William H. Fissell, IV, M.D.

Associate Professor


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Faculty Appointments
Associate Professor of Medicine
M.D., Medicine, Case Western Reserve University, Cleveland, OhioS.B., Massachusetts Institute of Technology, Cambridge, Massachusetts
Office Address
S3223 MCN
1161 21st Avenue South,
Nashville, TN 37232
Research Keywords
Epithelial cell culture tissue engineering bioartificial kidneys
Fissell WH. Introduction to Making Dialysis Adequate-Addressing its Limitations. Semin Dial [print-electronic]. 2016 Nov; 29(6): 423-4. PMID: 27678202, DOI: 10.1111/sdi.12545, ISSN: 1525-139X.

Shotwell MS, Nesbitt R, Madonia PN, Gould ER, Connor MJ, Salem C, Aduroja OA, Amde M, Groszek JJ, Wei P, Taylor ME, Tolwani AJ, Fissell WH. Pharmacokinetics and Pharmacodynamics of Extended Infusion Versus Short Infusion Piperacillin-Tazobactam in Critically Ill Patients Undergoing CRRT. Clin J Am Soc Nephrol [print-electronic]. 2016 Aug 8/8/2016; 11(8): 1377-83. PMID: 27197907, PMCID: PMC4974884, PII: CJN.10260915, DOI: 10.2215/CJN.10260915, ISSN: 1555-905X.

Vijayan A, Faubel S, Askenazi DJ, Cerda J, Fissell WH, Heung M, Humphreys BD, Koyner JL, Liu KD, Mour G, Nolin TD, Bihorac A, . Clinical Use of the Urine Biomarker [TIMP-2] × [IGFBP7] for Acute Kidney Injury Risk Assessment. Am. J. Kidney Dis [print-electronic]. 2016 Jul; 68(1): 19-28. PMID: 26948834, PMCID: PMC4921267, PII: S0272-6386(16)00141-4, DOI: 10.1053/j.ajkd.2015.12.033, ISSN: 1523-6838.

Kensinger C, Karp S, Kant R, Chui BW, Goldman K, Yeager T, Gould ER, Buck A, Laneve DC, Groszek JJ, Roy S, Fissell WH. First Implantation of Silicon Nanopore Membrane Hemofilters. ASAIO J. 2016 Jul; 62(4): 491-5. PMID: 26978710, PMCID: PMC4983406, DOI: 10.1097/MAT.0000000000000367, ISSN: 1538-943X.

Kim S, Heller J, Iqbal Z, Kant R, Kim EJ, Durack J, Saeed M, Do L, Hetts S, Wilson M, Brakeman P, Fissell WH, Roy S. Preliminary Diffusive Clearance of Silicon Nanopore Membranes in a Parallel Plate Configuration for Renal Replacement Therapy. ASAIO J. 2016 Mar; 62(2): 169-75. PMID: 26692401, PMCID: PMC4777646, DOI: 10.1097/MAT.0000000000000311, ISSN: 1538-943X.

Shotwell MS, Zhou M, Fissell WH. Optimal design of perturbations for individual two-compartment pharmacokinetic analysis. J Biopharm Stat [print-electronic]. 2016; 26(5): 803-15. PMID: 26247447, PMCID: PMC4744591, DOI: 10.1080/10543406.2015.1074918, ISSN: 1520-5711.

Kim S, Feinberg B, Kant R, Chui B, Goldman K, Park J, Moses W, Blaha C, Iqbal Z, Chow C, Wright N, Fissell WH, Zydney A, Roy S. Diffusive Silicon Nanopore Membranes for Hemodialysis Applications. PLoS ONE. 2016; 11(7): e0159526. PMID: 27438878, PMCID: PMC4954641, PII: PONE-D-16-08708, DOI: 10.1371/journal.pone.0159526, ISSN: 1932-6203.

de Caestecker M, Humphreys BD, Liu KD, Fissell WH, Cerda J, Nolin TD, Askenazi D, Mour G, Harrell FE, Pullen N, Okusa MD, Faubel S, . Bridging Translation by Improving Preclinical Study Design in AKI. J. Am. Soc. Nephrol [print-electronic]. 2015 Dec; 26(12): 2905-16. PMID: 26538634, PMCID: PMC4657852, PII: ASN.2015070832, DOI: 10.1681/ASN.2015070832, ISSN: 1533-3450.

Shotwell MS, Madonia PN, Connor MJ, Amde M, Salem C, Aduroja OA, Bauer SR, Groszek JJ, Fissell WH. Ciprofloxacin pharmacokinetics in critically ill patients receiving concomitant continuous venovenous hemodialysis [letter]. Am. J. Kidney Dis [print-electronic]. 2015 Jul; 66(1): 173-5. PMID: 25912840, PII: S0272-6386(15)00522-3, DOI: 10.1053/j.ajkd.2015.03.001, ISSN: 1523-6838.

Ferrell N, Sandoval RM, Bian A, Campos-Bilderback SB, Molitoris BA, Fissell WH. Shear stress is normalized in glomerular capillaries following ¿ nephrectomy. Am. J. Physiol. Renal Physiol [print-electronic]. 2015 Mar 3/15/2015; 308(6): F588-93. PMID: 25587117, PMCID: PMC4360039, PII: ajprenal.00290.2014, DOI: 10.1152/ajprenal.00290.2014, ISSN: 1522-1466.

Demirjian S, Fissell WH. Staying on target with continuous dialysis [editorial]. Clin J Am Soc Nephrol [print-electronic]. 2015 Jan 1/7/2015; 10(1): 7-8. PMID: 25538268, PMCID: PMC4284419, PII: CJN.11251114, DOI: 10.2215/CJN.11251114, ISSN: 1555-905X.

Fissell WH. Laboratory assays in renal failure: therapeutic drug monitoring. Semin Dial [print-electronic]. 2014 Nov; 27(6): 614-7. PMID: 24995571, DOI: 10.1111/sdi.12279, ISSN: 1525-139X.

Olorunsola OG, Kim SH, Chang R, Kuo YC, Hetts SW, Heller A, Kant R, Saeed M, Fissell WH, Roy S, Wilson MW. Imaging assessment of a portable hemodialysis device: detection of possible failure modes and monitoring of functional performance. Med Instrum (Luton). 2014 Mar 3/27/2014; 2(2): PMID: 25045526, PMCID: PMC4101171, DOI: 10.7243/2052-6962-2-2.

Humes HD, Buffington D, Westover AJ, Roy S, Fissell WH. The bioartificial kidney: current status and future promise. Pediatr. Nephrol [print-electronic]. 2014 Mar; 29(3): 343-51. PMID: 23619508, DOI: 10.1007/s00467-013-2467-y, ISSN: 1432-198X.

Golper TA, Fissell R, Fissell WH, Hartle PM, Sanders ML, Schulman G. Hemodialysis: core curriculum 2014. Am. J. Kidney Dis [print-electronic]. 2014 Jan; 63(1): 153-63. PMID: 24268927, PMCID: PMC4276338, PII: S0272-6386(13)01318-8, DOI: 10.1053/j.ajkd.2013.07.028, ISSN: 1523-6838.

Afshartous D, Bauer SR, Connor MJ, Aduroja OA, Amde M, Salem C, Groszek JJ, Fissell WH. Pharmacokinetics and pharmacodynamics of imipenem and meropenem in critically ill patients treated with continuous venovenous hemodialysis [letter]. Am. J. Kidney Dis [print-electronic]. 2014 Jan; 63(1): 170-1. PMID: 24145021, PII: S0272-6386(13)01201-8, DOI: 10.1053/j.ajkd.2013.08.015, ISSN: 1523-6838.

Fissell WH. What is nanotechnology? [editorial]. Adv Chronic Kidney Dis. 2013 Nov; 20(6): 452-3. PMID: 24206597, PII: S1548-5595(13)00129-8, DOI: 10.1053/j.ackd.2013.08.008, ISSN: 1548-5609.

Fissell WH, Roy S, Davenport A. Achieving more frequent and longer dialysis for the majority: wearable dialysis and implantable artificial kidney devices. Kidney Int [print-electronic]. 2013 Aug; 84(2): 256-64. PMID: 23407434, PII: ki2012466, DOI: 10.1038/ki.2012.466, ISSN: 1523-1755.

Ferrell N, Cameron KO, Groszek JJ, Hofmann CL, Li L, Smith RA, Bian A, Shintani A, Zydney AL, Fissell WH. Effects of pressure and electrical charge on macromolecular transport across bovine lens basement membrane. Biophys. J. 2013 Apr 4/2/2013; 104(7): 1476-84. PMID: 23561524, PMCID: PMC3617438, PII: S0006-3495(13)00261-0, DOI: 10.1016/j.bpj.2013.01.062, ISSN: 1542-0086.

Garg N, Fissell WH. Intradialytic hypotension: a case for going slow and looking carefully. Nephrol. Dial. Transplant [print-electronic]. 2013 Feb; 28(2): 247-9. PMID: 22848109, PII: gfs316, DOI: 10.1093/ndt/gfs316, ISSN: 1460-2385.

Fissell WH. Antimicrobial dosing in acute renal replacement. Adv Chronic Kidney Dis. 2013 Jan; 20(1): 85-93. PMID: 23265600, PMCID: PMC3807249, PII: S1548-5595(12)00194-2, DOI: 10.1053/j.ackd.2012.10.004, ISSN: 1548-5609.

Neuner EA, Ahrens CL, Groszek JJ, Isada C, Vogelbaum MA, Fissell WH, Bhimraj A. Use of therapeutic drug monitoring to treat Elizabethkingia meningoseptica meningitis and bacteraemia in an adult. J. Antimicrob. Chemother [print-electronic]. 2012 Jun; 67(6): 1558-60. PMID: 22357803, PMCID: PMC3350328, PII: dks053, DOI: 10.1093/jac/dks053, ISSN: 1460-2091.

Smith RA, Fissell WH, Fleischman AJ, Zorman CA. A low-cost automated streaming potential measurement system. J Lab Autom [print-electronic]. 2012 Apr; 17(2): 125-33. PMID: 22357558, PII: 2211068211425663, DOI: 10.1177/2211068211425663, ISSN: 2211-0682.

Fissell WH. Illuminating the glomerular filtration barrier, two photons at a time [editorial]. J. Am. Soc. Nephrol [print-electronic]. 2012 Mar; 23(3): 373-5. PMID: 22323639, PII: ASN.2012010067, DOI: 10.1681/ASN.2012010067, ISSN: 1533-3450.

Bauer SR, Salem C, Connor MJ, Groszek J, Taylor ME, Wei P, Tolwani AJ, Fissell WH. Pharmacokinetics and pharmacodynamics of piperacillin-tazobactam in 42 patients treated with concomitant CRRT. Clin J Am Soc Nephrol [print-electronic]. 2012 Mar; 7(3): 452-7. PMID: 22282479, PMCID: PMC3302674, PII: CJN.10741011, DOI: 10.2215/CJN.10741011, ISSN: 1555-905X.

Ferrell N, Ricci KB, Groszek J, Marmerstein JT, Fissell WH. Albumin handling by renal tubular epithelial cells in a microfluidic bioreactor. Biotechnol. Bioeng [print-electronic]. 2012 Mar; 109(3): 797-803. PMID: 22012446, PMCID: PMC3285552, DOI: 10.1002/bit.24339, ISSN: 1097-0290.

Demirjian S, Teo BW, Guzman JA, Heyka RJ, Paganini EP, Fissell WH, Schold JD, Schreiber MJ. Hypophosphatemia during continuous hemodialysis is associated with prolonged respiratory failure in patients with acute kidney injury. Nephrol. Dial. Transplant [print-electronic]. 2011 Nov; 26(11): 3508-14. PMID: 21382993, PII: gfr075, DOI: 10.1093/ndt/gfr075, ISSN: 1460-2385.

Axelsson J, Sverrisson K, Rippe A, Fissell W, Rippe B. Reduced diffusion of charge-modified, conformationally intact anionic Ficoll relative to neutral Ficoll across the rat glomerular filtration barrier in vivo. Am. J. Physiol. Renal Physiol [print-electronic]. 2011 Oct; 301(4): F708-12. PMID: 21775478, PII: ajprenal.00183.2011, DOI: 10.1152/ajprenal.00183.2011, ISSN: 1522-1466.

Bauer SR, Culver DA, Abraham S, Lam SW, Fissell WH, Wiedemann HP, Reddy AJ. Detectability of vasopressin in continuous venovenous hemodialysis effluent of patients with vasodilatory shock treated with exogenous arginine vasopressin. Pharmacotherapy. 2011 Sep; 31(9): 857-62. PMID: 21923586, DOI: 10.1592/phco.31.9.857, ISSN: 1875-9114.

Roy S, Goldman K, Marchant R, Zydney A, Brown D, Fleischman A, Conlisk A, Desai T, Duffy S, Humes H, Fissell W. Implanted renal replacement for end-stage renal disease. Panminerva Med. 2011 Sep; 53(3): 155-66. PMID: 21775942, PII: R41112615, ISSN: 1827-1898.

Muthusubramaniam L, Lowe R, Fissell WH, Li L, Marchant RE, Desai TA, Roy S. Hemocompatibility of silicon-based substrates for biomedical implant applications. Ann Biomed Eng [print-electronic]. 2011 Apr; 39(4): 1296-305. PMID: 21287275, PMCID: PMC3069312, DOI: 10.1007/s10439-011-0256-y, ISSN: 1573-9686.

Connor MJ, Salem C, Bauer SR, Hofmann CL, Groszek J, Butler R, Rehm SJ, Fissell WH. Therapeutic drug monitoring of piperacillin-tazobactam using spent dialysate effluent in patients receiving continuous venovenous hemodialysis. Antimicrob. Agents Chemother [print-electronic]. 2011 Feb; 55(2): 557-60. PMID: 21115798, PMCID: PMC3028791, PII: AAC.00548-10, DOI: 10.1128/AAC.00548-10, ISSN: 1098-6596.

Ferrell N, Groszek J, Li L, Smith R, Butler RS, Zorman CA, Roy S, Fissell WH. Basal lamina secreted by MDCK cells has size- and charge-selective properties. Am. J. Physiol. Renal Physiol [print-electronic]. 2011 Jan; 300(1): F86-90. PMID: 20980405, PMCID: PMC3023222, PII: ajprenal.00484.2010, DOI: 10.1152/ajprenal.00484.2010, ISSN: 1522-1466.

Ferrell N, Desai RR, Fleischman AJ, Roy S, Humes HD, Fissell WH. A microfluidic bioreactor with integrated transepithelial electrical resistance (TEER) measurement electrodes for evaluation of renal epithelial cells. Biotechnol. Bioeng. 2010 Nov 11/1/2010; 107(4): 707-16. PMID: 20552673, PMCID: PMC3903011, DOI: 10.1002/bit.22835, ISSN: 1097-0290.

Groszek J, Li L, Ferrell N, Smith R, Zorman CA, Hofmann CL, Roy S, Fissell WH. Molecular conformation and filtration properties of anionic Ficoll. Am. J. Physiol. Renal Physiol [print-electronic]. 2010 Oct; 299(4): F752-7. PMID: 20668097, PII: ajprenal.00324.2010, DOI: 10.1152/ajprenal.00324.2010, ISSN: 1522-1466.