Ardina J. Pruijssers, Ph.D.

Research Assistant Professor

ardina.pruijssers@vanderbilt.edu
Faculty Appointments
Research Assistant Professor of Pediatrics
Education
Ph.D., Entomology, University of Georgia, Athens, GeorgiaM.S., University of Wageningen, Wageningen, Netherlands
Publications
Heinrich MJ, Purcell CA, Pruijssers AJ, Zhao Y, Spurlock CF, Sriram S, Ogden KM, Dermody TS, Scholz MB, Crooke PS, Karijolich J, Aune TM. Endogenous double-stranded Alu RNA elements stimulate IFN-responses in relapsing remitting multiple sclerosis. J. Autoimmun [print-electronic]. 2019 Feb 2/27/2019; PMID: 30826177, PII: S0896-8411(18)30699-1, DOI: 10.1016/j.jaut.2019.02.003, ISSN: 1095-9157.

Choby JE, Monteith AJ, Himmel LE, Margaritis P, Shirey-Rice JK, Pruijssers A, Jerome RN, Pulley J, Skaar EP. PheWAS uncovers a pathological role of coagulation Factor X during Acinetobacter baumannii infection. Infect. Immun [print-electronic]. 2019 Feb 2/19/2019; PMID: 30782860, PII: IAI.00031-19, DOI: 10.1128/IAI.00031-19, ISSN: 1098-5522.

Pulley JM, Jerome RN, Shirey-Rice JK, Zaleski NM, Naylor HM, Pruijssers AJ, Jackson JC, Bernard GR, Holroyd KJ. Advocating for mutually beneficial access to shelved compounds [editorial]. Future Med Chem [print-electronic]. 2018 Jun 6/1/2018; 10(12): 1395-8. PMID: 29788759, DOI: 10.4155/fmc-2018-0090, ISSN: 1756-8927.

Brown JJ, Short SP, Stencel-Baerenwald J, Urbanek K, Pruijssers AJ, McAllister N, Ikizler M, Taylor G, Aravamudhan P, Khomandiak S, Jabri B, Williams CS, Dermody TS. Reovirus-Induced Apoptosis in the Intestine Limits Establishment of Enteric Infection. J. Virol [electronic-print]. 2018 May 5/15/2018; 92(10): PMID: 29514905, PMCID: PMC5923068, PII: JVI.02062-17, DOI: 10.1128/JVI.02062-17, ISSN: 1098-5514.

Wu AG, Pruijssers AJ, Brown JJ, Stencel-Baerenwald JE, Sutherland DM, Iskarpatyoti JA, Dermody TS. Age-dependent susceptibility to reovirus encephalitis in mice is influenced by maturation of the type-I interferon response. Pediatr. Res [print-electronic]. 2018 May; 83(5): 1057-66. PMID: 29364865, PMCID: PMC5959747, PII: pr201813, DOI: 10.1038/pr.2018.13, ISSN: 1530-0447.

Pulley JM, Jerome RN, Zaleski NM, Shirey-Rice JK, Pruijssers AJ, Lavieri RR, Chettiar SN, Naylor HM, Aronoff DM, Edwards DA, Niswender CM, Dugan LL, Crofford LJ, Bernard GR, Holroyd KJ. When Enough Is Enough: Decision Criteria for Moving a Known Drug into Clinical Testing for a New Indication in the Absence of Preclinical Efficacy Data. Assay Drug Dev Technol [print-electronic]. 2017 Dec; 15(8): 354-61. PMID: 29193979, PMCID: PMC5731541, DOI: 10.1089/adt.2017.821, ISSN: 1557-8127.

Bouziat R, Hinterleitner R, Brown JJ, Stencel-Baerenwald JE, Ikizler M, Mayassi T, Meisel M, Kim SM, Discepolo V, Pruijssers AJ, Ernest JD, Iskarpatyoti JA, Costes LM, Lawrence I, Palanski BA, Varma M, Zurenski MA, Khomandiak S, McAllister N, Aravamudhan P, Boehme KW, Hu F, Samsom JN, Reinecker HC, Kupfer SS, Guandalini S, Semrad CE, Abadie V, Khosla C, Barreiro LB, Xavier RJ, Ng A, Dermody TS, Jabri B. Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. Science. 2017 Apr 4/7/2017; 356(6333): 44-50. PMID: 28386004, PMCID: PMC5506690, PII: 356/6333/44, DOI: 10.1126/science.aah5298, ISSN: 1095-9203.

Lai CM, Boehme KW, Pruijssers AJ, Parekh VV, Van Kaer L, Parkos CA, Dermody TS. Endothelial JAM-A promotes reovirus viremia and bloodstream dissemination. J. Infect. Dis [print-electronic]. 2015 Feb 2/1/2015; 211(3): 383-93. PMID: 25149763, PMCID: PMC4351375, PII: jiu476, DOI: 10.1093/infdis/jiu476, ISSN: 1537-6613.

Zhang B, Chassaing B, Shi Z, Uchiyama R, Zhang Z, Denning TL, Crawford SE, Pruijssers AJ, Iskarpatyoti JA, Estes MK, Dermody TS, Ouyang W, Williams IR, Vijay-Kumar M, Gewirtz AT. Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18. Science. 2014 Nov 11/14/2014; 346(6211): 861-5. PMID: 25395539, PMCID: PMC4788408, PII: 346/6211/861, DOI: 10.1126/science.1256999, ISSN: 1095-9203.

Goubau D, Schlee M, Deddouche S, Pruijssers AJ, Zillinger T, Goldeck M, Schuberth C, Van der Veen AG, Fujimura T, Rehwinkel J, Iskarpatyoti JA, Barchet W, Ludwig J, Dermody TS, Hartmann G, Reis e Sousa C. Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates. Nature [print-electronic]. 2014 Oct 10/16/2014; 514(7522): 372-5. PMID: 25119032, PMCID: PMC4201573, DOI: 10.1038/nature13590, ISSN: 1476-4687.

Pruijssers AJ, Hengel H, Abel TW, Dermody TS. Apoptosis induction influences reovirus replication and virulence in newborn mice. J. Virol [print-electronic]. 2013 Dec; 87(23): 12980-9. PMID: 24067960, PMCID: PMC3838116, PII: JVI.01931-13, DOI: 10.1128/JVI.01931-13, ISSN: 1098-5514.

Frierson JM, Pruijssers AJ, Konopka JL, Reiter DM, Abel TW, Stehle T, Dermody TS. Utilization of sialylated glycans as coreceptors enhances the neurovirulence of serotype 3 reovirus. J. Virol [print-electronic]. 2012 Dec; 86(24): 13164-73. PMID: 23035227, PMCID: PMC3503066, PII: JVI.01822-12, DOI: 10.1128/JVI.01822-12, ISSN: 1098-5514.

Kuss SK, Best GT, Etheredge CA, Pruijssers AJ, Frierson JM, Hooper LV, Dermody TS, Pfeiffer JK. Intestinal microbiota promote enteric virus replication and systemic pathogenesis. Science. 2011 Oct 10/14/2011; 334(6053): 249-52. PMID: 21998395, PMCID: PMC3222156, PII: 334/6053/249, DOI: 10.1126/science.1211057, ISSN: 1095-9203.

Sen A, Pruijssers AJ, Dermody TS, GarcĂ­a-Sastre A, Greenberg HB. The early interferon response to rotavirus is regulated by PKR and depends on MAVS/IPS-1, RIG-I, MDA-5, and IRF3. J. Virol [print-electronic]. 2011 Apr; 85(8): 3717-32. PMID: 21307186, PMCID: PMC3126121, PII: JVI.02634-10, DOI: 10.1128/JVI.02634-10, ISSN: 1098-5514.

Eum JH, Bottjen RC, Pruijssers AJ, Clark KD, Strand MR. Characterization and kinetic analysis of protein tyrosine phosphatase-H2 from Microplitis demolitor bracovirus. Insect Biochem. Mol. Biol [print-electronic]. 2010 Sep; 40(9): 690-8. PMID: 20691785, PII: S0965-1748(10)00158-X, DOI: 10.1016/j.ibmb.2010.07.003, ISSN: 1879-0240.

Danthi P, Pruijssers AJ, Berger AK, Holm GH, Zinkel SS, Dermody TS. Bid regulates the pathogenesis of neurotropic reovirus. PLoS Pathog. 2010 Jul 7/1/2010; 6: e1000980. PMID: 20617182, PMCID: PMC2895667, DOI: 10.1371/journal.ppat.1000980, ISSN: 1553-7374.

Holm GH, Pruijssers AJ, Li L, Danthi P, Sherry B, Dermody TS. Interferon regulatory factor 3 attenuates reovirus myocarditis and contributes to viral clearance. J. Virol [print-electronic]. 2010 Jul; 84(14): 6900-8. PMID: 20463082, PMCID: PMC2898218, PII: JVI.01742-09, DOI: 10.1128/JVI.01742-09, ISSN: 1098-5514.

Pruijssers AJ, Falabella P, Eum JH, Pennacchio F, Brown MR, Strand MR. Infection by a symbiotic polydnavirus induces wasting and inhibits metamorphosis of the moth Pseudoplusia includens. J. Exp. Biol. 2009 Sep 9/15/2009; 212(18): 2998-3006. PMID: 19717683, PMCID: PMC2734494, PII: 212/18/2998, DOI: 10.1242/jeb.030635, ISSN: 1477-9145.

van Vugt JJ, van der Hulst RG, Pruijssers AJ, Verbaarschot P, Stouthamer R, de Jong H. Comparative AFLP reveals paternal sex ratio chromosome specific DNA sequences in the parasitoid wasp Trichogramma kaykai. Genome. 2009 May; 52(5): 447-55. PMID: 19448725, PII: g09-024, DOI: 10.1139/g09-024, ISSN: 0831-2796.

Suderman RJ, Pruijssers AJ, Strand MR. Protein tyrosine phosphatase-H2 from a polydnavirus induces apoptosis of insect cells. J. Gen. Virol. 2008 Jun; 89(Pt 6): 1411-20. PMID: 18474557, PII: 89/6/1411, DOI: 10.1099/vir.0.2008/000307-0, ISSN: 0022-1317.

Pruijssers AJ, Strand MR. PTP-H2 and PTP-H3 from Microplitis demolitor Bracovirus localize to focal adhesions and are antiphagocytic in insect immune cells. J. Virol [print-electronic]. 2007 Feb; 81(3): 1209-19. PMID: 17121799, PMCID: PMC1797498, PII: JVI.02189-06, DOI: 10.1128/JVI.02189-06, ISSN: 0022-538X.

Striepen B, Pruijssers AJ, Huang J, Li C, Gubbels MJ, Umejiego NN, Hedstrom L, Kissinger JC. Gene transfer in the evolution of parasite nucleotide biosynthesis. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2004 Mar 3/2/2004; 101(9): 3154-9. PMID: 14973196, PMCID: PMC365759, PII: 0304686101, DOI: 10.1073/pnas.0304686101, ISSN: 0027-8424.

Pijlman GP, Pruijssers AJ, Vlak JM. Identification of pif-2, a third conserved baculovirus gene required for per os infection of insects. J. Gen. Virol. 2003 Aug; 84(Pt 8): 2041-9. PMID: 12867634, DOI: 10.1099/vir.0.19133-0, ISSN: 0022-1317.