Jorge L. Gamboa, M.D., Ph.D.

Research Assistant Professor
Faculty Appointments
Research Assistant Professor of Medicine
Ph.D., PHYSIOLOGY, University of Kentucky, Lexington, KentuckyM.D., Universidad Peruana Cayetano Heredia, Lima, Peru
Roshanravan B, Kestenbaum B, Gamboa J, Jubrias SA, Ayers E, Curtin L, Himmelfarb J, de Boer IH, Conley KE. CKD and Muscle Mitochondrial Energetics. Am. J. Kidney Dis [print-electronic]. 2016 Jun 6/14/2016; PMID: 27312460, PII: S0272-6386(16)30172-X, DOI: 10.1053/j.ajkd.2016.05.011, ISSN: 1523-6838.

Gamboa JL, Billings FT, Bojanowski MT, Gilliam LA, Yu C, Roshanravan B, Roberts LJ, Himmelfarb J, Ikizler TA, Brown NJ. Mitochondrial dysfunction and oxidative stress in patients with chronic kidney disease. Physiol Rep. 2016 May; 4(9): PMID: 27162261, PII: 4/9/e12780, DOI: 10.14814/phy2.12780, ISSN: 2051-817X.

Gamboa JL, Devin JK, Ramirez CE, Yu C, Nian H, Lee RH, Brown NJ. Comparative effects of immediate-release and extended-release aspirin on basal and bradykinin-stimulated excretion of thromboxane and prostacyclin metabolites. Pharmacol Res Perspect. 2016 Apr; 4(2): e00221. PMID: 27069632, PMCID: PMC4804312, PII: PRP2221, DOI: 10.1002/prp2.221, ISSN: 2052-1707.

Ramirez CE, Nian H, Yu C, Gamboa JL, Luther JM, Brown NJ, Shibao CA. Treatment with Sildenafil Improves Insulin Sensitivity in Prediabetes: A Randomized, Controlled Trial. J. Clin. Endocrinol. Metab [print-electronic]. 2015 Dec; 100(12): 4533-40. PMID: 26580240, PMCID: PMC4667163, DOI: 10.1210/jc.2015-3415, ISSN: 1945-7197.

Wiener D, Gajardo-Meneses P, Ortega-Hernández V, Herrera-Cares C, Díaz S, Fernández W, Cornejo V, Gamboa J, Tapia T, Alvarez C, Carvallo P. BRCA1 and BARD1 colocalize mainly in the cytoplasm of breast cancer tumors, and their isoforms show differential expression. Breast Cancer Res. Treat [print-electronic]. 2015 Oct; 153(3): 669-78. PMID: 26395808, PII: 10.1007/s10549-015-3575-0, DOI: 10.1007/s10549-015-3575-0, ISSN: 1573-7217.

Gamboa JL, Pretorius M, Sprinkel KC, Brown NJ, Ikizler TA. Angiotensin converting enzyme inhibition increases ADMA concentration in patients on maintenance hemodialysis--a randomized cross-over study. BMC Nephrol. 2015; 16: 167. PMID: 26494370, PMCID: PMC4618919, PII: 10.1186/s12882-015-0162-x, DOI: 10.1186/s12882-015-0162-x, ISSN: 1471-2369.

Udpa N, Ronen R, Zhou D, Liang J, Stobdan T, Appenzeller O, Yin Y, Du Y, Guo L, Cao R, Wang Y, Jin X, Huang C, Jia W, Cao D, Guo G, Claydon VE, Hainsworth R, Gamboa JL, Zibenigus M, Zenebe G, Xue J, Liu S, Frazer KA, Li Y, Bafna V, Haddad GG. Whole genome sequencing of Ethiopian highlanders reveals conserved hypoxia tolerance genes. Genome Biol. 2014; 15(2): R36. PMID: 24555826, PMCID: PMC4054780, PII: gb-2014-15-2-r36, DOI: 10.1186/gb-2014-15-2-r36, ISSN: 1474-760X.

Cáceda R, Moskovciak T, Prendes-Alvarez S, Wojas J, Engel A, Wilker SH, Gamboa JL, Stowe ZN. Gender-specific effects of depression and suicidal ideation in prosocial behaviors. PLoS ONE. 2014; 9(9): e108733. PMID: 25259712, PMCID: PMC4178187, PII: PONE-D-13-52072, DOI: 10.1371/journal.pone.0108733, ISSN: 1932-6203.

Zhou D, Udpa N, Ronen R, Stobdan T, Liang J, Appenzeller O, Zhao HW, Yin Y, Du Y, Guo L, Cao R, Wang Y, Jin X, Huang C, Jia W, Cao D, Guo G, Gamboa JL, Villafuerte F, Callacondo D, Xue J, Liu S, Frazer KA, Li Y, Bafna V, Haddad GG. Whole-genome sequencing uncovers the genetic basis of chronic mountain sickness in Andean highlanders. Am. J. Hum. Genet [print-electronic]. 2013 Sep 9/5/2013; 93(3): 452-62. PMID: 23954164, PMCID: PMC3769925, PII: S0002-9297(13)00331-5, DOI: 10.1016/j.ajhg.2013.07.011, ISSN: 1537-6605.

Gamboa JL, Pretorius M, Todd-Tzanetos DR, Luther JM, Yu C, Ikizler TA, Brown NJ. Comparative effects of angiotensin-converting enzyme inhibition and angiotensin-receptor blockade on inflammation during hemodialysis. J. Am. Soc. Nephrol [print-electronic]. 2012 Feb; 23(2): 334-42. PMID: 22158433, PMCID: PMC3269170, PII: ASN.2011030287, DOI: 10.1681/ASN.2011030287, ISSN: 1533-3450.

Gamboa JL, Andrade FH. Muscle endurance and mitochondrial function after chronic normobaric hypoxia: contrast of respiratory and limb muscles. Pflugers Arch [print-electronic]. 2012 Feb; 463(2): 327-38. PMID: 22113781, PMCID: PMC3274731, DOI: 10.1007/s00424-011-1057-8, ISSN: 1432-2013.

Chan KE, Ikizler TA, Gamboa JL, Yu C, Hakim RM, Brown NJ. Combined angiotensin-converting enzyme inhibition and receptor blockade associate with increased risk of cardiovascular death in hemodialysis patients. Kidney Int [print-electronic]. 2011 Nov; 80(9): 978-85. PMID: 21775975, PMCID: PMC3656595, PII: ki2011228, DOI: 10.1038/ki.2011.228, ISSN: 1523-1755.

Garcia-Cazarin ML, Gamboa JL, Andrade FH. Rat diaphragm mitochondria have lower intrinsic respiratory rates than mitochondria in limb muscles. Am. J. Physiol. Regul. Integr. Comp. Physiol [print-electronic]. 2011 Jun; 300(6): R1311-5. PMID: 21389333, PMCID: PMC3119153, PII: ajpregu.00203.2010, DOI: 10.1152/ajpregu.00203.2010, ISSN: 1522-1490.

Gamboa JL, Garcia-Cazarin ML, Andrade FH. Chronic hypoxia increases insulin-stimulated glucose uptake in mouse soleus muscle. Am. J. Physiol. Regul. Integr. Comp. Physiol [print-electronic]. 2011 Jan; 300(1): R85-91. PMID: 20962202, PMCID: PMC3023279, PII: ajpregu.00078.2010, DOI: 10.1152/ajpregu.00078.2010, ISSN: 1522-1490.

Gamboa JL, Caceda R, Arregui A. Is depression the link between suicide and high altitude? [letter]. High Alt. Med. Biol. 2011; 12(4): 403-4; author reply 405. PMID: 22206568, DOI: 10.1089/ham.2011.1014, ISSN: 1557-8682.

Gamboa J, Blankenship DA, Niemi JP, Landreth GE, Karl M, Hilow E, Sundararajan S. Extension of the neuroprotective time window for thiazolidinediones in ischemic stroke is dependent on time of reperfusion. Neuroscience [print-electronic]. 2010 Oct 10/27/2010; 170(3): 846-57. PMID: 20691766, PMCID: PMC2939146, PII: S0306-4522(10)01067-5, DOI: 10.1016/j.neuroscience.2010.07.063, ISSN: 1873-7544.

Gamboa JL, Andrade FH. Mitochondrial content and distribution changes specific to mouse diaphragm after chronic normobaric hypoxia. Am. J. Physiol. Regul. Integr. Comp. Physiol [print-electronic]. 2010 Mar; 298(3): R575-83. PMID: 20007520, PMCID: PMC2838662, PII: 00320.2009, DOI: 10.1152/ajpregu.00320.2009, ISSN: 1522-1490.

McMullen CA, Ferry AL, Gamboa JL, Andrade FH, Dupont-Versteegden EE. Age-related changes of cell death pathways in rat extraocular muscle. Exp. Gerontol [print-electronic]. 2009 Jun; 44(6-7): 420-5. PMID: 19341788, PMCID: PMC2720059, PII: S0531-5565(09)00060-6, DOI: 10.1016/j.exger.2009.03.006, ISSN: 1873-6815.

Patel SP, Gamboa JL, McMullen CA, Rabchevsky A, Andrade FH. Lower respiratory capacity in extraocular muscle mitochondria: evidence for intrinsic differences in mitochondrial composition and function. Invest. Ophthalmol. Vis. Sci [print-electronic]. 2009 Jan; 50(1): 180-6. PMID: 18791171, PMCID: PMC2615070, PII: iovs.08-1911, DOI: 10.1167/iovs.08-1911, ISSN: 1552-5783.

Huicho L, Xing G, Qualls C, Rivera-Ch M, Gamboa JL, Verma A, Appenzeller O. Abnormal energy regulation in early life: childhood gene expression may predict subsequent chronic mountain sickness. BMC Pediatr. 2008; 8: 47. PMID: 18954447, PMCID: PMC2582028, PII: 1471-2431-8-47, DOI: 10.1186/1471-2431-8-47, ISSN: 1471-2431.

Xing G, Qualls C, Huicho L, Rivera-Ch M, Stobdan T, Slessarev M, Prisman E, Ito S, Wu H, Norboo A, Dolma D, Kunzang M, Norboo T, Gamboa JL, Claydon VE, Fisher J, Zenebe G, Gebremedhin A, Hainsworth R, Verma A, Appenzeller O. Adaptation and mal-adaptation to ambient hypoxia; Andean, Ethiopian and Himalayan patterns. PLoS ONE. 2008; 3(6): e2342. PMID: 18523639, PMCID: PMC2396283, DOI: 10.1371/journal.pone.0002342, ISSN: 1932-6203.

Victor NA, Wanderi EW, Gamboa J, Zhao X, Aronowski J, Deininger K, Lust WD, Landreth GE, Sundararajan S. Altered PPARgamma expression and activation after transient focal ischemia in rats. Eur. J. Neurosci. 2006 Sep; 24(6): 1653-63. PMID: 17004929, PII: EJN5037, DOI: 10.1111/j.1460-9568.2006.05037.x, ISSN: 0953-816X.

Appenzeller O, Minko T, Qualls C, Pozharov V, Gamboa J, Gamboa A, Pakunlu RI. Chronic hypoxia in Andeans; are there lessons for neurology at sea level?. J. Neurol. Sci [print-electronic]. 2006 Aug 8/15/2006; 247(1): 93-9. PMID: 16733057, PII: S0022-510X(06)00160-2, DOI: 10.1016/j.jns.2006.03.021, ISSN: 0022-510X.

Appenzeller O, Minko T, Qualls C, Pozharov V, Gamboa J, Gamboa A, Wang Y. Gene expression, autonomic function and chronic hypoxia:lessons from the Andes. Clin. Auton. Res [print-electronic]. 2006 Jun; 16(3): 217-22. PMID: 16583294, DOI: 10.1007/s10286-006-0338-3, ISSN: 0959-9851.

Gamboa A, Gamboa JL, Holmes C, Sharabi Y, Leon-Velarde F, Fischman GJ, Appenzeller O, Goldstein DS. Plasma catecholamines and blood volume in native Andeans during hypoxia and normoxia. Clin. Auton. Res. 2006 Feb; 16(1): 40-5. PMID: 16477494, DOI: 10.1007/s10286-006-0305-z, ISSN: 0959-9851.

Gamboa A, Gamboa JL. Comments on Point-Counterpoint "Positive effects of intermittent hypoxia (live high:train low) on exercise performance are/are not mediated primarily by augmented red cell volume" [letter]. J. Appl. Physiol. 2006 Jan; 100(1): 366-7. PMID: 16402429, ISSN: 8750-7587.

Appenzeller O, Minko T, Qualls C, Pozharov V, Gamboa J, Gamboa A, Wang Y. Migraine in the Andes and headache at sea level. Cephalalgia. 2005 Dec; 25(12): 1117-21. PMID: 16305600, PII: CHA973, DOI: 10.1111/j.1468-2982.2005.00973.x, ISSN: 0333-1024.

Zechel JL, Gamboa JL, Peterson AG, Puchowicz MA, Selman WR, Lust WD. Neuronal migration is transiently delayed by prenatal exposure to intermittent hypoxia. Birth Defects Res. B Dev. Reprod. Toxicol. 2005 Aug; 74(4): 287-99. PMID: 16094620, DOI: 10.1002/bdrb.20051, ISSN: 1542-9733.

Sundararajan S, Gamboa JL, Victor NA, Wanderi EW, Lust WD, Landreth GE. Peroxisome proliferator-activated receptor-gamma ligands reduce inflammation and infarction size in transient focal ischemia. Neuroscience. 2005; 130(3): 685-96. PMID: 15590152, PII: S0306-4522(04)00957-1, DOI: 10.1016/j.neuroscience.2004.10.021, ISSN: 0306-4522.

Appenzeller O, Passino C, Roach R, Gamboa J, Gamboa A, Bernardi L, Bonfichi M, Malcovati L. Cerebral vasoreactivity in Andeans and headache at sea level. J. Neurol. Sci. 2004 Apr 4/15/2004; 219(1-2): 101-6. PMID: 15050445, PII: S0022510X04000188, DOI: 10.1016/j.jns.2003.12.014, ISSN: 0022-510X.

Gamboa J, Macarlupú JL, Rivera-Chira M, Monge-C C, León-Velarde F. Effect of domperidone on ventilation and polycythemia after 5 weeks of chronic hypoxia in rats. Respir Physiol Neurobiol. 2003 Apr 4/15/2003; 135(1): 1-8. PMID: 12706060, PII: S156990480300065X, ISSN: 1569-9048.

Appenzeller O, Minko T, Pozharov V, Bonfichi M, Malcovati L, Gamboa J, Bernardi L. Gene expression in the Andes; relevance to neurology at sea level. J. Neurol. Sci. 2003 Mar 3/15/2003; 207(1-2): 37-41. PMID: 12614929, PII: S0022510X02003568, ISSN: 0022-510X.

Mouw G, Zechel JL, Gamboa J, Lust WD, Selman WR, Ratcheson RA. Activation of caspase-12, an endoplasmic reticulum resident caspase, after permanent focal ischemia in rat. Neuroreport. 2003 Feb 2/10/2003; 14(2): 183-6. PMID: 12598725, DOI: 10.1097/01.wnr.0000054277.81804.24, ISSN: 0959-4965.

Bernardi L, Roach RC, Keyl C, Spicuzza L, Passino C, Bonfichi M, Gamboa A, Gamboa J, Malcovati L, Schneider A, Casiraghi N, Mori A, Leon-Velarde F. Ventilation, autonomic function, sleep and erythropoietin. Chronic mountain sickness of Andean natives. Adv. Exp. Med. Biol. 2003; 543: 161-75. PMID: 14713121, ISSN: 0065-2598.

Appenzeller O, Thomas PK, Ponsford S, Gamboa JL, Cáceda R, Milner P. Acral paresthesias in the Andes and neurology at sea level. Neurology. 2002 Nov 11/26/2002; 59(10): 1532-5. PMID: 12451192, ISSN: 0028-3878.

Cáceda R, Gamboa JL, Boero JA, Monge-C C, Arregui A. Energetic metabolism in mouse cerebral cortex during chronic hypoxia. Neurosci. Lett. 2001 Apr 4/6/2001; 301(3): 171-4. PMID: 11257425, PII: S0304394001016305, ISSN: 0304-3940.

Thomas PK, King RH, Feng SF, Muddle JR, Workman JM, Gamboa J, Tapia R, Vargas M, Appenzeller O. Neurological manifestations in chronic mountain sickness: the burning feet-burning hands syndrome. J. Neurol. Neurosurg. Psychiatr. 2000 Oct; 69(4): 447-52. PMID: 10990502, PMCID: PMC1737143, ISSN: 0022-3050.

Gamboa J, Caceda R, Gamboa A, Monge-C C. Carbonic anhydrase activity in the red blood cells of sea level and high altitude natives. Biol. Res. 2000; 33(3-4): 207-8. PMID: 15696680, ISSN: 0716-9760.

Gamboa J, Rivera M, Leon-Velarde F, Salazar M, Monge-C C. Pentoxifylline and enalapril and its effect on polycythemia induced by hypobaric hypoxia in mice. Acta Andina. 1997; 6(2): 5-10.