Jun Qian, Ph.D.

Research Assistant Professor

jun.qian@vanderbilt.edu
Faculty Appointments
Research Assistant Professor of Medicine
Education
Ph.D., Xiangya School of Medicine, Xiangya, ChinaM.S., Hunan Medical University, Changsha, ChinaB.S., Hunan Medical University, Changsha, China
Research Description
My primary expertise is integrating biological omics data such as genomics, transcriptomics, proteomics and metabolomics with molecular and cellular experiments to discover and validate potential novel biomarkers that contribute to lung cancer development. My long term research interest is to understand the mechanisms by which amplified drive genes on 3q26-29 amplicon work cooperatively and their functional implications in lung cancer progression.
Publications
Ji X, Niu X, Qian J, Martucci V, Pendergrass SA, Gorlov IP, Amos CI, Denny JC, Massion PP, Aldrich MC. A Phenome-Wide Association Study Uncovers a Role for Autoimmunity in the Development of Chronic Obstructive Pulmonary Disease. Am. J. Respir. Cell Mol. Biol. 2018 Jun; 58(6): 777-9. PMID: 29856256, PMCID: PMC6002656, DOI: 10.1165/rcmb.2017-0409LE, ISSN: 1535-4989.

Ji X, Qian J, Rahman SMJ, Siska PJ, Zou Y, Harris BK, Hoeksema MD, Trenary IA, Heidi C, Eisenberg R, Rathmell JC, Young JD, Massion PP. XCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression. Oncogene [print-electronic]. 2018 May 5/23/2018; PMID: 29789716, PII: 10.1038/s41388-018-0307-z, DOI: 10.1038/s41388-018-0307-z, ISSN: 1476-5594.

Qian J, Massion PP. Next-generation molecular therapy in lung cancer [editorial]. Transl Lung Cancer Res. 2018 Feb; 7(Suppl 1): S31-S34. PMID: 29531901, PMCID: PMC5835629, PII: tlcr-07-S1-S31, DOI: 10.21037/tlcr.2018.01.03, ISSN: 2218-6751.

Qian J, Zhong J, Yan M, Cheng P, Shi H, Hao C, Gu Y, Lai L. Circulating a-Klotho is Related to Plasma Aldosterone and Its Follow-Up Change Predicts CKD Progression. Kidney Blood Press. Res [print-electronic]. 2018; 43(3): 836-46. PMID: 29843135, PII: 000490138, DOI: 10.1159/000490138, ISSN: 1423-0143.

Song C, Piva M, Sun L, Hong A, Moriceau G, Kong X, Zhang H, Lomeli S, Qian J, Yu CC, Damoiseaux R, Kelley MC, Dahlman KB, Scumpia PO, Sosman JA, Johnson DB, Ribas A, Hugo W, Lo RS. Recurrent Tumor Cell-Intrinsic and -Extrinsic Alterations during MAPKi-Induced Melanoma Regression and Early Adaptation. Cancer Discov [print-electronic]. 2017 Nov; 7(11): 1248-65. PMID: 28864476, PII: 2159-8290.CD-17-0401, DOI: 10.1158/2159-8290.CD-17-0401, ISSN: 2159-8290.

Qian J, Chen H, Ji X, Eisenberg R, Chakravarthy AB, Mayer IA, Massion PP. A 3q gene signature associated with triple negative breast cancer organ specific metastasis and response to neoadjuvant chemotherapy. Sci Rep. 2017 Apr 4/7/2017; 7: 45828. PMID: 28387221, PMCID: PMC5384279, PII: srep45828, DOI: 10.1038/srep45828, ISSN: 2045-2322.

Rahman SM, Ji X, Zimmerman LJ, Li M, Harris BK, Hoeksema MD, Trenary IA, Zou Y, Qian J, Slebos RJ, Beane J, Spira A, Shyr Y, Eisenberg R, Liebler DC, Young JD, Massion PP. The airway epithelium undergoes metabolic reprogramming in individuals at high risk for lung cancer. JCI Insight. 2016 Nov 11/17/2016; 1(19): e88814. PMID: 27882349, PMCID: PMC5111517, PII: 88814, DOI: 10.1172/jci.insight.88814, ISSN: 2379-3708.

Hassanein M, Qian J, Hoeksema MD, Wang J, Jacobovitz M, Ji X, Harris FT, Harris BK, Boyd KL, Chen H, Eisenberg R, Massion PP. Targeting SLC1a5-mediated glutamine dependence in non-small cell lung cancer. Int. J. Cancer [print-electronic]. 2015 Oct 10/1/2015; 137(7): 1587-97. PMID: 25821004, PMCID: PMC4640891, DOI: 10.1002/ijc.29535, ISSN: 1097-0215.

Qian J, Zou Y, Wang J, Zhang B, Massion PP. Global gene expression profiling reveals a suppressed immune response pathway associated with 3q amplification in squamous carcinoma of the lung. Genom Data. 2015 Sep; 5: 272-4. PMID: 26484266, PMCID: PMC4583673, PII: S2213-5960(15)00123-3, DOI: 10.1016/j.gdata.2015.06.014, ISSN: 2213-5960.

Qian J, Hassanein M, Hoeksema MD, Harris BK, Zou Y, Chen H, Lu P, Eisenberg R, Wang J, Espinosa A, Ji X, Harris FT, Rahman SM, Massion PP. The RNA binding protein FXR1 is a new driver in the 3q26-29 amplicon and predicts poor prognosis in human cancers. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2015 Mar 3/17/2015; 112(11): 3469-74. PMID: 25733852, PMCID: PMC4371932, PII: 1421975112, DOI: 10.1073/pnas.1421975112, ISSN: 1091-6490.

Harris FT, Rahman SM, Hassanein M, Qian J, Hoeksema MD, Chen H, Eisenberg R, Chaurand P, Caprioli RM, Shiota M, Massion PP. Acyl-coenzyme A-binding protein regulates Beta-oxidation required for growth and survival of non-small cell lung cancer. Cancer Prev Res (Phila) [print-electronic]. 2014 Jul; 7(7): 748-57. PMID: 24819876, PMCID: PMC4090029, PII: 1940-6207.CAPR-14-0057, DOI: 10.1158/1940-6207.CAPR-14-0057, ISSN: 1940-6215.

Wang J, Qian J, Hoeksema MD, Zou Y, Espinosa AV, Rahman SM, Zhang B, Massion PP. Integrative genomics analysis identifies candidate drivers at 3q26-29 amplicon in squamous cell carcinoma of the lung. Clin. Cancer Res [print-electronic]. 2013 Oct 10/15/2013; 19(20): 5580-90. PMID: 23908357, PMCID: PMC3807802, PII: 1078-0432.CCR-13-0594, DOI: 10.1158/1078-0432.CCR-13-0594, ISSN: 1078-0432.

Hassanein M, Hoeksema MD, Shiota M, Qian J, Harris BK, Chen H, Clark JE, Alborn WE, Eisenberg R, Massion PP. SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival. Clin. Cancer Res [print-electronic]. 2013 Feb 2/1/2013; 19(3): 560-70. PMID: 23213057, PMCID: PMC3697078, PII: 1078-0432.CCR-12-2334, DOI: 10.1158/1078-0432.CCR-12-2334, ISSN: 1078-0432.

Ocak S, Pedchenko TV, Chen H, Harris FT, Qian J, Polosukhin V, Pilette C, Sibille Y, Gonzalez AL, Massion PP. Loss of polymeric immunoglobulin receptor expression is associated with lung tumourigenesis. Eur. Respir. J [print-electronic]. 2012 May; 39(5): 1171-80. PMID: 21965228, PMCID: PMC3717253, PII: 09031936.00184410, DOI: 10.1183/09031936.00184410, ISSN: 1399-3003.

Qian J, Zou Y, Rahman JS, Lu B, Massion PP. Synergy between phosphatidylinositol 3-kinase/Akt pathway and Bcl-xL in the control of apoptosis in adenocarcinoma cells of the lung. Mol. Cancer Ther. 2009 Jan; 8(1): 101-9. PMID: 19139118, PMCID: PMC3110728, PII: 8/1/101, DOI: 10.1158/1535-7163.MCT-08-0973, ISSN: 1535-7163.

Qian J, Massion PP. Role of chromosome 3q amplification in lung cancer. J Thorac Oncol. 2008 Mar; 3(3): 212-5. PMID: 18317062, PII: 01243894-200803000-00004, DOI: 10.1097/JTO.0b013e3181663544, ISSN: 1556-1380.