Kshipra Singh, Ph.D.

Research Instructor

kshipra.singh@vanderbilt.edu
Faculty Appointments
Research Instructor in Medicine
Education
Ph.D., Central Drug Research Institute , Lucknow, IndiaM.Sc., Central Drug Research Institute , Lucknow, India
Office Address
2215 Garland Ave
Nashville, TN
Publications
Singh K, Al-Greene NT, Verriere TG, Coburn LA, Asim M, Barry DP, Allaman MM, Hardbower DM, Delgado AG, Piazuelo MB, Vallance BA, Gobert AP, Wilson KT. The L-Arginine Transporter Solute Carrier Family 7 Member 2 Mediates the Immunopathogenesis of Attaching and Effacing Bacteria. PLoS Pathog. 2016 Oct; 12(10): e1005984. PMID: 27783672, PII: PPATHOGENS-D-16-01126, DOI: 10.1371/journal.ppat.1005984, ISSN: 1553-7374.

Poindexter SV, Reddy VK, Mittal MK, Williams AM, Washington MK, Harris E, Mah A, Hiebert SW, Singh K, Chaturvedi R, Wilson KT, Lund PK, Williams CS. Transcriptional corepressor MTG16 regulates small intestinal crypt proliferation and crypt regeneration after radiation-induced injury. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2015 Mar 3/15/2015; 308(6): G562-71. PMID: 25573176, PMCID: PMC4360050, PII: ajpgi.00253.2014, DOI: 10.1152/ajpgi.00253.2014, ISSN: 1522-1547.

Van Kaer L, Algood HM, Singh K, Parekh VV, Greer MJ, Piazuelo MB, Weitkamp JH, Matta P, Chaturvedi R, Wilson KT, Olivares-Villagómez D. CD8aa¿ innate-type lymphocytes in the intestinal epithelium mediate mucosal immunity. Immunity [print-electronic]. 2014 Sep 9/18/2014; 41(3): 451-64. PMID: 25220211, PMCID: PMC4169715, PII: S1074-7613(14)00304-5, DOI: 10.1016/j.immuni.2014.08.010, ISSN: 1097-4180.

Williams CS, Bradley AM, Chaturvedi R, Singh K, Piazuelo MB, Chen X, McDonough EM, Schwartz DA, Brown CT, Allaman MM, Coburn LA, Horst SN, Beaulieu DB, Choksi YA, Washington MK, Williams AD, Fisher MA, Zinkel SS, Peek RM, Wilson KT, Hiebert SW. MTG16 contributes to colonic epithelial integrity in experimental colitis. Gut [print-electronic]. 2013 Oct; 62(10): 1446-55. PMID: 22833394, PMCID: PMC3663894, PII: gutjnl-2011-301439, DOI: 10.1136/gutjnl-2011-301439, ISSN: 1468-3288.

Singh K, Coburn LA, Barry DP, Asim M, Scull BP, Allaman MM, Lewis ND, Washington MK, Rosen MJ, Williams CS, Chaturvedi R, Wilson KT. Deletion of cationic amino acid transporter 2 exacerbates dextran sulfate sodium colitis and leads to an IL-17-predominant T cell response. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2013 Aug 8/1/2013; 305(3): G225-40. PMID: 23703655, PMCID: PMC3742860, PII: ajpgi.00091.2013, DOI: 10.1152/ajpgi.00091.2013, ISSN: 1522-1547.

Coburn LA, Horst SN, Chaturvedi R, Brown CT, Allaman MM, Scull BP, Singh K, Piazuelo MB, Chitnavis MV, Hodges ME, Rosen MJ, Williams CS, Slaughter JC, Beaulieu DB, Schwartz DA, Wilson KT. High-throughput multi-analyte Luminex profiling implicates eotaxin-1 in ulcerative colitis. PLoS ONE. 2013; 8(12): e82300. PMID: 24367513, PMCID: PMC3867379, PII: PONE-D-13-38373, DOI: 10.1371/journal.pone.0082300, ISSN: 1932-6203.

Barrett CW, Singh K, Motley AK, Lintel MK, Matafonova E, Bradley AM, Ning W, Poindexter SV, Parang B, Reddy VK, Chaturvedi R, Fingleton BM, Washington MK, Wilson KT, Davies SS, Hill KE, Burk RF, Williams CS. Dietary selenium deficiency exacerbates DSS-induced epithelial injury and AOM/DSS-induced tumorigenesis. PLoS ONE [electronic-print]. 2013; 8(7): e67845. PMID: 23861820, PMCID: PMC3701622, PII: PONE-D-13-14817, DOI: 10.1371/journal.pone.0067845, ISSN: 1932-6203.

Chang TC, Budenz DL, Liu A, Kim WI, Dang T, Li C, Iwach AG, Radhakrishnan S, Singh K. Long-term effect of phacoemulsification on intraocular pressure using phakic fellow eye as control. J Cataract Refract Surg [print-electronic]. 2012 May; 38(5): 866-70. PMID: 22370470, PII: S0886-3350(12)00141-1, DOI: 10.1016/j.jcrs.2012.01.016, ISSN: 1873-4502.

Singh K, Coburn LA, Barry DP, Boucher JL, Chaturvedi R, Wilson KT. L-arginine uptake by cationic amino acid transporter 2 is essential for colonic epithelial cell restitution. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2012 May 5/1/2012; 302(9): G1061-73. PMID: 22361732, PMCID: PMC3362080, PII: ajpgi.00544.2011, DOI: 10.1152/ajpgi.00544.2011, ISSN: 1522-1547.

Coburn LA, Gong X, Singh K, Asim M, Scull BP, Allaman MM, Williams CS, Rosen MJ, Washington MK, Barry DP, Piazuelo MB, Casero RA, Chaturvedi R, Zhao Z, Wilson KT. L-arginine supplementation improves responses to injury and inflammation in dextran sulfate sodium colitis. PLoS ONE [print-electronic]. 2012; 7(3): e33546. PMID: 22428068, PMCID: PMC3299802, PII: PONE-D-12-00729, DOI: 10.1371/journal.pone.0033546, ISSN: 1932-6203.

Olivares-Villagómez D, Algood HM, Singh K, Parekh VV, Ryan KE, Piazuelo MB, Wilson KT, Van Kaer L. Intestinal epithelial cells modulate CD4 T cell responses via the thymus leukemia antigen. J. Immunol [print-electronic]. 2011 Oct 10/15/2011; 187(8): 4051-60. PMID: 21900182, PMCID: PMC3186831, PII: jimmunol.1101052, DOI: 10.4049/jimmunol.1101052, ISSN: 1550-6606.

Lewis ND, Asim M, Barry DP, de Sablet T, Singh K, Piazuelo MB, Gobert AP, Chaturvedi R, Wilson KT. Immune evasion by Helicobacter pylori is mediated by induction of macrophage arginase II. J. Immunol [print-electronic]. 2011 Mar 3/15/2011; 186(6): 3632-41. PMID: 21296975, PMCID: PMC3069806, PII: jimmunol.1003431, DOI: 10.4049/jimmunol.1003431, ISSN: 1550-6606.

Singh K, Chaturvedi R, Barry DP, Coburn LA, Asim M, Lewis ND, Piazuelo MB, Washington MK, Vitek MP, Wilson KT. The apolipoprotein E-mimetic peptide COG112 inhibits NF-kappaB signaling, proinflammatory cytokine expression, and disease activity in murine models of colitis. J. Biol. Chem [print-electronic]. 2011 Feb 2/4/2011; 286(5): 3839-50. PMID: 21115487, PMCID: PMC3030385, PII: M110.176719, DOI: 10.1074/jbc.M110.176719, ISSN: 1083-351X.

Barry DP, Asim M, Scull BP, Piazuelo MB, de Sablet T, Lewis ND, Coburn LA, Singh K, Ellies LG, Gobert AP, Chaturvedi R, Wilson KT. Cationic amino acid transporter 2 enhances innate immunity during Helicobacter pylori infection. PLoS ONE [print-electronic]. 2011; 6(12): e29046. PMID: 22194986, PMCID: PMC3237590, PII: PONE-D-11-18825, DOI: 10.1371/journal.pone.0029046, ISSN: 1932-6203.

Barry DP, Asim M, Leiman DA, de Sablet T, Singh K, Casero RA, Chaturvedi R, Wilson KT. Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction. PLoS ONE. 2011; 6(2): e17510. PMID: 21386987, PMCID: PMC3046249, DOI: 10.1371/journal.pone.0017510, ISSN: 1932-6203.

Chaturvedi R, Asim M, Hoge S, Lewis ND, Singh K, Barry DP, de Sablet T, Piazuelo MB, Sarvaria AR, Cheng Y, Closs EI, Casero RA, Gobert AP, Wilson KT. Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production. Gastroenterology [print-electronic]. 2010 Nov; 139(5): 1686-98, 1698.e1. PMID: 20600019, PMCID: PMC2967614, PII: S0016-5085(10)01003-6, DOI: 10.1053/j.gastro.2010.06.060, ISSN: 1528-0012.

Asim M, Chaturvedi R, Hoge S, Lewis ND, Singh K, Barry DP, Algood HS, de Sablet T, Gobert AP, Wilson KT. Helicobacter pylori induces ERK-dependent formation of a phospho-c-Fos c-Jun activator protein-1 complex that causes apoptosis in macrophages. J. Biol. Chem [print-electronic]. 2010 Jun 6/25/2010; 285(26): 20343-57. PMID: 20410304, PMCID: PMC2888446, PII: M110.116988, DOI: 10.1074/jbc.M110.116988, ISSN: 1083-351X.

Lewis ND, Asim M, Barry DP, Singh K, de Sablet T, Boucher JL, Gobert AP, Chaturvedi R, Wilson KT. Arginase II restricts host defense to Helicobacter pylori by attenuating inducible nitric oxide synthase translation in macrophages. J. Immunol [print-electronic]. 2010 Mar 3/1/2010; 184(5): 2572-82. PMID: 20097867, PMCID: PMC2841360, PII: jimmunol.0902436, DOI: 10.4049/jimmunol.0902436, ISSN: 1550-6606.