Quinn Stanton Wells, Pharm.D., M.D.

Associate Professor

Faculty Appointments
Associate Professor of Medicine Associate Professor of Biomedical InformaticsAssociate Professor of Pharmacology
M.S., Interdisciplinary, Vanderbilt University, Nashville, TennesseeM.S.C.I., Clinical Investigation, Vanderbilt University, Nashville, TennesseeM.D., MEDICINE, University of Alabama, Birmingham, AlabamaPharm.D., Samford University, Birmingham, AlabamaB.S., East Tennessee State University, Johnson City, Tennessee
Assad TR, Hemnes AR, Larkin EK, Glazer AM, Xu M, Wells QS, Farber-Eger EH, Sheng Q, Shyr Y, Harrell FE, Newman JH, Brittain EL. Clinical and Biological Insights Into Combined Post- and Pre-Capillary Pulmonary Hypertension. J. Am. Coll. Cardiol. 2016 Dec 12/13/2016; 68(23): 2525-36. PMID: 27931609, PMCID: PMC5157701, PII: S0735-1097(16)36493-2, DOI: 10.1016/j.jacc.2016.09.942, ISSN: 1558-3597.

Mosley JD, van Driest SL, Wells QS, Shaffer CM, Edwards TL, Bastarache L, McCarty CA, Thompson W, Chute CG, Jarvik GP, Crosslin DR, Larson EB, Kullo IJ, Pacheco JA, Peissig PL, Brilliant MH, Linneman JG, Denny JC, Roden DM. Defining a Contemporary Ischemic Heart Disease Genetic Risk Profile Using Historical Data. Circ Cardiovasc Genet [print-electronic]. 2016 Dec; 9(6): 521-30. PMID: 27780847, PMCID: PMC5177499, PII: CIRCGENETICS.116.001530, DOI: 10.1161/CIRCGENETICS.116.001530, ISSN: 1942-3268.

Assad TR, Brittain EL, Wells QS, Farber-Eger EH, Halliday SJ, Doss LN, Xu M, Wang L, Harrell FE, Yu C, Robbins IM, Newman JH, Hemnes AR. Hemodynamic evidence of vascular remodeling in combined post- and precapillary pulmonary hypertension. Pulm Circ. 2016 Sep; 6(3): 313-21. PMID: 27683608, PMCID: PMC5019084, PII: PC2013344, DOI: 10.1086/688516, ISSN: 2045-8932.

Van Driest SL, Wells QS, Roden DM. Long QT Syndrome and Potentially Pathogenic Genetic Variants--In Reply [letter]. JAMA. 2016 Jun 6/14/2016; 315(22): 2467-8. PMID: 27299624, PII: 2528206, DOI: 10.1001/jama.2016.2921, ISSN: 1538-3598.

Mosley JD, Shaffer CM, Van Driest SL, Weeke PE, Wells QS, Karnes JH, Velez Edwards DR, Wei WQ, Teixeira PL, Bastarache L, Crawford DC, Li R, Manolio TA, Bottinger EP, McCarty CA, Linneman JG, Brilliant MH, Pacheco JA, Thompson W, Chisholm RL, Jarvik GP, Crosslin DR, Carrell DS, Baldwin E, Ralston J, Larson EB, Grafton J, Scrol A, Jouni H, Kullo IJ, Tromp G, Borthwick KM, Kuivaniemi H, Carey DJ, Ritchie MD, Bradford Y, Verma SS, Chute CG, Veluchamy A, Siddiqui MK, Palmer CN, Doney A, MahmoudPour SH, Maitland-van der Zee AH, Morris AD, Denny JC, Roden DM. A genome-wide association study identifies variants in KCNIP4 associated with ACE inhibitor-induced cough. Pharmacogenomics J [print-electronic]. 2016 Jun; 16(3): 231-7. PMID: 26169577, PMCID: PMC4713364, PII: tpj201551, DOI: 10.1038/tpj.2015.51, ISSN: 1473-1150.

Van Driest SL, Wells QS, Stallings S, Bush WS, Gordon A, Nickerson DA, Kim JH, Crosslin DR, Jarvik GP, Carrell DS, Ralston JD, Larson EB, Bielinski SJ, Olson JE, Ye Z, Kullo IJ, Abul-Husn NS, Scott SA, Bottinger E, Almoguera B, Connolly J, Chiavacci R, Hakonarson H, Rasmussen-Torvik LJ, Pan V, Persell SD, Smith M, Chisholm RL, Kitchner TE, He MM, Brilliant MH, Wallace JR, Doheny KF, Shoemaker MB, Li R, Manolio TA, Callis TE, Macaya D, Williams MS, Carey D, Kapplinger JD, Ackerman MJ, Ritchie MD, Denny JC, Roden DM. Association of Arrhythmia-Related Genetic Variants With Phenotypes Documented in Electronic Medical Records. JAMA. 2016 Jan 1/5/2016; 315(1): 47-57. PMID: 26746457, PMCID: PMC4758131, PII: 2480485, DOI: 10.1001/jama.2015.17701, ISSN: 1538-3598.

Bowton EA, Collier SP, Wang X, Sutcliffe CB, Van Driest SL, Couch LJ, Herrera M, Jerome RN, Slebos RJ, Alborn WE, Liebler DC, McNaughton CD, Mernaugh RL, Wells QS, Brown NJ, Roden DM, Pulley JM. Phenotype-Driven Plasma Biobanking Strategies and Methods. J Pers Med. 2015 May 5/14/2015; 5(2): 140-52. PMID: 26110578, PMCID: PMC4493492, PII: jpm5020140, DOI: 10.3390/jpm5020140.

Wang TJ, Wells QS. Vitamin D Deficiency and Heart Failure Risk: Not so Black and White? [editorial]. JACC Heart Fail [print-electronic]. 2015 May; 3(5): 357-9. PMID: 25863974, PII: S2213-1779(15)00090-6, DOI: 10.1016/j.jchf.2015.02.005, ISSN: 2213-1787.

Karnes JH, Cronin RM, Rollin J, Teumer A, Pouplard C, Shaffer CM, Blanquicett C, Bowton EA, Cowan JD, Mosley JD, Van Driest SL, Weeke PE, Wells QS, Bakchoul T, Denny JC, Greinacher A, Gruel Y, Roden DM. A genome-wide association study of heparin-induced thrombocytopenia using an electronic medical record. Thromb. Haemost [print-electronic]. 2015 Apr; 113(4): 772-81. PMID: 25503805, PMCID: PMC4433536, PII: 14-08-0670, DOI: 10.1160/TH14-08-0670, ISSN: 0340-6245.

Bowton E, Field JR, Wang S, Schildcrout JS, Van Driest SL, Delaney JT, Cowan J, Weeke P, Mosley JD, Wells QS, Karnes JH, Shaffer C, Peterson JF, Denny JC, Roden DM, Pulley JM. Biobanks and electronic medical records: enabling cost-effective research. Sci Transl Med. 2014 Apr 4/30/2014; 6(234): 234cm3. PMID: 24786321, PMCID: PMC4226414, PII: 6/234/234cm3, DOI: 10.1126/scitranslmed.3008604, ISSN: 1946-6242.

Weeke P, Mosley JD, Hanna D, Delaney JT, Shaffer C, Wells QS, Van Driest S, Karnes JH, Ingram C, Guo Y, Shyr Y, Norris K, Kannankeril PJ, Ramirez AH, Smith JD, Mardis ER, Nickerson D, George AL, Roden DM. Exome sequencing implicates an increased burden of rare potassium channel variants in the risk of drug-induced long QT interval syndrome. J. Am. Coll. Cardiol [print-electronic]. 2014 Apr 4/15/2014; 63(14): 1430-7. PMID: 24561134, PMCID: PMC4018823, PII: S0735-1097(14)00446-X, DOI: 10.1016/j.jacc.2014.01.031, ISSN: 1558-3597.

Mosley JD, Van Driest SL, Weeke PE, Delaney JT, Wells QS, Bastarache L, Roden DM, Denny JC. Integrating EMR-linked and in vivo functional genetic data to identify new genotype-phenotype associations. PLoS ONE. 2014; 9(6): e100322. PMID: 24949630, PMCID: PMC4065041, PII: PONE-D-14-03337, DOI: 10.1371/journal.pone.0100322, ISSN: 1932-6203.

Wells QS, Farber-Eger E, Crawford DC. Extraction of echocardiographic data from the electronic medical record is a rapid and efficient method for study of cardiac structure and function. J Clin Bioinforma. 2014; 4: 12. PMID: 25276338, PMCID: PMC4177384, PII: 2043-9113-4-12, DOI: 10.1186/2043-9113-4-12.

Weeke P, Delaney J, Mosley JD, Wells Q, Van Driest S, Norris K, Kucera G, Stubblefield T, Roden DM. QT variability during initial exposure to sotalol: experience based on a large electronic medical record. Europace [print-electronic]. 2013 Dec; 15(12): 1791-7. PMID: 23787903, PMCID: PMC3888125, PII: eut153, DOI: 10.1093/europace/eut153, ISSN: 1532-2092.

Wells QS, Becker JR, Su YR, Mosley JD, Weeke P, D'Aoust L, Ausborn NL, Ramirez AH, Pfotenhauer JP, Naftilan AJ, Markham L, Exil V, Roden DM, Hong CC. Whole exome sequencing identifies a causal RBM20 mutation in a large pedigree with familial dilated cardiomyopathy. Circ Cardiovasc Genet [print-electronic]. 2013 Aug; 6(4): 317-26. PMID: 23861363, PMCID: PMC3895490, PII: CIRCGENETICS.113.000011, DOI: 10.1161/CIRCGENETICS.113.000011, ISSN: 1942-3268.

Kolek MJ, Dresen WF, Wells QS, Ellis CR. Use of an antibacterial envelope is associated with reduced cardiac implantable electronic device infections in high-risk patients. Pacing Clin Electrophysiol [print-electronic]. 2013 Mar; 36(3): 354-61. PMID: 23252988, PMCID: PMC3949624, DOI: 10.1111/pace.12063, ISSN: 1540-8159.

Mosley JD, Van Driest SL, Larkin EK, Weeke PE, Witte JS, Wells QS, Karnes JH, Guo Y, Bastarache L, Olson LM, McCarty CA, Pacheco JA, Jarvik GP, Carrell DS, Larson EB, Crosslin DR, Kullo IJ, Tromp G, Kuivaniemi H, Carey DJ, Ritchie MD, Denny JC, Roden DM. Mechanistic phenotypes: an aggregative phenotyping strategy to identify disease mechanisms using GWAS data. PLoS ONE. 2013; 8(12): e81503. PMID: 24349080, PMCID: PMC3861317, PII: PONE-D-13-29989, DOI: 10.1371/journal.pone.0081503, ISSN: 1932-6203.

Hollenbeck RD, Wells Q, Pollock J, Kelley MB, Wagner CE, Cash ME, Scott C, Burns K, Jones I, Fredi JL, McPherson JA. Implementation of a standardized pathway for the treatment of cardiac arrest patients using therapeutic hypothermia: "CODE ICE". Crit Pathw Cardiol. 2012 Sep; 11(3): 91-8. PMID: 22825528, PII: 00132577-201209000-00001, DOI: 10.1097/HPC.0b013e31825b7bc3, ISSN: 1535-2811.

Dresen WF, Wells QS, Maron DJ, McPherson JA. Therapeutic procedures for coronary vasospasm-induced polymorphic ventricular tachycardia. Ther Adv Cardiovasc Dis [print-electronic]. 2012 Jun; 6(3): 115-21. PMID: 22547691, PII: 1753944712446303, DOI: 10.1177/1753944712446303, ISSN: 1753-9455.

Wells QS, Delaney JT, Roden DM. Genetic determinants of response to cardiovascular drugs. Curr. Opin. Cardiol. 2012 May; 27(3): 253-61. PMID: 22382501, PMCID: PMC3874723, DOI: 10.1097/HCO.0b013e32835220e3, ISSN: 1531-7080.

Wells QS, Ausborn NL, Funke BH, Pfotenhauer JP, Fredi JL, Baxter S, Disalvo TD, Hong CC. Familial dilated cardiomyopathy associated with congenital defects in the setting of a novel VCL mutation (Lys815Arg) in conjunction with a known MYPBC3 variant. Cardiogenetics. 2011 Aug 8/22/2011; 1(1): PMID: 24062880, PMCID: PMC3779542, DOI: 10.4081/cardiogenetics.2011.e10, ISSN: 2035-8253.

Palmisano BT, Rottman JN, Wells QS, DiSalvo TG, Hong CC. Familial evaluation for diagnosis of arrhythmogenic right ventricular dysplasia. Cardiology [print-electronic]. 2011; 119(1): 47-53. PMID: 21822014, PMCID: PMC3169361, PII: 000329834, DOI: 10.1159/000329834, ISSN: 1421-9751.

Wells Q, Hardin B, Raj SR, Darbar D. Sotalol-induced torsades de pointes precipitated during treatment with oseltamivir for H1N1 influenza. Heart Rhythm [print-electronic]. 2010 Oct; 7(10): 1454-7. PMID: 20656063, PMCID: PMC2946414, PII: S1547-5271(10)00735-6, DOI: 10.1016/j.hrthm.2010.07.025, ISSN: 1556-3871.

Wells QS, Lenihan DJ. Reversibility of left ventricular dysfunction resulting from chemotherapy: can this be expected?. Prog Cardiovasc Dis. 2010 Sep; 53(2): 140-8. PMID: 20728701, PII: S0033-0620(10)00110-6, DOI: 10.1016/j.pcad.2010.06.005, ISSN: 1873-1740.

Available Postdoctoral Position Details
Posted: 1/9/2020

A postdoctoral position is available for eligible candidates with training in genetics, programming, machine learning, data science and statistics. Our laboratory focuses on epidemiologic and genomic studies of cardiovascular traits. The approaches we use include epidemiologic methods including regression analyses and genome and exome-wide association studies using high-density SNP arrays (common variants as well as rare variants), whole exome/genome sequencing in families with cardiovascular disease, Phenome wide association studies (PheWAS), variant annotation and electronic phenotyping algorithms. Our laboratory is part of a multi-project American Heart Association funded Strategically Focused Vascular Research Network with an emphasis on the clinical and genetic determinants of peripheral artery disease, microvascular disease, and major adverse limb outcomes. The candidate should be able to analyze such data and have a Ph.D., M.D., or equivalent doctoral degree in biostatistics, statistics/statistical genetics or data science. The candidate is expected to gain cross-disciplinary training in statistical genetics, genetic epidemiology, epidemiology, bioinformatics and translational genomics. The post-doctoral fellow will contribute to other projects within the research network and take a leadership role on peer-reviewed publications and presentation of results at appropriate national meetings. In addition, they will also be given opportunities to develop their own project and encouraged to apply for independent funding.

Funding is available for one position lasting two years with an anticipated start date of July1, 2020. Must have a Ph.D., M.D., or equivalent doctoral degree in a field deemed relevant by the program. Research Fellowship is appropriate for individuals who have completed no more than one prior postdoctoral fellowship, at VUMC or elsewhere. Please attach the following required documents at the time of application:

    1. Current curriculum vitae and bibliography

    2. Three letters of recommendation, signed, on letterhead, describing:

        o Relationship to the applicant.

        o Past work/academic performance.

        o Work qualities/personal conduct.

        o Overall assessment of potential for success in research environment.

    3. Doctoral degree certification, if applicable: o Original or notarized copy of diploma or final transcript issued by school (English translation required).