Jerri Michelle Rook, Ph.D.

Research Associate Professor

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Faculty Appointments
Research Associate Professor of Pharmacology
Ph.D., PHARMACOLOGYPHD, University of Kansas, Kansas City, KansasB.A., Drury University , Springfield, Missouri
Office Address
8410 MRBIV
2215B Garland Avenue
Nashville, TN 37232
Research Description
Dr. Rook is a highly trained behavioral and systems neuropharmacologist who has a great deal of expertise with the use of biochemistry, molecular biology, behavioral pharmacology and imaging techniques to study the in vivo effects of GPCR ligands in preclinical animal models. She has made a number of contributions to the understanding of the roles of both metabotropic glutamate and muscarinic acetylcholine receptors in the regulation of brain function and behavior and in the development of novel therapeutic strategies for the treatment of central nervous system disorders. Currently, Dr. Rook is focused on the discovery and in vivo characterization of novel therapeutic strategies for the treatment of psychosis and cognitive deficits associated with schizophrenia and Alzheimer¿¿¿s disease.
Turlington M, Noetzel MJ, Chun A, Zhou Y, Gogliotti RD, Nguyen ED, Gregory KJ, Vinson PN, Rook JM, Gogi KK, Xiang Z, Bridges TM, Daniels JS, Jones C, Niswender CM, Meiler J, Conn PJ, Lindsley CW, Stauffer SR. Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide (ML254). J. Med. Chem [print-electronic]. 2013 Oct 10/24/2013; 56(20): 7976-96. PMID: 24050755, PMCID: PMC3908770, DOI: 10.1021/jm401028t, ISSN: 1520-4804.

Bridges TM, Rook JM, Noetzel MJ, Morrison RD, Zhou Y, Gogliotti RD, Vinson PN, Xiang Z, Jones CK, Niswender CM, Lindsley CW, Stauffer SR, Conn PJ, Daniels JS. Biotransformation of a novel positive allosteric modulator of metabotropic glutamate receptor subtype 5 contributes to seizure-like adverse events in rats involving a receptor agonism-dependent mechanism. Drug Metab. Dispos [print-electronic]. 2013 Sep; 41(9): 1703-14. PMID: 23821185, PMCID: PMC3876804, PII: dmd.113.052084, DOI: 10.1124/dmd.113.052084, ISSN: 1521-009X.

Rook JM, Noetzel MJ, Pouliot WA, Bridges TM, Vinson PN, Cho HP, Zhou Y, Gogliotti RD, Manka JT, Gregory KJ, Stauffer SR, Dudek FE, Xiang Z, Niswender CM, Daniels JS, Jones CK, Lindsley CW, Conn PJ. Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity. Biol. Psychiatry [print-electronic]. 2013 Mar 3/15/2013; 73(6): 501-9. PMID: 23140665, PMCID: PMC3572342, PII: S0006-3223(12)00806-2, DOI: 10.1016/j.biopsych.2012.09.012, ISSN: 1873-2402.

Gregory KJ, Noetzel MJ, Rook JM, Vinson PN, Stauffer SR, Rodriguez AL, Emmitte KA, Zhou Y, Chun AC, Felts AS, Chauder BA, Lindsley CW, Niswender CM, Conn PJ. Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships. Mol. Pharmacol [print-electronic]. 2012 Nov; 82(5): 860-75. PMID: 22863693, PMCID: PMC3477233, PII: mol.112.080531, DOI: 10.1124/mol.112.080531, ISSN: 1521-0111.

Noetzel MJ, Rook JM, Vinson PN, Cho HP, Days E, Zhou Y, Rodriguez AL, Lavreysen H, Stauffer SR, Niswender CM, Xiang Z, Daniels JS, Jones CK, Lindsley CW, Weaver CD, Conn PJ. Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function. Mol. Pharmacol [print-electronic]. 2012 Feb; 81(2): 120-33. PMID: 22021324, PMCID: PMC3263948, PII: mol.111.075184, DOI: 10.1124/mol.111.075184, ISSN: 1521-0111.

Tantawy MN, Peterson TE, Jones CK, Johnson K, Rook JM, Conn PJ, Baldwin RM, Ansari MS, Kessler RM. Impact of isoflurane anesthesia on D2 receptor occupancy by [18F]fallypride measured by microPET with a modified Logan plot. Synapse [print-electronic]. 2011 Nov; 65(11): 1173-80. PMID: 21584868, PMCID: PMC4078917, DOI: 10.1002/syn.20955, ISSN: 1098-2396.

Sheffler DJ, Gregory KJ, Rook JM, Conn PJ. Allosteric modulation of metabotropic glutamate receptors. Adv. Pharmacol. 2011; 62: 37-77. PMID: 21907906, PMCID: PMC3787868, PII: B978-0-12-385952-500010-5, DOI: 10.1016/B978-0-12-385952-5.00010-5, ISSN: 1557-8925.

Rodriguez AL, Grier MD, Jones CK, Herman EJ, Kane AS, Smith RL, Williams R, Zhou Y, Marlo JE, Days EL, Blatt TN, Jadhav S, Menon UN, Vinson PN, Rook JM, Stauffer SR, Niswender CM, Lindsley CW, Weaver CD, Conn PJ. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol. Pharmacol [print-electronic]. 2010 Dec; 78(6): 1105-23. PMID: 20923853, PMCID: PMC2993468, PII: mol.110.067207, DOI: 10.1124/mol.110.067207, ISSN: 1521-0111.

Sharma S, Kedrowski J, Rook JM, Smith RL, Jones CK, Rodriguez AL, Conn PJ, Lindsley CW. Discovery of molecular switches that modulate modes of metabotropic glutamate receptor subtype 5 (mGlu5) pharmacology in vitro and in vivo within a series of functionalized, regioisomeric 2- and 5-(phenylethynyl)pyrimidines. J. Med. Chem. 2009 Jul 7/23/2009; 52(14): 4103-6. PMID: 19537763, PMCID: PMC3192011, DOI: 10.1021/jm900654c, ISSN: 1520-4804.

Rook JM, Hasan W, McCarson KE. Morphine-induced early delays in wound closure: involvement of sensory neuropeptides and modification of neurokinin receptor expression. Biochem. Pharmacol [print-electronic]. 2009 Jun 6/1/2009; 77(11): 1747-55. PMID: 19428329, PMCID: PMC4159122, PII: S0006-2952(09)00153-1, DOI: 10.1016/j.bcp.2009.03.003, ISSN: 1873-2968.

Rook JM, Hasan W, McCarson KE. Temporal effects of topical morphine application on cutaneous wound healing. Anesthesiology. 2008 Jul; 109(1): 130-6. PMID: 18580183, PMCID: PMC2598738, PII: 00000542-200807000-00021, DOI: 10.1097/ALN.0b013e31817b5ac3, ISSN: 1528-1175.

Rook JM, McCarson KE. Delay of cutaneous wound closure by morphine via local blockade of peripheral tachykinin release. Biochem. Pharmacol [print-electronic]. 2007 Sep 9/1/2007; 74(5): 752-7. PMID: 17632084, PMCID: PMC1997302, PII: S0006-2952(07)00366-8, DOI: 10.1016/j.bcp.2007.06.005, ISSN: 1873-2968.