Christine M. Micheel, Ph.D.

Research Assistant Professor

christine.micheel@vanderbilt.edu

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Faculty Appointments
Research Assistant Professor of Medicine
Education
Ph.D., CHEMISTRY, University of California, Berkeley, CaliforniaA.B., Washington University, Saint Louis, Missouri
Office Address
2220 Pierce Ave
691 Preston Research Building
Nashville, TN 37232
Research Description
Christine Micheel joined the Vanderbilt-Ingram Cancer Center in December 2011 as managing editor for MyCancerGenome.org. Prior to moving to Nashville, Dr. Micheel spent four years at the Institute of Medicine (IOM) in Washington, DC, beginning in January 2008 as a Mirzayan Science and Technology Policy Graduate Fellow in the National Cancer Policy Forum (NCPF) and Board on Health Care Services. She was the study director for the studies Evolution of Translational Omics and Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease. Prior to her work at the IOM, Dr. Micheel held a postdoctoral position at the IBM Almaden Research Center in San Jose, Calif., where she studied interactions between biomolecules, such as DNA and antibodies, and nanomaterials. She completed her Ph.D. in chemistry from the University of California, Berkeley, with the support of a Howard Hughes Medical Institute Predoctoral Fellowship. Her research was focused on nanobioscience.
Research Keywords
cancer, oncology, nanoscience, precision medicine, personalized medicine, writing, editing
Publications
Meador CB, Micheel CM, Levy MA, Lovly CM, Horn L, Warner JL, Johnson DB, Zhao Z, Anderson IA, Sosman JA, Vnencak-Jones CL, Dahlman KB, Pao W. Beyond histology: translating tumor genotypes into clinically effective targeted therapies. Clin. Cancer Res [print-electronic]. 2014 May 5/1/2014; 20(9): 2264-75. PMID: 24599935, PMCID: PMC4008689, PII: 1078-0432.CCR-13-1591, DOI: 10.1158/1078-0432.CCR-13-1591, ISSN: 1078-0432.

Institute of Medicine. Evolution of translational omics: Lessons learned and the path forward, edited by Christine M. Micheel, Sharyl J. Nass, and Gilbert S. Omenn. 2012.

Wu Y, Levy MA, Micheel CM, Yeh P, Tang B, Cantrell MJ, Cooreman SM, Xu H. Identifying the status of genetic lesions in cancer clinical trial documents using machine learning. BMC Genomics [print-electronic]. 2012; 13 Suppl 8: S21. PMID: 23282337, PMCID: PMC3535695, PII: 1471-2164-13-S8-S21, DOI: 10.1186/1471-2164-13-S8-S21, ISSN: 1471-2164.

M. Patlak and C. M. Micheel, rapporteurs. Nanotechnology and oncology: Workshop summary. 2011.

A. Mack, E. Balogh, and C. M. Micheel, rapporteurs. Perspectives on biomarker and surrogate endpoint evaluation: Discussion forum summary. 2011.

Hung AM, Micheel CM, Bozano LD, Osterbur LW, Wallraff GM, Cha JN. Large-area spatially ordered arrays of gold nanoparticles directed by lithographically confined DNA origami. Nat Nanotechnol [print-electronic]. 2010 Feb; 5(2): 121-6. PMID: 20023644, PII: nnano.2009.450, DOI: 10.1038/nnano.2009.450, ISSN: 1748-3395.

Institute of Medicine. Evaluation of biomarkers and surrogate endpoints in chronic disease, edited by John R. Ball and Christine M. Micheel. 2010.

Kershner RJ, Bozano LD, Micheel CM, Hung AM, Fornof AR, Cha JN, Rettner CT, Bersani M, Frommer J, Rothemund PW, Wallraff GM. Placement and orientation of individual DNA shapes on lithographically patterned surfaces. Nat Nanotechnol [print-electronic]. 2009 Sep; 4(9): 557-61. PMID: 19734926, PII: nnano.2009.220, DOI: 10.1038/nnano.2009.220, ISSN: 1748-3395.

M. Patlak, S. Nass, and C. M. Micheel, rapporteurs. Multi-site phase III clinical trials and NCI cooperative groups: Workshop summary. 2009.

Zheng J, Lukeman PS, Sherman WB, Micheel C, Alivisatos AP, Constantinou PE, Seeman NC. Metallic nanoparticles used to estimate the structural integrity of DNA motifs. Biophys. J [print-electronic]. 2008 Oct; 95(7): 3340-8. PMID: 18621817, PMCID: PMC2547441, PII: biophysj.108.138479, DOI: 10.1529/biophysj.108.138479, ISSN: 1542-0086.

Micheel CM, Zanchet D, Alivisatos AP. Correlation analysis of TEM images of nanocrystal molecules. Langmuir [print-electronic]. 2008 Sep 9/16/2008; 24(18): 10084-8. PMID: 18702476, DOI: 10.1021/la801101k, ISSN: 0743-7463.

Claridge SA, Mastroianni AJ, Au YB, Liang HW, Micheel CM, Fr├ęchet JM, Alivisatos AP. Enzymatic ligation creates discrete multinanoparticle building blocks for self-assembly. J. Am. Chem. Soc [print-electronic]. 2008 Jul 7/23/2008; 130(29): 9598-605. PMID: 18588300, DOI: 10.1021/ja8026746, ISSN: 1520-5126.

M. Patlak, C. M. Micheel, and R. German, rapporteurs. Implementing colorectal cancer screening: Workshop summary. 2008.

Zheng J, Constantinou PE, Micheel C, Alivisatos AP, Kiehl RA, Seeman NC. Two-dimensional nanoparticle arrays show the organizational power of robust DNA motifs. Nano Lett. 2006 Jul; 6(7): 1502-4. PMID: 16834438, PMCID: PMC3465979, DOI: 10.1021/nl060994c, ISSN: 1530-6984.

Claridge, SA, Goh, SL, Frechet JMJ, Williams, SC, Micheel, CM Alivisatos AP. Directed assembly of discrete gold nanoparticle groupings using branched DNA scaffolds. 2005.

Fu A, Micheel CM, Cha J, Chang H, Yang H, Alivisatos AP. Discrete nanostructures of quantum dots/Au with DNA. J. Am. Chem. Soc. 2004 Sep 9/8/2004; 126(35): 10832-3. PMID: 15339154, DOI: 10.1021/ja046747x, ISSN: 0002-7863.

Parak, WJ, Gerion, D, Pellegrino, T, Zanchet, D, Micheel, C, Williams, SC, Boudreau, R, LeGros, MA, Larabell, CA, Alivisatos, AP. Biological applications of colloidal nanocrystals. 2003.

Parak, WJ, Pellegrino, T, Micheel, CM, Gerion, D, Williams, SC, Alivisatos, AP. Conformation of oligonucleotides attached to gold nanocrystals probed by gel electrophoresis. 2003.

Gerion D, Parak WJ, Williams SC, Zanchet D, Micheel CM, Alivisatos AP. Sorting fluorescent nanocrystals with DNA. J. Am. Chem. Soc. 2002 Jun 6/19/2002; 124(24): 7070-4. PMID: 12059231, PII: ja017822w, ISSN: 0002-7863.

Zanchet, D, Micheel, CM, Parak, WJ, Gerion, D, Williams, SC, Alivisatos, AP. Electrophoretic and structural studies of DNA-directed Au nanoparticle groupings. 2002.

Parak, WJ, Boudreau, R, LeGros, MA, Gerion, D, Zanchet, D, Micheel, CM, Williams, SC, Alivisatos, AP, Larabell, CA. Cell motility and metastatic potential studies based on quantum dot imaging of phagokinetic tracks. 2002.

Parak, WJ, Gerion, D, Zanchet, D, Woerz, A, Pellegrino, T, Micheel, CM, Williams, SC, Seitz, M, Bruehl, RE, Bryant, Z, Bustamante, C, Bertozzi, CR, Alivisatos, AP. Conjugation of DNA to silanized colloidal semiconductor nanocrystalline quantum dots. 2002.

Zanchet, D, Micheel, CM, Parak, WJ, Gerion, D, Alivisatos, AP. Electrophoretic isolation of discrete Au nanocrystal/DNA conjugates. 2001.