Oliver McDonald, Ph.D., M.D.

Assistant Professor

Faculty Appointments
Assistant Professor of Pathology, Microbiology and Immunology
M.D., MEDICINE, University of Virginia, Charlottesville, VirginiaPh.D., PHYSIOLOGY, University of Virginia, Charlottesville, VirginiaB.S., University of Tennessee, Chattanooga, Tennessee
Office Address
Vanderbilt University
Medical Center North C-3321 (2561)
1161 21st Avenue
Nashville, TN 37232
Research Description
Metabolic-epigenetic reprogramming during neoplastic transformation, malignant progression, and metastasis.
Clinical Description
Diagnostic histopathology of gastrointestinal, hepatic, and pancreaticobiliary disease
Research Keywords
Cancer, metabolism, epigenetics, chromatin
Clinical Research Keywords
Gastrointestinal and Liver Pathology
Bechard ME, Word AE, Tran AV, Liu X, Locasale JW, McDonald OG. Pentose conversions support the tumorigenesis of pancreatic cancer distant metastases. Oncogene [print-electronic]. 2018 May 5/30/2018; PMID: 29849117, PII: 10.1038/s41388-018-0346-5, DOI: 10.1038/s41388-018-0346-5, ISSN: 1476-5594.

Ludwik KA, McDonald OG, Brenin DR, Lannigan DA. ERa-Mediated Nuclear Sequestration of RSK2 Is Required for ER+ Breast Cancer Tumorigenesis. Cancer Res [print-electronic]. 2018 Apr 4/15/2018; 78(8): 2014-25. PMID: 29351904, PII: 0008-5472.CAN-17-2063, DOI: 10.1158/0008-5472.CAN-17-2063, ISSN: 1538-7445.

VandenBussche CJ, Adams CL, McDonald OG, Whitworth SA, Ali SZ. The fine needle aspiration of translocation sarcomas. Cytopathology [print-electronic]. 2017 Jul 7/17/2017; PMID: 28718513, DOI: 10.1111/cyt.12446, ISSN: 1365-2303.

Li C, Singh B, Graves-Deal R, Ma H, Starchenko A, Fry WH, Lu Y, Wang Y, Bogatcheva G, Khan MP, Milne GL, Zhao S, Ayers GD, Li N, Hu H, Washington MK, Yeatman TJ, McDonald OG, Liu Q, Coffey RJ. Three-dimensional culture system identifies a new mode of cetuximab resistance and disease-relevant genes in colorectal cancer. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2017 Apr 4/4/2017; 114(14): E2852-E2861. PMID: 28320945, PMCID: PMC5389279, PII: 1618297114, DOI: 10.1073/pnas.1618297114, ISSN: 1091-6490.

McDonald OG, Li X, Saunders T, Tryggvadottir R, Mentch SJ, Warmoes MO, Word AE, Carrer A, Salz TH, Natsume S, Stauffer KM, Makohon-Moore A, Zhong Y, Wu H, Wellen KE, Locasale JW, Iacobuzio-Donahue CA, Feinberg AP. Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis. Nat. Genet [print-electronic]. 2017 Jan 1/16/2017; PMID: 28092686, PII: ng.3753, DOI: 10.1038/ng.3753, ISSN: 1546-1718.

Sue PK, Salazar-Austin NM, McDonald OG, Rishi A, Cornish TC, Arav-Boger R. Cytomegalovirus Enterocolitis in Immunocompetent Young Children: A Report of Two Cases and Review of the Literature. Pediatr. Infect. Dis. J. 2016 May; 35(5): 573-6. PMID: 26862673, PMCID: PMC4829454, DOI: 10.1097/INF.0000000000001080, ISSN: 1532-0987.

Ma C, Park JY, Montgomery EA, Arnold CA, McDonald OG, Liu TC, Salaria SN, Limketkai BN, McGrath KM, Musahl T, Singhi AD. A Comparative Clinicopathologic Study of Collagenous Gastritis in Children and Adults: The Same Disorder With Associated Immune-mediated Diseases. Am. J. Surg. Pathol. 2015 Jun; 39(6): 802-12. PMID: 25871617, DOI: 10.1097/PAS.0000000000000441, ISSN: 1532-0979.

Prusevich P, Kalin JH, Ming SA, Basso M, Givens J, Li X, Hu J, Taylor MS, Cieniewicz AM, Hsiao PY, Huang R, Roberson H, Adejola N, Avery LB, Casero RA, Taverna SD, Qian J, Tackett AJ, Ratan RR, McDonald OG, Feinberg AP, Cole PA. A selective phenelzine analogue inhibitor of histone demethylase LSD1. ACS Chem. Biol [print-electronic]. 2014 Jun 6/20/2014; 9(6): 1284-93. PMID: 24707965, PMCID: PMC4076021, DOI: 10.1021/cb500018s, ISSN: 1554-8937.

McDonald OG, Maitra A, Hruban RH. Human correlates of provocative questions in pancreatic pathology. Adv Anat Pathol. 2012 Nov; 19(6): 351-62. PMID: 23060061, PMCID: PMC3487591, PII: 00125480-201211000-00001, DOI: 10.1097/PAP.0b013e318273f998, ISSN: 1533-4031.

McDonald OG, Wu H, Timp W, Doi A, Feinberg AP. Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition. Nat. Struct. Mol. Biol. 2011 Aug; 18(8): 867-74. PMID: 21725293, PMCID: PMC3150339, PII: nsmb.2084, DOI: 10.1038/nsmb.2084, ISSN: 1545-9985.

Hansen KD, Timp W, Bravo HC, Sabunciyan S, Langmead B, McDonald OG, Wen B, Wu H, Liu Y, Diep D, Briem E, Zhang K, Irizarry RA, Feinberg AP. Increased methylation variation in epigenetic domains across cancer types. Nat. Genet. 2011 Aug; 43(8): 768-75. PMID: 21706001, PMCID: PMC3145050, PII: ng.865, DOI: 10.1038/ng.865, ISSN: 1546-1718.

Hastings NE, Simmers MB, McDonald OG, Wamhoff BR, Blackman BR. Atherosclerosis-prone hemodynamics differentially regulates endothelial and smooth muscle cell phenotypes and promotes pro-inflammatory priming. Am. J. Physiol., Cell Physiol [print-electronic]. 2007 Dec; 293(6): C1824-33. PMID: 17913848, PII: 00385.2007, DOI: 10.1152/ajpcell.00385.2007, ISSN: 0363-6143.

McDonald OG, Owens GK. Programming smooth muscle plasticity with chromatin dynamics. Circ. Res. 2007 May 5/25/2007; 100(10): 1428-41. PMID: 17525382, PII: 100/10/1428, DOI: 10.1161/01.RES.0000266448.30370.a0, ISSN: 1524-4571.

Gan Q, Yoshida T, McDonald OG, Owens GK. Concise review: epigenetic mechanisms contribute to pluripotency and cell lineage determination of embryonic stem cells. Stem Cells [print-electronic]. 2007 Jan; 25(1): 2-9. PMID: 17023513, PII: 2006-0383, DOI: 10.1634/stemcells.2006-0383, ISSN: 1066-5099.

Davis CA, Haberland M, Arnold MA, Sutherland LB, McDonald OG, Richardson JA, Childs G, Harris S, Owens GK, Olson EN. PRISM/PRDM6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells. Mol. Cell. Biol. 2006 Apr; 26(7): 2626-36. PMID: 16537907, PMCID: PMC1430312, PII: 26/7/2626, DOI: 10.1128/MCB.26.7.2626-2636.2006, ISSN: 0270-7306.

McDonald OG, Wamhoff BR, Hoofnagle MH, Owens GK. Control of SRF binding to CArG box chromatin regulates smooth muscle gene expression in vivo. J. Clin. Invest. 2006 Jan; 116(1): 36-48. PMID: 16395403, PMCID: PMC1323266, DOI: 10.1172/JCI26505, ISSN: 0021-9738.

Liu Y, Sinha S, McDonald OG, Shang Y, Hoofnagle MH, Owens GK. Kruppel-like factor 4 abrogates myocardin-induced activation of smooth muscle gene expression. J. Biol. Chem [print-electronic]. 2005 Mar 3/11/2005; 280(10): 9719-27. PMID: 15623517, PII: M412862200, DOI: 10.1074/jbc.M412862200, ISSN: 0021-9258.

Hendrix JA, Wamhoff BR, McDonald OG, Sinha S, Yoshida T, Owens GK. 5' CArG degeneracy in smooth muscle alpha-actin is required for injury-induced gene suppression in vivo. J. Clin. Invest. 2005 Feb; 115(2): 418-27. PMID: 15690088, PMCID: PMC546420, DOI: 10.1172/JCI22648, ISSN: 0021-9738.

Wamhoff BR, Hoofnagle MH, Burns A, Sinha S, McDonald OG, Owens GK. A G/C element mediates repression of the SM22alpha promoter within phenotypically modulated smooth muscle cells in experimental atherosclerosis. Circ. Res [print-electronic]. 2004 Nov 11/12/2004; 95(10): 981-8. PMID: 15486317, PII: 01.RES.0000147961.09840.fb, DOI: 10.1161/01.RES.0000147961.09840.fb, ISSN: 1524-4571.

Wamhoff BR, Bowles DK, McDonald OG, Sinha S, Somlyo AP, Somlyo AV, Owens GK. L-type voltage-gated Ca2+ channels modulate expression of smooth muscle differentiation marker genes via a rho kinase/myocardin/SRF-dependent mechanism. Circ. Res [print-electronic]. 2004 Aug 8/20/2004; 95(4): 406-14. PMID: 15256479, PII: 01.RES.0000138582.36921.9e, DOI: 10.1161/01.RES.0000138582.36921.9e, ISSN: 1524-4571.

McDonald OG, Krynetski EY, Evans WE. Molecular haplotyping of genomic DNA for multiple single-nucleotide polymorphisms located kilobases apart using long-range polymerase chain reaction and intramolecular ligation. Pharmacogenetics. 2002 Mar; 12(2): 93-9. PMID: 11875363, ISSN: 0960-314X.