Allison Paroskie Wheeler, M.D.

Assistant Professor
Faculty Appointments
Assistant Professor of Pathology, Microbiology and Immunology Assistant Professor of Pediatrics
M.S.C.I., Clinical Investigation, Vanderbilt University, Nashville, TennesseeM.D., University of Massachusetts, Amherst, MassachusettsB.S., University of Massachusetts, Amherst, Massachusetts
Research Description
Dr. Wheeler's research is primarily focused on hemostatic disorders in pediatric patients. She is the research director of the Vanderbilt Hemophilia Treatment Center and as such participates in both observational and therapeutic trials. She has a particular interest in women's bleeding disorders.
Clinical Description
Dr. Wheeler participates in clinical work in the pathology and pediatric departments. She is the associate medical director of the blood bank and coagulation laboratory, and sees pediatric patients with homeostatic and other hematologic disorders.
Research Keywords
hemostatic disorders, pediatric, Hemophilia
Clinical Research Keywords
homeostatic, hematologic, blood bank, coagulation
McGuinn C, Cheng D, Aschman D, Carpenter SL, Sidonio R, Soni A, Tarantino MD, Wheeler AP, Dunn AL, . Radionuclide synovectomy/synoviorthesis (RS) in patients with bleeding disorders: A review of patient and procedure demographics and functional outcomes in the ATHNdataset. Haemophilia [print-electronic]. 2017 Nov; 23(6): 926-33. PMID: 28838029, DOI: 10.1111/hae.13318, ISSN: 1365-2516.

Patel PN, Arambula AM, Wheeler AP, Penn EB. Post-tonsillectomy hemorrhagic outcomes in children with bleeding disorders at a single institution. Int. J. Pediatr. Otorhinolaryngol [print-electronic]. 2017 Sep; 100: 216-22. PMID: 28802375, PII: S0165-5876(17)30327-0, DOI: 10.1016/j.ijporl.2017.07.014, ISSN: 1872-8464.

Wu JY, Stollings JL, Wheeler AP, Semler MW, Rice TW. Efficacy and Outcomes After Vasopressin Guideline Implementation in Septic Shock. Ann Pharmacother [print-electronic]. 2017 Jan; 51(1): 13-20. PMID: 27630192, PII: 1060028016669163, DOI: 10.1177/1060028016669163, ISSN: 1542-6270.

Wheeler AP, Gailani D. The Intrinsic Pathway of Coagulation as a Target for Antithrombotic Therapy. Hematol. Oncol. Clin. North Am. 2016 Oct; 30(5): 1099-114. PMID: 27637310, PMCID: PMC5028121, PII: S0889-8588(16)30059-4, DOI: 10.1016/j.hoc.2016.05.007, ISSN: 1558-1977.

Stollings JL, Wheeler AP, Rice TW. Incidence and characterization of acute kidney injury after acetaminophen overdose. J Crit Care [print-electronic]. 2016 Oct; 35: 191-4. PMID: 27481758, PII: S0883-9441(16)30126-5, DOI: 10.1016/j.jcrc.2016.06.004, ISSN: 1557-8615.

Wheeler AP, Gailani D. Why factor XI deficiency is a clinical concern. Expert Rev Hematol. 2016 Jul; 9(7): 629-37. PMID: 27216469, PMCID: PMC4950943, DOI: 10.1080/17474086.2016.1191944, ISSN: 1747-4094.

Semler MW, Marney AM, Rice TW, Nian H, Yu C, Wheeler AP, Brown NJ, . B-Type Natriuretic Peptide, Aldosterone, and Fluid Management in ARDS. Chest [print-electronic]. 2016 Jul; 150(1): 102-11. PMID: 27018313, PMCID: PMC4980545, PII: S0012-3692(16)45714-4, DOI: 10.1016/j.chest.2016.03.017, ISSN: 1931-3543.

Landsperger JS, Semler MW, Wang L, Byrne DW, Wheeler AP. Outcomes of Nurse Practitioner-Delivered Critical Care: A Prospective Cohort Study. Chest [print-electronic]. 2016 May; 149(5): 1146-54. PMID: 26836900, PMCID: PMC4944779, PII: S0012-3692(15)00344-X, DOI: 10.1016/j.chest.2015.12.015, ISSN: 1931-3543.

Semler MW, Wheeler AP, Thompson BT, Bernard GR, Wiedemann HP, Rice TW, . Impact of Initial Central Venous Pressure on Outcomes of Conservative Versus Liberal Fluid Management in Acute Respiratory Distress Syndrome. Crit. Care Med. 2016 Apr; 44(4): 782-9. PMID: 26741580, PMCID: PMC4792704, DOI: 10.1097/CCM.0000000000001555, ISSN: 1530-0293.

Murray TS, Rice TW, Wheeler AP, Phillips EJ, Dworski RT, Stollings JL. Medication Desensitization: Characterization of Outcomes and Risk Factors for Reactions. Ann Pharmacother [print-electronic]. 2016 Mar; 50(3): 203-8. PMID: 26783356, PII: 1060028015625660, DOI: 10.1177/1060028015625660, ISSN: 1542-6270.

Semler MW, Wheeler AP. Slow and Study: Support for a Randomized Trial of ß-Blockade in Sepsis-Associated Atrial Fibrillation [editorial]. Chest [print-electronic]. 2016 Jan; 149(1): 9-10. PMID: 26757282, PII: S0012-3692(15)00041-0, DOI: 10.1016/j.chest.2015.08.020, ISSN: 1931-3543.

Lammi MR, Aiello B, Burg GT, Rehman T, Douglas IS, Wheeler AP, deBoisblanc BP, . Response to fluid boluses in the fluid and catheter treatment trial. Chest. 2015 Oct; 148(4): 919-26. PMID: 26020673, PMCID: PMC4694152, PII: S0012-3692(15)50280-8, DOI: 10.1378/chest.15-0445, ISSN: 1931-3543.

Stollings JL, Foss JJ, Ely EW, Ambrose AM, Rice TW, Girard TD, Wheeler AP. Pharmacist leadership in ICU quality improvement: coordinating spontaneous awakening and breathing trials. Ann Pharmacother [print-electronic]. 2015 Aug; 49(8): 883-91. PMID: 25907528, PII: 1060028015582050, DOI: 10.1177/1060028015582050, ISSN: 1542-6270.

Semler MW, Weavind L, Hooper MH, Rice TW, Gowda SS, Nadas A, Song Y, Martin JB, Bernard GR, Wheeler AP. An Electronic Tool for the Evaluation and Treatment of Sepsis in the ICU: A Randomized Controlled Trial. Crit. Care Med. 2015 Aug; 43(8): 1595-602. PMID: 25867906, PMCID: PMC4506222, DOI: 10.1097/CCM.0000000000001020, ISSN: 1530-0293.

Wheeler AP. Size and How You Measure It Matters [editorial]. Chest. 2015 Jul; 148(1): 3-4. PMID: 26149546, PMCID: PMC4493877, PII: S0012-3692(15)50010-X, DOI: 10.1378/chest.15-0395, ISSN: 1931-3543.

Noto MJ, Wheeler AP. Understanding chlorhexidine decolonization strategies. Intensive Care Med [print-electronic]. 2015 Jul; 41(7): 1351-4. PMID: 26088910, DOI: 10.1007/s00134-015-3846-6, ISSN: 1432-1238.

Noto MJ, Rice TW, Wheeler AP. Chlorhexidine bathing and infections in critically ill patients--reply [letter]. JAMA. 2015 May 5/12/2015; 313(18): 1863-4. PMID: 25965240, PII: 2290631, DOI: 10.1001/jama.2015.3539, ISSN: 1538-3598.

Kyle JM, Stollings JL, White KD, Noto MJ, Wheeler AP. Fosfomycin for multidrug treatment of Klebsiella pneumoniae carbapenemase bacteremia. Ann Pharmacother. 2015 Mar; 49(3): 366-7. PMID: 25691478, PII: 49/3/366, DOI: 10.1177/1060028014564395, ISSN: 1542-6270.

Noto MJ, Domenico HJ, Byrne DW, Talbot T, Rice TW, Bernard GR, Wheeler AP. Chlorhexidine bathing and health care-associated infections: a randomized clinical trial. JAMA. 2015 Jan 1/27/2015; 313(4): 369-78. PMID: 25602496, PMCID: PMC4383133, PII: 2091544, DOI: 10.1001/jama.2014.18400, ISSN: 1538-3598.

Semler MW, Wheeler AP. Systemic inflammatory response syndrome after cardiac surgery: time for a change [editorial]. Chest. 2014 Jun; 145(6): 1181-2. PMID: 24889425, PII: S0012-3692(15)34780-2, DOI: 10.1378/chest.14-0438, ISSN: 1931-3543.

Landsperger JS, Wheeler AP. Central venous catheter insertion by advanced practice nurses: another demonstrated competency* [editorial]. Crit. Care Med. 2014 Mar; 42(3): 731-2. PMID: 24534961, PII: 00003246-201403000-00031, DOI: 10.1097/01.ccm.0000435683.06554.b0, ISSN: 1530-0293.

Mealer M, Kittelson J, Thompson BT, Wheeler AP, Magee JC, Sokol RJ, Moss M, Kahn MG. Remote source document verification in two national clinical trials networks: a pilot study. PLoS ONE. 2013; 8(12): e81890. PMID: 24349149, PMCID: PMC3857788, PII: PONE-D-13-23550, DOI: 10.1371/journal.pone.0081890, ISSN: 1932-6203.

Bastarache JA, Ware LB, Girard TD, Wheeler AP, Rice TW. Markers of inflammation and coagulation may be modulated by enteral feeding strategy. JPEN J Parenter Enteral Nutr [print-electronic]. 2012 Nov; 36(6): 732-40. PMID: 22318965, PMCID: PMC3726194, PII: 0148607111433054, DOI: 10.1177/0148607111433054, ISSN: 1941-2444.

Noto MJ, Wheeler AP. Macrolides for acute lung injury [editorial]. Chest. 2012 May; 141(5): 1131-2. PMID: 22553255, PMCID: PMC3342786, PII: S0012-3692(12)60260-8, DOI: 10.1378/chest.11-3245, ISSN: 1931-3543.

Rice TW, Morris S, Tortella BJ, Wheeler AP, Christensen MC. Deviations from evidence-based clinical management guidelines increase mortality in critically injured trauma patients*. Crit. Care Med. 2012 Mar; 40(3): 778-86. PMID: 22036858, DOI: 10.1097/CCM.0b013e318236f168, ISSN: 1530-0293.

Rice TW, Wheeler AP, Thompson BT, deBoisblanc BP, Steingrub J, Rock P, . Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury. JAMA [print-electronic]. 2011 Oct 10/12/2011; 306(14): 1574-81. PMID: 21976613, PMCID: PMC3770348, PII: jama.2011.1435, DOI: 10.1001/jama.2011.1435, ISSN: 1538-3598.

Rice TW, Mogan S, Hays MA, Bernard GR, Jensen GL, Wheeler AP. Randomized trial of initial trophic versus full-energy enteral nutrition in mechanically ventilated patients with acute respiratory failure. Crit. Care Med. 2011 May; 39(5): 967-74. PMID: 21242788, PMCID: PMC3102124, DOI: 10.1097/CCM.0b013e31820a905a, ISSN: 1530-0293.

Landsperger JS, Williams KJ, Hellervik SM, Chassan CB, Flemmons LN, Davidson SR, Evans ER, Bacigalupo ME, Wheeler AP. Implementation of a medical intensive care unit acute-care nurse practitioner service. Hosp Pract (1995). 2011 Apr; 39(2): 32-9. PMID: 21576895, DOI: 10.3810/hp.2011.04.392, ISSN: 2154-8331.

Rice TW, Ware LB, Haponik EF, Chiles C, Wheeler AP, Bernard GR, Steingrub JS, Hite RD, Matthay MA, Wright P, Ely EW, . Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid status. Crit Care [print-electronic]. 2011; 15(2): R86. PMID: 21385351, PMCID: PMC3219344, PII: cc10084, DOI: 10.1186/cc10084, ISSN: 1466-609X.

Rice TW, Wheeler AP, Bernard GR, Vincent JL, Angus DC, Aikawa N, Demeyer I, Sainati S, Amlot N, Cao C, Ii M, Matsuda H, Mouri K, Cohen J. A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis. Crit. Care Med. 2010 Aug; 38(8): 1685-94. PMID: 20562702, DOI: 10.1097/CCM.0b013e3181e7c5c9, ISSN: 1530-0293.

Wheeler AP, Rice TW. Coagulopathy in critically ill patients: part 2-soluble clotting factors and hemostatic testing. Chest. 2010 Jan; 137(1): 185-94. PMID: 20051403, PII: 10.1378/chest.08-2535, DOI: 10.1378/chest.08-2535, ISSN: 1931-3543.

Rice TW, Wheeler AP. Coagulopathy in critically ill patients: part 1: platelet disorders. Chest. 2009 Dec; 136(6): 1622-30. PMID: 19995764, PII: S0012-3692(09)60745-5, DOI: 10.1378/chest.08-2534, ISSN: 1931-3543.

Jackson JC, Hopkins RO, Miller RR, Gordon SM, Wheeler AP, Ely EW. Acute respiratory distress syndrome, sepsis, and cognitive decline: a review and case study. South. Med. J. 2009 Nov; 102(11): 1150-7. PMID: 19864995, PMCID: PMC3776422, DOI: 10.1097/SMJ.0b013e3181b6a592, ISSN: 1541-8243.

Martin JB, Wheeler AP. Approach to the patient with sepsis. Clin. Chest Med. 2009 Mar; 30(1): 1-16, vii. PMID: 19186277, PII: S0272-5231(08)00093-2, DOI: 10.1016/j.ccm.2008.09.005, ISSN: 1557-8216.

Berutti TW, Starmer J, Johnson KB, Patel NR, Wheeler AP, Rice T. Promoting adherence to ventilator management and ventilator weaning protocols. AMIA Annu Symp Proc. 2008 Nov 11/6/2008; 877. PMID: 18999172, ISSN: 1942-597X.

Wheeler AP. Recent developments in the diagnosis and management of severe sepsis. Chest. 2007 Dec; 132(6): 1967-76. PMID: 18079230, PII: S0012-3692(15)52474-4, DOI: 10.1378/chest.06-2535, ISSN: 0012-3692.

Lee P, DiPersio D, Jerome RN, Wheeler AP. Approaching and analyzing a large literature on vancomycin monitoring and pharmacokinetics. J Med Libr Assoc. 2007 Oct; 95(4): 374-80. PMID: 17971884, PMCID: PMC2000794, DOI: 10.3163/1536-5050.95.4.374, ISSN: 1558-9439.

Rice TW, Wheeler AP, Bernard GR, Hayden DL, Schoenfeld DA, Ware LB, . Comparison of the SpO2/FIO2 ratio and the PaO2/FIO2 ratio in patients with acute lung injury or ARDS. Chest [print-electronic]. 2007 Aug; 132(2): 410-7. PMID: 17573487, PII: S0012-3692(15)37431-6, DOI: 10.1378/chest.07-0617, ISSN: 0012-3692.

Wheeler AP, Bernard GR. Acute lung injury and the acute respiratory distress syndrome: a clinical review. Lancet. 2007 May 5/5/2007; 369(9572): 1553-64. PMID: 17482987, PII: S0140-6736(07)60604-7, DOI: 10.1016/S0140-6736(07)60604-7, ISSN: 1474-547X.

Rice TW, Wheeler AP, Morris PE, Paz HL, Russell JA, Edens TR, Bernard GR. Safety and efficacy of affinity-purified, anti-tumor necrosis factor-alpha, ovine fab for injection (CytoFab) in severe sepsis. Crit. Care Med. 2006 Sep; 34(9): 2271-81. PMID: 16810105, DOI: 10.1097/01.CCM.0000230385.82679.34, ISSN: 0090-3493.

, Wheeler AP, Bernard GR, Thompson BT, Schoenfeld D, Wiedemann HP, deBoisblanc B, Connors AF, Hite RD, Harabin AL. Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury. N. Engl. J. Med [print-electronic]. 2006 May 5/25/2006; 354(21): 2213-24. PMID: 16714768, PII: NEJMoa061895, DOI: 10.1056/NEJMoa061895, ISSN: 1533-4406.

Rice TW, Swope T, Bozeman S, Wheeler AP. Variation in enteral nutrition delivery in mechanically ventilated patients. Nutrition. 2005 Jul; 21(7-8): 786-92. PMID: 15975485, PII: S0899-9007(05)00133-4, DOI: 10.1016/j.nut.2004.11.014, ISSN: 0899-9007.

Bernard GR, Margolis BD, Shanies HM, Ely EW, Wheeler AP, Levy H, Wong K, Wright TJ, . Extended evaluation of recombinant human activated protein C United States Trial (ENHANCE US): a single-arm, phase 3B, multicenter study of drotrecogin alfa (activated) in severe sepsis. Chest. 2004 Jun; 125(6): 2206-16. PMID: 15189943, PII: S0012-3692(16)58997-1, ISSN: 0012-3692.

Ely EW, Truman B, Shintani A, Thomason JW, Wheeler AP, Gordon S, Francis J, Speroff T, Gautam S, Margolin R, Sessler CN, Dittus RS, Bernard GR. Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS). JAMA. 2003 Jun 6/11/2003; 289(22): 2983-91. PMID: 12799407, PII: 289/22/2983, DOI: 10.1001/jama.289.22.2983, ISSN: 1538-3598.

Ely EW, Wheeler AP, Thompson BT, Ancukiewicz M, Steinberg KP, Bernard GR. Recovery rate and prognosis in older persons who develop acute lung injury and the acute respiratory distress syndrome. Ann. Intern. Med. 2002 Jan 1/1/2002; 136(1): 25-36. PMID: 11777361, PII: 200201010-00008, ISSN: 0003-4819.

Holcomb BW, Wheeler AP, Ely EW. New ways to reduce unnecessary variation and improve outcomes in the intensive care unit. Curr Opin Crit Care. 2001 Aug; 7(4): 304-11. PMID: 11571430, ISSN: 1070-5295.

Mangialardi RJ, Martin GS, Bernard GR, Wheeler AP, Christman BW, Dupont WD, Higgins SB, Swindell BB. Hypoproteinemia predicts acute respiratory distress syndrome development, weight gain, and death in patients with sepsis. Ibuprofen in Sepsis Study Group. Crit. Care Med. 2000 Sep; 28(9): 3137-45. PMID: 11008971, ISSN: 0090-3493.

Arons MM, Wheeler AP, Bernard GR, Christman BW, Russell JA, Schein R, Summer WR, Steinberg KP, Fulkerson W, Wright P, Dupont WD, Swindell BB. Effects of ibuprofen on the physiology and survival of hypothermic sepsis. Ibuprofen in Sepsis Study Group. Crit. Care Med. 1999 Apr; 27(4): 699-707. PMID: 10321658, ISSN: 0090-3493.

Hartert TV, Wheeler AP, Sheller JR. Use of pulse oximetry to recognize severity of airflow obstruction in obstructive airway disease: correlation with pulsus paradoxus. Chest. 1999 Feb; 115(2): 475-81. PMID: 10027449, PII: S0012-3692(15)50593-X, ISSN: 0012-3692.

Wheeler AP, Bernard GR. Treating patients with severe sepsis. N. Engl. J. Med. 1999 Jan 1/21/1999; 340(3): 207-14. PMID: 9895401, DOI: 10.1056/NEJM199901213400307, ISSN: 0028-4793.

Price BJ, Bernard GR, Drew K, Foss J, Wheeler AP. Impact of a critical care pathway for unstable mechanically ventilated patients. Crit Care Nurs Clin North Am. 1998 Mar; 10(1): 75-85. PMID: 9644350, ISSN: 0899-5885.

Bernard GR, Wheeler AP, Arons MM, Morris PE, Paz HL, Russell JA, Wright PE. A trial of antioxidants N-acetylcysteine and procysteine in ARDS. The Antioxidant in ARDS Study Group. Chest. 1997 Jul; 112(1): 164-72. PMID: 9228372, PII: S0012-3692(15)47155-7, ISSN: 0012-3692.

Bernard GR, Wheeler AP, Russell JA, Schein R, Summer WR, Steinberg KP, Fulkerson WJ, Wright PE, Christman BW, Dupont WD, Higgins SB, Swindell BB. The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. N. Engl. J. Med. 1997 Mar 3/27/1997; 336(13): 912-8. PMID: 9070471, DOI: 10.1056/NEJM199703273361303, ISSN: 0028-4793.

Wheeler AP, Bernard GR. Applications of molecular biology and biotechnology: antibody therapy of sepsis. J Crit Care. 1996 Jun; 11(2): 77-94. PMID: 8727029, PII: S0883-9441(96)90023-4, ISSN: 0883-9441.

Carmichael LC, Dorinsky PM, Higgins SB, Bernard GR, Dupont WD, Swindell B, Wheeler AP. Diagnosis and therapy of acute respiratory distress syndrome in adults: an international survey. J Crit Care. 1996 Mar; 11(1): 9-18. PMID: 8904279, ISSN: 0883-9441.

Higgins SB, Jiang K, Plummer WD, Edens TR, Stroud MJ, Swindell BB, Wheeler AP, Bernard GR. Pivot/Remote: a distributed database for remote data entry in multi-center clinical trials. Medinfo. 1995; 8 Pt 2: 1097. PMID: 8591379, ISSN: 1569-6332.

Wheeler AP, Carroll FE, Bernard GR. Radiographic issues in adult respiratory distress syndrome. New Horiz. 1993 Nov; 1(4): 471-7. PMID: 8087568, ISSN: 1063-7389.

Wheeler AP. Sedation, analgesia, and paralysis in the intensive care unit. Chest. 1993 Aug; 104(2): 566-77. PMID: 8101798, PII: S0012-3692(16)35377-6, ISSN: 0012-3692.

Hardie WD, Wheeler AP, Wright PW, Swindell BB, Bernard GR. Effect of cyclooxygenase inhibition on amphotericin B-induced lung injury in awake sheep. J. Infect. Dis. 1992 Jul; 166(1): 134-8. PMID: 1607684, ISSN: 0022-1899.

Wheeler AP, Hardie WD, Bernard GR. The role of cyclooxygenase products in lung injury induced by tumor necrosis factor in sheep. Am. Rev. Respir. Dis. 1992 Mar; 145(3): 632-9. PMID: 1546845, DOI: 10.1164/ajrccm/145.3.632, ISSN: 0003-0805.

Wheeler AP, Hardie WD, Bernard G. Studies of an antiendotoxin antibody in preventing the physiologic changes of endotoxemia in awake sheep. Am. Rev. Respir. Dis. 1990 Oct; 142(4): 775-81. PMID: 2221582, DOI: 10.1164/ajrccm/142.4.775, ISSN: 0003-0805.

Wheeler AP, Jesmok G, Brigham KL. Tumor necrosis factor's effects on lung mechanics, gas exchange, and airway reactivity in sheep. J. Appl. Physiol. 1990 Jun; 68(6): 2542-9. PMID: 2384433, DOI: 10.1152/jappl.1990.68.6.2542, ISSN: 8750-7587.

Wheeler AP, Bernard GR. Minimal positive end expiratory pressure (PEEP): a safe, effective, defensible practice. Clin Intensive Care. 1990; 1(4): 175-9. PMID: 10149076, ISSN: 0956-3075.

Wheeler AP, Loyd JE. Fatal hemoptysis: aortobronchial fistula as a preventable cause of death. Crit. Care Med. 1989 Nov; 17(11): 1228-30. PMID: 2791602, ISSN: 0090-3493.

Wheeler AP, Graham BS. Atypical mycobacterial infections. South. Med. J. 1989 Oct; 82(10): 1250-8. PMID: 2678500, ISSN: 0038-4348.

Wheeler AP, Jaquiss RD, Newman JH. Physician practices in the treatment of pulmonary embolism and deep venous thrombosis. Arch. Intern. Med. 1988 Jun; 148(6): 1321-5. PMID: 3377615, ISSN: 0003-9926.