMC4961528, PII: CIRCRESAHA.116.308700, DOI: 10.1161/CIRCRESAHA.116.308700, ISSN: 1524-4571.

Itani HA, McMaster WG, Saleh MA, Nazarewicz RR, Mikolajczyk TP, Kaszuba AM, Konior A, Prejbisz A, Januszewicz A, Norlander AE, Chen W, Bonami RH, Marshall AF, Poffenberger G, Weyand CM, Madhur MS, Moore DJ, Harrison DG, Guzik TJ. Activation of Human T Cells in Hypertension: Studies of Humanized Mice and Hypertensive Humans. Hypertension [print-electronic]. 2016 Jul; 68(1): 123-32. PMID: 27217403, PMCID: PMC4900908, PII: HYPERTENSIONAHA.116.07237, DOI: 10.1161/HYPERTENSIONAHA.116.07237, ISSN: 1524-4563.

Itani HA, Dikalova AE, McMaster WG, Nazarewicz RR, Bikineyeva AT, Harrison DG, Dikalov SI. Mitochondrial Cyclophilin D in Vascular Oxidative Stress and Hypertension. Hypertension [print-electronic]. 2016 Jun; 67(6): 1218-27. PMID: 27067720, PMCID: PMC4865418, PII: HYPERTENSIONAHA.115.07085, DOI: 10.1161/HYPERTENSIONAHA.115.07085, ISSN: 1524-4563.

Bersi MR, Bellini C, Wu J, Montaniel KR, Harrison DG, Humphrey JD. Excessive Adventitial Remodeling Leads to Early Aortic Maladaptation in Angiotensin-Induced Hypertension. Hypertension [print-electronic]. 2016 Mar 3/21/2016; PMID: 27001298, PII: HYPERTENSIONAHA.115.06262, DOI: 10.1161/HYPERTENSIONAHA.115.06262, ISSN: 1524-4563.

Itani HA, Xiao L, Saleh MA, Wu J, Pilkinton MA, Dale BL, Barbaro NR, Foss JD, Kirabo A, Montaniel KR, Norlander AE, Chen W, Sato R, Navar LG, Mallal SA, Madhur MS, Bernstein KE, Harrison DG. CD70 Exacerbates Blood Pressure Elevation and Renal Damage in Response to Repeated Hypertensive Stimuli. Circ. Res [print-electronic]. 2016 Mar 3/17/2016; PMID: 26988069, PII: CIRCRESAHA.115.308111, DOI: 10.1161/CIRCRESAHA.115.308111, ISSN: 1524-4571.

Shirai T, Nazarewicz RR, Wallis BB, Yanes RE, Watanabe R, Hilhorst M, Tian L, Harrison DG, Giacomini JC, Assimes TL, Goronzy JJ, Weyand CM. The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease. J. Exp. Med [print-electronic]. 2016 Mar 3/7/2016; 213(3): 337-54. PMID: 26926996, PII: jem.20150900, DOI: 10.1084/jem.20150900, ISSN: 1540-9538.

Mikolajczyk TP, Nosalski R, Szczepaniak P, Budzyn K, Osmenda G, Skiba D, Sagan A, Wu J, Vinh A, Marvar PJ, Guzik B, Podolec J, Drummond G, Lob HE, Harrison DG, Guzik TJ. Role of chemokine RANTES in the regulation of perivascular inflammation, T-cell accumulation, and vascular dysfunction in hypertension. FASEB J [print-electronic]. 2016 Feb 2/12/2016; PMID: 26873938, PII: fj.201500088R, DOI: 10.1096/fj.201500088R, ISSN: 1530-6860.

Humphrey JD, Harrison DG, Figueroa CA, Lacolley P, Laurent S. Central Artery Stiffness in Hypertension and Aging: A Problem With Cause and Consequence. Circ. Res. 2016 Feb 2/5/2016; 118(3): 379-81. PMID: 26846637, PMCID: PMC4745997, PII: CIRCRESAHA.115.307722, DOI: 10.1161/CIRCRESAHA.115.307722, ISSN: 1524-4571.

Wu J, Montaniel KR, Saleh MA, Xiao L, Chen W, Owens GK, Humphrey JD, Majesky MW, Paik DT, Hatzopoulos AK, Madhur MS, Harrison DG. Origin of Matrix-Producing Cells That Contribute to Aortic Fibrosis in Hypertension. Hypertension [print-electronic]. 2016 Feb; 67(2): 461-8. PMID: 26693821, PMCID: PMC4713264, PII: HYPERTENSIONAHA.115.06123, DOI: 10.1161/HYPERTENSIONAHA.115.06123, ISSN: 1524-4563.

Perrien DS, Saleh MA, Takahashi K, Madhur MS, Harrison DG, Harris RC, Takahashi T. Novel methods for microCT-based analyses of vasculature in the renal cortex reveal a loss of perfusable arterioles and glomeruli in eNOS-/- mice. BMC Nephrol. 2016; 17(1): 24. PMID: 26936597, PMCID: PMC4776352, PII: 10.1186/s12882-016-0235-5, DOI: 10.1186/s12882-016-0235-5, ISSN: 1471-2369.

Shah KH, Shi P, Giani JF, Janjulia T, Bernstein EA, Li Y, Zhao T, Harrison DG, Bernstein KE, Shen XZ. Myeloid Suppressor Cells Accumulate and Regulate Blood Pressure in Hypertension. Circ. Res [print-electronic]. 2015 Oct 10/23/2015; 117(10): 858-69. PMID: 26294657, PMCID: PMC4619122, PII: CIRCRESAHA.115.306539, DOI: 10.1161/CIRCRESAHA.115.306539, ISSN: 1524-4571.

Xiao L, Kirabo A, Wu J, Saleh MA, Zhu L, Wang F, Takahashi T, Loperena R, Foss JD, Mernaugh RL, Chen W, Roberts J, Osborn JW, Itani HA, Harrison DG. Renal Denervation Prevents Immune Cell Activation and Renal Inflammation in Angiotensin II-Induced Hypertension. Circ. Res [print-electronic]. 2015 Aug 8/28/2015; 117(6): 547-57. PMID: 26156232, PMCID: PMC4629828, PII: CIRCRESAHA.115.306010, DOI: 10.1161/CIRCRESAHA.115.306010, ISSN: 1524-4571.

Itani HA, Harrison DG. Memories that last in hypertension. Am. J. Physiol. Renal Physiol [print-electronic]. 2015 Jun 6/1/2015; 308(11): F1197-9. PMID: 25834073, PMCID: PMC4451327, PII: ajprenal.00633.2014, DOI: 10.1152/ajprenal.00633.2014, ISSN: 1522-1466.

McMaster WG, Kirabo A, Madhur MS, Harrison DG. Inflammation, immunity, and hypertensive end-organ damage. Circ. Res. 2015 Mar 3/13/2015; 116(6): 1022-33. PMID: 25767287, PMCID: PMC4535695, PII: CIRCRESAHA.116.303697, DOI: 10.1161/CIRCRESAHA.116.303697, ISSN: 1524-4571.

Kamat NV, Thabet SR, Xiao L, Saleh MA, Kirabo A, Madhur MS, Delpire E, Harrison DG, McDonough AA. Renal transporter activation during angiotensin-II hypertension is blunted in interferon-¿-/- and interleukin-17A-/- mice. Hypertension [print-electronic]. 2015 Mar; 65(3): 569-76. PMID: 25601932, PMCID: PMC4326622, PII: HYPERTENSIONAHA.114.04975, DOI: 10.1161/HYPERTENSIONAHA.114.04975, ISSN: 1524-4563.

Huan T, Meng Q, Saleh MA, Norlander AE, Joehanes R, Zhu J, Chen BH, Zhang B, Johnson AD, Ying S, Courchesne P, Raghavachari N, Wang R, Liu P, , O'Donnell CJ, Vasan R, Munson PJ, Madhur MS, Harrison DG, Yang X, Levy D. Integrative network analysis reveals molecular mechanisms of blood pressure regulation. Mol. Syst. Biol. 2015 Jan; 11(1): 799. PMID: 25882670, PMCID: PMC4422556, ISSN: 1744-4292.

Hofmeister LH, Lee SH, Norlander AE, Montaniel KR, Chen W, Harrison DG, Sung HJ. Phage-display-guided nanocarrier targeting to atheroprone vasculature. ACS Nano [print-electronic]. 2015; 9(4): 4435-46. PMID: 25768046, PMCID: PMC4654777, DOI: 10.1021/acsnano.5b01048, ISSN: 1936-086X.

Nozik-Grayck E, Woods C, Taylor JM, Benninger RK, Johnson RD, Villegas LR, Stenmark KR, Harrison DG, Majka SM, Irwin D, Farrow KN. Selective depletion of vascular EC-SOD augments chronic hypoxic pulmonary hypertension. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2014 Dec 12/1/2014; 307(11): L868-76. PMID: 25326578, PMCID: PMC4254965, PII: ajplung.00096.2014, DOI: 10.1152/ajplung.00096.2014, ISSN: 1522-1504.

Trott DW, Thabet SR, Kirabo A, Saleh MA, Itani H, Norlander AE, Wu J, Goldstein A, Arendshorst WJ, Madhur MS, Chen W, Li CI, Shyr Y, Harrison DG. Oligoclonal CD8+ T cells play a critical role in the development of hypertension. Hypertension [print-electronic]. 2014 Nov; 64(5): 1108-15. PMID: 25259750, PMCID: PMC4191997, PII: HYPERTENSIONAHA.114.04147, DOI: 10.1161/HYPERTENSIONAHA.114.04147, ISSN: 1524-4563.

Youn JY, Siu KL, Lob HE, Itani H, Harrison DG, Cai H. Role of vascular oxidative stress in obesity and metabolic syndrome. Diabetes [print-electronic]. 2014 Jul; 63(7): 2344-55. PMID: 24550188, PMCID: PMC4066332, PII: db13-0719, DOI: 10.2337/db13-0719, ISSN: 1939-327X.

Trott DW, Harrison DG. The immune system in hypertension. Adv Physiol Educ. 2014 Mar; 38(1): 20-4. PMID: 24585465, PMCID: PMC4459918, PII: 38/1/20, DOI: 10.1152/advan.00063.2013, ISSN: 1522-1229.

Wu J, Thabet SR, Kirabo A, Trott DW, Saleh MA, Xiao L, Madhur MS, Chen W, Harrison DG. Inflammation and mechanical stretch promote aortic stiffening in hypertension through activation of p38 mitogen-activated protein kinase. Circ. Res [print-electronic]. 2014 Feb 2/14/2014; 114(4): 616-25. PMID: 24347665, PMCID: PMC4186716, PII: CIRCRESAHA.114.302157, DOI: 10.1161/CIRCRESAHA.114.302157, ISSN: 1524-4571.

Dikalov SI, Nazarewicz RR, Bikineyeva A, Hilenski L, Lassègue B, Griendling KK, Harrison DG, Dikalova AE. Nox2-induced production of mitochondrial superoxide in angiotensin II-mediated endothelial oxidative stress and hypertension. Antioxid. Redox Signal [print-electronic]. 2014 Jan 1/10/2014; 20(2): 281-94. PMID: 24053613, PMCID: PMC3887459, DOI: 10.1089/ars.2012.4918, ISSN: 1557-7716.

Dikalov SI, Harrison DG. Methods for detection of mitochondrial and cellular reactive oxygen species. Antioxid. Redox Signal [print-electronic]. 2014 Jan 1/10/2014; 20(2): 372-82. PMID: 22978713, PMCID: PMC3887411, DOI: 10.1089/ars.2012.4886, ISSN: 1557-7716.

Wolkow PP, Kosiniak-Kamysz W, Osmenda G, Wilk G, Bujak-Gizycka B, Ignacak A, Kanitkar M, Walus-Miarka M, Harrison DG, Korbut R, Malecki MT, Guzik TJ. GTP cyclohydrolase I gene polymorphisms are associated with endothelial dysfunction and oxidative stress in patients with type 2 diabetes mellitus. PLoS ONE. 2014; 9(11): e108587. PMID: 25369080, PMCID: PMC4219671, PII: PONE-D-14-23960, DOI: 10.1371/journal.pone.0108587, ISSN: 1932-6203.

Harrison DG. The mosaic theory revisited: common molecular mechanisms coordinating diverse organ and cellular events in hypertension. J Am Soc Hypertens. 2013 Jan; 7(1): 68-74. PMID: 23321405, PMCID: PMC3646628, PII: S1933-1711(12)00302-6, DOI: 10.1016/j.jash.2012.11.007, ISSN: 1878-7436.

Feng Q, Vickers KC, Anderson MP, Levin MG, Chen W, Harrison DG, Wilke RA. A common functional promoter variant links CNR1 gene expression to HDL cholesterol level. Nat Commun. 2013; 4: 1973. PMID: 23748922, PMCID: PMC3873874, PII: ncomms2973, DOI: 10.1038/ncomms2973, ISSN: 2041-1723.

Osgood MJ, Harrison DG, Sexton KW, Hocking KM, Voskresensky IV, Komalavilas P, Cheung-Flynn J, Guzman RJ, Brophy CM. Role of the renin-angiotensin system in the pathogenesis of intimal hyperplasia: therapeutic potential for prevention of vein graft failure?. Ann Vasc Surg [print-electronic]. 2012 Nov; 26(8): 1130-44. PMID: 22445245, PMCID: PMC4189806, PII: S0890-5096(12)00052-0, DOI: 10.1016/j.avsg.2011.12.001, ISSN: 1615-5947.

Hasty AH, Harrison DG. Endoplasmic reticulum stress and hypertension - a new paradigm?. J. Clin. Invest [print-electronic]. 2012 Nov; 122(11): 3859-61. PMID: 23064369, PMCID: PMC3484081, PII: 65173, DOI: 10.1172/JCI65173, ISSN: 1558-8238.

Harrison DG, Guzik TJ. Studies of the T-cell angiotensin receptor using cre-lox technology: an unan-T-cellpated result [editorial]. Circ. Res. 2012 Jun 6/8/2012; 110(12): 1543-5. PMID: 22679135, PII: 110/12/1543, DOI: 10.1161/CIRCRESAHA.112.271411, ISSN: 1524-4571.

Harrison DG, Marvar PJ, Titze JM. Vascular inflammatory cells in hypertension. Front Physiol. 2012; 3: 128. PMID: 22586409, PMCID: PMC3345946, DOI: 10.3389/fphys.2012.00128, ISSN: 1664-042X.

Lob HE, Vinh A, Li L, Blinder Y, Offermanns S, Harrison DG. Role of vascular extracellular superoxide dismutase in hypertension. Hypertension [print-electronic]. 2011 Aug; 58(2): 232-9. PMID: 21730294, PMCID: PMC3376381, PII: HYPERTENSIONAHA.111.172718, DOI: 10.1161/HYPERTENSIONAHA.111.172718, ISSN: 1524-4563.

Madhur MS, Funt SA, Li L, Vinh A, Chen W, Lob HE, Iwakura Y, Blinder Y, Rahman A, Quyyumi AA, Harrison DG. Role of interleukin 17 in inflammation, atherosclerosis, and vascular function in apolipoprotein e-deficient mice. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2011 Jul; 31(7): 1565-72. PMID: 21474820, PMCID: PMC3117048, PII: ATVBAHA.111.227629, DOI: 10.1161/ATVBAHA.111.227629, ISSN: 1524-4636.

Chen W, Li L, Brod T, Saeed O, Thabet S, Jansen T, Dikalov S, Weyand C, Goronzy J, Harrison DG. Role of increased guanosine triphosphate cyclohydrolase-1 expression and tetrahydrobiopterin levels upon T cell activation. J. Biol. Chem [print-electronic]. 2011 Apr 4/22/2011; 286(16): 13846-51. PMID: 21343293, PMCID: PMC3077585, PII: M110.191023, DOI: 10.1074/jbc.M110.191023, ISSN: 1083-351X.

Marvar PJ, Lob H, Vinh A, Zarreen F, Harrison DG. The central nervous system and inflammation in hypertension. Curr Opin Pharmacol [print-electronic]. 2011 Apr; 11(2): 156-61. PMID: 21196131, PMCID: PMC3075423, PII: S1471-4892(10)00178-5, DOI: 10.1016/j.coph.2010.12.001, ISSN: 1471-4973.

McDaniel MC, Galbraith EM, Jeroudi AM, Kashlan OR, Eshtehardi P, Suo J, Dhawan S, Voeltz M, Devireddy C, Oshinski J, Harrison DG, Giddens DP, Samady H. Localization of culprit lesions in coronary arteries of patients with ST-segment elevation myocardial infarctions: relation to bifurcations and curvatures. Am. Heart J [print-electronic]. 2011 Mar; 161(3): 508-15. PMID: 21392605, PII: S0002-8703(10)01046-X, DOI: 10.1016/j.ahj.2010.11.005, ISSN: 1097-6744.

Harrison DG, Guzik TJ, Lob HE, Madhur MS, Marvar PJ, Thabet SR, Vinh A, Weyand CM. Inflammation, immunity, and hypertension. Hypertension [print-electronic]. 2011 Feb; 57(2): 132-40. PMID: 21149826, PMCID: PMC3028593, PII: HYPERTENSIONAHA.110.163576, DOI: 10.1161/HYPERTENSIONAHA.110.163576, ISSN: 1524-4563.

Vinh A, Chen W, Blinder Y, Weiss D, Taylor WR, Goronzy JJ, Weyand CM, Harrison DG, Guzik TJ. Inhibition and genetic ablation of the B7/CD28 T-cell costimulation axis prevents experimental hypertension. Circulation [print-electronic]. 2010 Dec 12/14/2010; 122(24): 2529-37. PMID: 21126972, PMCID: PMC3064430, PII: CIRCULATIONAHA.109.930446, DOI: 10.1161/CIRCULATIONAHA.109.930446, ISSN: 1524-4539.

Oshiro H, Iwai T, Hirota M, Mitsudo K, Tohnai I, Minamimoto R, Omura-Minamisawa M, Nagashima Y, Yamanaka S, Fukui T, Kanazawa M, Sagawa H, Mita K, Nakayama T, Inayama Y. Primary sebaceous carcinoma of the tongue. Med Mol Morphol [print-electronic]. 2010 Dec; 43(4): 246-52. PMID: 21267703, DOI: 10.1007/s00795-010-0521-4, ISSN: 1860-1499.

Dikalova AE, Góngora MC, Harrison DG, Lambeth JD, Dikalov S, Griendling KK. Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2010 Sep; 299(3): H673-9. PMID: 20639222, PMCID: PMC2944492, PII: ajpheart.00242.2010, DOI: 10.1152/ajpheart.00242.2010, ISSN: 1522-1539.

Schneider MP, Sullivan JC, Wach PF, Boesen EI, Yamamoto T, Fukai T, Harrison DG, Pollock DM, Pollock JS. Protective role of extracellular superoxide dismutase in renal ischemia/reperfusion injury. Kidney Int [print-electronic]. 2010 Aug; 78(4): 374-81. PMID: 20505656, PMCID: PMC3888358, PII: ki2010141, DOI: 10.1038/ki.2010.141, ISSN: 1523-1755.

Marvar PJ, Thabet SR, Guzik TJ, Lob HE, McCann LA, Weyand C, Gordon FJ, Harrison DG. Central and peripheral mechanisms of T-lymphocyte activation and vascular inflammation produced by angiotensin II-induced hypertension. Circ. Res [print-electronic]. 2010 Jul 7/23/2010; 107(2): 263-70. PMID: 20558826, PMCID: PMC2921936, PII: CIRCRESAHA.110.217299, DOI: 10.1161/CIRCRESAHA.110.217299, ISSN: 1524-4571.

Dikalova AE, Bikineyeva AT, Budzyn K, Nazarewicz RR, McCann L, Lewis W, Harrison DG, Dikalov SI. Therapeutic targeting of mitochondrial superoxide in hypertension. Circ. Res [print-electronic]. 2010 Jul 7/9/2010; 107(1): 106-16. PMID: 20448215, PMCID: PMC2901409, PII: CIRCRESAHA.109.214601, DOI: 10.1161/CIRCRESAHA.109.214601, ISSN: 1524-4571.

Kalogeropoulos A, Georgiopoulou V, Psaty BM, Rodondi N, Smith AL, Harrison DG, Liu Y, Hoffmann U, Bauer DC, Newman AB, Kritchevsky SB, Harris TB, Butler J, . Inflammatory markers and incident heart failure risk in older adults: the Health ABC (Health, Aging, and Body Composition) study. J. Am. Coll. Cardiol. 2010 May 5/11/2010; 55(19): 2129-37. PMID: 20447537, PMCID: PMC3267799, PII: S0735-1097(10)00865-X, DOI: 10.1016/j.jacc.2009.12.045, ISSN: 1558-3597.

Harrison DG, Vinh A, Lob H, Madhur MS. Role of the adaptive immune system in hypertension. Curr Opin Pharmacol [print-electronic]. 2010 Apr; 10(2): 203-7. PMID: 20167535, PMCID: PMC2843787, PII: S1471-4892(10)00007-X, DOI: 10.1016/j.coph.2010.01.006, ISSN: 1471-4973.

Gongora MC, Harrison DG. NO solution for a radical problem: a TAL story [editorial]. Am. J. Physiol. Renal Physiol [print-electronic]. 2010 Apr; 298(4): F883-4. PMID: 20130124, PII: 00023.2010, DOI: 10.1152/ajprenal.00023.2010, ISSN: 1522-1466.

Li L, Rezvan A, Salerno JC, Husain A, Kwon K, Jo H, Harrison DG, Chen W. GTP cyclohydrolase I phosphorylation and interaction with GTP cyclohydrolase feedback regulatory protein provide novel regulation of endothelial tetrahydrobiopterin and nitric oxide. Circ. Res [print-electronic]. 2010 Feb 2/5/2010; 106(2): 328-36. PMID: 19926872, PMCID: PMC2818799, PII: CIRCRESAHA.109.210658, DOI: 10.1161/CIRCRESAHA.109.210658, ISSN: 1524-4571.

Silberman GA, Fan TH, Liu H, Jiao Z, Xiao HD, Lovelock JD, Boulden BM, Widder J, Fredd S, Bernstein KE, Wolska BM, Dikalov S, Harrison DG, Dudley SC. Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction. Circulation [print-electronic]. 2010 Feb 2/2/2010; 121(4): 519-28. PMID: 20083682, PMCID: PMC2819317, PII: CIRCULATIONAHA.109.883777, DOI: 10.1161/CIRCULATIONAHA.109.883777, ISSN: 1524-4539.

Madhur MS, Lob HE, McCann LA, Iwakura Y, Blinder Y, Guzik TJ, Harrison DG. Interleukin 17 promotes angiotensin II-induced hypertension and vascular dysfunction. Hypertension [print-electronic]. 2010 Feb; 55(2): 500-7. PMID: 20038749, PMCID: PMC2819301, PII: HYPERTENSIONAHA.109.145094, DOI: 10.1161/HYPERTENSIONAHA.109.145094, ISSN: 1524-4563.

Lob HE, Marvar PJ, Guzik TJ, Sharma S, McCann LA, Weyand C, Gordon FJ, Harrison DG. Induction of hypertension and peripheral inflammation by reduction of extracellular superoxide dismutase in the central nervous system. Hypertension [print-electronic]. 2010 Feb; 55(2): 277-83, 6p following 283. PMID: 20008675, PMCID: PMC2813894, PII: HYPERTENSIONAHA.109.142646, DOI: 10.1161/HYPERTENSIONAHA.109.142646, ISSN: 1524-4563.

Harrison DG, Chen W, Dikalov S, Li L. Regulation of endothelial cell tetrahydrobiopterin pathophysiological and therapeutic implications. Adv. Pharmacol. 2010; 60: 107-32. PMID: 21081217, PII: B978-0-12-385061-4.00005-2, DOI: 10.1016/B978-0-12-385061-4.00005-2, ISSN: 1557-8925.

Nam D, Ni CW, Rezvan A, Suo J, Budzyn K, Llanos A, Harrison DG, Giddens DP, Jo H. A model of disturbed flow-induced atherosclerosis in mouse carotid artery by partial ligation and a simple method of RNA isolation from carotid endothelium. J Vis Exp. 2010; (40): PMID: 20613706, PMCID: PMC3153900, PII: 1861, DOI: 10.3791/1861, ISSN: 1940-087X.

Harrison DG, Gongora MC. Oxidative stress and hypertension. Med. Clin. North Am. 2009 May; 93(3): 621-35. PMID: 19427495, PII: S0025-7125(09)00030-3, DOI: 10.1016/j.mcna.2009.02.015, ISSN: 1557-9859.

Jones R, Baker MB, Weber M, Harrison DG, Bao G, Searles CD. Molecular beacons can assess changes in expression and 3'-polyadenylation of human eNOS mRNA. Am. J. Physiol., Cell Physiol [print-electronic]. 2009 Mar; 296(3): C498-504. PMID: 19109525, PMCID: PMC2660266, PII: 00462.2008, DOI: 10.1152/ajpcell.00462.2008, ISSN: 0363-6143.

Hoch NE, Guzik TJ, Chen W, Deans T, Maalouf SA, Gratze P, Weyand C, Harrison DG. Regulation of T-cell function by endogenously produced angiotensin II. Am. J. Physiol. Regul. Integr. Comp. Physiol [print-electronic]. 2009 Feb; 296(2): R208-16. PMID: 19073907, PMCID: PMC2643984, PII: 90521.2008, DOI: 10.1152/ajpregu.90521.2008, ISSN: 0363-6119.

Guzik TJ, Chen W, Gongora MC, Guzik B, Lob HE, Mangalat D, Hoch N, Dikalov S, Rudzinski P, Kapelak B, Sadowski J, Harrison DG. Calcium-dependent NOX5 nicotinamide adenine dinucleotide phosphate oxidase contributes to vascular oxidative stress in human coronary artery disease. J. Am. Coll. Cardiol. 2008 Nov 11/25/2008; 52(22): 1803-9. PMID: 19022160, PMCID: PMC2593790, PII: S0735-1097(08)03057-X, DOI: 10.1016/j.jacc.2008.07.063, ISSN: 1558-3597.

Inoue N, Ohara Y, Fukai T, Harrison DG, Nishida K. Probucol improves endothelial-dependent relaxation and decreases vascular superoxide production in cholesterol-fed rabbits. Am. J. Med. Sci. 1998 Apr; 315(4): 242-7. PMID: 9537638, ISSN: 0002-9629.

Venema RC, Sayegh HS, Kent JD, Harrison DG. Identification, characterization, and comparison of the calmodulin-binding domains of the endothelial and inducible nitric oxide synthases. J. Biol. Chem. 1996 Mar 3/15/1996; 271(11): 6435-40. PMID: 8626444, ISSN: 0021-9258.

Harrison DG, Sayegh H, Ohara Y, Inoue N, Venema RC. Regulation of expression of the endothelial cell nitric oxide synthase. Clin. Exp. Pharmacol. Physiol. 1996 Mar; 23(3): 251-5. PMID: 8934617, ISSN: 0305-1870.

Uematsu M, Ohara Y, Navas JP, Nishida K, Murphy TJ, Alexander RW, Nerem RM, Harrison DG. Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress. Am. J. Physiol. 1995 Dec; 269(6 Pt 1): C1371-8. PMID: 8572165, ISSN: 0002-9513.

Ohara Y, Peterson TE, Sayegh HS, Subramanian RR, Wilcox JN, Harrison DG. Dietary correction of hypercholesterolemia in the rabbit normalizes endothelial superoxide anion production. Circulation. 1995 Aug 8/15/1995; 92(4): 898-903. PMID: 7641372, ISSN: 0009-7322.

Inoue N, Venema RC, Sayegh HS, Ohara Y, Murphy TJ, Harrison DG. Molecular regulation of the bovine endothelial cell nitric oxide synthase by transforming growth factor-beta 1. Arterioscler. Thromb. Vasc. Biol. 1995 Aug; 15(8): 1255-61. PMID: 7543000, ISSN: 1079-5642.

James NL, Harrison DG, Nerem RM. Effects of shear on endothelial cell calcium in the presence and absence of ATP. FASEB J. 1995 Jul; 9(10): 968-73. PMID: 7615166, ISSN: 0892-6638.

Venema RC, Sayegh HS, Arnal JF, Harrison DG. Role of the enzyme calmodulin-binding domain in membrane association and phospholipid inhibition of endothelial nitric oxide synthase. J. Biol. Chem. 1995 Jun 6/16/1995; 270(24): 14705-11. PMID: 7540177, ISSN: 0021-9258.

Münzel T, Giaid A, Kurz S, Stewart DJ, Harrison DG. Evidence for a role of endothelin 1 and protein kinase C in nitroglycerin tolerance. Proc. Natl. Acad. Sci. U.S.A. 1995 May 5/23/1995; 92(11): 5244-8. PMID: 7539147, PMCID: PMC41885, ISSN: 0027-8424.

Ohara Y, Sayegh HS, Yamin JJ, Harrison DG. Regulation of endothelial constitutive nitric oxide synthase by protein kinase C. Hypertension. 1995 Mar; 25(3): 415-20. PMID: 7533140, ISSN: 0194-911X.

Supari F, Ungerer T, Harrison DG, Williams JK. Fish oil treatment decreases superoxide anions in the myocardium and coronary arteries of atherosclerotic monkeys. Circulation. 1995 Feb 2/15/1995; 91(4): 1123-8. PMID: 7850950, ISSN: 0009-7322.

Münzel T, Sayegh H, Freeman BA, Tarpey MM, Harrison DG. Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance. J. Clin. Invest. 1995 Jan; 95(1): 187-94. PMID: 7814613, PMCID: PMC295403, DOI: 10.1172/JCI117637, ISSN: 0021-9738.

Harrison DG, Venema RC, Arnal JF, Inoue N, Ohara Y, Sayegh H, Murphy TJ. The endothelial cell nitric oxide synthase: is it really constitutively expressed?. Agents Actions Suppl. 1995; 45: 107-17. PMID: 7536382, ISSN: 0379-0363.

Arnal JF, Yamin J, Dockery S, Harrison DG. Regulation of endothelial nitric oxide synthase mRNA, protein, and activity during cell growth. Am. J. Physiol. 1994 Nov; 267(5 Pt 1): C1381-8. PMID: 7526698, ISSN: 0002-9513.

Venema RC, Nishida K, Alexander RW, Harrison DG, Murphy TJ. Organization of the bovine gene encoding the endothelial nitric oxide synthase. Biochim. Biophys. Acta. 1994 Aug 8/2/1994; 1218(3): 413-20. PMID: 7519447, ISSN: 0006-3002.

Ohara Y, Peterson TE, Zheng B, Kuo JF, Harrison DG. Lysophosphatidylcholine increases vascular superoxide anion production via protein kinase C activation. Arterioscler. Thromb. 1994 Jun; 14(6): 1007-13. PMID: 7515277, ISSN: 1049-8834.

Lamping KG, Bloom EN, Harrison DG. Regulation of native collateral vessel dilation after coronary occlusion in the dog. Am. J. Physiol. 1994 Feb; 266(2 Pt 2): H769-78. PMID: 8141378, ISSN: 0002-9513.

Wheatley RM, Dockery SP, Kurz MA, Sayegh HS, Harrison DG. Interactions of nitroglycerin and sulfhydryl-donating compounds in coronary microvessels. Am. J. Physiol. 1994 Jan; 266(1 Pt 2): H291-7. PMID: 8304511, ISSN: 0002-9513.

Delafontaine P, Lou H, Harrison DG, Bernstein KE. Sequence of a cDNA encoding dog insulin-like growth factor I. Gene. 1993 Aug 8/25/1993; 130(2): 305-6. PMID: 8359700, ISSN: 0378-1119.

Kurz MA, Boyer TD, Whalen R, Peterson TE, Harrison DG. Nitroglycerin metabolism in vascular tissue: role of glutathione S-transferases and relationship between NO. and NO2- formation. Biochem. J. 1993 Jun 6/1/1993; 292 ( Pt 2): 545-50. PMID: 8503888, PMCID: PMC1134244, ISSN: 0264-6021.

Ohara Y, Peterson TE, Harrison DG. Hypercholesterolemia increases endothelial superoxide anion production. J. Clin. Invest. 1993 Jun; 91(6): 2546-51. PMID: 8390482, PMCID: PMC443316, DOI: 10.1172/JCI116491, ISSN: 0021-9738.

Harrison DG, Bates JN. The nitrovasodilators. New ideas about old drugs. Circulation. 1993 May; 87(5): 1461-7. PMID: 8491000, ISSN: 0009-7322.

Nishida K, Harrison DG, Navas JP, Fisher AA, Dockery SP, Uematsu M, Nerem RM, Alexander RW, Murphy TJ. Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase. J. Clin. Invest. 1992 Nov; 90(5): 2092-6. PMID: 1385480, PMCID: PMC443276, DOI: 10.1172/JCI116092, ISSN: 0021-9738.

Harrison DG, Kurz MA, Quillen JE, Sellke FW, Mügge A. Normal and pathophysiologic considerations of endothelial regulation of vascular tone and their relevance to nitrate therapy. Am. J. Cardiol. 1992 Sep 9/24/1992; 70(8): 11B-17B. PMID: 1529921, ISSN: 0002-9149.

Myers PR, Guerra R, Harrison DG. Release of multiple endothelium-derived relaxing factors from porcine coronary arteries. J. Cardiovasc. Pharmacol. 1992 Sep; 20(3): 392-400. PMID: 1279283, ISSN: 0160-2446.

Münzel T, Mülsch A, Holtz J, Just H, Harrison DG, Bassenge E. Mechanisms of interaction between the sulfhydryl precursor L-methionine and glyceryl trinitrate. Circulation. 1992 Sep; 86(3): 995-1003. PMID: 1355413, ISSN: 0009-7322.

Quillen JE, Harrison DG. Vasomotor properties of porcine endocardial and epicardial microvessels. Am. J. Physiol. 1992 Apr; 262(4 Pt 2): H1143-8. PMID: 1566896, ISSN: 0002-9513.

Bates JN, Baker MT, Guerra R, Harrison DG. Nitric oxide generation from nitroprusside by vascular tissue. Evidence that reduction of the nitroprusside anion and cyanide loss are required. Biochem. Pharmacol. 1991 Dec 12/11/1991; 42 Suppl: S157-65. PMID: 1768273, ISSN: 0006-2952.

Komaru T, Lamping KG, Eastham CL, Harrison DG, Marcus ML, Dellsperger KC. Effect of an arginine analogue on acetylcholine-induced coronary microvascular dilatation in dogs. Am. J. Physiol. 1991 Dec; 261(6 Pt 2): H2001-7. PMID: 1750548, ISSN: 0002-9513.

Mügge A, Elwell JH, Peterson TE, Hofmeyer TG, Heistad DD, Harrison DG. Chronic treatment with polyethylene-glycolated superoxide dismutase partially restores endothelium-dependent vascular relaxations in cholesterol-fed rabbits. Circ. Res. 1991 Nov; 69(5): 1293-300. PMID: 1934359, ISSN: 0009-7330.

Tomanek RJ, Wessel TJ, Harrison DG. Capillary growth and geometry during long-term hypertension and myocardial hypertrophy in dogs. Am. J. Physiol. 1991 Oct; 261(4 Pt 2): H1011-8. PMID: 1833986, ISSN: 0002-9513.

Harrison DG, Treasure CB, Mügge A, Dellsperger KC, Lamping KG. Hypertension and the coronary circulation. With special attention to endothelial regulation. Am. J. Hypertens. 1991 Jul; 4(7 Pt 2): 454S-459S. PMID: 1910638, ISSN: 0895-7061.

Sellke FW, Tomanek RJ, Harrison DG. L-cysteine selectively potentiates nitroglycerin-induced dilation of small coronary microvessels. J. Pharmacol. Exp. Ther. 1991 Jul 7/1/1991; 258(1): 365-9. PMID: 1906539, ISSN: 0022-3565.

Harrison DG, Marcus ML, Dellsperger KC, Lamping KG, Tomanek RJ. Pathophysiology of myocardial perfusion in hypertension. Circulation. 1991 May; 83(5 Suppl): III14-8. PMID: 1827058, ISSN: 0009-7322.

Quillen JE, Sellke FW, Armstrong ML, Harrison DG. Long-term cholesterol feeding alters the reactivity of primate coronary microvessels to platelet products. Arterioscler. Thromb. 1991 May; 11(3): 639-44. PMID: 2029502, ISSN: 1049-8834.

Harrison DG, Simonetti I. Neurohumoral regulation of collateral perfusion. Circulation. 1991 May; 83(5 Suppl): III62-7. PMID: 1673648, ISSN: 0009-7322.

Mügge A, Peterson T, Harrison DG. Release of nitrogen oxides from cultured bovine aortic endothelial cells is not impaired by calcium channel antagonists. Circulation. 1991 Apr; 83(4): 1404-9. PMID: 1707354, ISSN: 0009-7322.

Kurz MA, Lamping KG, Bates JN, Eastham CL, Marcus ML, Harrison DG. Mechanisms responsible for the heterogeneous coronary microvascular response to nitroglycerin. Circ. Res. 1991 Mar; 68(3): 847-55. PMID: 1742870, ISSN: 0009-7330.

Myers PR, Banitt PF, Guerra R, Harrison DG. Role of the endothelium in modulation of the acetylcholine vasoconstrictor response in porcine coronary microvessels. Cardiovasc. Res. 1991 Feb; 25(2): 129-37. PMID: 1742764, ISSN: 0008-6363.

Mügge A, Elwell JH, Peterson TE, Harrison DG. Release of intact endothelium-derived relaxing factor depends on endothelial superoxide dismutase activity. Am. J. Physiol. 1991 Feb; 260(2 Pt 1): C219-25. PMID: 1847583, ISSN: 0002-9513.

Bates JN, Harrison DG, Myers PR, Minor RL. EDRF: nitrosylated compound or authentic nitric oxide. Basic Res. Cardiol. 1991; 86 Suppl 2: 17-26. PMID: 1953608, ISSN: 0300-8428.

Mügge A, Harrison DG. L-arginine does not restore endothelial dysfunction in atherosclerotic rabbit aorta in vitro. Blood Vessels. 1991; 28(5): 354-7. PMID: 1912602, ISSN: 0303-6847.

Minor RL, Myers PR, Guerra R, Bates JN, Harrison DG. Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta. J. Clin. Invest. 1990 Dec; 86(6): 2109-16. PMID: 2254462, PMCID: PMC329851, DOI: 10.1172/JCI114949, ISSN: 0021-9738.

Cappelli-Bigazzi M, Lamping KG, Nuno DW, Harrison DG. Leukocyte and platelet-derived factors augment canine coronary constriction to serotonin. Am. J. Physiol. 1990 Oct; 259(4 Pt 2): H1161-70. PMID: 2171364, ISSN: 0002-9513.

Quillen JE, Sellke FW, Brooks LA, Harrison DG. Ischemia-reperfusion impairs endothelium-dependent relaxation of coronary microvessels but does not affect large arteries. Circulation. 1990 Aug; 82(2): 586-94. PMID: 2372905, ISSN: 0009-7322.

Murphy S, Minor RL, Welk G, Harrison DG. Evidence for an astrocyte-derived vasorelaxing factor with properties similar to nitric oxide. J. Neurochem. 1990 Jul; 55(1): 349-51. PMID: 2113082, ISSN: 0022-3042.

Sellke FW, Quillen JE, Brooks LA, Harrison DG. Endothelial modulation of the coronary vasculature in vessels perfused via mature collaterals. Circulation. 1990 Jun; 81(6): 1938-47. PMID: 2111743, ISSN: 0009-7322.

Myers PR, Minor RL, Guerra R, Bates JN, Harrison DG. Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide. Nature. 1990 May 5/10/1990; 345(6271): 161-3. PMID: 2110626, DOI: 10.1038/345161a0, ISSN: 0028-0836.

Sellke FW, Armstrong ML, Harrison DG. Endothelium-dependent vascular relaxation is abnormal in the coronary microcirculation of atherosclerotic primates. Circulation. 1990 May; 81(5): 1586-93. PMID: 2110036, ISSN: 0009-7322.

Sellke FW, Myers PR, Bates JN, Harrison DG. Influence of vessel size on the sensitivity of porcine coronary microvessels to nitroglycerin. Am. J. Physiol. 1990 Feb; 258(2 Pt 2): H515-20. PMID: 2106798, ISSN: 0002-9513.

Armstrong ML, Heistad DD, Megan MB, Lopez JA, Harrison DG. Reversibility of atherosclerosis. Cardiovasc Clin. 1990; 20(3): 113-26. PMID: 2186855, ISSN: 0069-0384.

Harrison DG, Sellke FW, Quillen JE. Neurohumoral regulation of coronary collateral vasomotor tone. Basic Res. Cardiol. 1990; 85 Suppl 1: 121-9. PMID: 1982607, ISSN: 0300-8428.

Feldman RD, Christy JP, Paul ST, Harrison DG. Beta-adrenergic receptors on canine coronary collateral vessels: characterization and function. Am. J. Physiol. 1989 Nov; 257(5 Pt 2): H1634-9. PMID: 2574008, ISSN: 0002-9513.

Lopez JA, Armstrong ML, Harrison DG, Piegors DJ, Heistad DD. Vascular responses to leukocyte products in atherosclerotic primates. Circ. Res. 1989 Oct; 65(4): 1078-86. PMID: 2507195, ISSN: 0009-7330.

Tomanek RJ, Schalk KA, Marcus ML, Harrison DG. Coronary angiogenesis during long-term hypertension and left ventricular hypertrophy in dogs. Circ. Res. 1989 Aug; 65(2): 352-9. PMID: 2473855, ISSN: 0009-7330.

Myers PR, Banitt PF, Guerra R, Harrison DG. Characteristics of canine coronary resistance arteries: importance of endothelium. Am. J. Physiol. 1989 Aug; 257(2 Pt 2): H603-10. PMID: 2788367, ISSN: 0002-9513.

Peters KG, Marcus ML, Harrison DG. Vasopressin and the mature coronary collateral circulation. Circulation. 1989 Jun; 79(6): 1324-31. PMID: 2720931, ISSN: 0009-7322.

Myers PR, Guerra R, Harrison DG. Release of NO and EDRF from cultured bovine aortic endothelial cells. Am. J. Physiol. 1989 Apr; 256(4 Pt 2): H1030-7. PMID: 2784944, ISSN: 0002-9513.

Guerra R, Brotherton AF, Goodwin PJ, Clark CR, Armstrong ML, Harrison DG. Mechanisms of abnormal endothelium-dependent vascular relaxation in atherosclerosis: implications for altered autocrine and paracrine functions of EDRF. Blood Vessels. 1989; 26(5): 300-14. PMID: 2576820, ISSN: 0303-6847.

Lopez JA, Armstrong ML, Harrison DG, Piegors DJ, Heistad DD. Responsiveness of iliac collateral vessels to constrictor stimuli in atherosclerotic primates. Circ. Res. 1988 Dec; 63(6): 1020-8. PMID: 3197270, ISSN: 0009-7330.

Marcus ML, Harrison DG, White CW, McPherson DD, Wilson RF, Kerber RE. Assessing the physiologic significance of coronary obstructions in patients: importance of diffuse undetected atherosclerosis. Prog Cardiovasc Dis. 1988 Jul; 31(1): 39-56. PMID: 3293119, PII: 0033-0620(88)90010-2, ISSN: 0033-0620.

Harrison DG, Florentine MS, Brooks LA, Cooper SM, Marcus ML. The effect of hypertension and left ventricular hypertrophy on the lower range of coronary autoregulation. Circulation. 1988 May; 77(5): 1108-15. PMID: 2966018, ISSN: 0009-7322.

Marcus ML, Skorton DJ, Johnson MR, Collins SM, Harrison DG, Kerber RE. Visual estimates of percent diameter coronary stenosis: "a battered gold standard". J. Am. Coll. Cardiol. 1988 Apr; 11(4): 882-5. PMID: 3280642, PII: 0735-1097(88)90226-4, ISSN: 0735-1097.

Gumm DC, Cooper SM, Thompson SB, Marcus ML, Harrison DG. Influence of risk area size and location on native collateral resistance and ischemic zone perfusion. Am. J. Physiol. 1988 Mar; 254(3 Pt 2): H473-80. PMID: 3348425, ISSN: 0002-9513.

Harrison DG, Armstrong ML, Freiman PC, Heistad DD. Restoration of endothelium-dependent relaxation by dietary treatment of atherosclerosis. J. Clin. Invest. 1987 Dec; 80(6): 1808-11. PMID: 3680531, PMCID: PMC442458, DOI: 10.1172/JCI113276, ISSN: 0021-9738.

Inou T, Lamberth WC, Koyanagi S, Harrison DG, Eastham CL, Marcus ML. Relative importance of hypertension after coronary occlusion in chronic hypertensive dogs with LVH. Am. J. Physiol. 1987 Nov; 253(5 Pt 2): H1148-58. PMID: 2961280, ISSN: 0002-9513.

Harrison DG, Freiman PC, Armstrong ML, Marcus ML, Heistad DD. Alterations of vascular reactivity in atherosclerosis. Circ. Res. 1987 Nov; 61(5 Pt 2): II74-80. PMID: 2822287, ISSN: 0009-7330.

Heistad DD, Harrison DG, Armstrong ML. Serotonin and experimental vascular disease. Int. J. Cardiol. 1987 Feb; 14(2): 205-12. PMID: 3818136, ISSN: 0167-5273.

Marcus ML, Harrison DG, Chilian WM, Koyanagi S, Inou T, Tomanek RJ, Martins JB, Eastham CL, Hiratzka LF. Alterations in the coronary circulation in hypertrophied ventricles. Circulation. 1987 Jan; 75(1 Pt 2): I19-25. PMID: 2947748, ISSN: 0009-7322.

Marcus ML, Hiratzka LF, Doty DB, Wright CB, Harrison DG, White CW. Coronary obstructive lesions: assessing their physiological significance in humans. Ann. Thorac. Surg. 1986 Dec; 42(6 Suppl): S5-8. PMID: 3789872, ISSN: 0003-4975.

Harrison DG, Chapman MP, Christy JP, Marcus ML. Studies of functional site of origin of native coronary collaterals. Am. J. Physiol. 1986 Dec; 251(6 Pt 2): H1217-24. PMID: 3789176, ISSN: 0002-9513.

Harrison DG, Chilian WM, Marcus ML. Absence of functioning alpha-adrenergic receptors in mature canine coronary collaterals. Circ. Res. 1986 Aug; 59(2): 133-42. PMID: 2874899, ISSN: 0009-7330.

Marcus ML, Harrison DG, White CW, Hiratzka LF. Assessing the physiological significance of coronary obstruction in man. Can J Cardiol. 1986 Jul; Suppl A: 195A-199A. PMID: 3756587, ISSN: 0828-282X.

Freiman PC, Mitchell GG, Heistad DD, Armstrong ML, Harrison DG. Atherosclerosis impairs endothelium-dependent vascular relaxation to acetylcholine and thrombin in primates. Circ. Res. 1986 Jun; 58(6): 783-9. PMID: 3087655, ISSN: 0009-7330.

Johnson MR, Brayden GP, Ericksen EE, Collins SM, Skorton DJ, Harrison DG, Marcus ML, White CW. Changes in cross-sectional area of the coronary lumen in the six months after angioplasty: a quantitative analysis of the variable response to percutaneous transluminal angioplasty. Circulation. 1986 Mar; 73(3): 467-75. PMID: 2936530, ISSN: 0009-7322.

Marcus ML, Hiratzka LF, White CW, Harrison DG, Eastham CL, Kerber RE. Application of Doppler technology to studies of the coronary circulation. Cardiovasc Clin. 1986; 17(1): 33-43. PMID: 2945638, ISSN: 0069-0384.

Chilian WM, Harrison DG, Haws CW, Snyder WD, Marcus ML. Adrenergic coronary tone during submaximal exercise in the dog is produced by circulating catecholamines. Evidence for adrenergic denervation supersensitivity in the myocardium but not in coronary vessels. Circ. Res. 1986 Jan; 58(1): 68-82. PMID: 3002658, ISSN: 0009-7330.

Roberts N, Harrison DG, Reimer KA, Crain BS, Wagner GS. Right ventricular infarction with shock but without significant left ventricular infarction: a new clinical syndrome. Am. Heart J. 1985 Nov; 110(5): 1047-53. PMID: 4061257, ISSN: 0002-8703.

Harrison DG, Barnes DH, Hiratzka LF, Eastham CL, Kerber RE, Marcus ML. The effect of cardiac hypertrophy on the coronary collateral circulation. Circulation. 1985 Jun; 71(6): 1135-45. PMID: 3158452, ISSN: 0009-7322.

Harrison DG, White CW, Hiratzka LF, Doty DB, Barnes DH, Eastham CL, Marcus ML. The value of lesion cross-sectional area determined by quantitative coronary angiography in assessing the physiologic significance of proximal left anterior descending coronary arterial stenoses. Circulation. 1984 Jun; 69(6): 1111-9. PMID: 6713615, ISSN: 0009-7322.

Harrison DG, Ferguson DW, Collins SM, Skorton DJ, Ericksen EE, Kioschos JM, Marcus ML, White CW. Rethrombosis after reperfusion with streptokinase: importance of geometry of residual lesions. Circulation. 1984 May; 69(5): 991-9. PMID: 6705173, ISSN: 0009-7322.

White CW, Wright CB, Doty DB, Hiratza LF, Eastham CL, Harrison DG, Marcus ML. Does visual interpretation of the coronary arteriogram predict the physiologic importance of a coronary stenosis?. N. Engl. J. Med. 1984 Mar 3/29/1984; 310(13): 819-24. PMID: 6700670, DOI: 10.1056/NEJM198403293101304, ISSN: 0028-4793.

Anderson CI, Harrison DG, Stack NC, Hindman NB, Ideker RE, Palmeri ST, Selvester RH, Wagner GS. Evaluation of serial QRS changes during acute inferior myocardial infarction using a QRS scoring system. Am. J. Cardiol. 1983 Aug; 52(3): 252-6. PMID: 6869269, PII: 0002-9149(83)90117-0, ISSN: 0002-9149.

Koyanagi S, Eastham CL, Harrison DG, Marcus ML. Transmural variation in the relationship between myocardial infarct size and risk area. Am. J. Physiol. 1982 May; 242(5): H867-74. PMID: 6282144, ISSN: 0002-9513.

Baker JT, Bramlet DA, Lester RM, Harrison DG, Roe CR, Cobb FR. Myocardial infarct extension: incidence and relationship to survival. Circulation. 1982 May; 65(5): 918-23. PMID: 7074753, ISSN: 0009-7322.

Palmeri ST, Harrison DG, Cobb FR, Morris KG, Harrell FE, Ideker RE, Selvester RH, Wagner GS. A QRS scoring system for assessing left ventricular function after myocardial infarction. N. Engl. J. Med. 1982 Jan 1/7/1982; 306(1): 4-9. PMID: 7053469, DOI: 10.1056/NEJM198201073060102, ISSN: 0028-4793.

Koyanagi S, Eastham CL, Harrison DG, Marcus ML. Increased size of myocardial infarction in dogs with chronic hypertension and left ventricular hypertrophy. Circ. Res. 1982 Jan; 50(1): 55-62. PMID: 6459194, ISSN: 0009-7330.