Lisa R. Young, M.D.

Associate Professor

lisa.young@vanderbilt.edu

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Faculty Appointments
Associate Professor of Pediatrics Associate Professor of Cell and Developmental BiologyAssociate Professor of MedicineJanie Robinson and John Moore Lee Chair in Pediatrics
Education
M.D., Duke University, Durham, North CarolinaB.A., University of Virginia, Charlottesville, Virginia
Office Address
2200 Children's Way
11215 Doctor's Office Tower
Nashville, TN 37232
Research Keywords
pulmonary, epithelial biology, macrophage biology, intracellular trafficking, interstitial lung disease, pulmonary fibrosis, alveolar homeostasis, genetic lung disease, biomarkers
Publications
Kook S, Qi A, Wang P, Meng S, Gulleman P, Young LR, Guttentag SH. Gene-edited MLE-15 Cells as a Model for the Hermansky Pudlak Syndromes. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2017 Nov 11/30/2017; PMID: 29190429, DOI: 10.1165/rcmb.2017-0324MA, ISSN: 1535-4989.

Benjamin JT, Meer RV, Slaughter JC, Steele S, Plosa EJ, Sucre JM, Moore PE, Aschner JL, Blackwell TS, Young LR. Inverse Relationship Between Soluble RAGE and Risk for Bronchopulmonary Dysplasia. Am. J. Respir. Crit. Care Med [print-electronic]. 2017 Oct 10/16/2017; PMID: 29035091, DOI: 10.1164/rccm.201707-1445LE, ISSN: 1535-4970.

McCormack FX, Gupta N, Finlay GR, Young LR, Johnson SR, Cottin V, Wilson KC, Moss J, . Reply: The ATS/JRS Guidelines on Lymphangioleiomyomatosis: Filling in the Gaps. Am. J. Respir. Crit. Care Med. 2017 Sep 9/1/2017; 196(5): 660-1. PMID: 28288285, DOI: 10.1164/rccm.201702-0417LE, ISSN: 1535-4970.

Lu C, Lee HS, Pappas GP, Dilling DF, Burger CD, Shifren A, Veeraraghavan S, Chapman JT, Parambil J, Ruoss SJ, Young LR, Hammes SR, Kopras EJ, Roads T, Krischer JP, McCormack FX, . A Phase II Clinical Trial of an Aromatase Inhibitor for Postmenopausal Women with Lymphangioleiomyomatosis. Ann Am Thorac Soc. 2017 Jun; 14(6): 919-28. PMID: 28570161, DOI: 10.1513/AnnalsATS.201610-824OC, ISSN: 2325-6621.

Kropski JA, Young LR, Blackwell TS, Loyd JE. Reply: The Genetic Diagnosis of Interstitial Lung Disease: A Need for an International Consensus. Am. J. Respir. Crit. Care Med. 2017 Jun 6/1/2017; 195(11): 1539-40. PMID: 28569574, PMCID: PMC5470755, DOI: 10.1164/rccm.201612-2520LE, ISSN: 1535-4970.

Kropski JA, Young LR, Cogan JD, Mitchell DB, Lancaster LH, Worrell JA, Markin C, Liu N, Mason WR, Fingerlin TE, Schwartz DA, Lawson WE, Blackwell TS, Phillips JA, Loyd JE. Genetic Evaluation and Testing of Patients and Families with Idiopathic Pulmonary Fibrosis. Am. J. Respir. Crit. Care Med. 2017 Jun 6/1/2017; 195(11): 1423-8. PMID: 27786550, PMCID: PMC5470751, DOI: 10.1164/rccm.201609-1820PP, ISSN: 1535-4970.

Young LR, Trapnell BC, Mandl KD, Swarr DT, Wambach JA, Blaisdell CJ. Accelerating Scientific Advancement for Pediatric Rare Lung Disease Research. Report from a National Institutes of Health-NHLBI Workshop, September 3 and 4, 2015. Ann Am Thorac Soc. 2016 Dec; 13(12): 385-93. PMID: 27925785, PMCID: PMC5291498, DOI: 10.1513/AnnalsATS.201605-402OT, ISSN: 2325-6621.

O'Brien KJ, Lozier J, Cullinane AR, Osorio B, Nghiem K, Speransky V, Zein WM, Mullikin JC, Neff AT, Simon KL, Malicdan MC, Gahl WA, Young LR, Gochuico BR. Identification of a novel mutation in HPS6 in a patient with hemophilia B and oculocutaneous albinism. Mol. Genet. Metab [print-electronic]. 2016 Nov; 119(3): 284-7. PMID: 27641950, PMCID: PMC5083180, PII: S1096-7192(16)30211-6, DOI: 10.1016/j.ymgme.2016.08.009, ISSN: 1096-7206.

Takada T, Mikami A, Kitamura N, Seyama K, Inoue Y, Nagai K, Suzuki M, Moriyama H, Akasaka K, Tazawa R, Hirai T, Mishima M, Hayashida M, Hirose M, Sugimoto C, Arai T, Hattori N, Watanabe K, Tamada T, Yoshizawa H, Akazawa K, Tanaka T, Yagi K, Young LR, McCormack FX, Nakata K. Efficacy and Safety of Long-Term Sirolimus Therapy for Asian Patients with Lymphangioleiomyomatosis. Ann Am Thorac Soc. 2016 Nov; 13(11): 1912-22. PMID: 27513278, DOI: 10.1513/AnnalsATS.201605-335OC, ISSN: 2325-6621.

Young LR, Gulleman PM, Short CW, Tanjore H, Sherrill T, Qi A, McBride AP, Zaynagetdinov R, Benjamin JT, Lawson WE, Novitskiy SV, Blackwell TS. Epithelial-macrophage interactions determine pulmonary fibrosis susceptibility in Hermansky-Pudlak syndrome. JCI Insight. 2016 Oct 10/20/2016; 1(17): e88947. PMID: 27777976, PMCID: PMC5070955, PII: 88947, DOI: 10.1172/jci.insight.88947, ISSN: 2379-3708.

Vicary GW, Vergne Y, Santiago-Cornier A, Young LR, Roman J. Pulmonary Fibrosis in Hermansky-Pudlak Syndrome. Ann Am Thorac Soc. 2016 Oct; 13(10): 1839-46. PMID: 27529121, PMCID: PMC5466158, DOI: 10.1513/AnnalsATS.201603-186FR, ISSN: 2325-6621.

El-Chemaly S, Young LR. Hermansky-Pudlak Syndrome. Clin. Chest Med [print-electronic]. 2016 Sep; 37(3): 505-11. PMID: 27514596, PMCID: PMC4987498, PII: S0272-5231(16)30049-1, DOI: 10.1016/j.ccm.2016.04.012, ISSN: 1557-8216.

Sahin M, Henske EP, Manning BD, Ess KC, Bissler JJ, Klann E, Kwiatkowski DJ, Roberds SL, Silva AJ, Hillaire-Clarke CS, Young LR, Zervas M, Mamounas LA, . Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference. Pediatr. Neurol [print-electronic]. 2016 Jul; 60: 1-12. PMID: 27267556, PMCID: PMC4921275, PII: S0887-8994(16)30167-9, DOI: 10.1016/j.pediatrneurol.2016.03.015, ISSN: 1873-5150.

Benjamin JT, van der Meer R, Im AM, Plosa EJ, Zaynagetdinov R, Burman A, Havrilla ME, Gleaves LA, Polosukhin VV, Deutsch GH, Yanagisawa H, Davidson JM, Prince LS, Young LR, Blackwell TS. Epithelial-Derived Inflammation Disrupts Elastin Assembly and Alters Saccular Stage Lung Development. Am. J. Pathol [print-electronic]. 2016 Jul; 186(7): 1786-800. PMID: 27181406, PMCID: PMC4929391, PII: S0002-9440(16)30065-7, DOI: 10.1016/j.ajpath.2016.02.016, ISSN: 1525-2191.

Saxon JA, Sherrill TP, Polosukhin VV, Sai J, Zaynagetdinov R, McLoed AG, Gulleman PM, Barham W, Cheng DS, Hunt RP, Gleaves LA, Richmond A, Young LR, Yull FE, Blackwell TS. Epithelial NF-¿B signaling promotes EGFR-driven lung carcinogenesis via macrophage recruitment. Oncoimmunology. 2016 Jun; 5(6): e1168549. PMID: 27471643, PII: 1168549, DOI: 10.1080/2162402X.2016.1168549, ISSN: 2162-4011.

Young LR, Vece TJ, Guillerman RP. Response [letter]. Chest. 2016 Jun; 149(6): 1579-80. PMID: 27287578, PII: S0012-3692(16)45718-1, DOI: 10.1016/j.chest.2016.03.020, ISSN: 1931-3543.

Nevel RJ, Garnett ET, Worrell JA, Morton RL, Nogee LM, Blackwell TS, Young LR. Persistent Lung Disease in Adults with NKX2.1 Mutation and Familial Neuroendocrine Cell Hyperplasia of Infancy (NEHI). Ann Am Thorac Soc [print-electronic]. 2016 May 5/17/2016; PMID: 27187870, DOI: 10.1513/AnnalsATS.201603-155BC, ISSN: 2325-6621.

Kook S, Wang P, Young LR, Schwake M, Saftig P, Weng X, Meng Y, Neculai D, Marks MS, Gonzales L, Beers MF, Guttentag S. Impaired Lysosomal Integral Membrane Protein 2-dependent Peroxiredoxin 6 Delivery to Lamellar Bodies Accounts for Altered Alveolar Phospholipid Content in Adaptor Protein-3-deficient pearl Mice. J. Biol. Chem [print-electronic]. 2016 Apr 4/15/2016; 291(16): 8414-27. PMID: 26907692, PMCID: PMC4861416, PII: M116.720201, DOI: 10.1074/jbc.M116.720201, ISSN: 1083-351X.

Deutsch GH, Young LR. Lipofibroblast Phenotype in Pulmonary Interstitial Glycogenosis. Am. J. Respir. Crit. Care Med. 2016 Mar 3/15/2016; 193(6): 694-6. PMID: 26977970, PMCID: PMC4824941, DOI: 10.1164/rccm.201509-1809LE, ISSN: 1535-4970.

Houin PR, Deterding RR, Young LR. Exacerbations in neuroendocrine cell hyperplasia of infancy are characterized by increased air trapping. Pediatr. Pulmonol [print-electronic]. 2016 Mar; 51(3): E9-12. PMID: 26642007, DOI: 10.1002/ppul.23347, ISSN: 1099-0496.

Vece TJ, Young LR. Update on Diffuse Lung Disease in Children. Chest [print-electronic]. 2016 Mar; 149(3): 836-45. PMID: 26502226, PII: S0012-3692(15)00068-9, DOI: 10.1378/chest.15-1986, ISSN: 1931-3543.

Zaynagetdinov R, Sherrill TP, Gleaves LA, Hunt P, Han W, McLoed AG, Saxon JA, Tanjore H, Gulleman PM, Young LR, Blackwell TS. Chronic NF-¿B activation links COPD and lung cancer through generation of an immunosuppressive microenvironment in the lungs. Oncotarget. 2016 Feb 2/2/2016; 7(5): 5470-82. PMID: 26756215, PMCID: PMC4868699, PII: 6562, DOI: 10.18632/oncotarget.6562, ISSN: 1949-2553.

O'Connor MG, Wurth M, Young LR. Rare Becomes More Common: Recognizing Neuroendocrine Cell Hyperplasia of Infancy in Everyday Pulmonary Consultations. Ann Am Thorac Soc. 2015 Nov; 12(11): 1730-2. PMID: 26540427, PMCID: PMC4724893, DOI: 10.1513/AnnalsATS.201507-422LE, ISSN: 2325-6621.

Fan LL, Dishop MK, Galambos C, Askin FB, White FV, Langston C, Liptzin DR, Kroehl ME, Deutsch GH, Young LR, Kurland G, Hagood J, Dell S, Trapnell BC, Deterding RR, . Diffuse Lung Disease in Biopsied Children 2 to 18 Years of Age. Application of the chILD Classification Scheme. Ann Am Thorac Soc. 2015 Oct; 12(10): 1498-505. PMID: 26291470, PMCID: PMC4627419, DOI: 10.1513/AnnalsATS.201501-064OC, ISSN: 2325-6621.

Gupta N, Meraj R, Tanase D, James LE, Seyama K, Lynch DA, Akira M, Meyer CA, Ruoss SJ, Burger CD, Young LR, Almoosa KF, Veeraraghavan S, Barker AF, Lee AS, Dilling DF, Inoue Y, Cudzilo CJ, Zafar MA, McCormack FX. Accuracy of chest high-resolution computed tomography in diagnosing diffuse cystic lung diseases [letter]. Eur. Respir. J [print-electronic]. 2015 Oct; 46(4): 1196-9. PMID: 26160866, PII: 13993003.00570-2015, DOI: 10.1183/13993003.00570-2015, ISSN: 1399-3003.

Lo B, Zhang K, Lu W, Zheng L, Zhang Q, Kanellopoulou C, Zhang Y, Liu Z, Fritz JM, Marsh R, Husami A, Kissell D, Nortman S, Chaturvedi V, Haines H, Young LR, Mo J, Filipovich AH, Bleesing JJ, Mustillo P, Stephens M, Rueda CM, Chougnet CA, Hoebe K, McElwee J, Hughes JD, Karakoc-Aydiner E, Matthews HF, Price S, Su HC, Rao VK, Lenardo MJ, Jordan MB. AUTOIMMUNE DISEASE. Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy. Science. 2015 Jul 7/24/2015; 349(6246): 436-40. PMID: 26206937, PII: 349/6246/436, DOI: 10.1126/science.aaa1663, ISSN: 1095-9203.

Han W, Zaynagetdinov R, Yull FE, Polosukhin VV, Gleaves LA, Tanjore H, Young LR, Peterson TE, Manning HC, Prince LS, Blackwell TS. Molecular imaging of folate receptor ß-positive macrophages during acute lung inflammation. Am. J. Respir. Cell Mol. Biol. 2015 Jul; 53(1): 50-9. PMID: 25375039, PMCID: PMC4566110, DOI: 10.1165/rcmb.2014-0289OC, ISSN: 1535-4989.

Wolf MS, Chadha AD, Carroll CM, Borinstein SC, Young LR. Unusual progression and subsequent improvement in cystic lung disease in a child with radiation-induced lung injury. Pediatr Radiol [print-electronic]. 2015 Jul; 45(7): 1086-90. PMID: 25434733, PMCID: PMC4452450, DOI: 10.1007/s00247-014-3223-6, ISSN: 1432-1998.

Kropski JA, Pritchett JM, Zoz DF, Crossno PF, Markin C, Garnett ET, Degryse AL, Mitchell DB, Polosukhin VV, Rickman OB, Choi L, Cheng DS, McConaha ME, Jones BR, Gleaves LA, McMahon FB, Worrell JA, Solus JF, Ware LB, Lee JW, Massion PP, Zaynagetdinov R, White ES, Kurtis JD, Johnson JE, Groshong SD, Lancaster LH, Young LR, Steele MP, Phillips Iii JA, Cogan JD, Loyd JE, Lawson WE, Blackwell TS. Extensive phenotyping of individuals at risk for familial interstitial pneumonia reveals clues to the pathogenesis of interstitial lung disease. Am. J. Respir. Crit. Care Med. 2015 Feb 2/15/2015; 191(4): 417-26. PMID: 25389906, PMCID: PMC4351594, DOI: 10.1164/rccm.201406-1162OC, ISSN: 1535-4970.

Plosa EJ, Young LR, Gulleman PM, Polosukhin VV, Zaynagetdinov R, Benjamin JT, Im AM, van der Meer R, Gleaves LA, Bulus N, Han W, Prince LS, Blackwell TS, Zent R. Epithelial ß1 integrin is required for lung branching morphogenesis and alveolarization. Development [print-electronic]. 2014 Dec; 141(24): 4751-62. PMID: 25395457, PMCID: PMC4299273, PII: dev.117200, DOI: 10.1242/dev.117200, ISSN: 1477-9129.

Kuo CS, Young LR. Interstitial lung disease in children. Curr. Opin. Pediatr. 2014 Jun; 26(3): 320-7. PMID: 24752172, PMCID: PMC4130649, DOI: 10.1097/MOP.0000000000000094, ISSN: 1531-698X.

Rosas IO, Dellaripa PF, Lederer DJ, Khanna D, Young LR, Martinez FJ. Interstitial lung disease: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases. Ann Am Thorac Soc. 2014 Apr; 11 Suppl 3: S169-77. PMID: 24754826, PMCID: PMC4112506, DOI: 10.1513/AnnalsATS.201312-429LD, ISSN: 2325-6621.

Zafar MA, McCormack FX, Rahman S, Tencza C, Wikenheiser-Brokamp KA, Young LR, Shizukuda Y, Elwing JM. Pulmonary vascular shunts in exercise-intolerant patients with lymphangioleiomyomatosis [letter]. Am. J. Respir. Crit. Care Med. 2013 Nov 11/1/2013; 188(9): 1167-70. PMID: 24180449, DOI: 10.1164/rccm.201304-0618LE, ISSN: 1535-4970.

Soares JJ, Deutsch GH, Moore PE, Fazili MF, Austin ED, Brown RF, Sokolow AG, Hilmes MA, Young LR. Childhood interstitial lung diseases: an 18-year retrospective analysis. Pediatrics [print-electronic]. 2013 Oct; 132(4): 684-91. PMID: 24081995, PMCID: PMC3784299, PII: peds.2013-1780, DOI: 10.1542/peds.2013-1780, ISSN: 1098-4275.

Young LR, Deutsch GH, Bokulic RE, Brody AS, Nogee LM. A mutation in TTF1/NKX2.1 is associated with familial neuroendocrine cell hyperplasia of infancy. Chest. 2013 Oct; 144(4): 1199-206. PMID: 23787483, PMCID: PMC3787915, PII: 1698750, DOI: 10.1378/chest.13-0811, ISSN: 1931-3543.

Krueger DA, Northrup H, . Tuberous sclerosis complex surveillance and management: recommendations of the 2012 International Tuberous Sclerosis Complex Consensus Conference. Pediatr. Neurol. 2013 Oct; 49(4): 255-65. PMID: 24053983, PMCID: PMC4058297, PII: S0887-8994(13)00491-8, DOI: 10.1016/j.pediatrneurol.2013.08.002, ISSN: 1873-5150.

Northrup H, Krueger DA, . Tuberous sclerosis complex diagnostic criteria update: recommendations of the 2012 Iinternational Tuberous Sclerosis Complex Consensus Conference. Pediatr. Neurol. 2013 Oct; 49(4): 243-54. PMID: 24053982, PMCID: PMC4080684, PII: S0887-8994(13)00490-6, DOI: 10.1016/j.pediatrneurol.2013.08.001, ISSN: 1873-5150.

Hamvas A, Deterding RR, Wert SE, White FV, Dishop MK, Alfano DN, Halbower AC, Planer B, Stephan MJ, Uchida DA, Williames LD, Rosenfeld JA, Lebel RR, Young LR, Cole FS, Nogee LM. Heterogeneous pulmonary phenotypes associated with mutations in the thyroid transcription factor gene NKX2-1. Chest. 2013 Sep; 144(3): 794-804. PMID: 23430038, PMCID: PMC3760742, PII: 1655028, DOI: 10.1378/chest.12-2502, ISSN: 1931-3543.

Kurland G, Deterding RR, Hagood JS, Young LR, Brody AS, Castile RG, Dell S, Fan LL, Hamvas A, Hilman BC, Langston C, Nogee LM, Redding GJ, . An official American Thoracic Society clinical practice guideline: classification, evaluation, and management of childhood interstitial lung disease in infancy. Am. J. Respir. Crit. Care Med. 2013 Aug 8/1/2013; 188(3): 376-94. PMID: 23905526, PMCID: PMC3778735, DOI: 10.1164/rccm.201305-0923ST, ISSN: 1535-4970.

Cudzilo CJ, Szczesniak RD, Brody AS, Rattan MS, Krueger DA, Bissler JJ, Franz DN, McCormack FX, Young LR. Lymphangioleiomyomatosis screening in women with tuberous sclerosis. Chest. 2013 Aug; 144(2): 578-85. PMID: 23539171, PII: 1672803, DOI: 10.1378/chest.12-2813, ISSN: 1931-3543.

McCormack FX, Wilmott C, Young LR, Wikenheiser-Brokamp K. An atoll variant that mocks. Am. J. Respir. Crit. Care Med. 2013 Jul 7/1/2013; 188(1): 110. PMID: 23815723, DOI: 10.1164/rccm.201211-1975IM, ISSN: 1535-4970.

Swigris JJ, Lee HS, Cohen M, Inoue Y, Moss J, Singer LG, Young LR, McCormack FX, . St. George's Respiratory Questionnaire has longitudinal construct validity in lymphangioleiomyomatosis. Chest. 2013 Jun; 143(6): 1671-8. PMID: 23328755, PMCID: PMC3673663, PII: 1557659, DOI: 10.1378/chest.12-0161, ISSN: 1931-3543.

Young LR, Lee HS, Inoue Y, Moss J, Singer LG , Strange C , Nakata K, Barker AF , Chapman JT, Brantly ML, Stocks JM, Brown KK, Lynch JP, III, Goldberg HJ , Downey GP, Swigris JJ , Taveira-DaSilva AM, Krischer JP, Trapnell BC, McCormack FX for the MILES Trial Group.. Serum VEGF-D concentration as a biomarker of lymphangioleiomyomatosis severity and treatment response: a prospective analysis of the Multicenter International Lymphangioleiomyomatosis Efficacy of Sirolimus (MILES) Trial. 2013.

Kropski JA, Lawson WE, Young LR, Blackwell TS. Genetic studies provide clues on the pathogenesis of idiopathic pulmonary fibrosis. Dis Model Mech. 2013 Jan; 6(1): 9-17. PMID: 23268535, PMCID: PMC3529334, PII: 6/1/9, DOI: 10.1242/dmm.010736, ISSN: 1754-8411.

Meraj R, Wikenheiser-Brokamp KA, Young LR, Byrnes S, McCormack FX. Utility of transbronchial biopsy in the diagnosis of lymphangioleiomyomatosis. Front Med [print-electronic]. 2012 Dec; 6(4): 395-405. PMID: 23224417, DOI: 10.1007/s11684-012-0231-5, ISSN: 2095-0225.

Young LR, Gulleman PM, Bridges JP, Weaver TE, Deutsch GH, Blackwell TS, McCormack FX. The alveolar epithelium determines susceptibility to lung fibrosis in Hermansky-Pudlak syndrome. Am. J. Respir. Crit. Care Med [print-electronic]. 2012 Nov 11/15/2012; 186(10): 1014-24. PMID: 23043085, PMCID: PMC3530211, PII: rccm.201207-1206OC, DOI: 10.1164/rccm.201207-1206OC, ISSN: 1535-4970.

Meraj R, Wikenheiser-Brokamp KA, Young LR, McCormack FX. Lymphangioleiomyomatosis: new concepts in pathogenesis, diagnosis, and treatment. Semin Respir Crit Care Med [print-electronic]. 2012 Oct; 33(5): 486-97. PMID: 23001803, DOI: 10.1055/s-0032-1325159, ISSN: 1098-9048.

Young LR, Brody AS, Inge TH, Acton JD, Bokulic RE, Langston C, Deutsch GH. Neuroendocrine cell distribution and frequency distinguish neuroendocrine cell hyperplasia of infancy from other pulmonary disorders. Chest [print-electronic]. 2011 May; 139(5): 1060-71. PMID: 20884725, PII: chest.10-1304, DOI: 10.1378/chest.10-1304, ISSN: 1931-3543.

McCormack FX, Inoue Y, Moss J, Singer LG, Strange C, Nakata K, Barker AF, Chapman JT, Brantly ML, Stocks JM, Brown KK, Lynch JP, Goldberg HJ, Young LR, Kinder BW, Downey GP, Sullivan EJ, Colby TV, McKay RT, Cohen MM, Korbee L, Taveira-DaSilva AM, Lee HS, Krischer JP, Trapnell BC, , . Efficacy and safety of sirolimus in lymphangioleiomyomatosis. N. Engl. J. Med [print-electronic]. 2011 Apr 4/28/2011; 364(17): 1595-606. PMID: 21410393, PMCID: PMC3118601, DOI: 10.1056/NEJMoa1100391, ISSN: 1533-4406.

Suzuki T, Sakagami T, Young LR, Carey BC, Wood RE, Luisetti M, Wert SE, Rubin BK, Kevill K, Chalk C, Whitsett JA, Stevens C, Nogee LM, Campo I, Trapnell BC. Hereditary pulmonary alveolar proteinosis: pathogenesis, presentation, diagnosis, and therapy. Am. J. Respir. Crit. Care Med [print-electronic]. 2010 Nov 11/15/2010; 182(10): 1292-304. PMID: 20622029, PMCID: PMC3001266, PII: 201002-0271OC, DOI: 10.1164/rccm.201002-0271OC, ISSN: 1535-4970.

Deutsch GH, Young LR. Pulmonary interstitial glycogenosis: words of caution. Pediatr Radiol [print-electronic]. 2010 Sep; 40(9): 1471-5. PMID: 20593171, DOI: 10.1007/s00247-010-1730-7, ISSN: 1432-1998.

Young LR, Vandyke R, Gulleman PM, Inoue Y, Brown KK, Schmidt LS, Linehan WM, Hajjar F, Kinder BW, Trapnell BC, Bissler JJ, Franz DN, McCormack FX. Serum vascular endothelial growth factor-D prospectively distinguishes lymphangioleiomyomatosis from other diseases. Chest [print-electronic]. 2010 Sep; 138(3): 674-81. PMID: 20382711, PMCID: PMC2940071, PII: chest.10-0573, DOI: 10.1378/chest.10-0573, ISSN: 1931-3543.

Kinder BW, Sherman AC, Young LR, Hagaman JT, Oprescu N, Byrnes S, McCormack FX. Predictors for clinical trial participation in the rare lung disease lymphangioleiomyomatosis. Respir Med [print-electronic]. 2010 Apr; 104(4): 578-83. PMID: 19962873, PMCID: PMC4407662, PII: S0954-6111(09)00367-9, DOI: 10.1016/j.rmed.2009.09.023, ISSN: 1532-3064.

Deterding RR, Brody AS, Hagood JS, Young LR. Round Table Discussion: Children's Interstitial Lung Disease. Pediatr Allergy Immunol Pulmonol. 2010 Mar; 23(1): 91-6. PMID: 22332034, PMCID: PMC3269224, PII: 10.1089/ped.2010.2304, DOI: 10.1089/ped.2010.2304, ISSN: 2151-321X.

Brody AS, Guillerman RP, Hay TC, Wagner BD, Young LR, Deutsch GH, Fan LL, Deterding RR. Neuroendocrine cell hyperplasia of infancy: diagnosis with high-resolution CT. AJR Am J Roentgenol. 2010 Jan; 194(1): 238-44. PMID: 20028928, PMCID: PMC3785715, PII: 194/1/238, DOI: 10.2214/AJR.09.3385, ISSN: 1546-3141.

Caldwell CC, Chen Y, Goetzmann HS, Hao Y, Borchers MT, Hassett DJ, Young LR, Mavrodi D, Thomashow L, Lau GW. Pseudomonas aeruginosa exotoxin pyocyanin causes cystic fibrosis airway pathogenesis. Am. J. Pathol [print-electronic]. 2009 Dec; 175(6): 2473-88. PMID: 19893030, PMCID: PMC2789600, PII: S0002-9440(10)60756-0, DOI: 10.2353/ajpath.2009.090166, ISSN: 1525-2191.

Deutsch GH, Young LR. Histologic resolution of pulmonary interstitial glycogenosis. Pediatr. Dev. Pathol. 2009 Nov; 12(6): 475-80. PMID: 19320535, PII: 08-12-0575, DOI: 10.2350/08-12-0575.1, ISSN: 1093-5266.

Young LR, Franz DN, Nagarkatte P, Fletcher CD, Wikenheiser-Brokamp KA, Galsky MD, Corbridge TC, Lam AP, Gelfand MJ, McCormack FX. Utility of [18F]2-fluoro-2-deoxyglucose-PET in sporadic and tuberous sclerosis-associated lymphangioleiomyomatosis. Chest [print-electronic]. 2009 Sep; 136(3): 926-33. PMID: 19349386, PMCID: PMC3198490, PII: chest.09-0336, DOI: 10.1378/chest.09-0336, ISSN: 1931-3543.

Schmithorst VJ, Altes TA, Young LR, Franz DN, Bissler JJ, McCormack FX, Dardzinski BJ, Brody AS. Automated algorithm for quantifying the extent of cystic change on volumetric chest CT: initial results in Lymphangioleiomyomatosis. AJR Am J Roentgenol. 2009 Apr; 192(4): 1037-44. PMID: 19304711, PII: 192/4/1037, DOI: 10.2214/AJR.07.3334, ISSN: 1546-3141.

Young LR, Nogee LM, Barnett B, Panos RJ, Colby TV, Deutsch GH. Usual interstitial pneumonia in an adolescent with ABCA3 mutations. Chest. 2008 Jul; 134(1): 192-5. PMID: 18628224, PII: 134/1/192, DOI: 10.1378/chest.07-2652, ISSN: 0012-3692.

Young LR, Inoue Y, McCormack FX. Diagnostic potential of serum VEGF-D for lymphangioleiomyomatosis [letter]. N. Engl. J. Med. 2008 Jan 1/10/2008; 358(2): 199-200. PMID: 18184970, PMCID: PMC3804557, PII: 358/2/199, DOI: 10.1056/NEJMc0707517, ISSN: 1533-4406.

Bissler JJ, McCormack FX, Young LR, Elwing JM, Chuck G, Leonard JM, Schmithorst VJ, Laor T, Brody AS, Bean J, Salisbury S, Franz DN. Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis. N. Engl. J. Med. 2008 Jan 1/10/2008; 358(2): 140-51. PMID: 18184959, PMCID: PMC3398441, PII: 358/2/140, DOI: 10.1056/NEJMoa063564, ISSN: 1533-4406.

Deutsch GH, Young LR, Deterding RR, Fan LL, Dell SD, Bean JA, Brody AS, Nogee LM, Trapnell BC, Langston C, , Albright EA, Askin FB, Baker P, Chou PM, Cool CM, Coventry SC, Cutz E, Davis MM, Dishop MK, Galambos C, Patterson K, Travis WD, Wert SE, White FV, . Diffuse lung disease in young children: application of a novel classification scheme. Am. J. Respir. Crit. Care Med [print-electronic]. 2007 Dec 12/1/2007; 176(11): 1120-8. PMID: 17885266, PMCID: PMC2176101, PII: 200703-393OC, DOI: 10.1164/rccm.200703-393OC, ISSN: 1535-4970.

Thomas H, Risma KA, Graham TB, Brody AS, Deutsch GH, Young LR, Joseph PM. A kindred of children with interstitial lung disease. Chest. 2007 Jul; 132(1): 221-30. PMID: 17625084, PII: 132/1/221, DOI: 10.1378/chest.06-2476, ISSN: 0012-3692.

Young LR, Pasula R, Gulleman PM, Deutsch GH, McCormack FX. Susceptibility of Hermansky-Pudlak mice to bleomycin-induced type II cell apoptosis and fibrosis. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2007 Jul; 37(1): 67-74. PMID: 17363777, PMCID: PMC1899346, PII: 2006-0469OC, DOI: 10.1165/rcmb.2006-0469OC, ISSN: 1044-1549.

Prestridge A, Wooldridge J, Deutsch G, Young LR, Wert SE, Whitsett JA, Nogee L. Persistent tachypnea and hypoxia in a 3-month-old term infant. J. Pediatr. 2006 Nov; 149(5): 702-6. PMID: 17095348, PII: S0022-3476(06)00697-4, DOI: 10.1016/j.jpeds.2006.07.032, ISSN: 0022-3476.

Almoosa KF, Ryu JH, Mendez J, Huggins JT, Young LR, Sullivan EJ, Maurer J, McCormack FX, Sahn SA. Management of pneumothorax in lymphangioleiomyomatosis: effects on recurrence and lung transplantation complications. Chest. 2006 May; 129(5): 1274-81. PMID: 16685019, PII: 129/5/1274, DOI: 10.1378/chest.129.5.1274, ISSN: 0012-3692.

Young LR, Almoosa KF, Pollock-Barziv S, Coutinho M, McCormack FX, Sahn SA. Patient perspectives on management of pneumothorax in lymphangioleiomyomatosis. Chest. 2006 May; 129(5): 1267-73. PMID: 16685018, PII: 129/5/1267, DOI: 10.1378/chest.129.5.1267, ISSN: 0012-3692.

Young LR, Borchers MT, Allen HL, Gibbons RS, McCormack FX. Lung-restricted macrophage activation in the pearl mouse model of Hermansky-Pudlak syndrome. J. Immunol. 2006 Apr 4/1/2006; 176(7): 4361-8. PMID: 16547274, PMCID: PMC3783655, PII: 176/7/4361, ISSN: 0022-1767.

Available Postdoctoral Position Details
Posted: 11/20/2014
A NIH-funded postdoctoral position is available in the laboratory of Dr. Lisa Young in the Division of Pulmonary Medicine. Our lab studies how epithelial dysfunction results in pulmonary fibrosis, with particular interest in heritable disorders. Current projects in the lab are focused on alveolar epithelial cell biology including the
consequences of intracellular trafficking defects, cross-talk between alveolar epithelial cells, macrophages, and other effector cell populations, and oxidative stress. Other projects include focus on discovery of the genetic basis of human lung diseases and development of biomarkers. Experience in cellular and molecular biology is strongly desired.

Interested candidates are asked to send a C.V. and names of 3 references to Lisa.Young@Vanderbilt.edu.