Faculty Appointments
Associate Professor of Medicine
Associate Professor of Biomedical Informatics
Education
Ph.D., Peking Union Medical College, Beijing, China
Office Address
23rd Ave S @ Pierce Ave. VUMC
Nashville , TN 37233
Nashville , TN 37233
Publications
Postmus I, Warren HR, Trompet S, Arsenault BJ, Avery CL, Bis JC, Chasman DI, de Keyser CE, Deshmukh HA, Evans DS, Feng Q, Li X, Smit RA, Smith AV, Sun F, Taylor KD, Arnold AM, Barnes MR, Barratt BJ, Betteridge J, Boekholdt SM, Boerwinkle E, Buckley BM, Chen YI, de Craen AJ, Cummings SR, Denny JC, Dubé MP, Durrington PN, Eiriksdottir G, Ford I, Guo X, Harris TB, Heckbert SR, Hofman A, Hovingh GK, Kastelein JJ, Launer LJ, Liu CT, Liu Y, Lumley T, McKeigue PM, Munroe PB, Neil A, Nickerson DA, Nyberg F, O'Brien E, O'Donnell CJ, Post W, Poulter N, Vasan RS, Rice K, Rich SS, Rivadeneira F, Sattar N, Sever P, Shaw-Hawkins S, Shields DC, Slagboom PE, Smith NL, Smith JD, Sotoodehnia N, Stanton A, Stott DJ, Stricker BH, Stürmer T, Uitterlinden AG, Wei WQ, Westendorp RG, Whitsel EA, Wiggins KL, Wilke RA, Ballantyne CM, Colhoun HM, Cupples LA, Franco OH, Gudnason V, Hitman G, Palmer CN, Psaty BM, Ridker PM, Stafford JM, Stein CM, Tardif JC, Caulfield MJ, Jukema JW, Rotter JI, Krauss RM. Meta-analysis of genome-wide association studies of HDL cholesterol response to statins. J. Med. Genet [print-electronic]. 2016 Sep 9/1/2016; PMID: 27587472, PII: jmedgenet-2016-103966, DOI: 10.1136/jmedgenet-2016-103966, ISSN: 1468-6244.
Feng Q, Wei WQ, Chung CP, Levinson RT, Bastarache L, Denny JC, Stein CM. The effect of genetic variation in PCSK9 on the LDL-cholesterol response to statin therapy. Pharmacogenomics J [print-electronic]. 2016 Feb 2/23/2016; PMID: 26902539, PMCID: PMC4995153, PII: tpj20163, DOI: 10.1038/tpj.2016.3, ISSN: 1473-1150.
Iwuchukwu OF, Feng Q, Wei WQ, Jiang L, Jiang M, Xu H, Denny JC, Wilke RA, Krauss RM, Roden DM, Stein CM. Genetic variation in the UGT1A locus is associated with simvastatin efficacy in a clinical practice setting. Pharmacogenomics. 2014 Nov; 15(14): 1739-47. PMID: 25493567, PMCID: PMC4292894, DOI: 10.2217/pgs.14.128, ISSN: 1744-8042.
Postmus I, Trompet S, Deshmukh HA, Barnes MR, Li X, Warren HR, Chasman DI, Zhou K, Arsenault BJ, Donnelly LA, Wiggins KL, Avery CL, Griffin P, Feng Q, Taylor KD, Li G, Evans DS, Smith AV, de Keyser CE, Johnson AD, de Craen AJ, Stott DJ, Buckley BM, Ford I, Westendorp RG, Slagboom PE, Sattar N, Munroe PB, Sever P, Poulter N, Stanton A, Shields DC, O'Brien E, Shaw-Hawkins S, Chen YD, Nickerson DA, Smith JD, Dubé MP, Boekholdt SM, Hovingh GK, Kastelein JJ, McKeigue PM, Betteridge J, Neil A, Durrington PN, Doney A, Carr F, Morris A, McCarthy MI, Groop L, Ahlqvist E, , Bis JC, Rice K, Smith NL, Lumley T, Whitsel EA, Stürmer T, Boerwinkle E, Ngwa JS, O'Donnell CJ, Vasan RS, Wei WQ, Wilke RA, Liu CT, Sun F, Guo X, Heckbert SR, Post W, Sotoodehnia N, Arnold AM, Stafford JM, Ding J, Herrington DM, Kritchevsky SB, Eiriksdottir G, Launer LJ, Harris TB, Chu AY, Giulianini F, MacFadyen JG, Barratt BJ, Nyberg F, Stricker BH, Uitterlinden AG, Hofman A, Rivadeneira F, Emilsson V, Franco OH, Ridker PM, Gudnason V, Liu Y, Denny JC, Ballantyne CM, Rotter JI, Adrienne Cupples L, Psaty BM, Palmer CN, Tardif JC, Colhoun HM, Hitman G, Krauss RM, Wouter Jukema J, Caulfield MJ. Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. Nat Commun. 2014 Oct 10/28/2014; 5: 5068. PMID: 25350695, PMCID: PMC4220464, PII: ncomms6068, DOI: 10.1038/ncomms6068, ISSN: 2041-1723.
Ramsey LB, Johnson SG, Caudle KE, Haidar CE, Voora D, Wilke RA, Maxwell WD, McLeod HL, Krauss RM, Roden DM, Feng Q, Cooper-DeHoff RM, Gong L, Klein TE, Wadelius M, Niemi M. The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update. Clin. Pharmacol. Ther [print-electronic]. 2014 Oct; 96(4): 423-8. PMID: 24918167, PMCID: PMC4169720, PII: clpt2014125, DOI: 10.1038/clpt.2014.125.
Wei WQ, Feng Q, Jiang L, Waitara MS, Iwuchukwu OF, Roden DM, Jiang M, Xu H, Krauss RM, Rotter JI, Nickerson DA, Davis RL, Berg RL, Peissig PL, McCarty CA, Wilke RA, Denny JC. Characterization of statin dose response in electronic medical records. Clin. Pharmacol. Ther [print-electronic]. 2014 Mar; 95(3): 331-8. PMID: 24096969, PMCID: PMC3944214, PII: clpt2013202, DOI: 10.1038/clpt.2013.202, ISSN: 1532-6535.
Feng Q. Approach to clinical and genetic characterization of statin-induced myopathy. Methods Mol. Biol. 2014; 1175: 67-90. PMID: 25150867, DOI: 10.1007/978-1-4939-0956-8_5, ISSN: 1940-6029.
Wei WQ, Feng Q, Weeke P, Bush W, Waitara MS, Iwuchukwu OF, Roden DM, Wilke RA, Stein CM, Denny JC. Creation and Validation of an EMR-based Algorithm for Identifying Major Adverse Cardiac Events while on Statins. AMIA Jt Summits Transl Sci Proc. 2014; 2014: 112-9. PMID: 25717410, PMCID: PMC4333709.
Feng Q, Vickers KC, Anderson MP, Levin MG, Chen W, Harrison DG, Wilke RA. A common functional promoter variant links CNR1 gene expression to HDL cholesterol level. Nat Commun. 2013; 4: 1973. PMID: 23748922, PMCID: PMC3873874, PII: ncomms2973, DOI: 10.1038/ncomms2973, ISSN: 2041-1723.
Wilke RA, Ramsey LB, Johnson SG, Maxwell WD, McLeod HL, Voora D, Krauss RM, Roden DM, Feng Q, Cooper-Dehoff RM, Gong L, Klein TE, Wadelius M, Niemi M, . The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy. Clin. Pharmacol. Ther [print-electronic]. 2012 Jul; 92(1): 112-7. PMID: 22617227, PMCID: PMC3384438, PII: clpt201257, DOI: 10.1038/clpt.2012.57.
Feng Q, Wilke RA, Baye TM. Individualized risk for statin-induced myopathy: current knowledge, emerging challenges and potential solutions. Pharmacogenomics. 2012 Apr; 13(5): 579-94. PMID: 22462750, PMCID: PMC3337775, DOI: 10.2217/pgs.12.11, ISSN: 1744-8042.
Silver HJ, Niswender KD, Keil CD, Jiang L, Feng Q, Chiu S, Krauss RM, Wilke RA. CNR1 genotype influences HDL-cholesterol response to change in dietary fat intake. PLoS ONE [print-electronic]. 2012; 7(5): e36166. PMID: 22567136, PMCID: PMC3342253, PII: PONE-D-11-20311, DOI: 10.1371/journal.pone.0036166, ISSN: 1932-6203.
Feng Q, Jiang L, Berg RL, Antonik M, MacKinney E, Gunnell-Santoro J, McCarty CA, Wilke RA. A common CNR1 (cannabinoid receptor 1) haplotype attenuates the decrease in HDL cholesterol that typically accompanies weight gain. PLoS ONE. 2010 Dec 12/31/2010; 5(12): e15779. PMID: 21209828, PMCID: PMC3013130, DOI: 10.1371/journal.pone.0015779, ISSN: 1932-6203.
Feng Q, Wei WQ, Chung CP, Levinson RT, Bastarache L, Denny JC, Stein CM. The effect of genetic variation in PCSK9 on the LDL-cholesterol response to statin therapy. Pharmacogenomics J [print-electronic]. 2016 Feb 2/23/2016; PMID: 26902539, PMCID: PMC4995153, PII: tpj20163, DOI: 10.1038/tpj.2016.3, ISSN: 1473-1150.
Iwuchukwu OF, Feng Q, Wei WQ, Jiang L, Jiang M, Xu H, Denny JC, Wilke RA, Krauss RM, Roden DM, Stein CM. Genetic variation in the UGT1A locus is associated with simvastatin efficacy in a clinical practice setting. Pharmacogenomics. 2014 Nov; 15(14): 1739-47. PMID: 25493567, PMCID: PMC4292894, DOI: 10.2217/pgs.14.128, ISSN: 1744-8042.
Postmus I, Trompet S, Deshmukh HA, Barnes MR, Li X, Warren HR, Chasman DI, Zhou K, Arsenault BJ, Donnelly LA, Wiggins KL, Avery CL, Griffin P, Feng Q, Taylor KD, Li G, Evans DS, Smith AV, de Keyser CE, Johnson AD, de Craen AJ, Stott DJ, Buckley BM, Ford I, Westendorp RG, Slagboom PE, Sattar N, Munroe PB, Sever P, Poulter N, Stanton A, Shields DC, O'Brien E, Shaw-Hawkins S, Chen YD, Nickerson DA, Smith JD, Dubé MP, Boekholdt SM, Hovingh GK, Kastelein JJ, McKeigue PM, Betteridge J, Neil A, Durrington PN, Doney A, Carr F, Morris A, McCarthy MI, Groop L, Ahlqvist E, , Bis JC, Rice K, Smith NL, Lumley T, Whitsel EA, Stürmer T, Boerwinkle E, Ngwa JS, O'Donnell CJ, Vasan RS, Wei WQ, Wilke RA, Liu CT, Sun F, Guo X, Heckbert SR, Post W, Sotoodehnia N, Arnold AM, Stafford JM, Ding J, Herrington DM, Kritchevsky SB, Eiriksdottir G, Launer LJ, Harris TB, Chu AY, Giulianini F, MacFadyen JG, Barratt BJ, Nyberg F, Stricker BH, Uitterlinden AG, Hofman A, Rivadeneira F, Emilsson V, Franco OH, Ridker PM, Gudnason V, Liu Y, Denny JC, Ballantyne CM, Rotter JI, Adrienne Cupples L, Psaty BM, Palmer CN, Tardif JC, Colhoun HM, Hitman G, Krauss RM, Wouter Jukema J, Caulfield MJ. Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. Nat Commun. 2014 Oct 10/28/2014; 5: 5068. PMID: 25350695, PMCID: PMC4220464, PII: ncomms6068, DOI: 10.1038/ncomms6068, ISSN: 2041-1723.
Ramsey LB, Johnson SG, Caudle KE, Haidar CE, Voora D, Wilke RA, Maxwell WD, McLeod HL, Krauss RM, Roden DM, Feng Q, Cooper-DeHoff RM, Gong L, Klein TE, Wadelius M, Niemi M. The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update. Clin. Pharmacol. Ther [print-electronic]. 2014 Oct; 96(4): 423-8. PMID: 24918167, PMCID: PMC4169720, PII: clpt2014125, DOI: 10.1038/clpt.2014.125.
Wei WQ, Feng Q, Jiang L, Waitara MS, Iwuchukwu OF, Roden DM, Jiang M, Xu H, Krauss RM, Rotter JI, Nickerson DA, Davis RL, Berg RL, Peissig PL, McCarty CA, Wilke RA, Denny JC. Characterization of statin dose response in electronic medical records. Clin. Pharmacol. Ther [print-electronic]. 2014 Mar; 95(3): 331-8. PMID: 24096969, PMCID: PMC3944214, PII: clpt2013202, DOI: 10.1038/clpt.2013.202, ISSN: 1532-6535.
Feng Q. Approach to clinical and genetic characterization of statin-induced myopathy. Methods Mol. Biol. 2014; 1175: 67-90. PMID: 25150867, DOI: 10.1007/978-1-4939-0956-8_5, ISSN: 1940-6029.
Wei WQ, Feng Q, Weeke P, Bush W, Waitara MS, Iwuchukwu OF, Roden DM, Wilke RA, Stein CM, Denny JC. Creation and Validation of an EMR-based Algorithm for Identifying Major Adverse Cardiac Events while on Statins. AMIA Jt Summits Transl Sci Proc. 2014; 2014: 112-9. PMID: 25717410, PMCID: PMC4333709.
Feng Q, Vickers KC, Anderson MP, Levin MG, Chen W, Harrison DG, Wilke RA. A common functional promoter variant links CNR1 gene expression to HDL cholesterol level. Nat Commun. 2013; 4: 1973. PMID: 23748922, PMCID: PMC3873874, PII: ncomms2973, DOI: 10.1038/ncomms2973, ISSN: 2041-1723.
Wilke RA, Ramsey LB, Johnson SG, Maxwell WD, McLeod HL, Voora D, Krauss RM, Roden DM, Feng Q, Cooper-Dehoff RM, Gong L, Klein TE, Wadelius M, Niemi M, . The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy. Clin. Pharmacol. Ther [print-electronic]. 2012 Jul; 92(1): 112-7. PMID: 22617227, PMCID: PMC3384438, PII: clpt201257, DOI: 10.1038/clpt.2012.57.
Feng Q, Wilke RA, Baye TM. Individualized risk for statin-induced myopathy: current knowledge, emerging challenges and potential solutions. Pharmacogenomics. 2012 Apr; 13(5): 579-94. PMID: 22462750, PMCID: PMC3337775, DOI: 10.2217/pgs.12.11, ISSN: 1744-8042.
Silver HJ, Niswender KD, Keil CD, Jiang L, Feng Q, Chiu S, Krauss RM, Wilke RA. CNR1 genotype influences HDL-cholesterol response to change in dietary fat intake. PLoS ONE [print-electronic]. 2012; 7(5): e36166. PMID: 22567136, PMCID: PMC3342253, PII: PONE-D-11-20311, DOI: 10.1371/journal.pone.0036166, ISSN: 1932-6203.
Feng Q, Jiang L, Berg RL, Antonik M, MacKinney E, Gunnell-Santoro J, McCarty CA, Wilke RA. A common CNR1 (cannabinoid receptor 1) haplotype attenuates the decrease in HDL cholesterol that typically accompanies weight gain. PLoS ONE. 2010 Dec 12/31/2010; 5(12): e15779. PMID: 21209828, PMCID: PMC3013130, DOI: 10.1371/journal.pone.0015779, ISSN: 1932-6203.