Lori Chaffin Jordan, M.D., Ph.D.

Associate Professor


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Faculty Appointments
Associate Professor of Pediatrics
Ph.D., Johns Hopkins University, Baltimore, MarylandM.D., University of Oklahoma Health Science Center, Oklahoma City, OklahomaB.S., College of William & Mary, Williamsburg, Virginia
Office Address
2200 Children's Way, DOT 11242
Nashville, TN 37232
Research Description
I direct the pediatric stroke program at Vanderbilt University and previously directed a similar program at Johns Hopkins University. My research focuses on predicting and improving outcome after hemorrhagic and ischemic stroke in children and young adults. Our lab focuses on brain imaging, cerebral autoregulation and on outcome assessment in children with stroke. I am a co-investigator in the International Pediatric Stroke Study and several other multicenter NIH funded trials in children with stroke, including Vascular Effects of Infection in Pediatric Stroke, the Silent Infarct Transfusion Trial and study of hydroxyurea for primary stroke prevention in young children. I have a PhD in clinical investigation from the Johns Hopkins Bloomberg School of Public Health. **NOTE: FULL AT THIS TIME FOR UNDERGRADUATE RESEARCH 8.1.16”

Research Keywords
Pediatric ischemic and hemorrhagic stroke clinical research
Grelli KN, Gindville MC, Walker CH, Jordan LC. Association of Blood Pressure, Blood Glucose, and Temperature With Neurological Outcome After Childhood Stroke. JAMA Neurol. 2016 Jul 7/1/2016; 73(7): 829-35. PMID: 27214847, PII: 2524245, DOI: 10.1001/jamaneurol.2016.0992, ISSN: 2168-6157.

Hawks C, Jordan LC, Gindville M, Ichord RN, Licht DJ, Beslow LA. Educational Placement After Pediatric Intracerebral Hemorrhage. Pediatr. Neurol [print-electronic]. 2016 May 5/10/2016; PMID: 27262667, PII: S0887-8994(16)30095-9, DOI: 10.1016/j.pediatrneurol.2016.05.004, ISSN: 1873-5150.

Kassim AA, Pruthi S, Day M, Rodeghier M, Gindville MC, Brodsky MA, DeBaun MR, Jordan LC. Silent cerebral infarcts and cerebral aneurysms are prevalent in adults with sickle cell anemia [letter]. Blood [print-electronic]. 2016 Apr 4/21/2016; 127(16): 2038-40. PMID: 26941400, PII: blood-2016-01-694562, DOI: 10.1182/blood-2016-01-694562, ISSN: 1528-0020.

Ladner TR, Donahue MJ, Arteaga DF, Faraco CC, Roach BA, Davis LT, Jordan LC, Froehler MT, Strother MK. Prior Infarcts, Reactivity, and Angiography in Moyamoya Disease (PIRAMD): a scoring system for moyamoya severity based on multimodal hemodynamic imaging. J. Neurosurg [print-electronic]. 2016 Mar 3/11/2016; 1-9. PMID: 26967789, DOI: 10.3171/2015.11.JNS15562, ISSN: 1933-0693.

Adil MM, Beslow LA, Qureshi AI, Malik AA, Jordan LC. Hypertension is Associated With Increased Mortality in Children Hospitalized With Arterial Ischemic Stroke. Pediatr. Neurol [print-electronic]. 2016 Mar; 56: 25-9. PMID: 26746784, PII: S0887-8994(15)30089-8, DOI: 10.1016/j.pediatrneurol.2015.11.002, ISSN: 1873-5150.

Jordan LC, Gindville MC, Scott AO, Juttukonda MR, Strother MK, Kassim AA, Chen SC, Lu H, Pruthi S, Shyr Y, Donahue MJ. Non-invasive imaging of oxygen extraction fraction in adults with sickle cell anaemia. Brain [print-electronic]. 2016 Mar; 139(Pt 3): 738-50. PMID: 26823369, PII: awv397, DOI: 10.1093/brain/awv397, ISSN: 1460-2156.

Faraco CC, Strother MK, Siero JC, Arteaga DF, Scott AO, Jordan LC, Donahue MJ. The cumulative influence of hyperoxia and hypercapnia on blood oxygenation and R*2. J. Cereb. Blood Flow Metab [print-electronic]. 2015 Dec; 35(12): 2032-42. PMID: 26174329, PMCID: PMC4671125, PII: jcbfm2015168, DOI: 10.1038/jcbfm.2015.168, ISSN: 1559-7016.

Ladner TR, He L, Jordan LC, Cooper C, Froehler MT, Mocco J. Mechanical thrombectomy for acute stroke in childhood: how much does restricted diffusion matter?. J Neurointerv Surg [print-electronic]. 2015 Dec; 7(12): e40. PMID: 25406473, PII: neurintsurg-2014-011465.rep, DOI: 10.1136/neurintsurg-2014-011465.rep, ISSN: 1759-8486.

He L, Ladner TR, Pruthi S, Day MA, Desai AA, Jordan LC, Froehler MT. Rule of 5: angiographic diameters of cervicocerebral arteries in children and compatibility with adult neurointerventional devices. J Neurointerv Surg [print-electronic]. 2015 Nov 11/6/2015; PMID: 26546602, PII: neurintsurg-2015-012034, DOI: 10.1136/neurintsurg-2015-012034, ISSN: 1759-8486.

Desai AA, Strother MK, Faraco CC, Morgan VL, Ladner TR, Dethrage LM, Jordan LC, Donahue MJ. The Contribution of Common Surgically Implanted Hardware to Functional MR Imaging Artifacts. AJNR Am J Neuroradiol [print-electronic]. 2015 Nov; 36(11): 2068-73. PMID: 26272973, PMCID: PMC4644697, PII: ajnr.A4419, DOI: 10.3174/ajnr.A4419, ISSN: 1936-959X.

Murphy LK, Compas BE, Reeslund KL, Gindville MC, Mah ML, Markham LW, Jordan LC. Cognitive and attentional functioning in adolescents and young adults with Tetralogy of Fallot and d-transposition of the great arteries. Child Neuropsychol [print-electronic]. 2015 Sep 9/20/2015; 1-12. PMID: 26388325, PMCID: PMC4800023, DOI: 10.1080/09297049.2015.1087488, ISSN: 1744-4136.

Ladner TR, Mahdi J, Gindville MC, Gordon A, Harris ZL, Crossman K, Pruthi S, Abramo TJ, Jordan LC. Pediatric Acute Stroke Protocol Activation in a Children's Hospital Emergency Department. Stroke [print-electronic]. 2015 Aug; 46(8): 2328-31. PMID: 26138119, PII: STROKEAHA.115.009961, DOI: 10.1161/STROKEAHA.115.009961, ISSN: 1524-4628.

Adil MM, Qureshi AI, Beslow LA, Malik AA, Jordan LC. Factors Associated With Increased In-Hospital Mortality Among Children With Intracerebral Hemorrhage. J. Child Neurol [print-electronic]. 2015 Jul; 30(8): 1024-8. PMID: 25348418, PMCID: PMC4411178, PII: 0883073814552191, DOI: 10.1177/0883073814552191, ISSN: 1708-8283.

Ladner TR, Mahdi J, Attia A, Froehler MT, Le TM, Lorinc AN, Mocco J, Naftel RP, Newton AT, Pruthi S, Tenenholz T, Vance EH, Wushensky CA, Wellons JC, Jordan LC. A multispecialty pediatric neurovascular conference: a model for interdisciplinary management of complex disease. Pediatr. Neurol [print-electronic]. 2015 Feb; 52(2): 165-73. PMID: 25693581, PII: S0887-8994(14)00608-0, DOI: 10.1016/j.pediatrneurol.2014.10.010, ISSN: 1873-5150.

Jordan LC. Thrombolytics for acute stroke in children: eligibility, practice variability, and pediatric stroke centers. Dev Med Child Neurol [print-electronic]. 2015 Feb; 57(2): 115-6. PMID: 25312683, DOI: 10.1111/dmcn.12604, ISSN: 1469-8749.

Jordan LC, Ichord RN, Reinhartz O, Humpl T, Pruthi S, Tjossem C, Rosenthal DN. Neurological complications and outcomes in the Berlin Heart EXCOR® pediatric investigational device exemption trial. J Am Heart Assoc. 2015 Jan; 4(1): e001429. PMID: 25613996, PMCID: PMC4330068, PII: jah3824, DOI: 10.1161/JAHA.114.001429, ISSN: 2047-9980.

Sinclair AJ, Fox CK, Ichord RN, Almond CS, Bernard TJ, Beslow LA, Chan AK, Cheung M, deVeber G, Dowling MM, Friedman N, Giglia TM, Guilliams KP, Humpl T, Licht DJ, Mackay MT, Jordan LC. Stroke in children with cardiac disease: report from the International Pediatric Stroke Study Group Symposium. Pediatr. Neurol [print-electronic]. 2015 Jan; 52(1): 5-15. PMID: 25532775, PMCID: PMC4936915, PII: S0887-8994(14)00590-6, DOI: 10.1016/j.pediatrneurol.2014.09.016, ISSN: 1873-5150.

Ahn AK, Honeybrook A, Jordan LC, Singer RJ, Tylor DA. Stroke after adenotonsillectomy in patients with undiagnosed moyamoya syndrome. JAMA Otolaryngol Head Neck Surg. 2014 Nov; 140(11): 1061-4. PMID: 25257069, PII: 1906229, DOI: 10.1001/jamaoto.2014.1990, ISSN: 2168-619X.

Lee JK, Brady KM, Chung SE, Jennings JM, Whitaker EE, Aganga D, Easley RB, Heitmiller K, Jamrogowicz JL, Larson AC, Lee JH, Jordan LC, Hogue CW, Lehmann CU, Bembea MM, Hunt EA, Koehler RC, Shaffner DH. A pilot study of cerebrovascular reactivity autoregulation after pediatric cardiac arrest. Resuscitation [print-electronic]. 2014 Oct; 85(10): 1387-93. PMID: 25046743, PMCID: PMC4164565, PII: S0300-9572(14)00649-2, DOI: 10.1016/j.resuscitation.2014.07.006, ISSN: 1873-1570.

Arteaga DF, Strother MK, Faraco CC, Jordan LC, Ladner TR, Dethrage LM, Singer RJ, Mocco J, Clemmons PF, Ayad MJ, Donahue MJ. The vascular steal phenomenon is an incomplete contributor to negative cerebrovascular reactivity in patients with symptomatic intracranial stenosis. J. Cereb. Blood Flow Metab [print-electronic]. 2014 Sep; 34(9): 1453-62. PMID: 24917040, PMCID: PMC4158662, PII: jcbfm2014106, DOI: 10.1038/jcbfm.2014.106, ISSN: 1559-7016.

Donahue MJ, Dethrage LM, Faraco CC, Jordan LC, Clemmons P, Singer R, Mocco J, Shyr Y, Desai A, O'Duffy A, Riebau D, Hermann L, Connors J, Kirshner H, Strother MK. Routine clinical evaluation of cerebrovascular reserve capacity using carbogen in patients with intracranial stenosis. Stroke [print-electronic]. 2014 Aug; 45(8): 2335-41. PMID: 24938845, PMCID: PMC4118584, PII: STROKEAHA.114.005975, DOI: 10.1161/STROKEAHA.114.005975, ISSN: 1524-4628.

Bernard TJ, Rivkin MJ, Scholz K, deVeber G, Kirton A, Gill JC, Chan AK, Hovinga CA, Ichord RN, Grotta JC, Jordan LC, Benedict S, Friedman NR, Dowling MM, Elbers J, Torres M, Sultan S, Cummings DD, Grabowski EF, McMillan HJ, Beslow LA, Amlie-Lefond C, . Emergence of the primary pediatric stroke center: impact of the thrombolysis in pediatric stroke trial. Stroke [print-electronic]. 2014 Jul; 45(7): 2018-23. PMID: 24916908, PMCID: PMC4083478, PII: STROKEAHA.114.004919, DOI: 10.1161/STROKEAHA.114.004919, ISSN: 1524-4628.

Schulte R, Jordan LC, Morad A, Naftel RP, Wellons JC, Sidonio R. Rise in late onset vitamin K deficiency bleeding in young infants because of omission or refusal of prophylaxis at birth. Pediatr. Neurol [print-electronic]. 2014 Jun; 50(6): 564-8. PMID: 24842255, PII: S0887-8994(14)00141-6, DOI: 10.1016/j.pediatrneurol.2014.02.013, ISSN: 1873-5150.

Adil MM, Qureshi AI, Beslow LA, Jordan LC. Transient ischemic attack requiring hospitalization of children in the United States: kids' inpatient database 2003 to 2009. Stroke [print-electronic]. 2014 Mar; 45(3): 887-8. PMID: 24523040, PMCID: PMC3954473, PII: STROKEAHA.113.004526, DOI: 10.1161/STROKEAHA.113.004526, ISSN: 1524-4628.

Beslow LA, Ichord RN, Gindville MC, Kleinman JT, Bastian RA, Smith SE, Licht DJ, Hillis AE, Jordan LC. Frequency of hematoma expansion after spontaneous intracerebral hemorrhage in children. JAMA Neurol. 2014 Feb; 71(2): 165-71. PMID: 24296993, PMCID: PMC3945946, PII: 1787686, DOI: 10.1001/jamaneurol.2013.4672, ISSN: 2168-6157.

Ladner TR, He L, Jordan LC, Cooper C, Froehler MT, Mocco J. Mechanical thrombectomy for acute stroke in childhood: how much does restricted diffusion matter?. BMJ Case Rep. 2014; 2014: PMID: 25391820, PII: bcr-2014-011465, DOI: 10.1136/bcr-2014-011465, ISSN: 1757-790X.

Beslow LA, Ichord RN, Gindville MC, Kleinman JT, Engelmann K, Bastian RA, Licht DJ, Smith SE, Hillis AE, Jordan LC. Pediatric intracerebral hemorrhage score: a simple grading scale for intracerebral hemorrhage in children. Stroke [print-electronic]. 2014 Jan; 45(1): 66-70. PMID: 24281231, PMCID: PMC3910321, PII: STROKEAHA.113.003448, DOI: 10.1161/STROKEAHA.113.003448, ISSN: 1524-4628.

Jordan LC, Casella JF, DeBaun MR. Prospects for primary stroke prevention in children with sickle cell anaemia. Br. J. Haematol [print-electronic]. 2012 Apr; 157(1): 14-25. PMID: 22224940, PMCID: PMC3400704, DOI: 10.1111/j.1365-2141.2011.09005.x, ISSN: 1365-2141.

Engelmann KA, Jordan LC. Outcome measures used in pediatric stroke studies: a systematic review. Arch. Neurol. 2012 Jan; 69(1): 23-7. PMID: 22232344, PMCID: PMC3397390, PII: 69/1/23, DOI: 10.1001/archneurol.2011.1015, ISSN: 1538-3687.

Jordan LC, Hillis AE. Challenges in the diagnosis and treatment of pediatric stroke. Nat Rev Neurol [print-electronic]. 2011 Apr; 7(4): 199-208. PMID: 21386815, PMCID: PMC3383861, PII: nrneurol.2011.23, DOI: 10.1038/nrneurol.2011.23, ISSN: 1759-4766.

Kleinman JT, Hillis AE, Jordan LC. ABC/2: estimating intracerebral haemorrhage volume and total brain volume, and predicting outcome in children. Dev Med Child Neurol [print-electronic]. 2011 Mar; 53(3): 281-4. PMID: 20875043, PMCID: PMC3026070, DOI: 10.1111/j.1469-8749.2010.03798.x, ISSN: 1469-8749.

Beslow LA, Jordan LC. Pediatric stroke: the importance of cerebral arteriopathy and vascular malformations. Childs Nerv Syst [print-electronic]. 2010 Oct; 26(10): 1263-73. PMID: 20625743, PMCID: PMC3061823, DOI: 10.1007/s00381-010-1208-9, ISSN: 1433-0350.

Sepelyak K, Gailloud P, Jordan LC. Thrombosis of a developmental venous anomaly with hemorrhagic venous infarction. Arch. Neurol. 2010 Aug; 67(8): 1028. PMID: 20697060, PMCID: PMC2920504, PII: 67/8/1028, DOI: 10.1001/archneurol.2010.176, ISSN: 1538-3687.

Jordan LC, McKinstry RC, Kraut MA, Ball WS, Vendt BA, Casella JF, DeBaun MR, Strouse JJ, . Incidental findings on brain magnetic resonance imaging of children with sickle cell disease. Pediatrics [print-electronic]. 2010 Jul; 126(1): 53-61. PMID: 20547639, PMCID: PMC3153884, PII: peds.2009-2800, DOI: 10.1542/peds.2009-2800, ISSN: 1098-4275.

Jordan LC, Rafay MF, Smith SE, Askalan R, Zamel KM, deVeber G, Ashwal S, . Antithrombotic treatment in neonatal cerebral sinovenous thrombosis: results of the International Pediatric Stroke Study. J. Pediatr [print-electronic]. 2010 May; 156(5): 704-10, 710.e1. PMID: 20149389, PMCID: PMC2854210, PII: S0022-3476(09)01196-2, DOI: 10.1016/j.jpeds.2009.11.061, ISSN: 1097-6833.

Sepelyak K, Gailloud P, Jordan LC. Athletics, minor trauma, and pediatric arterial ischemic stroke. Eur. J. Pediatr [print-electronic]. 2010 May; 169(5): 557-62. PMID: 19760434, PMCID: PMC2836396, DOI: 10.1007/s00431-009-1066-1, ISSN: 1432-1076.

Beslow LA, Ichord RN, Kasner SE, Mullen MT, Licht DJ, Smith SE, Storm PB, Jordan LC, Messé SR. ABC/XYZ estimates intracerebral hemorrhage volume as a percent of total brain volume in children. Stroke [print-electronic]. 2010 Apr; 41(4): 691-4. PMID: 20181678, PMCID: PMC2930766, PII: STROKEAHA.109.566430, DOI: 10.1161/STROKEAHA.109.566430, ISSN: 1524-4628.

Kleinman JT, Gailloud P, Jordan LC. Recovery from spatial neglect and hemiplegia in a child despite a large anterior circulation stroke and Wallerian degeneration. J. Child Neurol [print-electronic]. 2010 Apr; 25(4): 500-3. PMID: 19850563, PMCID: PMC2854167, PII: 0883073809339060, DOI: 10.1177/0883073809339060, ISSN: 1708-8283.

Beslow LA, Licht DJ, Smith SE, Storm PB, Heuer GG, Zimmerman RA, Feiler AM, Kasner SE, Ichord RN, Jordan LC. Predictors of outcome in childhood intracerebral hemorrhage: a prospective consecutive cohort study. Stroke [print-electronic]. 2010 Feb; 41(2): 313-8. PMID: 20019325, PMCID: PMC2821039, PII: STROKEAHA.109.568071, DOI: 10.1161/STROKEAHA.109.568071, ISSN: 1524-4628.

Jordan LC, Duffner PK. Early-onset stroke and cerebrovascular disease in adult survivors of childhood cancer [editorial]. Neurology [print-electronic]. 2009 Dec 12/1/2009; 73(22): 1816-7. PMID: 19846829, PII: WNL.0b013e3181c33b10, DOI: 10.1212/WNL.0b013e3181c33b10, ISSN: 1526-632X.

Jordan LC. Stroke: thrombolysis in childhood arterial ischemic stroke. Nature reviews. Neurology. 2009 Sep; 5(9) Sect. 473,4.

Strouse JJ, Jordan LC, Lanzkron S, Casella JF. The excess burden of stroke in hospitalized adults with sickle cell disease. Am. J. Hematol. 2009 Sep; 84(9): 548-52. PMID: 19623672, PMCID: PMC2737603, DOI: 10.1002/ajh.21476, ISSN: 1096-8652.

Jordan LC, Strouse JJ. Will submandibular TCD prevent stroke in children with sickle cell anemia? [editorial]. Neurology [print-electronic]. 2009 Aug 8/4/2009; 73(5): 340-1. PMID: 19553590, PII: WNL.0b013e3181b1221e, DOI: 10.1212/WNL.0b013e3181b1221e, ISSN: 1526-632X.

Jordan LC, Kleinman JT, Hillis AE. Intracerebral hemorrhage volume predicts poor neurologic outcome in children. Stroke [print-electronic]. 2009 May; 40(5): 1666-71. PMID: 19286576, PMCID: PMC2830068, PII: STROKEAHA.108.541383, DOI: 10.1161/STROKEAHA.108.541383, ISSN: 1524-4628.

Jordan LC, Johnston SC, Wu YW, Sidney S, Fullerton HJ. The importance of cerebral aneurysms in childhood hemorrhagic stroke: a population-based study. Stroke [print-electronic]. 2009 Feb; 40(2): 400-5. PMID: 19023102, PMCID: PMC2764740, PII: STROKEAHA.108.518761, DOI: 10.1161/STROKEAHA.108.518761, ISSN: 1524-4628.

Jordan LC. Assessment and treatment of stroke in children. Curr Treat Options Neurol. 2008 Nov; 10(6): 399-409. PMID: 18990308, ISSN: 1092-8480.

Available Postdoctoral Position Details
Posted: 7/7/2016

We have an opening for a full-time post-doctoral fellow to carry out research in advanced MR imaging and related image analysis in patients with cerebrovascular disease (cervical and intracranial stenosis). The fellow will be involved in an NIH-funded clinical research program focusing on early detection of stroke risk factors in several populations of patients (including children and adults with sickle cell disease, adults with cerebral vasculopathy and intracranial stenosis) with an emphasis on cerebrovascular reactivity, collateral perfusion, and cerebral blood volume. Fellowship research activities will include interacting with clinicians and coordinating patient studies, neuroimaging data acquisition, data analysis, manuscript preparation, and conference presentations. The fellow will gain experience in the supervision and mentorship of undergraduate and graduate research trainees and research staff. The candidate will develop his/her own independent research projects under the mentorship of fellowship supervisors, Drs. Manus Donahue and Lori Jordan. An area of training emphasis for this fellowship is mentoring the candidate in grant writing with several intramural and extramural funding sources available for the fellow to develop an independently-funded project.

Candidates should have a PhD in biomedical engineering, biophysics, computer science, neuroscience, or a related discipline at the time of fellowship appointment with prior experience in MR analysis, preferably BOLD fMRI and/or ASL, and an interest in learning new techniques. Programming skills in Matlab, Unix/Linux and scientific computing, as well as experience with FSL or FreeSurfer, are highly desired. Due to new NIH funding, the full-time position is available immediately and is available for up to three years. Candidates must be able to meet eligibility requirements to work in the United States at the time of appointment and continue working legally for the proposed term of employment. Excellent written and oral communication skills are required.

Application Instructions To apply, please email Manus Donahue (m.donahue@vanderbilt.edu) and Lori Jordan (lori.jordan@vanderbilt.edu) with a cover letter detailing your interest in this position (including your past relevant research and work experiences), your current curriculum vitae, and contact information for three references (to include at least one professional and one academic reference). Be sure to specify in your cover letter that you are applying for the “Neuroimaging Post-doctoral Fellowship in Stroke and Cerebrovascular Disease.” Applications will be considered on a rolling basis, so early submission is strongly encouraged.