Fernando Elijovich, M.D.

Professor

fernando.elijovich@vanderbilt.edu
Faculty Appointments
Professor of Medicine
Education
M.D., Universidad de Buenos Aires, Buenos Aires, ArgentinaB.A., Universidad de Buenos Aires, Buenos Aires, ArgentinaB.S., Universidad de Buenos Aires, Buenos Aires, Argentina
Office Address
Division of Clinical Phamacology
536 RRB
Clinical Research Keywords
hypertension, salt-sensitivity of blood pressure, insulin resistance
Publications
Laffer CL, Scott RC, Titze JM, Luft FC, Elijovich F. Hemodynamics and Salt-and-Water Balance Link Sodium Storage and Vascular Dysfunction in Salt-Sensitive Subjects. Hypertension [print-electronic]. 2016 Jul; 68(1): 195-203. PMID: 27160204, PMCID: PMC4900938, PII: HYPERTENSIONAHA.116.07289, DOI: 10.1161/HYPERTENSIONAHA.116.07289, ISSN: 1524-4563.

Arnold AC, Okamoto LE, Gamboa A, Black BK, Raj SR, Elijovich F, Robertson D, Shibao CA, Biaggioni I. Mineralocorticoid Receptor Activation Contributes to the Supine Hypertension of Autonomic Failure. Hypertension [print-electronic]. 2016 Feb; 67(2): 424-9. PMID: 26644241, PII: HYPERTENSIONAHA.115.06617, DOI: 10.1161/HYPERTENSIONAHA.115.06617, ISSN: 1524-4563.

Fudim M, Groom KL, Laffer CL, Netterville JL, Robertson D, Elijovich F. Effects of carotid body tumor resection on the blood pressure of essential hypertensive patients. J Am Soc Hypertens [print-electronic]. 2015 Jun; 9(6): 435-42. PMID: 26051925, PII: S1933-1711(15)00109-6, DOI: 10.1016/j.jash.2015.03.006, ISSN: 1878-7436.

Elijovich F. Effect of a siRNA on the cost and quality of American medicine [letter]. Am. J. Med. 2014 Oct; 127(10): e29. PMID: 25311076, PII: S0002-9343(14)00562-2, DOI: 10.1016/j.amjmed.2014.06.021, ISSN: 1555-7162.

Fudim M, Ely EW, Laffer CL, Elijovich F. Diagnosis of pheochromocytoma on physical examination. Eur. Heart J [print-electronic]. 2014 Jul; 35(26): 1705. PMID: 24334718, PII: eht536, DOI: 10.1093/eurheartj/eht536, ISSN: 1522-9645.

Laffer CL, Elijovich F, Eckert GJ, Tu W, Pratt JH, Brown NJ. Genetic variation in CYP4A11 and blood pressure response to mineralocorticoid receptor antagonism or ENaC inhibition: an exploratory pilot study in African Americans. J Am Soc Hypertens [print-electronic]. 2014 Jul; 8(7): 475-80. PMID: 25064769, PMCID: PMC4115247, PII: S1933-1711(14)00546-4, DOI: 10.1016/j.jash.2014.04.011, ISSN: 1878-7436.

Elijovich F, Laffer CL. The issue of African ancestry in Caribbean Hispanics and salt sensitivity of blood pressure [letter]. J Am Soc Hypertens [print-electronic]. 2014 Jan; 8(1): 71. PMID: 23731653, PII: S1933-1711(13)00088-0, DOI: 10.1016/j.jash.2013.04.012, ISSN: 1878-7436.

Elijovich F, Laffer CL. A cautious view of the relationship between ambulatory blood pressure monitoring data and salt-sensitivity of blood pressure [letter]. J. Hypertens. 2013 Sep; 31(9): 1909. PMID: 24107666, PII: 00004872-201309000-00022, DOI: 10.1097/HJH.0b013e328363525f, ISSN: 1473-5598.

Elijovich F, Laffer C. Obesity, blood pressure, and cardiovascular outcomes [letter]. Lancet. 2013 Jun 6/8/2013; 381(9882): 1981. PMID: 23746890, PII: S0140-6736(13)61192-7, DOI: 10.1016/S0140-6736(13)61192-7, ISSN: 1474-547X.

Laffer CL, Elijovich F. Differential predictors of insulin resistance in nondiabetic salt-resistant and salt-sensitive subjects. Hypertension [print-electronic]. 2013 Mar; 61(3): 707-15. PMID: 23283360, PMCID: PMC3591466, PII: HYPERTENSIONAHA.111.00423, DOI: 10.1161/HYPERTENSIONAHA.111.00423, ISSN: 1524-4563.

Elijovich F. Of sommeliers and wine drinkers [letter]. Arch. Intern. Med. 2012 Jul 7/23/2012; 172(14): 1111-2; author reply 1113. PMID: 22825066, PII: 1222584, DOI: 10.1001/archinternmed.2012.2057, ISSN: 1538-3679.

Nichols J, Elijovich F, Laffer CL. Lack of validation of a same-day outpatient protocol for determination of salt sensitivity of blood pressure. Hypertension [print-electronic]. 2012 Feb; 59(2): 390-4. PMID: 22184320, PII: HYPERTENSIONAHA.111.185835, DOI: 10.1161/HYPERTENSIONAHA.111.185835, ISSN: 1524-4563.

Laffer CL, Elijovich F. Salt Sensitivity of Blood Pressure. In Robertson D, Biaggioni I, Burnstock G, Low PA, Paton JFR (eds) Primer on the Autonomic Nervous System (3rd Ed). Academic Press, Oxford UK. 2012.

Elijovich F, Laffer CL. Detrimental effects of dual ACEI-ARB therapy: is the (pro)renin receptor the culprit?. Kidney Int. 2011 Nov; 80(9): 911-4. PMID: 21997507, PII: ki2011264, DOI: 10.1038/ki.2011.264, ISSN: 1523-1755.

Laffer CL, Elijovich F. A critical appraisal of the clinical effectiveness of a fixed combination of valsartan, amlodipine, and hydrochlorothiazide in achieving blood pressure goals. Integr Blood Press Control [print-electronic]. 2011; 4: 1-5. PMID: 21949633, PMCID: PMC3172079, PII: ibpc-4-001, DOI: 10.2147/IBPC.S6562, ISSN: 1178-7104.

Elijovich F, Laffer CL. Acute stroke: lower blood pressure looks better and better [editorial]. Hypertension [print-electronic]. 2010 Nov; 56(5): 808-10. PMID: 20823376, PII: HYPERTENSIONAHA.110.159038, DOI: 10.1161/HYPERTENSIONAHA.110.159038, ISSN: 1524-4563.

Laffer CL, Elijovich F. Inflammation and therapy for hypertension. Curr. Hypertens. Rep. 2010 Aug; 12(4): 233-42. PMID: 20524088, DOI: 10.1007/s11906-010-0125-3, ISSN: 1534-3111.

Elijovich F, Laffer C. A role for single-pill triple therapy in hypertension. Ther Adv Cardiovasc Dis [print-electronic]. 2009 Jun; 3(3): 231-40. PMID: 19443512, PII: 1753944709334947, DOI: 10.1177/1753944709334947, ISSN: 1753-9447.

Elijovich F, Laffer CL. The relationship between CYP4A11 and human hypertension [letter]. J. Hypertens. 2008 Aug; 26(8): 1712-4. PMID: 18622255, PII: 00004872-200808000-00034, DOI: 10.1097/HJH.0b013e3283000504, ISSN: 0263-6352.

Laffer CL, Gainer JV, Waterman MR, Capdevila JH, Laniado-Schwartzman M, Nasjletti A, Brown NJ, Elijovich F. The T8590C polymorphism of CYP4A11 and 20-hydroxyeicosatetraenoic acid in essential hypertension. Hypertension [print-electronic]. 2008 Mar; 51(3): 767-72. PMID: 18227405, PMCID: PMC2365894, PII: HYPERTENSIONAHA.107.102921, DOI: 10.1161/HYPERTENSIONAHA.107.102921, ISSN: 1524-4563.

Elijovich F, Laffer CL. Salt Sensitivity. In Izzo JL, Sica DA, Black HR (eds) Hypertension Primer(4th Ed): The Essentials of High Blood Pressure. Lippincott Williams & Wilkins, Philadelphia, PA. 2008.

Elijovich F, Laffer CL. Cushing's syndrome and human glucocorticoid hypertension. In Lip GYH, Hall JE (eds) Comprehensive Hypertension. Mosby-Elsevier, Philadelphia, PA. 2007.

Elijovich F. 20-HETE and salt-sensitivity of blood pressure a novel emerging concept. Am. J. Hypertens. 2006 Nov; 19(11): 1181-2. PMID: 17070432, PII: S0895-7061(06)00352-9, DOI: 10.1016/j.amjhyper.2006.05.013, ISSN: 0895-7061.

Laffer CL, Bolterman RJ, Romero JC, Elijovich F. Effect of salt on isoprostanes in salt-sensitive essential hypertension. Hypertension [print-electronic]. 2006 Mar; 47(3): 434-40. PMID: 16432053, PII: 01.HYP.0000202480.06735.82, DOI: 10.1161/01.HYP.0000202480.06735.82, ISSN: 1524-4563.

Elijovich F. Fair reallocation of health care dollars should resuscitate the dead Texas horse [letter]. Am. J. Med. 2005 Feb; 118(2): 201. PMID: 15694914, PII: S0002-9343(04)00707-7, DOI: 10.1016/j.amjmed.2004.08.025, ISSN: 0002-9343.

Elijovich F. Campaign to revitalise academic medicine: funding needs to be on the discussion table [letter]. BMJ. 2004 Jun 6/5/2004; 328(7452): 1376. PMID: 15178623, PMCID: PMC420328, PII: 328/7452/1376-b, DOI: 10.1136/bmj.328.7452.1376-b, ISSN: 1756-1833.

Elijovich F, Laffer CL. Masked hypertension: a clinical entity or statistical gymnastics? [editorial]. Clin. Auton. Res. 2004 Jun; 14(3): 140-2. PMID: 15241640, DOI: 10.1007/s10286-004-0189-8, ISSN: 0959-9851.

Elijovich F. Is sodium restriction important to hypertension? The argument against. J Clin Hypertens (Greenwich). 2004 Jun; 6(6): 337-9. PMID: 15187497, ISSN: 1524-6175.

Elijovich F, Laffer CL, Schiffrin EL, Gavras H, Amador E. Endothelin-aldosterone interaction and proteinuria in low-renin hypertension. J. Hypertens. 2004 Mar; 22(3): 573-82. PMID: 15076164, PII: 00004872-200403000-00021, ISSN: 0263-6352.

Laffer CL, Laniado-Schwartzman M, Nasjletti A, Elijovich F. 20-HETE and circulating insulin in essential hypertension with obesity. Hypertension [print-electronic]. 2004 Feb; 43(2): 388-92. PMID: 14707157, PII: 01.HYP.0000112224.87290.3a, DOI: 10.1161/01.HYP.0000112224.87290.3a, ISSN: 1524-4563.

Dickinson M, Laffer CL, Elijovich F. The Physiology of Renal Artery Disease. In Abela, GS (ed) Peripheral Vascular Disease: Basic Diagnostic and Therapeutic Approaches. Lippincott Williams & Wilkins, Philadelphia, PA. 2004.

Laffer CL, Laniado-Schwartzman M, Wang MH, Nasjletti A, Elijovich F. 20-HETE and furosemide-induced natriuresis in salt-sensitive essential hypertension. Hypertension [print-electronic]. 2003 Mar; 41(3 Pt 2): 703-8. PMID: 12623983, PII: 01.HYP.0000051888.91497.47, DOI: 10.1161/01.HYP.0000051888.91497.47, ISSN: 1524-4563.

Laffer CL, Laniado-Schwartzman M, Wang MH, Nasjletti A, Elijovich F. Differential regulation of natriuresis by 20-hydroxyeicosatetraenoic Acid in human salt-sensitive versus salt-resistant hypertension. Circulation. 2003 Feb 2/4/2003; 107(4): 574-8. PMID: 12566369, ISSN: 1524-4539.

Laffer CL, Laniado-Schwartzman M, Wang MH, Nasjletti A, Elijovich F. Cardiovascular extended abstracts. 2003.

Laffer CL, Elijovich F. Essential hypertension of Caribbean Hispanics: sodium, renin, and response to therapy. J Clin Hypertens (Greenwich). 2002 Jul; 4(4): 266-73. PMID: 12147929, ISSN: 1524-6175.

Elijovich F, Laffer CL. Participation of renal and circulating endothelin in salt-sensitive essential hypertension. J Hum Hypertens. 2002 Jul; 16(7): 459-67. PMID: 12080429, DOI: 10.1038/sj.jhh.1001419, ISSN: 0950-9240.

Elijovich F, Laffer CL, Amador E, Gavras H, Bresnahan MR, Schiffrin EL. Regulation of plasma endothelin by salt in salt-sensitive hypertension. Circulation. 2001 Jan 1/16/2001; 103(2): 263-8. PMID: 11208687, ISSN: 0009-7322.

Laffer CL, Elijovich F. Three angiotensin paradigms in one patient: etiology of hypertension, glomerular hemodynamics and long term glomerular protection. In Wang DH (ed): Methods in Molecular Medicine: Angiotensin Protocols. Humana Press Inc, Totowa, NJ. 2001.

Baima J, Nicolaou M, Schwartz F, DeStefano AL, Manolis A, Gavras I, Laffer C, Elijovich F, Farrer L, Baldwin CT, Gavras H. Evidence for linkage between essential hypertension and a putative locus on human chromosome 17. Hypertension. 1999 Jul; 34(1): 4-7. PMID: 10406815, ISSN: 0194-911X.

Wang DH, Elijovich F. Modulation and function of extrarenal angiotensin receptors. Cell Biochem. Biophys. 1999; 31(1): 1-17. PMID: 10505665, DOI: 10.1007/BF02738152, ISSN: 1085-9195.

Laffer C, Amador E, Elijovich F. Significance of Treating Metabolic Cardiovascular Risk Factors in New York Hispanics with Essential Hypertension. 1998.

Elijovich F. Essential Hypertension: the good news and the unanswered questions (Editorial). 1998.

Elijovich F, Laffer CL, Romero JC. Pathogenesis of essential hypertension: The kidney, slow pressor responses to angiotensin II and oxidative stress. 1998.

Elijovich F, Laffer C. The role of telemedicine in the management of essential hypertension. In Viegas SF and Dunn K (Eds.): Telemedicine-Practicing in the Information Age. Lippincott-Raven Publishers. Philadelphia-New York. 1998.

Elijovich F, Laffer CL, Schiffrin EL. The effects of atenolol and zofenopril on plasma atrial natriuretic peptide are due to their interactions with target organ damage of essential hypertensive patients. J Hum Hypertens. 1997 May; 11(5): 313-9. PMID: 9205939, ISSN: 0950-9240.

Elijovich F, Zhao HW, Laffer CL, Du Y, DiPette DJ, Inagami T, Wang DH. Regulation of growth of the adrenal gland in DOC-salt hypertension. Role of angiotensin II receptor subtypes. Hypertension. 1997 Jan; 29(1 Pt 2): 408-13. PMID: 9039135, ISSN: 0194-911X.

Elijovich F. Plasma metanephrines in the diagnosis of pheochromocytoma [letter]. Ann. Intern. Med. 1996 Apr 4/1/1996; 124(7): 694-5. PMID: 8607605, ISSN: 0003-4819.

Laffer CL, Elijovich F. Suboptimal outcome of management of metabolic cardiovascular risk factors in Hispanic patients with essential hypertension. Hypertension. 1995 Dec; 26(6 Pt 2): 1079-84. PMID: 7498972, ISSN: 0194-911X.

Kelleher JP, Elijovich F, Laffer CL, Padilla M. Cough induced by angiotensin-converting-enzyme inhibitors: Airway responses to inhalation of methacholine in patients who have essential hypertension. Mt. Sinai J. Med. 1995 Nov; 62(6): 445-52. PMID: 8692160, ISSN: 0027-2507.

Laffer CL, Elijovich F. Predictors of the pressor response to the clinic visit in essential hypertensives with and without diabetes mellitus. Clin. Auton. Res. 1994 Dec; 4(6): 323-9. PMID: 7711468, ISSN: 0959-9851.

Nemeth GG, Elijovich F, Schanzer H. Hepatic artery aneurysm simulating a pancreatic mass. J Cardiovasc Surg (Torino). 1992 Sep; 33(5): 629-31. PMID: 1447286, ISSN: 0021-9509.

Elijovich F, Laffer CL. Bayesian analysis supports use of ambulatory blood pressure monitors for screening. Hypertension. 1992 Feb; 19(2 Suppl): II268-72. PMID: 1735591, ISSN: 0194-911X.

Elijovich F, Laffer CL. Magnitude, reproducibility, and components of the pressor response to the clinic. Hypertension. 1990 Feb; 15(2 Suppl): I161-5. PMID: 2298472, ISSN: 0194-911X.

Krakoff LR, Elijovich F, Barry C. The role of vasopressin in experimental and clinical hypertension. Am. J. Kidney Dis. 1985 Apr; 5(4): A40-7. PMID: 3887902, PII: S0272638685000397, ISSN: 0272-6386.

Elijovich F, Krakoff LR. Vasopressin in experimental and clinical hypertension. In Edwards CRW and Carey RM (Eds.): Clinical Endocrinology, volume 3: Essential Hypertension as an Endocrine Disease. Butterworths International Medical Reviews. Butterworths & Co. Ltd., Kent England. 1985.

Elijovich F, Barry CR, Krakoff LR, Kirchberger M. Differential effect of vasopressin on angiotensin and norepinephrine pressor action in rats. Am. J. Physiol. 1984 Dec; 247(6 Pt 2): H973-7. PMID: 6507644, ISSN: 0002-9513.

Kaufmann H, Elijovich F, Yahr MD. An unusual cause of tetany: surreptitious use of furosemide. Mt. Sinai J. Med. 1984 Sep; 51(5): 625-8. PMID: 6333628, ISSN: 0027-2507.

Elijovich F, Kirchberger M, Barry CR, Krakoff LR. Maintenance of arterial pressure by vasopressin and angiotensin II after adrenalectomy. Hypertension. 1983 Nov; 5(6 Pt 3): V53-6. PMID: 6654464, ISSN: 0194-911X.

Dziedzic SW, Elijovich F, Felton K, Yeager K, Krakoff LR. Effect of guanabenz on blood pressure responses to posture and exercise. Clin. Pharmacol. Ther. 1983 Feb; 33(2): 151-5. PMID: 6337003, PII: 0009-9236(83)90158-3, ISSN: 0009-9236.

Elijovich F, Krakoff LR. Mechanism of the response to captopril in glucocorticoid hypertension. Clin Exp Hypertens A. 1982; 4(9-10): 1795-814. PMID: 6291817, ISSN: 0730-0077.

Gorkin JU, Elijovich F, Dziedzic SW, Krakoff LR. Addition of acebutolol to diuretics in hypertension. Clin. Pharmacol. Ther. 1981 Dec; 30(6): 739-44. PMID: 6118215, PII: 0009-9236(81)90006-0, ISSN: 0009-9236.

Krakoff LR, Elijovich F. Cushing's syndrome and exogenous glucocorticoid hypertension. Clin Endocrinol Metab. 1981 Nov; 10(3): 479-88. PMID: 6284416, ISSN: 0300-595X.

Elijovich F, Krakoff LR. Effect of ganglionic blockade on pressor responses to angiotensin II during converting enzyme inhibition. Proc. Soc. Exp. Biol. Med. 1980 Sep; 164(4): 556-60. PMID: 6106203, ISSN: 0037-9727.

Elijovich F, Krakoff LR. Effect of converting enzyme inhibition on glucocorticoid hypertension in the rat. Am. J. Physiol. 1980 Jun; 238(6): H844-8. PMID: 6247927, ISSN: 0002-9513.

Elijovisch F, Krakoff LR. Captopril associated granulocytopenia in hypertension after renal transplantation. Lancet. 1980 Apr 4/26/1980; 1(8174): 927-8. PMID: 6103273, PII: S0140-6736(80)92095-4, ISSN: 0140-6736.

Elijovich F, Grassi DG, Costa JA, Domínguez MP. [Tricuspid candidiasic endocarditis surgically treated]. Medicina (B Aires). 1977 Mar; 37(2): 168-72. PMID: 331026, ISSN: 0025-7680.

Elijovich F. Systemic Candidiasis. 1977.

Agrest A, Finkielman S, Elijovich F. [Hemodynamics of arterial hypertension in Cushing's syndrome]. Medicina (B Aires). 1974 Sep; 34(5): 457-62. PMID: 4437383, ISSN: 0025-7680.

Agrest A, Elijovich F, Semeniuk G. Effects of sodium nitroprusside infusion on hemodynamics and PRA in malignant hypertensive patients. 1973.

Elijovich F, Agrest A, Castagnino H. [Experience on 50 cases of bacterial endocarditis]. Medicina (B Aires). 1973 Jan; 33(1): 1-25. PMID: 4699737, ISSN: 0025-7680.

Agrest A, Elijovich F, Finkielman S. [Hemodynamic effects of angiotensin]. Medicina (B Aires). 1972 Jul; 32: Suppl 1:74-7. PMID: 4342067, ISSN: 0025-7680.

Paz RA, Elijovich F, Barcat JA, Sanchez-Avalos JC. Fatal simultaneous thrombocytopenic purpura in siblings. Br Med J. 1969 Dec 12/20/1969; 4(5685): 727-8. PMID: 5389730, PMCID: PMC1630114, ISSN: 0007-1447.