Nathan E. Brummel, M.D.

Assistant Professor

Visit Lab Site

Faculty Appointments
Assistant Professor of Medicine
M.S.C.I., Clinical Investigation, Vanderbilt University, Nashville, TennesseeM.D., University of Missouri, Saint Louis, MissouriM.S., Creighton University, Omaha, NebraskaB.S., Creighton University, Omaha, Nebraska
Office Address
2525 West End Avenue
Nashville, TN
Research Description
Dr. Brummel is an Instructor in Medicine in the Division of Allergy, Pulmonary and Critical Medicine at the Vanderbilt School of Medicine, in Nashville, Tennessee. He graduated from Creighton University with a bachelor's degree in biology and later a master's degree in Biomedical Sciences. He completed his medical degree at the University of Missouri-Columbia, where as a junior and senior medical student he served as president of the graduate and professional student government organization. He trained in Internal Medicine, including a Chief Residency, at The Ohio State University Wexner Medical Center in Columbus, Ohio before moving to Nashville to pursue further training in Pulmonary Disease and Critical Care Medicine at Vanderbilt School of Medicine. He is board certified in Internal Medicine, Pulmonary Diseases and Critical Care Medicine. He is a graduate of the Vanderbilt School of Medicine’s Master of Science in Clinical Investigation program. His research interests are geriatric critical care, delirium in the ICU and long-term cognitive impairment following critical illness. He recently served as PI of a randomized trial of early cognitive therapy for critically ill patients. The NIA and the Vanderbilt Clinical and Translational Scholars program currently fund his work. For more details regarding his work, please contact him for a copy of his Curriculum Vitae.
Research Keywords
Delirium; critical care; mechanical ventilation; sedation; aging and critical illness; long-term cognitive outcomes following critical illness; disability following critical illness
Marra A, Pandharipande PP, Girard TD, Patel MB, Hughes CG, Jackson JC, Thompson JL, Chandrasekhar R, Ely EW, Brummel NE. Cooccurrence of Post-Intensive Care Syndrome Problems Among 406 Survivors of Critical Illness. Crit. Care Med [print-electronic]. 2018 May 5/21/2018; PMID: 29787415, DOI: 10.1097/CCM.0000000000003218, ISSN: 1530-0293.

Brummel NE, Ferrante LE. Integrating Geriatric Principles into Critical Care Medicine: The Time Is Now. Ann Am Thorac Soc. 2018 May; 15(5): 518-22. PMID: 29298089, PMCID: PMC5949609, DOI: 10.1513/AnnalsATS.201710-793IP, ISSN: 2325-6621.

Abdel-Kader K, Girard TD, Brummel NE, Saunders CT, Blume JD, Clark AJ, Vincz AJ, Ely EW, Jackson JC, Bell SP, Archer KR, Ikizler TA, Pandharipande PP, Siew ED. Acute Kidney Injury and Subsequent Frailty Status in Survivors of Critical Illness: A Secondary Analysis. Crit. Care Med. 2018 May; 46(5): e380-e388. PMID: 29373362, PMCID: PMC5899022, DOI: 10.1097/CCM.0000000000003003, ISSN: 1530-0293.

Hughes CG, Patel MB, Brummel NE, Thompson JL, McNeil JB, Pandharipande PP, Jackson JC, Chandrasekhar R, Ware LB, Ely EW, Girard TD. Relationships between markers of neurologic and endothelial injury during critical illness and long-term cognitive impairment and disability. Intensive Care Med [print-electronic]. 2018 Mar; 44(3): 345-55. PMID: 29523900, PMCID: PMC5870884, PII: 10.1007/s00134-018-5120-1, DOI: 10.1007/s00134-018-5120-1, ISSN: 1432-1238.

Girard TD, Thompson JL, Pandharipande PP, Brummel NE, Jackson JC, Patel MB, Hughes CG, Chandrasekhar R, Pun BT, Boehm LM, Elstad MR, Goodman RB, Bernard GR, Dittus RS, Ely EW. Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study. Lancet Respir Med. 2018 Mar; 6(3): 213-22. PMID: 29508705, PII: S2213-2600(18)30062-6, DOI: 10.1016/S2213-2600(18)30062-6, ISSN: 2213-2619.

Brummel NE, Boehm LM, Girard TD, Pandharipande PP, Jackson JC, Hughes CG, Patel MB, Han JH, Vasilevskis EE, Thompson JL, Chandrasekhar R, Bernard GR, Dittus RS, Ely EW. Subsyndromal Delirium and Institutionalization Among Patients With Critical Illness. Am. J. Crit. Care. 2017 Nov; 26(6): 447-55. PMID: 29092867, PMCID: PMC5831547, PII: 26/6/447, DOI: 10.4037/ajcc2017263, ISSN: 1937-710X.

Brummel NE, Bell SP, Girard TD, Pandharipande PP, Jackson JC, Morandi A, Thompson JL, Chandrasekhar R, Bernard GR, Dittus RS, Gill TM, Ely EW. Frailty and Subsequent Disability and Mortality among Patients with Critical Illness. Am. J. Respir. Crit. Care Med. 2017 Jul 7/1/2017; 196(1): 64-72. PMID: 27922747, PMCID: PMC5519959, DOI: 10.1164/rccm.201605-0939OC, ISSN: 1535-4970.

Han JH, Brummel NE, Chandrasekhar R, Wilson JE, Liu X, Vasilevskis EE, Girard TD, Carlo ME, Dittus RS, Schnelle JF, Ely EW. Exploring Delirium's Heterogeneity: Association Between Arousal Subtypes at Initial Presentation and 6-Month Mortality in Older Emergency Department Patients. Am J Geriatr Psychiatry [print-electronic]. 2017 Mar; 25(3): 233-42. PMID: 27623552, PMCID: PMC5321606, PII: S1064-7481(16)30138-5, DOI: 10.1016/j.jagp.2016.05.016, ISSN: 1545-7214.

Hughes CG, Patel MB, Jackson JC, Girard TD, Geevarghese SK, Norman BC, Thompson JL, Chandrasekhar R, Brummel NE, May AK, Elstad MR, Wasserstein ML, Goodman RB, Moons KG, Dittus RS, Ely EW, Pandharipande PP, . Surgery and Anesthesia Exposure Is Not a Risk Factor for Cognitive Impairment After Major Noncardiac Surgery and Critical Illness. Ann. Surg [print-electronic]. 2016 Jul 7/18/2016; PMID: 27433893, DOI: 10.1097/SLA.0000000000001885, ISSN: 1528-1140.

Norman BC, Jackson JC, Graves JA, Girard TD, Pandharipande PP, Brummel NE, Wang L, Thompson JL, Chandrasekhar R, Ely EW. Employment Outcomes After Critical Illness: An Analysis of the Bringing to Light the Risk Factors and Incidence of Neuropsychological Dysfunction in ICU Survivors Cohort. Crit. Care Med [print-electronic]. 2016 May 5/11/2016; PMID: 27171492, DOI: 10.1097/CCM.0000000000001849, ISSN: 1530-0293.

Wilson JE, Brummel NE, Stollings JL. Benzodiazepine-associated delirium dosing strategy or cumulative dose? [letter]. Intensive Care Med. 2015 Dec; 41(12): 2245-6. PMID: 26493385, PII: 10.1007/s00134-015-4101-x, DOI: 10.1007/s00134-015-4101-x, ISSN: 1432-1238.

Robinson TN, Walston JD, Brummel NE, Deiner S, Brown CH, Kennedy M, Hurria A. Frailty for Surgeons: Review of a National Institute on Aging Conference on Frailty for Specialists. J. Am. Coll. Surg [print-electronic]. 2015 Dec; 221(6): 1083-92. PMID: 26422746, PMCID: PMC4673051, PII: S1072-7515(15)01489-1, DOI: 10.1016/j.jamcollsurg.2015.08.428, ISSN: 1879-1190.

Morandi A, Brummel NE, Pandharipande P. Melatonin and the future of critically ill patients' outcomes [editorial]. Minerva Anestesiol [print-electronic]. 2015 Dec; 81(12): 1277-9. PMID: 26505226, PII: R02Y9999N00A150143, ISSN: 1827-1596.

Hughes CG, Brummel NE, Girard TD, Graves AJ, Ely EW, Pandharipande PP. Change in endothelial vascular reactivity and acute brain dysfunction during critical illness [letter]. Br J Anaesth. 2015 Nov; 115(5): 794-5. PMID: 26475809, PMCID: PMC4608489, PII: aev332, DOI: 10.1093/bja/aev332, ISSN: 1471-6771.

Brummel NE, Balas MC, Morandi A, Ferrante LE, Gill TM, Ely EW. Understanding and reducing disability in older adults following critical illness. Crit. Care Med. 2015 Jun; 43(6): 1265-75. PMID: 25756418, PMCID: PMC4640688, DOI: 10.1097/CCM.0000000000000924, ISSN: 1530-0293.

Jackson JC, Pandharipande PP, Girard TD, Brummel NE, Thompson JL, Hughes CG, Pun BT, Vasilevskis EE, Morandi A, Shintani AK, Hopkins RO, Bernard GR, Dittus RS, Ely EW, . Depression, post-traumatic stress disorder, and functional disability in survivors of critical illness in the BRAIN-ICU study: a longitudinal cohort study. Lancet Respir Med [print-electronic]. 2014 May; 2(5): 369-79. PMID: 24815803, PMCID: PMC4107313, PII: S2213-2600(14)70051-7, DOI: 10.1016/S2213-2600(14)70051-7, ISSN: 2213-2619.

Brummel NE, Girard TD, Ely EW, Pandharipande PP, Morandi A, Hughes CG, Graves AJ, Shintani A, Murphy E, Work B, Pun BT, Boehm L, Gill TM, Dittus RS, Jackson JC. Feasibility and safety of early combined cognitive and physical therapy for critically ill medical and surgical patients: the Activity and Cognitive Therapy in ICU (ACT-ICU) trial. Intensive Care Med [print-electronic]. 2014 Mar; 40(3): 370-9. PMID: 24257969, PMCID: PMC3943568, DOI: 10.1007/s00134-013-3136-0, ISSN: 1432-1238.

Brummel NE, Jackson JC, Pandharipande PP, Thompson JL, Shintani AK, Dittus RS, Gill TM, Bernard GR, Ely EW, Girard TD. Delirium in the ICU and subsequent long-term disability among survivors of mechanical ventilation. Crit. Care Med. 2014 Feb; 42(2): 369-77. PMID: 24158172, PMCID: PMC3947028, DOI: 10.1097/CCM.0b013e3182a645bd, ISSN: 1530-0293.

Brummel NE, Ely EW. Sedation level and the prevalence of delirium [letter]. Intensive Care Med [print-electronic]. 2014 Jan; 40(1): 135. PMID: 23982729, PMCID: PMC3869188, DOI: 10.1007/s00134-013-3083-9, ISSN: 1432-1238.

Pandharipande PP, Girard TD, Jackson JC, Morandi A, Thompson JL, Pun BT, Brummel NE, Hughes CG, Vasilevskis EE, Shintani AK, Moons KG, Geevarghese SK, Canonico A, Hopkins RO, Bernard GR, Dittus RS, Ely EW, . Long-term cognitive impairment after critical illness. N. Engl. J. Med. 2013 Oct 10/3/2013; 369(14): 1306-16. PMID: 24088092, PMCID: PMC3922401, DOI: 10.1056/NEJMoa1301372, ISSN: 1533-4406.

Brummel NE, Vasilevskis EE, Han JH, Boehm L, Pun BT, Ely EW. Implementing delirium screening in the ICU: secrets to success. Crit. Care Med. 2013 Sep; 41(9): 2196-208. PMID: 23896832, PMCID: PMC3772682, DOI: 10.1097/CCM.0b013e31829a6f1e, ISSN: 1530-0293.

Brummel NE, Girard TD. Preventing delirium in the intensive care unit. Crit Care Clin. 2013 Jan; 29(1): 51-65. PMID: 23182527, PMCID: PMC3508697, PII: S0749-0704(12)00084-X, DOI: 10.1016/j.ccc.2012.10.007, ISSN: 1557-8232.

Brummel NE, Jackson JC, Girard TD, Pandharipande PP, Schiro E, Work B, Pun BT, Boehm L, Gill TM, Ely EW. A combined early cognitive and physical rehabilitation program for people who are critically ill: the activity and cognitive therapy in the intensive care unit (ACT-ICU) trial. Phys Ther [print-electronic]. 2012 Dec; 92(12): 1580-92. PMID: 22577067, PMCID: PMC3513484, PII: ptj.20110414, DOI: 10.2522/ptj.20110414, ISSN: 1538-6724.

Hughes CG, Brummel NE, Vasilevskis EE, Girard TD, Pandharipande PP. Future directions of delirium research and management. Best Pract Res Clin Anaesthesiol. 2012 Sep; 26(3): 395-405. PMID: 23040289, PMCID: PMC3638881, PII: S1521-6896(12)00054-7, DOI: 10.1016/j.bpa.2012.08.004, ISSN: 1878-1608.

Jackson JC, Ely EW, Morey MC, Anderson VM, Denne LB, Clune J, Siebert CS, Archer KR, Torres R, Janz D, Schiro E, Jones J, Shintani AK, Levine B, Pun BT, Thompson J, Brummel NE, Hoenig H. Cognitive and physical rehabilitation of intensive care unit survivors: results of the RETURN randomized controlled pilot investigation. Crit. Care Med. 2012 Apr; 40(4): 1088-97. PMID: 22080631, PMCID: PMC3755871, DOI: 10.1097/CCM.0b013e3182373115, ISSN: 1530-0293.

Brummel NE, Pugh ME, Fessel JP. Outcomes in elderly intensive care unit patients, pulmonary hypertension in sickle cell disease, and total liquid ventilation for therapeutic hypothermia after cardiac arrest in rabbits. Am. J. Respir. Crit. Care Med. 2012 Feb 2/15/2012; 185(4): 453-4. PMID: 22336678, PMCID: PMC3297099, PII: 185/4/453, DOI: 10.1164/rccm.201109-1608RR, ISSN: 1535-4970.

Morandi A, Brummel NE, Ely EW. Sedation, delirium and mechanical ventilation: the 'ABCDE' approach. Curr Opin Crit Care. 2011 Feb; 17(1): 43-9. PMID: 21169829, DOI: 10.1097/MCC.0b013e3283427243, ISSN: 1531-7072.

Brummel NE, Girard TD. Are we sedating more than just the brain?. Crit Care [print-electronic]. 2011; 15(3): 163. PMID: 21672277, PMCID: PMC3218986, PII: cc10233, DOI: 10.1186/cc10233, ISSN: 1466-609X.