Luis E. Okamoto, M.D.

Research Assistant Professor

luis.e.okamoto@vanderbilt.edu
Faculty Appointments
Research Assistant Professor of Medicine
Education
M.D., Universidad Peruana Cayetano Heredia, Lima, Peru
Publications
Okamoto LE, Diedrich A, Baudenbacher FJ, Harder R, Whitfield JS, Iqbal F, Gamboa A, Shibao CA, Black BK, Raj SR, Robertson D, Biaggioni I. Efficacy of Servo-Controlled Splanchnic Venous Compression in the Treatment of Orthostatic Hypotension: A Randomized Comparison With Midodrine. Hypertension [print-electronic]. 2016 Aug; 68(2): 418-26. PMID: 27271310, PMCID: PMC4945429, PII: HYPERTENSIONAHA.116.07199, DOI: 10.1161/HYPERTENSIONAHA.116.07199, ISSN: 1524-4563.

Shibao CA, Celedonio JE, Ramirez CE, Love-Gregory L, Arnold AC, Choi L, Okamoto LE, Gamboa A, Biaggioni I, Abumrad NN, Abumrad NA. A Common CD36 Variant Influences Endothelial Function and Response to Treatment with Phosphodiesterase 5 Inhibition. J. Clin. Endocrinol. Metab [print-electronic]. 2016 Jul; 101(7): 2751-8. PMID: 27144937, PMCID: PMC4929841, DOI: 10.1210/jc.2016-1294, ISSN: 1945-7197.

Arnold AC, Okamoto LE, Gamboa A, Black BK, Raj SR, Elijovich F, Robertson D, Shibao CA, Biaggioni I. Mineralocorticoid Receptor Activation Contributes to the Supine Hypertension of Autonomic Failure. Hypertension [print-electronic]. 2016 Feb; 67(2): 424-9. PMID: 26644241, PMCID: PMC4748950, PII: HYPERTENSIONAHA.115.06617, DOI: 10.1161/HYPERTENSIONAHA.115.06617, ISSN: 1524-4563.

Okamoto LE, Raj SR, Gamboa A, Shibao CA, Arnold AC, Garland EM, Black BK, Farley G, Diedrich A, Biaggioni I. Sympathetic activation is associated with increased IL-6, but not CRP in the absence of obesity: lessons from postural tachycardia syndrome and obesity. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2015 Dec 12/15/2015; 309(12): H2098-107. PMID: 26453329, PMCID: PMC4698423, PII: ajpheart.00409.2015, DOI: 10.1152/ajpheart.00409.2015, ISSN: 1522-1539.

Celedonio JE, Arnold AC, Dupont WD, Ramirez CE, Diedrich A, Okamoto LE, Raj SR, Robertson D, Peltier AC, Biaggioni I, Shibao CA. Residual sympathetic tone is associated with reduced insulin sensitivity in patients with autonomic failure. Clin. Auton. Res [print-electronic]. 2015 Oct; 25(5): 309-15. PMID: 26359268, PMCID: PMC4785595, PII: 10.1007/s10286-015-0307-9, DOI: 10.1007/s10286-015-0307-9, ISSN: 0959-9851.

Gamboa A, Paranjape SY, Black BK, Arnold AC, Figueroa R, Okamoto LE, Nwazue VC, Diedrich A, Plummer WD, Dupont WD, Robertson D, Raj SR. Inspiratory resistance improves postural tachycardia: a randomized study. Circ Arrhythm Electrophysiol [print-electronic]. 2015 Jun; 8(3): 651-8. PMID: 25792354, PMCID: PMC4472504, PII: CIRCEP.114.002605, DOI: 10.1161/CIRCEP.114.002605, ISSN: 1941-3084.

Ramirez CE, Okamoto LE, Arnold AC, Gamboa A, Diedrich A, Choi L, Raj SR, Robertson D, Biaggioni I, Shibao CA. Efficacy of atomoxetine versus midodrine for the treatment of orthostatic hypotension in autonomic failure. Hypertension [print-electronic]. 2014 Dec; 64(6): 1235-40. PMID: 25185131, PMCID: PMC4231172, PII: HYPERTENSIONAHA.114.04225, DOI: 10.1161/HYPERTENSIONAHA.114.04225, ISSN: 1524-4563.

Okamoto LE, Gamboa A, Shibao CA, Arnold AC, Choi L, Black BK, Raj SR, Robertson D, Biaggioni I. Nebivolol, but not metoprolol, lowers blood pressure in nitric oxide-sensitive human hypertension. Hypertension [print-electronic]. 2014 Dec; 64(6): 1241-7. PMID: 25267802, PMCID: PMC4230998, PII: HYPERTENSIONAHA.114.04116, DOI: 10.1161/HYPERTENSIONAHA.114.04116, ISSN: 1524-4563.

Gamboa A, Okamoto LE, Arnold AC, Figueroa RA, Diedrich A, Raj SR, Paranjape SY, Farley G, Abumrad N, Biaggioni I. Autonomic blockade improves insulin sensitivity in obese subjects. Hypertension [print-electronic]. 2014 Oct; 64(4): 867-74. PMID: 25001269, PMCID: PMC4162826, PII: HYPERTENSIONAHA.114.03738, DOI: 10.1161/HYPERTENSIONAHA.114.03738, ISSN: 1524-4563.

Figueroa RA, Arnold AC, Nwazue VC, Okamoto LE, Paranjape SY, Black BK, Diedrich A, Robertson D, Biaggioni I, Raj SR, Gamboa A. Acute volume loading and exercise capacity in postural tachycardia syndrome. J. Appl. Physiol [print-electronic]. 2014 Sep 9/15/2014; 117(6): 663-8. PMID: 25059240, PMCID: PMC4157162, PII: japplphysiol.00367.2014, DOI: 10.1152/japplphysiol.00367.2014, ISSN: 1522-1601.

Arnold AC, Ramirez CE, Choi L, Okamoto LE, Gamboa A, Diedrich A, Raj SR, Robertson D, Biaggioni I, Shibao CA. Combination ergotamine and caffeine improves seated blood pressure and presyncopal symptoms in autonomic failure. Front Physiol. 2014; 5: 270. PMID: 25104940, PMCID: PMC4109567, DOI: 10.3389/fphys.2014.00270.

Arnold AC, Okamoto LE, Diedrich A, Paranjape SY, Raj SR, Biaggioni I, Gamboa A. Low-dose propranolol and exercise capacity in postural tachycardia syndrome: a randomized study. Neurology [print-electronic]. 2013 May 5/21/2013; 80(21): 1927-33. PMID: 23616163, PMCID: PMC3716342, PII: WNL.0b013e318293e310, DOI: 10.1212/WNL.0b013e318293e310, ISSN: 1526-632X.

Arnold AC, Okamoto LE, Gamboa A, Shibao C, Raj SR, Robertson D, Biaggioni I. Angiotensin II, independent of plasma renin activity, contributes to the hypertension of autonomic failure. Hypertension [print-electronic]. 2013 Mar; 61(3): 701-6. PMID: 23266540, PMCID: PMC3573256, PII: HYPERTENSIONAHA.111.00377, DOI: 10.1161/HYPERTENSIONAHA.111.00377, ISSN: 1524-4563.

Gamboa A, Okamoto LE, Raj SR, Diedrich A, Shibao CA, Robertson D, Biaggioni I. Nitric oxide and regulation of heart rate in patients with postural tachycardia syndrome and healthy subjects. Hypertension [print-electronic]. 2013 Feb; 61(2): 376-81. PMID: 23283362, PMCID: PMC3621717, PII: HYPERTENSIONAHA.111.00203, DOI: 10.1161/HYPERTENSIONAHA.111.00203, ISSN: 1524-4563.

Gamboa A, Okamoto LE, Diedrich A, Choi L, Robertson D, Farley G, Paranjape S, Biaggioni I. Sympathetic activation and nitric oxide function in early hypertension. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2012 Apr 4/1/2012; 302(7): H1438-43. PMID: 22287587, PMCID: PMC3330790, PII: ajpheart.01020.2011, DOI: 10.1152/ajpheart.01020.2011, ISSN: 1522-1539.

Okamoto LE, Shibao C, Gamboa A, Choi L, Diedrich A, Raj SR, Black BK, Robertson D, Biaggioni I. Synergistic effect of norepinephrine transporter blockade and a-2 antagonism on blood pressure in autonomic failure. Hypertension [print-electronic]. 2012 Mar; 59(3): 650-6. PMID: 22311903, PMCID: PMC3312003, PII: HYPERTENSIONAHA.111.184812, DOI: 10.1161/HYPERTENSIONAHA.111.184812, ISSN: 1524-4563.

Okamoto LE, Raj SR, Peltier A, Gamboa A, Shibao C, Diedrich A, Black BK, Robertson D, Biaggioni I. Neurohumoral and haemodynamic profile in postural tachycardia and chronic fatigue syndromes. Clin. Sci. 2012 Feb; 122(4): 183-92. PMID: 21906029, PMCID: PMC3203411, PII: CS20110200, DOI: 10.1042/CS20110200, ISSN: 1470-8736.

Shibao C, Okamoto LE, Gamboa A, Yu C, Diedrich A, Raj SR, Robertson D, Biaggioni I. Comparative efficacy of yohimbine against pyridostigmine for the treatment of orthostatic hypotension in autonomic failure. Hypertension [print-electronic]. 2010 Nov; 56(5): 847-51. PMID: 20837887, PMCID: PMC2959129, PII: HYPERTENSIONAHA.110.154898, DOI: 10.1161/HYPERTENSIONAHA.110.154898, ISSN: 1524-4563.

Okamoto LE, Gamboa A, Shibao C, Black BK, Diedrich A, Raj SR, Robertson D, Biaggioni I. Nocturnal blood pressure dipping in the hypertension of autonomic failure. Hypertension [print-electronic]. 2009 Feb; 53(2): 363-9. PMID: 19047577, PMCID: PMC2665259, PII: HYPERTENSIONAHA.108.124552, DOI: 10.1161/HYPERTENSIONAHA.108.124552, ISSN: 1524-4563.