Robert Frank Cornell, M.D.

Assistant Professor

robert.f.cornell@vanderbilt.edu
Faculty Appointments
Assistant Professor of Medicine
Education
M.D., Trinity Dublin University, Dublin, IrelandB.S., Saint Louis University, Saint Louis, Missouri
Office Address
777 Preston Research Building
Vanderbilt University Medical Center
Nashville, TN 37272
Research Description
Clinical Trials and research: Phase I Clinical Trial Development; Multiple Myeloma Clinical; Light Chain Amyloidosis; Waldenstrom's Macroglobulinemia; Autologous Stem Cell Transplantation; Cardio-oncology
Clinical Description
Multiple Myeloma; Light Chain Amyloidosis; Waldenstrom's Macroglobulinemia; Autologous Stem Cell Transplantation; Cardio-oncology
Publications
Fradley MG, Groarke JD, Laubach J, Alsina M, Lenihan DJ, Cornell RF, Maglio M, Shain KH, Richardson PG, Moslehi J. Recurrent cardiotoxicity potentiated by the interaction of proteasome inhibitor and immunomodulatory therapy for the treatment of multiple myeloma. Br. J. Haematol [print-electronic]. 2018 Jan; 180(2): 271-5. PMID: 29048105, DOI: 10.1111/bjh.14970, ISSN: 1365-2141.

Kumar SK, Dispenzieri A, Fraser R, Mingwei F, Akpek G, Cornell R, Kharfan-Dabaja M, Freytes C, Hashmi S, Hildebrandt G, Holmberg L, Kyle R, Lazarus H, Lee C, Mikhael J, Nishihori T, Tay J, Usmani S, Vesole D, Vij R, Wirk B, Krishnan A, Gasparetto C, Mark T, Nieto Y, Hari P, D'Souza A. Early relapse after autologous hematopoietic cell transplantation remains a poor prognostic factor in multiple myeloma but outcomes have improved over time. Leukemia [print-electronic]. 2017 Nov 11/16/2017; PMID: 29263438, PII: leu2017331, DOI: 10.1038/leu.2017.331, ISSN: 1476-5551.

Oke O, Sethi T, Goodman S, Phillips S, Decker I, Rubinstein S, Concepcion B, Horst S, Jagasia M, Kassim A, Harrell SL, Langone A, Lenihan D, Rawling KT, Slosky D, Cornell RF. Outcomes from Autologous Hematopoietic Cell Transplantation versus Chemotherapy Alone for the Management of Light Chain Amyloidosis. Biol. Blood Marrow Transplant [print-electronic]. 2017 Sep; 23(9): 1473-7. PMID: 28546074, PII: S1083-8791(17)30467-6, DOI: 10.1016/j.bbmt.2017.05.020, ISSN: 1523-6536.

Rubinstein S, Cornell RF, Du L, Concepcion B, Goodman S, Harrell S, Horst S, Lenihan D, Slosky D, Fogo A, Langone A. Novel pathologic scoring tools predict end-stage kidney disease in light chain (AL) amyloidosis. Amyloid [print-electronic]. 2017 Sep; 24(3): 205-11. PMID: 28758811, DOI: 10.1080/13506129.2017.1360272, ISSN: 1744-2818.

Decker I, Goodman SA, Phillips SE, Lenihan DJ, Cornell RF. The six-minute walk test is a valuable measure of functional change following chemotherapy for AL (light-chain) cardiac amyloidosis [letter]. Br. J. Haematol [print-electronic]. 2017 May; 177(3): 481-3. PMID: 28295184, DOI: 10.1111/bjh.14585, ISSN: 1365-2141.

Ritts AJ, Cornell RF, Swiger K, Singh J, Goodman S, Lenihan DJ. Current Concepts of Cardiac Amyloidosis: Diagnosis, Clinical Management, and the Need for Collaboration. Heart Fail Clin. 2017 Apr; 13(2): 409-16. PMID: 28279425, PII: S1551-7136(16)30164-7, DOI: 10.1016/j.hfc.2016.12.003, ISSN: 1551-7136.

Cornell RF, Bachanova V, D'Souza A, Woo-Ahn K, Martens M, Huang J, Al-Homsi AS, Chhabra S, Copelan E, Diaz MA, Freytes CO, Gale RP, Ganguly S, Hamadani M, Hildebrandt G, Kamble RT, Kharfan-Dabaja M, Kindwall-Keller T, Lazarus HM, Marks DI, Nishihori T, Olsson RF, Saad A, Usmani S, Vesole DH, Yared J, Mark T, Nieto Y, Hari P. Allogeneic Transplantation for Relapsed Waldenström Macroglobulinemia and Lymphoplasmacytic Lymphoma. Biol. Blood Marrow Transplant [print-electronic]. 2017 Jan; 23(1): 60-6. PMID: 27789362, PMCID: PMC5182098, PII: S1083-8791(16)30424-4, DOI: 10.1016/j.bbmt.2016.10.010, ISSN: 1523-6536.

Dimopoulos MA, Trotman J, Tedeschi A, Matous JV, Macdonald D, Tam C, Tournilhac O, Ma S, Oriol A, Heffner LT, Shustik C, García-Sanz R, Cornell RF, de Larrea CF, Castillo JJ, Granell M, Kyrtsonis MC, Leblond V, Symeonidis A, Kastritis E, Singh P, Li J, Graef T, Bilotti E, Treon S, Buske C, . Ibrutinib for patients with rituximab-refractory Waldenström's macroglobulinaemia (iNNOVATE): an open-label substudy of an international, multicentre, phase 3 trial. Lancet Oncol [print-electronic]. 2016 Dec 12/9/2016; PMID: 27956157, PII: S1470-2045(16)30632-5, DOI: 10.1016/S1470-2045(16)30632-5, ISSN: 1474-5488.

Cornell RF, D'Souza A, Kassim AA, Costa LJ, Innis-Shelton RD, Zhang MJ, Huang J, Abidi M, Aiello J, Akpek G, Bashey A, Bashir Q, Cerny J, Comenzo R, Diaz MA, Freytes C, Gale RP, Ganguly S, Hamadani M, Hashmi S, Holmberg L, Hossain N, Kamble RT, Kharfan-Dabaja M, Kindwall-Keller T, Kyle R, Kumar S, Lazarus H, Lee C, Maiolino A, Marks DI, Meehan K, Mikhael J, Nath R, Nishihori T, Olsson RF, Ramanathan M, Saad A, Seo S, Usmani S, Vesole D, Vij R, Vogl D, Wirk BM, Yared J, Krishnan A, Mark T, Nieto Y, Hari P. Maintenance versus Induction Therapy Choice on Outcomes after Autologous Transplantation for Multiple Myeloma. Biol. Blood Marrow Transplant [print-electronic]. 2016 Nov 11/15/2016; PMID: 27864161, PII: S1083-8791(16)30489-X, DOI: 10.1016/j.bbmt.2016.11.011, ISSN: 1523-6536.

Clark CA, Cornell RF, Scott EC, Chung J, Costa LJ. Management of relapsed and refractory multiple myeloma in modern times: Incorporating new agents into decision-making. Am. J. Hematol [print-electronic]. 2016 Oct; 91(10): 1044-51. PMID: 27415608, DOI: 10.1002/ajh.24478, ISSN: 1096-8652.

Li W, Garcia D, Cornell RF, Gailani D, Laubach J, Maglio ME, Richardson PG, Moslehi J. Cardiovascular and Thrombotic Complications of Novel Multiple Myeloma Therapies: A Review. JAMA Oncol [print-electronic]. 2016 Sep 9/15/2016; PMID: 27632640, PII: 2552679, DOI: 10.1001/jamaoncol.2016.3350, ISSN: 2374-2445.

Lenihan DJ, Hartlage G, DeCara J, Blaes A, Finet JE, Lyon AR, Cornell RF, Moslehi J, Oliveira GH, Murtagh G, Fisch M, Zeevi G, Iakobishvili Z, Witteles R, Patel A, Harrison E, Fradley M, Curigliano G, Lenneman CG, Magalhaes A, Krone R, Porter C, Parasher S, Dent S, Douglas P, Carver J. Cardio-Oncology Training: A Proposal From the International Cardioncology Society and Canadian Cardiac Oncology Network for a New Multidisciplinary Specialty. J. Card. Fail [print-electronic]. 2016 Jun; 22(6): 465-71. PMID: 27038642, PII: S1071-9164(16)30005-7, DOI: 10.1016/j.cardfail.2016.03.012, ISSN: 1532-8414.

Cornell RF, Kassim AA. Evolving paradigms in the treatment of relapsed/refractory multiple myeloma: increased options and increased complexity. Bone Marrow Transplant [print-electronic]. 2016 Apr; 51(4): 479-91. PMID: 26726946, PMCID: PMC4827007, PII: bmt2015307, DOI: 10.1038/bmt.2015.307, ISSN: 1476-5365.

Li W, Cornell RF, Lenihan D, Slosky D, Jagasia M, Piazza G, Moslehi J. Cardiovascular Complications of Novel Multiple Myeloma Treatments. Circulation. 2016 Mar 3/1/2016; 133(9): 908-12. PMID: 26927008, PII: CIRCULATIONAHA.115.018351, DOI: 10.1161/CIRCULATIONAHA.115.018351, ISSN: 1524-4539.

Cornell RF, Hari P, Drobyski WR. Engraftment Syndrome after Autologous Stem Cell Transplantation: An Update Unifying the Definition and Management Approach. Biol. Blood Marrow Transplant [print-electronic]. 2015 Dec; 21(12): 2061-8. PMID: 26327628, PMCID: PMC4639405, PII: S1083-8791(15)00578-9, DOI: 10.1016/j.bbmt.2015.08.030, ISSN: 1523-6536.

Uy GL, Costa LJ, Hari PN, Zhang MJ, Huang JX, Anderson KC, Bredeson CN, Callander NS, Cornell RF, Perez MA, Dispenzieri A, Freytes CO, Gale RP, Garfall A, Gertz MA, Gibson J, Hamadani M, Lazarus HM, Kalaycio ME, Kamble RT, Kharfan-Dabaja MA, Krishnan AY, Kumar SK, Kyle RA, Landau HJ, Lee CH, Maiolino A, Marks DI, Mark TM, Munker R, Nishihori T, Olsson RF, Ramanathan M, Rodriguez TE, Saad AA, Savani BN, Schiller GJ, Schouten HC, Schriber JR, Scott E, Seo S, Sharma M, Ganguly S, Stadtmauer EA, Tay J, To LB, Vesole DH, Vogl DT, Wagner JL, Wirk B, Wood WA, D'Souza A. Contribution of chemotherapy mobilization to disease control in multiple myeloma treated with autologous hematopoietic cell transplantation. Bone Marrow Transplant [print-electronic]. 2015 Dec; 50(12): 1513-8. PMID: 26301967, PMCID: PMC4548821, PII: bmt2015190, DOI: 10.1038/bmt.2015.190, ISSN: 1476-5365.

D'Souza A, Dispenzieri A, Wirk B, Zhang MJ, Huang J, Gertz MA, Kyle RA, Kumar S, Comenzo RL, Peter Gale R, Lazarus HM, Savani BN, Cornell RF, Weiss BM, Vogl DT, Freytes CO, Scott EC, Landau HJ, Moreb JS, Costa LJ, Ramanathan M, Callander NS, Kamble RT, Olsson RF, Ganguly S, Nishihori T, Kindwall-Keller TL, Wood WA, Mark TM, Hari P. Improved Outcomes After Autologous Hematopoietic Cell Transplantation for Light Chain Amyloidosis: A Center for International Blood and Marrow Transplant Research Study. J. Clin. Oncol [print-electronic]. 2015 Nov 11/10/2015; 33(32): 3741-9. PMID: 26371138, PII: JCO.2015.62.4015, DOI: 10.1200/JCO.2015.62.4015, ISSN: 1527-7755.

Sherrod AM, Hari P, Mosse CA, Walker RC, Cornell RF. Minimal residual disease testing after stem cell transplantation for multiple myeloma. Bone Marrow Transplant [print-electronic]. 2015 Jul 7/20/2015; PMID: 26191950, PII: bmt2015164, DOI: 10.1038/bmt.2015.164, ISSN: 1476-5365.

Cornell RF, Zhong X, Arce-Lara C, Atallah E, Blust L, Drobyski WR, Fenske TS, Pasquini MC, Rizzo JD, Saber W, Hari PN. Bortezomib-based induction for transplant ineligible AL amyloidosis and feasibility of later transplantation. Bone Marrow Transplant [print-electronic]. 2015 Jul; 50(7): 914-7. PMID: 25915809, PII: bmt201573, DOI: 10.1038/bmt.2015.73, ISSN: 1476-5365.

Grandin EW, Ky B, Cornell RF, Carver J, Lenihan DJ. Patterns of cardiac toxicity associated with irreversible proteasome inhibition in the treatment of multiple myeloma. J. Card. Fail [print-electronic]. 2015 Feb; 21(2): 138-44. PMID: 25433360, PII: S1071-9164(14)01307-4, DOI: 10.1016/j.cardfail.2014.11.008, ISSN: 1532-8414.

Cornell RF, Burns LJ, Bachanova V. Why Waldenstrom macroglobulinemia is not just another indolent lymphoma. 2014.

Cornell RF, Hari P, Zhang MJ, Zhong X, Thompson J, Fenske TS, Horowitz MM, Komorowski R, Palmer J, Pasquini MC, Rizzo JD, Saber W, Thomas M, Drobyski WR. Divergent effects of novel immunomodulatory agents and cyclophosphamide on the risk of engraftment syndrome after autologous peripheral blood stem cell transplantation for multiple myeloma. Biol. Blood Marrow Transplant [print-electronic]. 2013 Sep; 19(9): 1368-73. PMID: 23806770, PII: S1083-8791(13)00288-7, DOI: 10.1016/j.bbmt.2013.06.017, ISSN: 1523-6536.

Cornell RF, Kelly DF, Bordo G, Carroll TB, Duong HT, Kim J, Takasumi Y, Thomas JP, Wong YL, Findling JW. Chemotherapy-induced regression of an adrenocorticotropin-secreting pituitary carcinoma accompanied by secondary adrenal insufficiency. Case Rep Endocrinol [print-electronic]. 2013; 2013: 675298. PMID: 24455332, PMCID: PMC3881387, DOI: 10.1155/2013/675298, ISSN: 2090-6501.

Cornell RF, Palmer J, Komorowski R, Drobyski WR. Surgical resection as definitive treatment for refractory GVHD of the colon. Bone Marrow Transplant [print-electronic]. 2012 Oct; 47(10): 1366-7. PMID: 22327134, PII: bmt201215, DOI: 10.1038/bmt.2012.15, ISSN: 1476-5365.

Cornell RF, Palmer J. Adult acute leukemia. Dis Mon. 2012 Apr; 58(4): 219-38. PMID: 22449370, PII: S0011-5029(12)00012-0, DOI: 10.1016/j.disamonth.2012.01.011, ISSN: 1557-8194.

Cornell RF, Fenske TS.. Indolent B-Cell Non-Hodgkin Lymphoma. 2011.

Cornell RF, Randolph TR. The minimum concentration of fibrinogen needed for platelet aggregation using ADP. Clin Lab Sci. 2002; 15(1): 30-6. PMID: 12778954, ISSN: 0894-959X.