Anna Dikalova, Ph.D.

Research Assistant Professor

anna.dikalova@vanderbilt.edu
Faculty Appointments
Research Assistant Professor of Medicine
Education
Ph.D., Institute of Cytology & Genetics, Siberia, RussiaM.S., Novosibirsk State University, Novosibirsk, Russia
Office Address
2215 B Garland Avenue
1125 MRB4/Light Hall
Nashville, TN 37232-0656
Publications
Dikalova A, Aschner JL, Kaplowitz MR, Summar M, Fike CD. Tetrahydrobiopterin oral therapy recouples eNOS and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2016 Oct 10/1/2016; 311(4): L743-L753. PMID: 27542807, PII: ajplung.00238.2016, DOI: 10.1152/ajplung.00238.2016, ISSN: 1522-1504.

Itani HA, Dikalova AE, McMaster WG, Nazarewicz RR, Bikineyeva AT, Harrison DG, Dikalov SI. Mitochondrial Cyclophilin D in Vascular Oxidative Stress and Hypertension. Hypertension [print-electronic]. 2016 Jun; 67(6): 1218-27. PMID: 27067720, PMCID: PMC4865418, PII: HYPERTENSIONAHA.115.07085, DOI: 10.1161/HYPERTENSIONAHA.115.07085, ISSN: 1524-4563.

Dikalov SI, Dikalova AE. Contribution of mitochondrial oxidative stress to hypertension. Curr. Opin. Nephrol. Hypertens. 2016 Mar; 25(2): 73-80. PMID: 26717313, PMCID: PMC4766975, DOI: 10.1097/MNH.0000000000000198, ISSN: 1473-6543.

Choi H, Dikalova A, Stark RJ, Lamb FS. C-Jun N-terminal kinase attenuates TNFa signaling by reducing Nox1-dependent endosomal ROS production in vascular smooth muscle cells. Free Radic. Biol. Med [print-electronic]. 2015 Sep; 86: 219-27. PMID: 26001727, PII: S0891-5849(15)00226-9, DOI: 10.1016/j.freeradbiomed.2015.05.015, ISSN: 1873-4596.

Fike CD, Dikalova A, Kaplowitz MR, Cunningham G, Summar M, Aschner JL. Rescue Treatment with L-Citrulline Inhibits Hypoxia-Induced Pulmonary Hypertension in Newborn Pigs. Am. J. Respir. Cell Mol. Biol. 2015 Aug; 53(2): 255-64. PMID: 25536367, PMCID: PMC4566047, DOI: 10.1165/rcmb.2014-0351OC, ISSN: 1535-4989.

Dikalova AE, Kirilyuk IA, Dikalov SI. Antihypertensive effect of mitochondria-targeted proxyl nitroxides. Redox Biol [print-electronic]. 2015; 4: 355-62. PMID: 25677087, PMCID: PMC4326181, PII: S2213-2317(14)00136-0, DOI: 10.1016/j.redox.2014.12.012, ISSN: 2213-2317.

Dikalov SI, Nazarewicz RR, Bikineyeva A, Hilenski L, Lass├Ęgue B, Griendling KK, Harrison DG, Dikalova AE. Nox2-induced production of mitochondrial superoxide in angiotensin II-mediated endothelial oxidative stress and hypertension. Antioxid. Redox Signal [print-electronic]. 2014 Jan 1/10/2014; 20(2): 281-94. PMID: 24053613, PMCID: PMC3887459, DOI: 10.1089/ars.2012.4918, ISSN: 1557-7716.

Dikalova A, Fagiana A, Aschner JL, Aschner M, Summar M, Fike CD. Sodium-coupled neutral amino acid transporter 1 (SNAT1) modulates L-citrulline transport and nitric oxide (NO) signaling in piglet pulmonary arterial endothelial cells. PLoS ONE. 2014; 9(1): e85730. PMID: 24454923, PMCID: PMC3893279, PII: PONE-D-13-33824, DOI: 10.1371/journal.pone.0085730, ISSN: 1932-6203.

Nazarewicz RR, Dikalova AE, Bikineyeva A, Dikalov SI. Nox2 as a potential target of mitochondrial superoxide and its role in endothelial oxidative stress. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2013 Oct 10/15/2013; 305(8): H1131-40. PMID: 23955717, PMCID: PMC3798790, PII: ajpheart.00063.2013, DOI: 10.1152/ajpheart.00063.2013, ISSN: 1522-1539.

Nazarewicz RR, Dikalova A, Bikineyeva A, Ivanov S, Kirilyuk IA, Grigor'ev IA, Dikalov SI. Does scavenging of mitochondrial superoxide attenuate cancer prosurvival signaling pathways?. Antioxid. Redox Signal [print-electronic]. 2013 Aug 8/1/2013; 19(4): 344-9. PMID: 23373855, PMCID: PMC3700017, DOI: 10.1089/ars.2013.5185, ISSN: 1557-7716.

Fike CD, Dikalova A, Slaughter JC, Kaplowitz MR, Zhang Y, Aschner JL. Reactive oxygen species-reducing strategies improve pulmonary arterial responses to nitric oxide in piglets with chronic hypoxia-induced pulmonary hypertension. Antioxid. Redox Signal [print-electronic]. 2013 May 5/10/2013; 18(14): 1727-38. PMID: 23244497, PMCID: PMC3619184, DOI: 10.1089/ars.2012.4823, ISSN: 1557-7716.