Seth J. Karp, M.D.


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Faculty Appointments
Chair of the Section of Surgical Sciences Professor of Surgery Professor of AnesthesiologyH. William Scott Jr. Chair in Surgery
M.D., Massachusetts Institute of Technology, Cambridge, MassachusettsM.A., Harvard University, Cambridge, MassachusettsA.B., Harvard University, Cambridge, Massachusetts
Office Address
1161 21st Avenue South
Nashville, TN 37232-2730
Research Description
Dr. Karp's basic research laboratory investigates the mechanisms of liver regeneration. In particular, he is interested in molecules and mechanisms necessary for liver regeneration, as well as how liver cells interact and pattern the surrounding extracellular matrix.
His clinical research interests include increasing the number of organs available for transplantation, optimizing the use of all organs, and understanding and improving disparities in access to care for rural and underserved populations.
Clinical Description
Liver transplantation
Lynch RJ, Magliocca JF, Hundley JC, Karp SJ. Moving past "think local, act global": A perspective on geographic disparity. Am. J. Transplant [print-electronic]. 2019 Jul; 19(7): 1907-11. PMID: 30125467, DOI: 10.1111/ajt.15079, ISSN: 1600-6143.

Godown J, Hall M, Thompson B, Thurm C, Jabs K, Gillis LA, Hafberg ET, Alexopoulos S, Karp SJ, Soslow JH. Expanding analytic possibilities in pediatric solid organ transplantation through linkage of administrative and clinical registry databases. Pediatr Transplant [print-electronic]. 2019 May; 23(3): e13379. PMID: 30793448, PMCID: PMC6853795, DOI: 10.1111/petr.13379, ISSN: 1399-3046.

O'Dell HW, McMichael BJ, Lee S, Karp JL, VanHorn RL, Karp SJ. Public attitudes toward contemporary issues in liver allocation. Am. J. Transplant [print-electronic]. 2019 Apr; 19(4): 1212-7. PMID: 30582275, DOI: 10.1111/ajt.15227, ISSN: 1600-6143.

Lynch RJ, Ye F, Sheng Q, Zhao Z, Karp SJ. State-Based Liver Distribution: Broad Sharing With Less Harm to Vulnerable and Underserved Communities Compared With Concentric Circles. Liver Transpl [print-electronic]. 2019 Apr; 25(4): 588-97. PMID: 30873761, DOI: 10.1002/lt.25425, ISSN: 1527-6473.

Karp SJ. The Importance of Outcome Metrics in Allocation Policy. Transplantation. 2018 Dec; 102(12): 1968-9. PMID: 29944620, DOI: 10.1097/TP.0000000000002342, ISSN: 1534-6080.

Ye F, Sheng Q, Feurer ID, Zhao Z, Fan R, Teng J, Ping J, Rega SA, Hanto DW, Shyr Y, Karp SJ. Directed solutions to address differences in access to liver transplantation. Am. J. Transplant [print-electronic]. 2018 Nov; 18(11): 2670-8. PMID: 29689125, DOI: 10.1111/ajt.14889, ISSN: 1600-6143.

Gerber DA, Baliga P, Karp SJ. Allocation of Donor Livers for Transplantation: A Contemporary Struggle. JAMA Surg. 2018 Sep 9/1/2018; 153(9): 787-8. PMID: 29926088, PII: 2685267, DOI: 10.1001/jamasurg.2018.1519, ISSN: 2168-6262.

Kensinger CD, Feurer ID, Karp SJ. An Outcome-Based Approach to Assign MELD Exception Points for Patients With Hepatocellular Cancer. Transplantation. 2017 Sep; 101(9): 2056-61. PMID: 28471871, DOI: 10.1097/TP.0000000000001812, ISSN: 1534-6080.

Oya Y, Masuzaki R, Tsugawa D, Ray KC, Dou Y, Karp SJ. Dicer-dependent production of microRNA221 in hepatocytes inhibits p27 and is required for liver regeneration in mice. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2017 May 5/1/2017; 312(5): G464-G473. PMID: 28232457, PMCID: PMC5451560, PII: ajpgi.00383.2016, DOI: 10.1152/ajpgi.00383.2016, ISSN: 1522-1547.

Goldberg DS, Karp SJ, McCauley ME, Markmann JF, Croome KP, Taner CB, Heimbach JK, Leise MD, Fryer JP, Bohorquez HE, Cohen AJ, Gilroy RK, Kumer SC, Foley DP, Karim AS, Hernandez-Alejandro R, Levstik MA, Abt PL. Interpreting Outcomes in DCDD Liver Transplantation: First Report of the Multicenter IDOL Consortium. Transplantation. 2017 May; 101(5): 1067-73. PMID: 28114173, DOI: 10.1097/TP.0000000000001656, ISSN: 1534-6080.

Masuzaki R, Karp SJ, Omata M. NAFLD as a risk factor for HCC: new rules of engagement? [editorial]. Hepatol Int [print-electronic]. 2016 Jul; 10(4): 533-4. PMID: 27146835, PMCID: PMC4939149, PII: 10.1007/s12072-016-9731-8, DOI: 10.1007/s12072-016-9731-8, ISSN: 1936-0541.

Karp SJ. Netrin-1: Needed Help for Throughput in the ER in Patients With Liver Disease [editorial]. Cell Mol Gastroenterol Hepatol. 2016 May; 2(3): 255. PMID: 28174715, PMCID: PMC5042363, PII: S2352-345X(16)30004-2, DOI: 10.1016/j.jcmgh.2016.02.006, ISSN: 2352-345X.

Masuzaki R, Zhao S, Valerius MT, Tsugawa D, Oya Y, Ray KC, Karp SJ. SOCS2 Balances Metabolic and Restorative Requirements during Liver Regeneration. J. Biol. Chem [print-electronic]. 2016 Feb 2/12/2016; 291(7): 3346-58. PMID: 26703468, PMCID: PMC4751379, PII: M115.703264, DOI: 10.1074/jbc.M115.703264, ISSN: 1083-351X.

Karp SJ. A Role for Extracellular Vesicles in Liver Fibrosis [editorial]. Cell Mol Gastroenterol Hepatol. 2015 Nov; 1(6): 572-3. PMID: 28210700, PMCID: PMC5301879, PII: S2352-345X(15)00156-3, DOI: 10.1016/j.jcmgh.2015.09.003, ISSN: 2352-345X.

Karp SJ. Biology of hepatocyte regeneration in acute liver failure. Liver Transpl. 2015 Nov; 21 Suppl 1: S34-5. PMID: 26342203, DOI: 10.1002/lt.24320, ISSN: 1527-6473.

Simmons AJ, Banerjee A, McKinley ET, Scurrah CR, Herring CA, Gewin LS, Masuzaki R, Karp SJ, Franklin JL, Gerdes MJ, Irish JM, Coffey RJ, Lau KS. Cytometry-based single-cell analysis of intact epithelial signaling reveals MAPK activation divergent from TNF-a-induced apoptosis in vivo. Mol. Syst. Biol. 2015 Oct 10/30/2015; 11(10): 835. PMID: 26519361, PMCID: PMC4631206, DOI: 10.15252/msb.20156282, ISSN: 1744-4292.

Masuzaki R, Yu H, Kingsley P, Marnett L, Zhao Z, Karp SJ. Functional Implications of Biochemical and Molecular Characteristics of Donation After Circulatory Death Livers. Transplant Direct. 2015 Jun; 1(5): e18. PMID: 27500220, PMCID: PMC4946467, PII: TXD50006, DOI: 10.1097/TXD.0000000000000527, ISSN: 2373-8731.

Tsugawa D, Oya Y, Masuzaki R, Ray K, Engers DW, Dib M, Do N, Kuramitsu K, Ho K, Frist A, Yu PB, Bloch KD, Lindsley CW, Hopkins CR, Hong CC, Karp SJ. Specific activin receptor-like kinase 3 inhibitors enhance liver regeneration. J. Pharmacol. Exp. Ther [print-electronic]. 2014 Dec; 351(3): 549-58. PMID: 25271257, PMCID: PMC4244585, PII: jpet.114.216903, DOI: 10.1124/jpet.114.216903, ISSN: 1521-0103.

Masuzaki R, Zhao SR, Csizmadia E, Yannas I, Karp SJ. Scar formation and lack of regeneration in adult and neonatal liver after stromal injury. Wound Repair Regen [print-electronic]. 2013 Jan; 21(1): 122-30. PMID: 23228176, DOI: 10.1111/j.1524-475X.2012.00868.x, ISSN: 1524-475X.

Karp SJ, Mannon RB. What's New, What's Hot in Solid Organ Transplantation? Summary of the American Transplant Congress 2011. Am. J. Transplant [print-electronic]. 2011 Nov; 11(11): 2308-16. PMID: 21967066, DOI: 10.1111/j.1600-6143.2011.03774.x, ISSN: 1600-6143.