Paul A. Newhouse, M.D.


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Faculty Appointments
Professor of Psychiatry and Behavioral Sciences Professor of MedicineProfessor of PharmacologyJim Turner Chair in Cognitive Disorders
M.D., Loyola Stritch School of Medicine, Chicago, IllinoisB.S., Kansas State University, Manhattan, Kansas
Office Address
Department of Psychiatry
Vanderbilt University School of Medicine
1601 23rd Ave. South
Nashville, TN 37212
Research Description
The cognitive basis for neuropsychiatric disorders, the effects of brain cholinergic systems and sex hormones on human cognitive functioning, and experimental medicine including the development of novel treatments for Alzheimer’s disease and other disorders of cognitive aging.
Clinical Description
Dr. Newhouse joined the faculty in 2011 and holds the Jim Turner Chair of Cognitive Disorders at Vanderbilt University School of Medicine and is Professor of Psychiatry, Pharmacology, and Medicine. He is Director of the Center for Cognitive Medicine and the Division of Geriatric Psychiatry in the Department of Psychiatry and Behavioral Sciences at Vanderbilt University Medical Center. He is also Training Director for the Vanderbilt TVHS Geriatric Psychiatry Fellowship. He is also a physician-­-scientist at the VA Tennessee Valley Health Systems Geriatric Research, Education, and Clinical Center (GRECC).

Dr. Newhouse's research has focused on central nicotinic mechanisms in aging and the role of nicotinic receptor systems in normal and disordered cognitive functioning in humans. He has also emphasized the development of novel cholinergic agents for clinical use in cognitive disorders. A second major focus includes studying the interaction of estrogen and related molecules on central cholinergic systems in relation to cognitive and emotional aging through the use of novel pharmacologic-­-imaging methodologies.
Clinical Research Keywords
The diagnosis, treatment, and management of cognitive disorders of aging including Alzheimer's disease and related dementing disorders.