Warren D. Taylor, M.D.


Faculty Appointments
Professor of Psychiatry and Behavioral Sciences James G. Blakemore Chair in Psychiatry
M.H.S., Duke University, Durham, North CarolinaM.D., University of South Florida, Tampa, FloridaB.S., University of South Florida, Tampa, Florida
Office Address
1601 23rd Avenue South
Nashville, TN 37212
Research Description
Dr. Warren Taylor joined the Vanderbilt Center for Cognitive Medicine and Department of Psychiatry in 2012 and currently serves as the Director of the Division of Geriatric Psychiatry. He is engaged in research examining the interface between aging and depression, examining neurobiological factors influencing the occurrence and outcomes of late-life depression. Current work utilizes neuroimaging, clinical, and cognitive measures, and clinical trial elements to better understand how biological differences influence the response to antidepressant medications. He is also an active research mentor, mentoring a range of individuals from medical students to junior faculty, both at Vanderbilt and nationally.
Research Keywords
Depression, aging, neuroimaging, cognition, outcomes
Gandelman JA, Newhouse P, Taylor WD. Nicotine and networks: Potential for enhancement of mood and cognition in late-life depression. Neurosci Biobehav Rev [print-electronic]. 2017 Aug 8/30/2017; PMID: 28859996, PII: S0149-7634(17)30179-3, DOI: 10.1016/j.neubiorev.2017.08.018, ISSN: 1873-7528.

Albert K, Hiscox J, Boyd B, Dumas J, Taylor W, Newhouse P. Estrogen enhances hippocampal gray-matter volume in young and older postmenopausal women: a prospective dose-response study. Neurobiol. Aging [print-electronic]. 2017 Aug; 56: 1-6. PMID: 28478324, PII: S0197-4580(17)30116-1, DOI: 10.1016/j.neurobiolaging.2017.03.033, ISSN: 1558-1497.

Park JH, Jeon BH, Lee JS, Newhouse PA, Taylor WD, Boyd BD, Kim KW, Kim MD. CADASIL as a Useful Medical Model and Genetic Form of Vascular Depression. Am J Geriatr Psychiatry [print-electronic]. 2017 Jul; 25(7): 719-27. PMID: 28434675, PII: S1064-7481(17)30273-7, DOI: 10.1016/j.jagp.2017.03.013, ISSN: 1545-7214.

Abi Zeid Daou M, Boyd BD, Donahue MJ, Albert K, Taylor WD. Frontocingulate cerebral blood flow and cerebrovascular reactivity associated with antidepressant response in late-life depression. J Affect Disord [print-electronic]. 2017 Jun; 215: 103-10. PMID: 28324779, PMCID: PMC5472992, PII: S0165-0327(17)30441-X, DOI: 10.1016/j.jad.2017.03.027, ISSN: 1573-2517.

Riddle M, Potter GG, McQuoid DR, Steffens DC, Beyer JL, Taylor WD. Longitudinal Cognitive Outcomes of Clinical Phenotypes of Late-Life Depression. Am J Geriatr Psychiatry [print-electronic]. 2017 Mar 3/28/2017; PMID: 28479153, PII: S1064-7481(17)30276-2, DOI: 10.1016/j.jagp.2017.03.016, ISSN: 1545-7214.

Taylor WD. Lack of a Role for Alzheimer's Disease Pathology in Late-Life Depression, or Just No Relationship With Amyloid?. Am J Psychiatry. 2017 Mar 3/1/2017; 174(3): 197-8. PMID: 28245690, PMCID: PMC5438229, DOI: 10.1176/appi.ajp.2016.16111317, ISSN: 1535-7228.

Albert K, Gau V, Taylor WD, Newhouse PA. Attention bias in older women with remitted depression is associated with enhanced amygdala activity and functional connectivity. J Affect Disord [print-electronic]. 2017 Mar 3/1/2017; 210: 49-56. PMID: 28012352, PMCID: PMC5292067, PII: S0165-0327(16)31315-5, DOI: 10.1016/j.jad.2016.12.010, ISSN: 1573-2517.

Rutherford BR, Taylor WD, Brown PJ, Sneed JR, Roose SP. Biological Aging and the Future of Geriatric Psychiatry. J. Gerontol. A Biol. Sci. Med. Sci. 2017 Mar 3/1/2017; 72(3): 343-52. PMID: 27994004, PII: glw241, DOI: 10.1093/gerona/glw241, ISSN: 1758-535X.

Taylor WD, Boyd B, Turner R, McQuoid DR, Ashley-Koch A, MacFall JR, Saleh A, Potter GG. APOE e4 associated with preserved executive function performance and maintenance of temporal and cingulate brain volumes in younger adults. Brain Imaging Behav. 2017 Feb; 11(1): 194-204. PMID: 26843007, PMCID: PMC4972704, PII: 10.1007/s11682-016-9522-9, DOI: 10.1007/s11682-016-9522-9, ISSN: 1931-7565.

Saleh A, Potter GG, McQuoid DR, Boyd B, Turner R, MacFall JR, Taylor WD. Effects of early life stress on depression, cognitive performance and brain morphology. Psychol Med [print-electronic]. 2017 Jan; 47(1): 171-81. PMID: 27682320, PMCID: PMC5195852, PII: S0033291716002403, DOI: 10.1017/S0033291716002403, ISSN: 1469-8978.

Johnson AD, McQuoid DR, Steffens DC, Payne ME, Beyer JL, Taylor WD. Effects of stressful life events on cerebral white matter hyperintensity progression. Int J Geriatr Psychiatry [print-electronic]. 2016 Dec 12/28/2016; PMID: 28029184, PMCID: PMC5489375, DOI: 10.1002/gps.4644, ISSN: 1099-1166.

Aizenstein HJ, Baskys A, Boldrini M, Butters MA, Diniz BS, Jaiswal MK, Jellinger KA, Kruglov LS, Meshandin IA, Mijajlovic MD, Niklewski G, Pospos S, Raju K, Richter K, Steffens DC, Taylor WD, Tene O. Vascular depression consensus report - a critical update [editorial]. BMC Med. 2016 Nov 11/3/2016; 14(1): 161. PMID: 27806704, PMCID: PMC5093970, PII: 10.1186/s12916-016-0720-5, DOI: 10.1186/s12916-016-0720-5, ISSN: 1741-7015.

Taylor WD. Computerized Cognitive Remediation for Geriatric Depression: Dawn of a New Treatment Modality? [editorial]. Am J Geriatr Psychiatry [print-electronic]. 2016 Oct; 24(10): 821-2. PMID: 27591159, PII: S1064-7481(16)30172-5, DOI: 10.1016/j.jagp.2016.07.007, ISSN: 1545-7214.

Taylor WD. Moderators of Remission in Patients With Late-Life Depression: Where Do We Go Next? [editorial]. JAMA Psychiatry. 2016 Apr; 73(4): 319-20. PMID: 26963364, PMCID: PMC5054742, PII: 2497724, DOI: 10.1001/jamapsychiatry.2015.3458, ISSN: 2168-6238.

Weinstein JJ, Rogers BP, Taylor WD, Boyd BD, Cowan RL, Shelton KM, Salomon RM. Effects of acute tryptophan depletion on raphé functional connectivity in depression. Psychiatry Res [print-electronic]. 2015 Nov 11/30/2015; 234(2): 164-71. PMID: 26411798, PMCID: PMC4631618, PII: S0925-4927(15)30074-3, DOI: 10.1016/j.pscychresns.2015.08.015, ISSN: 1872-7123.

Taylor WD, Boyd B, McQuoid DR, Kudra K, Saleh A, MacFall JR. Widespread white matter but focal gray matter alterations in depressed individuals with thoughts of death. Prog. Neuropsychopharmacol. Biol. Psychiatry [print-electronic]. 2015 Oct 10/1/2015; 62: 22-8. PMID: 25963377, PMCID: PMC4458419, PII: S0278-5846(15)00091-3, DOI: 10.1016/j.pnpbp.2015.05.001, ISSN: 1878-4216.

Park JH, Lee SB, Lee JJ, Yoon JC, Han JW, Kim TH, Jeong HG, Newhouse PA, Taylor WD, Kim JH, Woo JI, Kim KW. Epidemiology of MRI-defined vascular depression: A longitudinal, community-based study in Korean elders. J Affect Disord [print-electronic]. 2015 Jul 7/15/2015; 180: 200-6. PMID: 25913805, PII: S0165-0327(15)00223-2, DOI: 10.1016/j.jad.2015.04.008, ISSN: 1573-2517.

Riddle M, McQuoid DR, Potter GG, Steffens DC, Taylor WD. Disability but not social support predicts cognitive deterioration in late-life depression. Int Psychogeriatr [print-electronic]. 2015 May; 27(5): 707-14. PMID: 25475430, PMCID: PMC4385394, PII: S1041610214002543, DOI: 10.1017/S1041610214002543, ISSN: 1741-203X.

Horst S, Chao A, Rosen M, Nohl A, Duley C, Wagnon JH, Beaulieu DB, Taylor W, Gaines L, Schwartz DA. Treatment with immunosuppressive therapy may improve depressive symptoms in patients with inflammatory bowel disease. Dig. Dis. Sci [print-electronic]. 2015 Feb; 60(2): 465-70. PMID: 25274158, DOI: 10.1007/s10620-014-3375-0, ISSN: 1573-2568.

Garbett KA, Vereczkei A, Kálmán S, Brown JA, Taylor WD, Faludi G, Korade Ž, Shelton RC, Mirnics K. Coordinated messenger RNA/microRNA changes in fibroblasts of patients with major depression. Biol. Psychiatry [print-electronic]. 2015 Feb 2/1/2015; 77(3): 256-65. PMID: 25016317, PMCID: PMC4254393, PII: S0006-3223(14)00376-X, DOI: 10.1016/j.biopsych.2014.05.015, ISSN: 1873-2402.

Taylor WD, McQuoid DR, Payne ME, Zannas AS, MacFall JR, Steffens DC. Hippocampus atrophy and the longitudinal course of late-life depression. Am J Geriatr Psychiatry [print-electronic]. 2014 Dec; 22(12): 1504-12. PMID: 24378256, PMCID: PMC4031313, PII: S1064-7481(13)00415-6, DOI: 10.1016/j.jagp.2013.11.004, ISSN: 1545-7214.

Zannas AS, McQuoid DR, Payne ME, MacFall JR, Ashley-Koch A, Steffens DC, Potter GG, Taylor WD. Association of gene variants of the renin-angiotensin system with accelerated hippocampal volume loss and cognitive decline in old age. Am J Psychiatry. 2014 Nov 11/1/2014; 171(11): 1214-21. PMID: 25124854, PMCID: PMC4329281, PII: 1897783, DOI: 10.1176/appi.ajp.2014.13111543, ISSN: 1535-7228.

Taylor WD, Kudra K, Zhao Z, Steffens DC, MacFall JR. Cingulum bundle white matter lesions influence antidepressant response in late-life depression: a pilot study. J Affect Disord [print-electronic]. 2014 Jun; 162: 8-11. PMID: 24766997, PMCID: PMC4030539, PII: S0165-0327(14)00142-6, DOI: 10.1016/j.jad.2014.03.031, ISSN: 1573-2517.

Zurkovsky L, Taylor WD, Newhouse PA. Cognition as a therapeutic target in late-life depression: potential for nicotinic therapeutics. Biochem. Pharmacol [print-electronic]. 2013 Oct 10/15/2013; 86(8): 1133-44. PMID: 23933385, PMCID: PMC3856552, PII: S0006-2952(13)00484-X, DOI: 10.1016/j.bcp.2013.07.032, ISSN: 1873-2968.

Taylor WD, Aizenstein HJ, Alexopoulos GS. The vascular depression hypothesis: mechanisms linking vascular disease with depression. Mol. Psychiatry [print-electronic]. 2013 Sep; 18(9): 963-74. PMID: 23439482, PMCID: PMC3674224, PII: mp201320, DOI: 10.1038/mp.2013.20, ISSN: 1476-5578.

Available Postdoctoral Position Details
Posted: 9/13/2017

Postdoctoral Fellowships in Psychosis, and Mood Disorders and Aging

The Center for Cognitive Medicine, Department of Psychiatry & Behavioral Sciences, Vanderbilt University School of Medicine

The Center for Cognitive Medicine is excited to announce two (2) newly available Postdoctoral Fellowships, one in Psychosis, and one in Mood Disorders and Aging. We are seeking highly motivated Ph.D. graduates with research experience in cognitive neuroscience, psychosis, mood disorders, or aging. The ideal candidates will have a strong publication record and may have either significant training and experience in neuroimaging, or strong training in clinical psychology or neuropsychology. Preference will be given to individuals interested in pursuing an academic career with a desire to lead independent projects and publish as a first author. Both recent graduates and those pursuing a second postdoctoral fellowship are welcome.

Psychosis Fellow: As a member of the Woodward lab (www.woodwardlab.com), the Psychosis Fellow will work on studies examining brain dysconnectivity and cognitive impairment in psychotic disorders. Current work is focused in particular on thalamocortical connectivity and cognitive networks supporting attention, working memory, and processing speed. This fellow will have the opportunity to work within a First-Episode Psychosis Program and interface with other investigators, students, and fellows.

Mood Disorders and Aging Fellow: Working with Dr. Warren D. Taylor, this Fellow will work on studies examining functional and structural neuroimaging biomarkers related to clinical and cognitive outcomes of depression in older adults. Current work focuses on neuroimaging markers of response to antidepressant medications, clinical-behavioral-imaging phenotyping of late-life depression, and determination of target engagement of novel therapeutic approaches. This fellow will have the opportunity to interface with other investigators, students and fellows focused on both cognitive aging, dementia, and mood disorders.

Both Fellows will also have opportunities to pursue additional research interests through access to secondary datasets, including local repositories of clinical, cognitive, neuroimaging, and genetic data; publically-available datasets (e.g. Human Connectome Project, Autism Brain Imaging Data Exchange, etc.); collaborations with other faculty in the Center and within the Vanderbilt community, including the Vanderbilt University Institute for Imaging Sciences (http://www.vuiis.vanderbilt.edu) and the Medical Imaging and Statistical Interpretation lab (https://my.vanderbilt.edu/masi/); and availability of competitive pilot data funding.

The Center for Cognitive Medicine is housed within the Department of Psychiatry and Behavioral Sciences. The Center has a series of dynamic and collaborative programs investigating the neural basis of psychiatric and cognitive disorders, focusing on depression, cognitive changes with aging, dementia, and psychosis. The Vanderbilt University Medical Center is a national leader in research and provides world-class neuroimaging facilities. Nashville is ranked as one of the best cities to work and live.


- Graduate degree (Ph.D.) in clinical psychology, cognitive psychology, neuroscience, biomedical engineering, or a related discipline;

- For individuals with clinical backgrounds, interest in and preferably experience with neuroimaging analysis, including structural and functional MRI and/or diffusion tensor imaging;

- For individuals with neuroscience backgrounds, expertise in neuroimaging analyses and experience with neuroimaging software packages (e.g., SPM, FSL, etc.);

- Experience with statistics as demonstrated by graduate-level coursework and publication record;

- While not required, familiarity with MATLAB is advantageous.

Duration: 2 years with advancement to the second year dependent upon satisfactory progress during the first year. The appointment may be extended beyond 2 years contingent on funding and satisfactory performance based on annual reviews.

Salary and Benefits: Salary will be commensurate with NIH postdoctoral stipends (see https://grants.nih.gov/grants/guide/notice-files/NOT-OD-16-131.html). Fellows are also eligible for benefits provided to regular employees of Vanderbilt University Medical Center, including health insurance. Interested candidates must be eligible to work in the United States.

Applying: Interested candidates should send a cover letter (250 words or less) indicating which Fellowship they are interested in (psychosis and/or mood disorders and aging) and describing their research interests along with their CV to Dr. Warren Taylor (warren.d.taylor@vanderbilt.edu) and Dr. Neil Woodward (neil.woodward@vanderbilt.edu). Eligible candidates may then be asked for up to three references.