Angela L. Jefferson, Ph.D.

Professor

angela.jefferson@vanderbilt.edu

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Faculty Appointments
Professor of Neurology Professor of Medicine
Education
Ph.D., Drexel University, Philadelphia, PennsylvaniaM.A., Loyola College, Baltimore, MarylandB.A., Lynchburg College , Lynchburg, Virginia
Office Address
Vanderbilt Memory & Alzheimer's Center
1207 17th Avenue South, Suite 204
Nashville, TN 37212
Research Description
My research program investigates cardiovascular and cerebrovascular mechanisms affecting the pathogenesis and clinical manifestation of Alzheimer’s disease and cerebrovascular disease in humans.
Research Keywords
Alzheimer's disease, mild cognitive impairment, vascular cognitive aging, cardiovascular function, cerebral hemodynamics
Publications
Lane EM, Hohman TJ, Jefferson AL, . Insulin-like growth factor binding protein-2 interactions with Alzheimer's disease biomarkers. Brain Imaging Behav [print-electronic]. 2016 Nov 11/5/2016; PMID: 27817134, PMCID: PMC5419882, PII: 10.1007/s11682-016-9636-0, DOI: 10.1007/s11682-016-9636-0, ISSN: 1931-7565.

Jefferson AL, Gifford KA, Acosta LM, Bell SP, Donahue MJ, Davis LT, Gottlieb J, Gupta DK, Hohman TJ, Lane EM, Libon DJ, Mendes LA, Niswender K, Pechman KR, Rane S, Ruberg FL, Su YR, Zetterberg H, Liu D. The Vanderbilt Memory & Aging Project: Study Design and Baseline Cohort Overview. J. Alzheimers Dis. 2016 Mar 3/8/2016; 52(2): 539-59. PMID: 26967211, PMCID: PMC4866875, PII: JAD150914, DOI: 10.3233/JAD-150914, ISSN: 1875-8908.

Hohman TJ, Samuels LR, Liu D, Gifford KA, Mukherjee S, Benson EM, Abel T, Ruberg FL, Jefferson AL, . Stroke risk interacts with Alzheimer's disease biomarkers on brain aging outcomes. Neurobiol. Aging [print-electronic]. 2015 Sep; 36(9): 2501-8. PMID: 26119224, PMCID: PMC4523400, PII: S0197-4580(15)00305-X, DOI: 10.1016/j.neurobiolaging.2015.05.021, ISSN: 1558-1497.

Jefferson AL, Gifford KA, Damon S, Chapman GW, Liu D, Sparling J, Dobromyslin V, Salat D, . Gray & white matter tissue contrast differentiates Mild Cognitive Impairment converters from non-converters. Brain Imaging Behav. 2015 Jun; 9(2): 141-8. PMID: 24493370, PMCID: PMC4146750, DOI: 10.1007/s11682-014-9291-2, ISSN: 1931-7565.

Hohman TJ, Bell SP, Jefferson AL, . The role of vascular endothelial growth factor in neurodegeneration and cognitive decline: exploring interactions with biomarkers of Alzheimer disease. JAMA Neurol. 2015 May; 72(5): 520-9. PMID: 25751166, PMCID: PMC4428948, PII: 2190749, DOI: 10.1001/jamaneurol.2014.4761, ISSN: 2168-6157.

Jefferson AL, Beiser AS, Himali JJ, Seshadri S, O'Donnell CJ, Manning WJ, Wolf PA, Au R, Benjamin EJ. Low cardiac index is associated with incident dementia and Alzheimer disease: the Framingham Heart Study. Circulation [print-electronic]. 2015 Apr 4/14/2015; 131(15): 1333-9. PMID: 25700178, PMCID: PMC4398627, PII: CIRCULATIONAHA.114.012438, DOI: 10.1161/CIRCULATIONAHA.114.012438, ISSN: 1524-4539.

Jefferson AL, Beiser AS, Seshadri S, Wolf PA, Au R. APOE and mild cognitive impairment: the Framingham Heart Study. Age Ageing [print-electronic]. 2015 Mar; 44(2): 307-11. PMID: 25497326, PMCID: PMC4400527, PII: afu183, DOI: 10.1093/ageing/afu183, ISSN: 1468-2834.

Jefferson AL, Hohman TJ, Liu D, Haj-Hassan S, Gifford KA, Benson EM, Skinner JS, Lu Z, Sparling J, Sumner EC, Bell S, Ruberg FL. Adverse vascular risk is related to cognitive decline in older adults. J. Alzheimers Dis. 2015; 44(4): 1361-73. PMID: 25471188, PMCID: PMC4336578, PII: 306700R180011678, DOI: 10.3233/JAD-141812, ISSN: 1875-8908.

Jefferson AL. Vascular risk factors and midlife cognition: rethinking the exposure window [editorial]. Circulation [print-electronic]. 2014 Apr 4/15/2014; 129(15): 1548-50. PMID: 24687776, PMCID: PMC4618666, PII: CIRCULATIONAHA.114.008906, DOI: 10.1161/CIRCULATIONAHA.114.008906, ISSN: 1524-4539.

Gifford KA, Badaracco M, Liu D, Tripodis Y, Gentile A, Lu Z, Palmisano J, Jefferson AL. Blood pressure and cognition among older adults: a meta-analysis. Arch Clin Neuropsychol [print-electronic]. 2013 Nov; 28(7): 649-64. PMID: 23838685, PMCID: PMC3807830, PII: act046, DOI: 10.1093/arclin/act046, ISSN: 1873-5843.