Bhuminder Singh, Ph.D.

Assistant Professor

bhuminder.singh@vanderbilt.edu

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Faculty Appointments
Assistant Professor of Medicine
Education
Ph.D., Molecular/Cancer Biology, Max Planck Institute of Biochemistry, Munich, GermanyM.Sc., Biomedical Sciences, University of Delhi, Delhi, IndiaB.Sc., University of Delhi, Delhi, India
Office Address
2213 Garland Avenue
10415A, MRB-IV
Nashville, TN 37232-0441
Publications
Li C, Singh B, Graves-Deal R, Ma H, Starchenko A, Fry WH, Lu Y, Wang Y, Bogatcheva G, Khan MP, Milne GL, Zhao S, Ayers GD, Li N, Hu H, Washington MK, Yeatman TJ, McDonald OG, Liu Q, Coffey RJ. Three-dimensional culture system identifies a new mode of cetuximab resistance and disease-relevant genes in colorectal cancer. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2017 Apr 4/4/2017; 114(14): E2852-E2861. PMID: 28320945, PMCID: PMC5389279, PII: 1618297114, DOI: 10.1073/pnas.1618297114, ISSN: 1091-6490.

Starchenko A, Graves-Deal R, Yang YP, Li C, Zent R, Singh B, Coffey RJ. Clustering of Integrin alpha 5 at the lateral membrane restores epithelial polarity in invasive colorectal cancer cells. Mol. Biol. Cell [print-electronic]. 2017 Mar 3/29/2017; PMID: 28356422, PII: mbc.E16-12-0852, DOI: 10.1091/mbc.E16-12-0852, ISSN: 1939-4586.

Singh B, Bogatcheva G, Starchenko A, Sinnaeve J, Lapierre LA, Williams JA, Goldenring JR, Coffey RJ. Induction of lateral lumens through disruption of a monoleucine-based basolateral-sorting motif in betacellulin. J. Cell. Sci [print-electronic]. 2015 Sep 9/15/2015; 128(18): 3444-55. PMID: 26272915, PMCID: PMC4582402, PII: jcs.170852, DOI: 10.1242/jcs.170852, ISSN: 1477-9137.

Singh B, Coffey RJ. From wavy hair to naked proteins: the role of transforming growth factor alpha in health and disease. Semin. Cell Dev. Biol [print-electronic]. 2014 Apr; 28: 12-21. PMID: 24631356, PMCID: PMC4105142, PII: S1084-9521(14)00031-7, DOI: 10.1016/j.semcdb.2014.03.003, ISSN: 1096-3634.

Singh B, Coffey RJ. Trafficking of epidermal growth factor receptor ligands in polarized epithelial cells. Annu. Rev. Physiol [print-electronic]. 2014; 76: 275-300. PMID: 24215440, PMCID: PMC4180094, DOI: 10.1146/annurev-physiol-021113-170406, ISSN: 1545-1585.

Singh B, Bogatcheva G, Washington MK, Coffey RJ. Transformation of polarized epithelial cells by apical mistrafficking of epiregulin. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2013 May 5/28/2013; 110(22): 8960-5. PMID: 23671122, PMCID: PMC3670353, PII: 1305508110, DOI: 10.1073/pnas.1305508110, ISSN: 1091-6490.

Gephart JD, Singh B, Higginbotham JN, Franklin JL, Gonzalez A, Fölsch H, Coffey RJ. Identification of a novel mono-leucine basolateral sorting motif within the cytoplasmic domain of amphiregulin. Traffic [print-electronic]. 2011 Dec; 12(12): 1793-804. PMID: 21917092, PMCID: PMC3886124, DOI: 10.1111/j.1600-0854.2011.01282.x, ISSN: 1600-0854.

Singh B, Schneider M, Knyazev P, Ullrich A. UV-induced EGFR signal transactivation is dependent on proligand shedding by activated metalloproteases in skin cancer cell lines. Int. J. Cancer. 2009 Feb 2/1/2009; 124(3): 531-9. PMID: 19003995, DOI: 10.1002/ijc.23974, ISSN: 1097-0215.

Chopra P, Singh B, Singh R, Vohra R, Koul A, Meena LS, Koduri H, Ghildiyal M, Deol P, Das TK, Tyagi AK, Singh Y. Phosphoprotein phosphatase of Mycobacterium tuberculosis dephosphorylates serine-threonine kinases PknA and PknB. Biochem. Biophys. Res. Commun. 2003 Nov 11/7/2003; 311(1): 112-20. PMID: 14575702, PII: S0006291X03020011, ISSN: 0006-291X.