Joshua A. Bauer, Ph.D.

Research Assistant Professor

joshua.a.bauer@vanderbilt.edu

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Faculty Appointments
Research Assistant Professor of Biochemistry
Education
Ph.D., Pharmacology, University of Michigan, Ann Arbor, MichiganB.S., Pharmacology and Toxicology, University of Wisconsin, Madison, Wisconsin
Office Address
824 Robinson Research Building
2200 Pierce Avenue
Nashville, TN 37232
Research Keywords
Within the Vanderbilt High Throughput Screening Facility, I facilitate the development and implementation of technologies to enable the discovery of chemical modulators of a variety of molecular targets and pathways in cancer cell biology. I also help develop pharmacological discoveries for anti-cancer agents and identify new lead compounds that benefit both mechanistic studies and drug discovery/development. My research interests are focused on bioinformatic and chemical genomic approaches to identify novel cancer targets and to better understand the molecular and genetic mechanisms that underlie how cancer cells respond to therapeutics. A main goal is to identify novel strategies to overcome therapy resistance that will have clinical application.
Publications
Knowlton JJ, Fernández de Castro I, Ashbrook AW, Gestaut DR, Zamora PF, Bauer JA, Forrest JC, Frydman J, Risco C, Dermody TS. The TRiC chaperonin controls reovirus replication through outer-capsid folding. Nat Microbiol [print-electronic]. 2018 Apr; 3(4): 481-93. PMID: 29531365, PMCID: PMC5874176, PII: 10.1038/s41564-018-0122-x, DOI: 10.1038/s41564-018-0122-x, ISSN: 2058-5276.

Ichihara E, Westover D, Meador CB, Yan Y, Bauer JA, Lu P, Ye F, Kulick A, de Stanchina E, McEwen R, Ladanyi M, Cross D, Pao W, Lovly CM. SFK/FAK Signaling Attenuates Osimertinib Efficacy in Both Drug-Sensitive and Drug-Resistant Models of EGFR-Mutant Lung Cancer. Cancer Res [print-electronic]. 2017 Jun 6/1/2017; 77(11): 2990-3000. PMID: 28416483, PMCID: PMC5467531, PII: 0008-5472.CAN-16-2300, DOI: 10.1158/0008-5472.CAN-16-2300, ISSN: 1538-7445.

Jansen VM, Bhola NE, Bauer JA, Formisano L, Lee KM, Hutchinson KE, Witkiewicz AK, Moore PD, Estrada MV, Sánchez V, Ericsson PG, Sanders ME, Pohlmann PR, Pishvaian MJ, Riddle DA, Dugger TC, Wei W, Knudsen ES, Arteaga CL. Kinome-Wide RNA Interference Screen Reveals a Role for PDK1 in Acquired Resistance to CDK4/6 Inhibition in ER-Positive Breast Cancer. Cancer Res [print-electronic]. 2017 May 5/1/2017; 77(9): 2488-99. PMID: 28249908, PMCID: PMC5421398, PII: 0008-5472.CAN-16-2653, DOI: 10.1158/0008-5472.CAN-16-2653, ISSN: 1538-7445.

Ashbrook AW, Lentscher AJ, Zamora PF, Silva LA, May NA, Bauer JA, Morrison TE, Dermody TS. Antagonism of the Sodium-Potassium ATPase Impairs Chikungunya Virus Infection. MBio. 2016 May 5/24/2016; 7(3): PMID: 27222471, PMCID: PMC4895112, PII: mBio.00693-16, DOI: 10.1128/mBio.00693-16, ISSN: 2150-7511.

Kumar KK, Lowe EW, Aboud AA, Neely MD, Redha R, Bauer JA, Odak M, Weaver CD, Meiler J, Aschner M, Bowman AB. Cellular manganese content is developmentally regulated in human dopaminergic neurons. Sci Rep. 2014 Oct 10/28/2014; 4: 6801. PMID: 25348053, PMCID: PMC4210885, PII: srep06801, DOI: 10.1038/srep06801, ISSN: 2045-2322.

Balko JM, Giltnane JM, Wang K, Schwarz LJ, Young CD, Cook RS, Owens P, Sanders ME, Kuba MG, Sánchez V, Kurupi R, Moore PD, Pinto JA, Doimi FD, Gómez H, Horiuchi D, Goga A, Lehmann BD, Bauer JA, Pietenpol JA, Ross JS, Palmer GA, Yelensky R, Cronin M, Miller VA, Stephens PJ, Arteaga CL. Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets. Cancer Discov [print-electronic]. 2014 Feb; 4(2): 232-45. PMID: 24356096, PMCID: PMC3946308, PII: 2159-8290.CD-13-0286, DOI: 10.1158/2159-8290.CD-13-0286, ISSN: 2159-8290.

Xie J, Wang C, Virostko J, Manning HC, Pham W, Bauer J, Gore JC. A novel reporter system for molecular imaging and high-throughput screening of anticancer drugs. Chembiochem [print-electronic]. 2013 Aug 8/19/2013; 14(12): 1494-503. PMID: 23881799, PMCID: PMC3819221, DOI: 10.1002/cbic.201300142, ISSN: 1439-7633.

Guo Y, Sheng Q, Samuels DC, Lehmann B, Bauer JA, Pietenpol J, Shyr Y. Comparative study of exome copy number variation estimation tools using array comparative genomic hybridization as control. Biomed Res Int [print-electronic]. 2013; 2013: 915636. PMID: 24303503, PMCID: PMC3835197, DOI: 10.1155/2013/915636, ISSN: 2314-6141.

Ye F, Bauer JA, Pietenpol JA, Shyr Y. Analysis of high-throughput RNAi screening data in identifying genes mediating sensitivity to chemotherapeutic drugs: statistical approaches and perspectives. BMC Genomics [print-electronic]. 2012; 13 Suppl 8: S3. PMID: 23281588, PMCID: PMC3535706, PII: 1471-2164-13-S8-S3, DOI: 10.1186/1471-2164-13-S8-S3, ISSN: 1471-2164.

Chen X, Li J, Gray WH, Lehmann BD, Bauer JA, Shyr Y, Pietenpol JA. TNBCtype: A Subtyping Tool for Triple-Negative Breast Cancer. Cancer Inform [print-electronic]. 2012; 11: 147-56. PMID: 22872785, PMCID: PMC3412597, PII: cin-11-2012-147, DOI: 10.4137/CIN.S9983, ISSN: 1176-9351.

Lehmann BD, Bauer JA, Chen X, Sanders ME, Chakravarthy AB, Shyr Y, Pietenpol JA. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J. Clin. Invest. 2011 Jul; 121(7): 2750-67. PMID: 21633166, PMCID: PMC3127435, PII: 45014, DOI: 10.1172/JCI45014, ISSN: 1558-8238.

Bauer JA, Chakravarthy AB, Rosenbluth JM, Mi D, Seeley EH, De Matos Granja-Ingram N, Olivares MG, Kelley MC, Mayer IA, Meszoely IM, Means-Powell JA, Johnson KN, Tsai CJ, Ayers GD, Sanders ME, Schneider RJ, Formenti SC, Caprioli RM, Pietenpol JA. Identification of markers of taxane sensitivity using proteomic and genomic analyses of breast tumors from patients receiving neoadjuvant paclitaxel and radiation. Clin. Cancer Res [print-electronic]. 2010 Jan 1/15/2010; 16(2): 681-90. PMID: 20068102, PMCID: PMC2892225, PII: 1078-0432.CCR-09-1091, DOI: 10.1158/1078-0432.CCR-09-1091, ISSN: 1078-0432.

Bauer JA, Ye F, Marshall CB, Lehmann BD, Pendleton CS, Shyr Y, Arteaga CL, Pietenpol JA. RNA interference (RNAi) screening approach identifies agents that enhance paclitaxel activity in breast cancer cells. Breast Cancer Res [print-electronic]. 2010; 12(3): R41. PMID: 20576088, PMCID: PMC2917036, PII: bcr2595, DOI: 10.1186/bcr2595, ISSN: 1465-542X.