Sergey Dikalov, Ph.D.

Research Associate Professor

sergey.dikalov@vanderbilt.edu

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Faculty Appointments
Research Associate Professor of Medicine
Education
M.S., Novosibirsk State University, Novosibirsk, RussiaPh.D., Russian Academy of Science, Siberian Branch, Novosibirsk, Russia , Novosibirsk, Russia
Publications
Bhardwaj V, Horvat A, Korolkova O, Washington KM, El-Rifai W, Dikalov SI, Zaika AI. Prevention of DNA damage in Barrett's esophageal cells exposed to acidic bile salts. Carcinogenesis [print-electronic]. 2016 Sep 9/21/2016; PMID: 27655834, PII: bgw100, DOI: 10.1093/carcin/bgw100, ISSN: 1460-2180.

Bhardwaj V, Horvat A, Korolkova O, Washington KM, El-Rifai W, Dikalov SI, Zaika AI. Prevention of DNA damage in Barrett's esophageal cells exposed to acidic bile salts. Carcinogenesis [print-electronic]. 2016 Sep 9/21/2016; PMID: 27655834, PII: bgw100, DOI: 10.1093/carcin/bgw100, ISSN: 1460-2180.

Itani HA, Dikalova AE, McMaster WG, Nazarewicz RR, Bikineyeva AT, Harrison DG, Dikalov SI. Mitochondrial Cyclophilin D in Vascular Oxidative Stress and Hypertension. Hypertension [print-electronic]. 2016 Jun; 67(6): 1218-27. PMID: 27067720, PMCID: PMC4865418, PII: HYPERTENSIONAHA.115.07085, DOI: 10.1161/HYPERTENSIONAHA.115.07085, ISSN: 1524-4563.

Itani HA, Dikalova AE, McMaster WG, Nazarewicz RR, Bikineyeva AT, Harrison DG, Dikalov SI. Mitochondrial Cyclophilin D in Vascular Oxidative Stress and Hypertension. Hypertension [print-electronic]. 2016 Jun; 67(6): 1218-27. PMID: 27067720, PMCID: PMC4865418, PII: HYPERTENSIONAHA.115.07085, DOI: 10.1161/HYPERTENSIONAHA.115.07085, ISSN: 1524-4563.

Vergeade A, Bertram CC, Bikineyeva AT, Zackert WE, Zinkel SS, May JM, Dikalov SI, Roberts LJ, Boutaud O. Cardiolipin fatty acid remodeling regulates mitochondrial function by modifying the electron entry point in the respiratory chain. Mitochondrion [print-electronic]. 2016 May; 28: 88-95. PMID: 27085476, PMCID: PMC4860904, PII: S1567-7249(16)30021-6, DOI: 10.1016/j.mito.2016.04.002, ISSN: 1872-8278.

Vergeade A, Bertram CC, Bikineyeva AT, Zackert WE, Zinkel SS, May JM, Dikalov SI, Roberts LJ, Boutaud O. Cardiolipin fatty acid remodeling regulates mitochondrial function by modifying the electron entry point in the respiratory chain. Mitochondrion [print-electronic]. 2016 May; 28: 88-95. PMID: 27085476, PMCID: PMC4860904, PII: S1567-7249(16)30021-6, DOI: 10.1016/j.mito.2016.04.002, ISSN: 1872-8278.

Shaver CM, Upchurch CP, Janz DR, Grove BS, Putz ND, Wickersham NE, Dikalov SI, Ware LB, Bastarache JA. Cell-free hemoglobin: a novel mediator of acute lung injury. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2016 Mar 3/15/2016; 310(6): L532-41. PMID: 26773065, PMCID: PMC4796260, PII: ajplung.00155.2015, DOI: 10.1152/ajplung.00155.2015, ISSN: 1522-1504.

Shaver CM, Upchurch CP, Janz DR, Grove BS, Putz ND, Wickersham NE, Dikalov SI, Ware LB, Bastarache JA. Cell-free hemoglobin: a novel mediator of acute lung injury. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2016 Mar 3/15/2016; 310(6): L532-41. PMID: 26773065, PMCID: PMC4796260, PII: ajplung.00155.2015, DOI: 10.1152/ajplung.00155.2015, ISSN: 1522-1504.

Dikalov SI, Dikalova AE. Contribution of mitochondrial oxidative stress to hypertension. Curr. Opin. Nephrol. Hypertens. 2016 Mar; 25(2): 73-80. PMID: 26717313, PMCID: PMC4766975, DOI: 10.1097/MNH.0000000000000198, ISSN: 1473-6543.

Dikalov SI, Dikalova AE. Contribution of mitochondrial oxidative stress to hypertension. Curr. Opin. Nephrol. Hypertens. 2016 Mar; 25(2): 73-80. PMID: 26717313, PMCID: PMC4766975, DOI: 10.1097/MNH.0000000000000198, ISSN: 1473-6543.

Sidorova TN, Yermalitskaya LV, Mace LC, Wells KS, Boutaud O, Prinsen JK, Davies SS, Roberts LJ, Dikalov SI, Glabe CG, Amarnath V, Barnett JV, Murray KT. Reactive ¿-ketoaldehydes promote protein misfolding and preamyloid oligomer formation in rapidly-activated atrial cells. J. Mol. Cell. Cardiol [print-electronic]. 2015 Feb; 79: 295-302. PMID: 25463275, PMCID: PMC4302000, PII: S0022-2828(14)00373-3, DOI: 10.1016/j.yjmcc.2014.11.013, ISSN: 1095-8584.

Sidorova TN, Yermalitskaya LV, Mace LC, Wells KS, Boutaud O, Prinsen JK, Davies SS, Roberts LJ, Dikalov SI, Glabe CG, Amarnath V, Barnett JV, Murray KT. Reactive ¿-ketoaldehydes promote protein misfolding and preamyloid oligomer formation in rapidly-activated atrial cells. J. Mol. Cell. Cardiol [print-electronic]. 2015 Feb; 79: 295-302. PMID: 25463275, PMCID: PMC4302000, PII: S0022-2828(14)00373-3, DOI: 10.1016/j.yjmcc.2014.11.013, ISSN: 1095-8584.

Dikalova AE, Kirilyuk IA, Dikalov SI. Antihypertensive effect of mitochondria-targeted proxyl nitroxides. Redox Biol [print-electronic]. 2015; 4: 355-62. PMID: 25677087, PMCID: PMC4326181, PII: S2213-2317(14)00136-0, DOI: 10.1016/j.redox.2014.12.012, ISSN: 2213-2317.

Dikalova AE, Kirilyuk IA, Dikalov SI. Antihypertensive effect of mitochondria-targeted proxyl nitroxides. Redox Biol [print-electronic]. 2015; 4: 355-62. PMID: 25677087, PMCID: PMC4326181, PII: S2213-2317(14)00136-0, DOI: 10.1016/j.redox.2014.12.012, ISSN: 2213-2317.

Dikalov SI, Nazarewicz RR, Bikineyeva A, Hilenski L, Lassègue B, Griendling KK, Harrison DG, Dikalova AE. Nox2-induced production of mitochondrial superoxide in angiotensin II-mediated endothelial oxidative stress and hypertension. Antioxid. Redox Signal [print-electronic]. 2014 Jan 1/10/2014; 20(2): 281-94. PMID: 24053613, PMCID: PMC3887459, DOI: 10.1089/ars.2012.4918, ISSN: 1557-7716.

Dikalov SI, Harrison DG. Methods for detection of mitochondrial and cellular reactive oxygen species. Antioxid. Redox Signal [print-electronic]. 2014 Jan 1/10/2014; 20(2): 372-82. PMID: 22978713, PMCID: PMC3887411, DOI: 10.1089/ars.2012.4886, ISSN: 1557-7716.

Dikalov SI, Ungvari Z. Role of mitochondrial oxidative stress in hypertension. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2013 Nov 11/15/2013; 305(10): H1417-27. PMID: 24043248, PMCID: PMC3840266, PII: ajpheart.00089.2013, DOI: 10.1152/ajpheart.00089.2013, ISSN: 1522-1539.

Dikalov SI, Ungvari Z. Role of mitochondrial oxidative stress in hypertension. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2013 Nov 11/15/2013; 305(10): H1417-27. PMID: 24043248, PMCID: PMC3840266, PII: ajpheart.00089.2013, DOI: 10.1152/ajpheart.00089.2013, ISSN: 1522-1539.

Nazarewicz RR, Dikalova AE, Bikineyeva A, Dikalov SI. Nox2 as a potential target of mitochondrial superoxide and its role in endothelial oxidative stress. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2013 Oct 10/15/2013; 305(8): H1131-40. PMID: 23955717, PMCID: PMC3798790, PII: ajpheart.00063.2013, DOI: 10.1152/ajpheart.00063.2013, ISSN: 1522-1539.

Nazarewicz RR, Dikalova AE, Bikineyeva A, Dikalov SI. Nox2 as a potential target of mitochondrial superoxide and its role in endothelial oxidative stress. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2013 Oct 10/15/2013; 305(8): H1131-40. PMID: 23955717, PMCID: PMC3798790, PII: ajpheart.00063.2013, DOI: 10.1152/ajpheart.00063.2013, ISSN: 1522-1539.

Dikalov SI, Nazarewicz RR. Angiotensin II-induced production of mitochondrial reactive oxygen species: potential mechanisms and relevance for cardiovascular disease. Antioxid. Redox Signal [print-electronic]. 2013 Oct 10/1/2013; 19(10): 1085-94. PMID: 22443458, PMCID: PMC3771548, DOI: 10.1089/ars.2012.4604, ISSN: 1557-7716.

Nazarewicz RR, Dikalova A, Bikineyeva A, Ivanov S, Kirilyuk IA, Grigor'ev IA, Dikalov SI. Does scavenging of mitochondrial superoxide attenuate cancer prosurvival signaling pathways?. Antioxid. Redox Signal [print-electronic]. 2013 Aug 8/1/2013; 19(4): 344-9. PMID: 23373855, PMCID: PMC3700017, DOI: 10.1089/ars.2013.5185, ISSN: 1557-7716.

Nazarewicz RR, Dikalov SI. Mitochondrial ROS in the prohypertensive immune response. Am. J. Physiol. Regul. Integr. Comp. Physiol [print-electronic]. 2013 Jul 7/15/2013; 305(2): R98-100. PMID: 23657641, PMCID: PMC3726999, PII: ajpregu.00208.2013, DOI: 10.1152/ajpregu.00208.2013, ISSN: 1522-1490.

Nazarewicz RR, Bikineyeva A, Dikalov SI. Rapid and specific measurements of superoxide using fluorescence spectroscopy. J Biomol Screen [print-electronic]. 2013 Apr; 18(4): 498-503. PMID: 23190737, PMCID: PMC4210376, PII: 1087057112468765, DOI: 10.1177/1087057112468765, ISSN: 1552-454X.

May JM, Qu ZC, Nazarewicz R, Dikalov S. Ascorbic acid efficiently enhances neuronal synthesis of norepinephrine from dopamine. Brain Res. Bull [print-electronic]. 2013 Jan; 90: 35-42. PMID: 23022576, PMCID: PMC3527656, PII: S0361-9230(12)00209-2, DOI: 10.1016/j.brainresbull.2012.09.009, ISSN: 1873-2747.

Wakeman CA, Hammer ND, Stauff DL, Attia AS, Anzaldi LL, Dikalov SI, Calcutt MW, Skaar EP. Menaquinone biosynthesis potentiates haem toxicity in Staphylococcus aureus. Mol. Microbiol [print-electronic]. 2012 Dec; 86(6): 1376-92. PMID: 23043465, PMCID: PMC3524387, DOI: 10.1111/mmi.12063, ISSN: 1365-2958.

Dikalov SI, Li W, Doughan AK, Blanco RR, Zafari AM. Mitochondrial reactive oxygen species and calcium uptake regulate activation of phagocytic NADPH oxidase. Am. J. Physiol. Regul. Integr. Comp. Physiol [print-electronic]. 2012 May 5/15/2012; 302(10): R1134-42. PMID: 22442197, PMCID: PMC3362147, PII: ajpregu.00842.2010, DOI: 10.1152/ajpregu.00842.2010, ISSN: 1522-1490.

Dikalov S. Cross talk between mitochondria and NADPH oxidases. Free Radic. Biol. Med [print-electronic]. 2011 Oct 10/1/2011; 51(7): 1289-301. PMID: 21777669, PMCID: PMC3163726, PII: S0891-5849(11)00427-8, DOI: 10.1016/j.freeradbiomed.2011.06.033, ISSN: 1873-4596.