Alexander H. Gelbard, M.D.

Associate Professor

alexander.gelbard@vanderbilt.edu
Faculty Appointments
Associate Professor of Otolaryngology
Education
M.D., MEDICINE, Tulane University, New Orleans, LouisianaB.S., Stanford University, Stanford, California
Clinical Description

Dr. Gelbard is a board certified Otolaryngologist at Vanderbilt University in Nashville Tennessee specializing in adult laryngeal and tracheal disease. He completed his undergraduate education at Stanford University, medical school at Tulane School of Medicine, and internship and residency at the Baylor College of Medicine in Houston Texas. Dr. Gelbard completed a postdoctoral research fellowship in Immunology at the MD Anderson Cancer Center as well as a clinical fellowship in Laryngeal Surgery at Vanderbilt School of Medicine. He has authored numerous peer-reviewed articles and book chapters and lectures internationally on adult airway disease. He currently is Co-director of the Vanderbilt Complex Airway Center (AeroVU). Additionally, he is principle investigator of an externally funded prospective multi-institutional study of idiopathic subglottic stenosis (iSGS), and managing director of the North American Airway Collaborative (NoAAC). NoAAC is a funded, multi-institutional consortium with 40 participating centers in the United States and Europe that works to exchange information concerning the treatment of adult airway disease. It is composed of outstanding collaborators who pursue a unique combination of genetic, molecular, and epidemiologic based approaches to investigate the critical factors underlying the pathogenesis and outcomes of laryngotracheal stenosis.
Publications
de la Fuente J, Garrett CG, Ossoff R, Vinson K, Francis DO, Gelbard A. A Case Series of the Probability Density and Cumulative Distribution of Laryngeal Disease in a Tertiary Care Voice Center. Ann. Otol. Rhinol. Laryngol [print-electronic]. 2017 Nov; 126(11): 748-54. PMID: 28949246, DOI: 10.1177/0003489417728945, ISSN: 1943-572X.

Noud M, Hovis K, Gelbard A, Sathe NA, Penson DF, Feurer ID, McPheeters ML, Francis DO. Patient-Reported Outcome Measures in Upper Airway-Related Dyspnea: A Systematic Review. JAMA Otolaryngol Head Neck Surg. 2017 Aug 8/1/2017; 143(8): 824-31. PMID: 28594976, PMCID: PMC5604091, PII: 2630822, DOI: 10.1001/jamaoto.2017.0348, ISSN: 2168-619X.

Daniero JJ, Ekbom DC, Gelbard A, Akst LM, Hillel AT. Inaugural Symposium on Advanced Surgical Techniques in Adult Airway Reconstruction: Proceedings of the North American Airway Collaborative (NoAAC). JAMA Otolaryngol Head Neck Surg. 2017 Jun 6/1/2017; 143(6): 609-13. PMID: 28418443, PMCID: PMC5518235, PII: 2616161, DOI: 10.1001/jamaoto.2016.4126, ISSN: 2168-619X.

Gelbard A, Katsantonis NG, Mizuta M, Newcomb D, Rotsinger J, Rousseau B, Daniero JJ, Edell ES, Ekbom DC, Kasperbauer JL, Hillel AT, Yang L, Garrett CG, Netterville JL, Wootten CT, Francis DO, Stratton C, Jenkins K, McGregor TL, Gaddy JA, Blackwell TS, Drake WP. Molecular analysis of idiopathic subglottic stenosis for Mycobacterium species. Laryngoscope [print-electronic]. 2017 Jan; 127(1): 179-85. PMID: 27295947, PMCID: PMC5156582, DOI: 10.1002/lary.26097, ISSN: 1531-4995.

Gelbard A, Katsantonis NG, Mizuta M, Newcomb D, Rotsinger J, Rousseau B, Daniero JJ, Edell ES, Ekbom DC, Kasperbauer JL, Hillel AT, Yang L, Garrett CG, Netterville JL, Wootten CT, Francis DO, Stratton C, Jenkins K, McGregor TL, Gaddy JA, Blackwell TS, Drake WP. Idiopathic subglottic stenosis is associated with activation of the inflammatory IL-17A/IL-23 axis. Laryngoscope [print-electronic]. 2016 Nov; 126(11): E356-E361. PMID: 27296163, PMCID: PMC5077677, DOI: 10.1002/lary.26098, ISSN: 1531-4995.

Yawn RJ, Yawn JR, Gelbard A, Wootten CT. Tracheocutaneous fistula repair with autologous auricular cartilage cap graft. Laryngoscope [print-electronic]. 2016 Sep; 126(9): 2085-8. PMID: 27297140, DOI: 10.1002/lary.25756, ISSN: 1531-4995.

Gelbard A, Donovan DT, Ongkasuwan J, Nouraei SA, Sandhu G, Benninger MS, Bryson PC, Lorenz RR, Tierney WS, Hillel AT, Gadkaree SK, Lott DG, Edell ES, Ekbom DC, Kasperbauer JL, Maldonado F, Schindler JS, Smith ME, Daniero JJ, Garrett CG, Netterville JL, Rickman OB, Sinard RJ, Wootten CT, Francis DO. Disease homogeneity and treatment heterogeneity in idiopathic subglottic stenosis. Laryngoscope [print-electronic]. 2016 Jun; 126(6): 1390-6. PMID: 26536285, DOI: 10.1002/lary.25708, ISSN: 1531-4995.

Yawn RJ, Daniero JJ, Gelbard A, Wootten CT. Novel application of the Sonopet for endoscopic posterior split and cartilage graft laryngoplasty. Laryngoscope [print-electronic]. 2016 Apr; 126(4): 941-4. PMID: 26541889, DOI: 10.1002/lary.25596, ISSN: 1531-4995.

Latuska RF, Kuhl NO, Garrett CG, Berry JM, Gelbard A. Severe bradycardia associated with suspension laryngoscopy. Laryngoscope [print-electronic]. 2016 Apr; 126(4): 949-50. PMID: 26526978, DOI: 10.1002/lary.25590, ISSN: 1531-4995.

Hillel AT, Karatayli-Ozgursoy S, Samad I, Best SR, Pandian V, Giraldez L, Gross J, Wootten C, Gelbard A, Akst LM, Johns MM, . Predictors of Posterior Glottic Stenosis: A Multi-Institutional Case-Control Study. Ann. Otol. Rhinol. Laryngol [print-electronic]. 2016 Mar; 125(3): 257-63. PMID: 26466860, PMCID: PMC4742396, PII: 0003489415608867, DOI: 10.1177/0003489415608867, ISSN: 0003-4894.

Lennon CJ, Gelbard A, Bartow C, Garrett CG, Netterville JL, Wootten CT. Dysphagia Following Airway Reconstruction in Adults. JAMA Otolaryngol Head Neck Surg. 2016 Jan; 142(1): 20-4. PMID: 26561927, PII: 2469809, DOI: 10.1001/jamaoto.2015.2562, ISSN: 2168-619X.

Francis DO, Williamson K, Hovis K, Gelbard A, Merati AL, Penson DF, Netterville JL, Garrett CG. Effect of injection augmentation on need for framework surgery in unilateral vocal fold paralysis. Laryngoscope [print-electronic]. 2016 Jan; 126(1): 128-34. PMID: 26153268, PMCID: PMC4704988, DOI: 10.1002/lary.25431, ISSN: 1531-4995.

Hillel AT, Gelbard A. Unleashing rapamycin in fibrosis [editorial]. Oncotarget. 2015 Jun 6/30/2015; 6(18): 15722-3. PMID: 26158293, PMCID: PMC4599220, PII: 4652, DOI: 10.18632/oncotarget.4652, ISSN: 1949-2553.

Gelbard A, Francis DO, Sandulache VC, Simmons JC, Donovan DT, Ongkasuwan J. Causes and consequences of adult laryngotracheal stenosis. Laryngoscope [print-electronic]. 2015 May; 125(5): 1137-43. PMID: 25290987, PMCID: PMC4562418, DOI: 10.1002/lary.24956, ISSN: 1531-4995.

Gelbard A, Hale KS, Takahashi Y, Davies M, Kupferman ME, El-Naggar AK, Myers JN, Hanna EY. Molecular profiling of sinonasal undifferentiated carcinoma. Head Neck [print-electronic]. 2014 Jan; 36(1): 15-21. PMID: 23633104, PMCID: PMC3874284, DOI: 10.1002/hed.23267, ISSN: 1097-0347.

Sandulache VC, Kubik MW, Skinner HD, Malsky JA, Gelbard AH, Zevallos JP. Impact of race/ethnicity on laryngeal cancer in patients treated at a Veterans Affairs Medical Center. Laryngoscope [print-electronic]. 2013 Sep; 123(9): 2170-5. PMID: 23729204, DOI: 10.1002/lary.24058, ISSN: 1531-4995.

Takahashi Y, Kupferman ME, Bell D, Jiffar T, Lee JG, Xie TX, Li NW, Zhao M, Frederick MJ, Gelbard A, Myers JN, Hanna EY. Establishment and characterization of novel cell lines from sinonasal undifferentiated carcinoma. Clin. Cancer Res [print-electronic]. 2012 Nov 11/15/2012; 18(22): 6178-87. PMID: 23032744, PMCID: PMC3513379, PII: 1078-0432.CCR-12-1876, DOI: 10.1158/1078-0432.CCR-12-1876, ISSN: 1078-0432.

Liu C, Lewis CM, Lou Y, Xu C, Peng W, Yang Y, Gelbard AH, Lizée G, Zhou D, Overwijk WW, Hwu P. Agonistic antibody to CD40 boosts the antitumor activity of adoptively transferred T cells in vivo. J. Immunother. 2012 Apr; 35(3): 276-82. PMID: 22421945, PMCID: PMC3860320, DOI: 10.1097/CJI.0b013e31824e7f43, ISSN: 1537-4513.

Li HS, Gelbard A, Martinez GJ, Esashi E, Zhang H, Nguyen-Jackson H, Liu YJ, Overwijk WW, Watowich SS. Cell-intrinsic role for IFN-a-STAT1 signals in regulating murine Peyer patch plasmacytoid dendritic cells and conditioning an inflammatory response. Blood [print-electronic]. 2011 Oct 10/6/2011; 118(14): 3879-89. PMID: 21828128, PMCID: PMC3193265, PII: blood-2011-04-349761, DOI: 10.1182/blood-2011-04-349761, ISSN: 1528-0020.

Lou Y, Liu C, Lizée G, Peng W, Xu C, Ye Y, Rabinovich BA, Hailemichael Y, Gelbard A, Zhou D, Overwijk WW, Hwu P. Antitumor activity mediated by CpG: the route of administration is critical. J. Immunother. 2011 Apr; 34(3): 279-88. PMID: 21389870, DOI: 10.1097/CJI.0b013e31820d2a05, ISSN: 1537-4513.

Glotzbach JP, Januszyk M, Vial IN, Wong VW, Gelbard A, Kalisky T, Thangarajah H, Longaker MT, Quake SR, Chu G, Gurtner GC. An information theoretic, microfluidic-based single cell analysis permits identification of subpopulations among putatively homogeneous stem cells. PLoS ONE [print-electronic]. 2011; 6(6): e21211. PMID: 21731674, PMCID: PMC3120839, PII: PONE-D-11-03929, DOI: 10.1371/journal.pone.0021211, ISSN: 1932-6203.

Kong LY, Gelbard A, Wei J, Reina-Ortiz C, Wang Y, Yang EC, Hailemichael Y, Fokt I, Jayakumar A, Qiao W, Fuller GN, Overwijk WW, Priebe W, Heimberger AB. Inhibition of p-STAT3 enhances IFN-alpha efficacy against metastatic melanoma in a murine model. Clin. Cancer Res [print-electronic]. 2010 May 5/1/2010; 16(9): 2550-61. PMID: 20388845, PMCID: PMC2936966, PII: 1078-0432.CCR-10-0279, DOI: 10.1158/1078-0432.CCR-10-0279, ISSN: 1078-0432.

Sikora AG, Gelbard A, Davies MA, Sano D, Ekmekcioglu S, Kwon J, Hailemichael Y, Jayaraman P, Myers JN, Grimm EA, Overwijk WW. Targeted inhibition of inducible nitric oxide synthase inhibits growth of human melanoma in vivo and synergizes with chemotherapy. Clin. Cancer Res [print-electronic]. 2010 Mar 3/15/2010; 16(6): 1834-44. PMID: 20215556, PMCID: PMC2858983, PII: 1078-0432.CCR-09-3123, DOI: 10.1158/1078-0432.CCR-09-3123, ISSN: 1078-0432.

Sikora AG, Jaffarzad N, Hailemichael Y, Gelbard A, Stonier SW, Schluns KS, Frasca L, Lou Y, Liu C, Andersson HA, Hwu P, Overwijk WW. IFN-alpha enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activity. J. Immunol. 2009 Jun 6/15/2009; 182(12): 7398-407. PMID: 19494262, PMCID: PMC2774140, PII: 182/12/7398, DOI: 10.4049/jimmunol.0802982, ISSN: 1550-6606.

Thapa P, Zhang G, Xia C, Gelbard A, Overwijk WW, Liu C, Hwu P, Chang DZ, Courtney A, Sastry JK, Wang PG, Li C, Zhou D. Nanoparticle formulated alpha-galactosylceramide activates NKT cells without inducing anergy. Vaccine [print-electronic]. 2009 May 5/26/2009; 27(25-26): 3484-8. PMID: 19200815, PMCID: PMC5772602, PII: S0264-410X(09)00127-3, DOI: 10.1016/j.vaccine.2009.01.047, ISSN: 0264-410X.

Gelbard A, Kupferman ME, Jasser SA, Chen W, El-Naggar AK, Myers JN, Hanna EY. An orthotopic murine model of sinonasal malignancy. Clin. Cancer Res. 2008 Nov 11/15/2008; 14(22): 7348-57. PMID: 19010850, PMCID: PMC5428892, PII: 14/22/7348, DOI: 10.1158/1078-0432.CCR-08-0977, ISSN: 1078-0432.

Chakraborty M, Gelbard A, Carrasquillo JA, Yu S, Mamede M, Paik CH, Camphausen K, Schlom J, Hodge JW. Use of radiolabeled monoclonal antibody to enhance vaccine-mediated antitumor effects. Cancer Immunol. Immunother [print-electronic]. 2008 Aug; 57(8): 1173-83. PMID: 18256832, DOI: 10.1007/s00262-008-0449-x, ISSN: 0340-7004.

Gelbard A, Garnett CT, Abrams SI, Patel V, Gutkind JS, Palena C, Tsang KY, Schlom J, Hodge JW. Combination chemotherapy and radiation of human squamous cell carcinoma of the head and neck augments CTL-mediated lysis. Clin. Cancer Res. 2006 Mar 3/15/2006; 12(6): 1897-905. PMID: 16551875, PMCID: PMC1865094, PII: 12/6/1897, DOI: 10.1158/1078-0432.CCR-05-1761, ISSN: 1078-0432.