Simon A. Mallal, M.B.B.S.

Faculty Appointments
Professor of Medicine Professor of Biomedical InformaticsMajor E.B. Stahlman Chair in Infectious Diseases and InflammationProfessor of Pathology, Microbiology and Immunology
M.B.B.S., Immunology and Infectious Disease, University of Western Australia, Perth, Australia
Office Address
2525 West End Ave
Nashville, TN 37203
Magaret A, Dong L, John M, Mallal SA, James I, Warren T, Gaudieri S, Koelle DM, Wald A. HLA Class I and II alleles, heterozygosity and HLA-KIR interactions are associated with rates of genital HSV shedding and lesions. Genes Immun [print-electronic]. 2016 Nov 11/17/2016; PMID: 27853144, PII: gene201642, DOI: 10.1038/gene.2016.42, ISSN: 1476-5470.

Gitschlag BL, Kirby CS, Samuels DC, Gangula RD, Mallal SA, Patel MR. Homeostatic Responses Regulate Selfish Mitochondrial Genome Dynamics in C. elegans. Cell Metab. 2016 Jul 7/12/2016; 24(1): 91-103. PMID: 27411011, PII: S1550-4131(16)30294-7, DOI: 10.1016/j.cmet.2016.06.008, ISSN: 1932-7420.

Itani HA, Xiao L, Saleh MA, Wu J, Pilkinton MA, Dale BL, Barbaro NR, Foss JD, Kirabo A, Montaniel KR, Norlander AE, Chen W, Sato R, Navar LG, Mallal SA, Madhur MS, Bernstein KE, Harrison DG. CD70 Exacerbates Blood Pressure Elevation and Renal Damage in Response to Repeated Hypertensive Stimuli. Circ. Res [print-electronic]. 2016 Apr 4/15/2016; 118(8): 1233-43. PMID: 26988069, PMCID: PMC4833561, PII: CIRCRESAHA.115.308111, DOI: 10.1161/CIRCRESAHA.115.308111, ISSN: 1524-4571.

Loi S, Dushyanthen S, Beavis PA, Salgado R, Denkert C, Savas P, Combs S, Rimm DL, Giltnane JM, Estrada MV, Sánchez V, Sanders ME, Cook RS, Pilkinton MA, Mallal SA, Wang K, Miller VA, Stephens PJ, Yelensky R, Doimi FD, Gómez H, Ryzhov SV, Darcy PK, Arteaga CL, Balko JM. RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors. Clin. Cancer Res [print-electronic]. 2016 Mar 3/15/2016; 22(6): 1499-509. PMID: 26515496, PMCID: PMC4794351, PII: 1078-0432.CCR-15-1125, DOI: 10.1158/1078-0432.CCR-15-1125, ISSN: 1078-0432.

Jing L, Laing KJ, Dong L, Russell RM, Barlow RS, Haas JG, Ramchandani MS, Johnston C, Buus S, Redwood AJ, White KD, Mallal SA, Phillips EJ, Posavad CM, Wald A, Koelle DM. Extensive CD4 and CD8 T Cell Cross-Reactivity between Alphaherpesviruses. J. Immunol [print-electronic]. 2016 Mar 3/1/2016; 196(5): 2205-18. PMID: 26810224, PMCID: PMC4761520, PII: jimmunol.1502366, DOI: 10.4049/jimmunol.1502366, ISSN: 1550-6606.

Zhou W, Toki S, Zhang J, Goleniewksa K, Newcomb DC, Cephus JY, Dulek DE, Bloodworth MH, Stier MT, Polosuhkin V, Gangula RD, Mallal SA, Broide DH, Peebles RS. Prostaglandin I2 Signaling and Inhibition of Group 2 Innate Lymphoid Cell Responses. Am. J. Respir. Crit. Care Med. 2016 Jan 1/1/2016; 193(1): 31-42. PMID: 26378386, PMCID: PMC4731613, DOI: 10.1164/rccm.201410-1793OC, ISSN: 1535-4970.

Hemler JA, Phillips EJ, Mallal SA, Kendall PL. The evolving story of human leukocyte antigen and the immunogenetics of peanut allergy. Ann. Allergy Asthma Immunol [print-electronic]. 2015 Dec; 115(6): 471-6. PMID: 26522257, PII: S1081-1206(15)00693-6, DOI: 10.1016/j.anai.2015.10.008, ISSN: 1534-4436.

Wheatley LM, Plaut M, Schwaninger JM, Banerji A, Castells M, Finkelman FD, Gleich GJ, Guttman-Yassky E, Mallal SA, Naisbitt DJ, Ostrov DA, Phillips EJ, Pichler WJ, Platts-Mills TA, Roujeau JC, Schwartz LB, Trepanier LA. Report from the National Institute of Allergy and Infectious Diseases workshop on drug allergy. J. Allergy Clin. Immunol. 2015 Aug; 136(2): 262-71.e2. PMID: 26254053, PMCID: PMC4529958, PII: S0091-6749(15)00733-2, DOI: 10.1016/j.jaci.2015.05.027, ISSN: 1097-6825.

Pavlos R, Mallal S, Ostrov D, Buus S, Metushi I, Peters B, Phillips E. T cell-mediated hypersensitivity reactions to drugs. Annu. Rev. Med [print-electronic]. 2015; 66: 439-54. PMID: 25386935, PMCID: PMC4295772, DOI: 10.1146/annurev-med-050913-022745, ISSN: 1545-326X.

Keane NM, Pavlos RK, McKinnon E, Lucas A, Rive C, Blyth CC, Dunn D, Lucas M, Mallal S, Phillips E. HLA Class I restricted CD8+ and Class II restricted CD4+ T cells are implicated in the pathogenesis of nevirapine hypersensitivity. AIDS. 2014 Aug 8/24/2014; 28(13): 1891-901. PMID: 24911354, DOI: 10.1097/QAD.0000000000000345, ISSN: 1473-5571.

Chikata T, Carlson JM, Tamura Y, Borghan MA, Naruto T, Hashimoto M, Murakoshi H, Le AQ, Mallal S, John M, Gatanaga H, Oka S, Brumme ZL, Takiguchi M. Host-specific adaptation of HIV-1 subtype B in the Japanese population. J. Virol [print-electronic]. 2014 May; 88(9): 4764-75. PMID: 24522911, PMCID: PMC3993807, PII: JVI.00147-14, DOI: 10.1128/JVI.00147-14, ISSN: 1098-5514.

Payne RP, Branch S, Kløverpris H, Matthews PC, Koofhethile CK, Strong T, Adland E, Leitman E, Frater J, Ndung'u T, Hunter E, Haubrich R, Mothe B, Edwards A, Riddell L, Chen F, Harrigan PR, Brumme ZL, Mallal S, John M, Jooste JP, Shapiro R, Deeks SG, Walker BD, Brander C, Landis C, Carlson JM, Prado JG, Goulder PJ. Differential escape patterns within the dominant HLA-B*57:03-restricted HIV Gag epitope reflect distinct clade-specific functional constraints. J. Virol [print-electronic]. 2014 May; 88(9): 4668-78. PMID: 24501417, PMCID: PMC3993828, PII: JVI.03303-13, DOI: 10.1128/JVI.03303-13, ISSN: 1098-5514.

Schlub TE, Grimm AJ, Smyth RP, Cromer D, Chopra A, Mallal S, Venturi V, Waugh C, Mak J, Davenport MP. Fifteen to twenty percent of HIV substitution mutations are associated with recombination. J. Virol [print-electronic]. 2014 Apr; 88(7): 3837-49. PMID: 24453357, PMCID: PMC3993552, PII: JVI.03136-13, DOI: 10.1128/JVI.03136-13, ISSN: 1098-5514.

Smyth RP, Schlub TE, Grimm AJ, Waugh C, Ellenberg P, Chopra A, Mallal S, Cromer D, Mak J, Davenport MP. Identifying recombination hot spots in the HIV-1 genome. J. Virol [print-electronic]. 2014 Mar; 88(5): 2891-902. PMID: 24371048, PMCID: PMC3958072, PII: JVI.03014-13, DOI: 10.1128/JVI.03014-13, ISSN: 1098-5514.

Pavlos R, Mallal S, Ostrov D, Pompeu Y, Phillips E. Fever, rash, and systemic symptoms: understanding the role of virus and HLA in severe cutaneous drug allergy. J Allergy Clin Immunol Pract. 2014 Jan; 2(1): 21-33. PMID: 24565765, PMCID: PMC4020624, PII: S2213-2198(13)00452-2, DOI: 10.1016/j.jaip.2013.11.005, ISSN: 2213-2198.

Li H, Blair L, Chen Y, Learn G, Pfafferott K, John M, Bhattacharya T, Hahn BH, Mallal S, Shaw GM, Bar KJ. Molecular mechanisms of HIV type 1 prophylaxis failure revealed by single-genome sequencing. J. Infect. Dis [print-electronic]. 2013 Nov 11/15/2013; 208(10): 1598-603. PMID: 24023257, PMCID: PMC3805246, PII: jit485, DOI: 10.1093/infdis/jit485, ISSN: 1537-6613.

Hertz T, Oshansky CM, Roddam PL, DeVincenzo JP, Caniza MA, Jojic N, Mallal S, Phillips E, James I, Halloran ME, Thomas PG, Corey L. HLA targeting efficiency correlates with human T-cell response magnitude and with mortality from influenza A infection. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2013 Aug 8/13/2013; 110(33): 13492-7. PMID: 23878211, PMCID: PMC3746844, PII: 1221555110, DOI: 10.1073/pnas.1221555110, ISSN: 1091-6490.

Rodríguez-Sáinz C, Valor L, Hernández DC, Gil J, Carbone J, Pascual-Bernaldez M, Rodríguez-Alcántara F, Martínez I, Vicario JL, Mallal S, Fernández-Cruz E. Flow cytometry analysis with a new FITC-conjugated monoclonal antibody-3E12 for HLA-B*57:01 rapid screening in prevention of abacavir hypersensitivity in HIV-1-infected patients. HIV Clin Trials. 2013 Jul; 14(4): 160-4. PMID: 23924588, PII: 3667211182143T65, DOI: 10.1310/hct1404-160, ISSN: 1528-4336.

Apps R, Qi Y, Carlson JM, Chen H, Gao X, Thomas R, Yuki Y, Del Prete GQ, Goulder P, Brumme ZL, Brumme CJ, John M, Mallal S, Nelson G, Bosch R, Heckerman D, Stein JL, Soderberg KA, Moody MA, Denny TN, Zeng X, Fang J, Moffett A, Lifson JD, Goedert JJ, Buchbinder S, Kirk GD, Fellay J, McLaren P, Deeks SG, Pereyra F, Walker B, Michael NL, Weintrob A, Wolinsky S, Liao W, Carrington M. Influence of HLA-C expression level on HIV control. Science. 2013 Apr 4/5/2013; 340(6128): 87-91. PMID: 23559252, PMCID: PMC3784322, PII: 340/6128/87, DOI: 10.1126/science.1232685, ISSN: 1095-9203.

Bronke C, Almeida CA, McKinnon E, Roberts SG, Keane NM, Chopra A, Carlson JM, Heckerman D, Mallal S, John M. HIV escape mutations occur preferentially at HLA-binding sites of CD8 T-cell epitopes. AIDS. 2013 Mar 3/27/2013; 27(6): 899-905. PMID: 23276808, PMCID: PMC3818524, DOI: 10.1097/QAD.0b013e32835e1616, ISSN: 1473-5571.

Phillips E, Bartlett JA, Sanne I, Lederman MM, Hinkle J, Rousseau F, Dunn D, Pavlos R, James I, Mallal SA, Haas DW. Associations between HLA-DRB1*0102, HLA-B*5801, and hepatotoxicity during initiation of nevirapine-containing regimens in South Africa [letter]. J. Acquir. Immune Defic. Syndr. 2013 Feb 2/1/2013; 62(2): e55-7. PMID: 23328091, PMCID: PMC3551216, PII: 00126334-201302010-00021, DOI: 10.1097/QAI.0b013e31827ca50f, ISSN: 1944-7884.

Yagita Y, Kuse N, Kuroki K, Gatanaga H, Carlson JM, Chikata T, Brumme ZL, Murakoshi H, Akahoshi T, Pfeifer N, Mallal S, John M, Ose T, Matsubara H, Kanda R, Fukunaga Y, Honda K, Kawashima Y, Ariumi Y, Oka S, Maenaka K, Takiguchi M. Distinct HIV-1 escape patterns selected by cytotoxic T cells with identical epitope specificity. J. Virol [print-electronic]. 2013 Feb; 87(4): 2253-63. PMID: 23236061, PMCID: PMC3571484, PII: JVI.02572-12, DOI: 10.1128/JVI.02572-12, ISSN: 1098-5514.

Phillips EJ, Mallal SA. HLA-B*5701 and flucloxacillin associated drug-induced liver disease [letter]. AIDS. 2013 Jan 1/28/2013; 27(3): 491-2. PMID: 23291545, PII: 00002030-201301280-00025, DOI: 10.1097/QAD.0b013e32835ca9d5, ISSN: 1473-5571.

McLaren PJ, Coulonges C, Ripke S, van den Berg L, Buchbinder S, Carrington M, Cossarizza A, Dalmau J, Deeks SG, Delaneau O, De Luca A, Goedert JJ, Haas D, Herbeck JT, Kathiresan S, Kirk GD, Lambotte O, Luo M, Mallal S, van Manen D, Martinez-Picado J, Meyer L, Miro JM, Mullins JI, Obel N, O'Brien SJ, Pereyra F, Plummer FA, Poli G, Qi Y, Rucart P, Sandhu MS, Shea PR, Schuitemaker H, Theodorou I, Vannberg F, Veldink J, Walker BD, Weintrob A, Winkler CA, Wolinsky S, Telenti A, Goldstein DB, de Bakker PI, Zagury JF, Fellay J. Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls. PLoS Pathog [print-electronic]. 2013; 9(7): e1003515. PMID: 23935489, PMCID: PMC3723635, PII: PPATHOGENS-D-13-00729, DOI: 10.1371/journal.ppat.1003515, ISSN: 1553-7374.

Herrmann S, McKinnon E, Hyland NB, Lalanne C, Mallal S, Nolan D, Chassany O, Duracinsky M. HIV-related stigma and physical symptoms have a persistent influence on health-related quality of life in Australians with HIV infection. Health Qual Life Outcomes. 2013; 11: 56. PMID: 23566318, PMCID: PMC3623897, PII: 1477-7525-11-56, DOI: 10.1186/1477-7525-11-56, ISSN: 1477-7525.

Carlson JM, Brumme CJ, Martin E, Listgarten J, Brockman MA, Le AQ, Chui CK, Cotton LA, Knapp DJ, Riddler SA, Haubrich R, Nelson G, Pfeifer N, Deziel CE, Heckerman D, Apps R, Carrington M, Mallal S, Harrigan PR, John M, Brumme ZL, . Correlates of protective cellular immunity revealed by analysis of population-level immune escape pathways in HIV-1. J. Virol [print-electronic]. 2012 Dec; 86(24): 13202-16. PMID: 23055555, PMCID: PMC3503140, PII: JVI.01998-12, DOI: 10.1128/JVI.01998-12, ISSN: 1098-5514.

Pompeu YA, Stewart JD, Mallal S, Phillips E, Peters B, Ostrov DA. The structural basis of HLA-associated drug hypersensitivity syndromes. Immunol. Rev. 2012 Nov; 250(1): 158-66. PMID: 23046128, DOI: 10.1111/j.1600-065X.2012.01163.x, ISSN: 1600-065X.

Herrmann S, Wardrop J, John M, Gaudieri S, Lucas M, Mallal S, Nolan D. The impact of visa status and Medicare eligibility on people diagnosed with HIV in Western Australia: a qualitative report. Sex Health. 2012 Nov; 9(5): 407-13. PMID: 22950904, PII: SH11181, DOI: 10.1071/SH11181, ISSN: 1448-5028.

Pavlos R, Mallal S, Phillips E. HLA and pharmacogenetics of drug hypersensitivity. Pharmacogenomics. 2012 Aug; 13(11): 1285-306. PMID: 22920398, DOI: 10.2217/pgs.12.108, ISSN: 1744-8042.

Ostrov DA, Grant BJ, Pompeu YA, Sidney J, Harndahl M, Southwood S, Oseroff C, Lu S, Jakoncic J, de Oliveira CA, Yang L, Mei H, Shi L, Shabanowitz J, English AM, Wriston A, Lucas A, Phillips E, Mallal S, Grey HM, Sette A, Hunt DF, Buus S, Peters B. Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2012 Jun 6/19/2012; 109(25): 9959-64. PMID: 22645359, PMCID: PMC3382472, PII: 1207934109, DOI: 10.1073/pnas.1207934109, ISSN: 1091-6490.